David C. Tscharke
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View article: Herpes simplex virus type 1 impairs mucosal-associated invariant T cells
Herpes simplex virus type 1 impairs mucosal-associated invariant T cells Open
Herpes simplex virus type 1 (HSV-1) is a highly successful pathogen that infects mucosal sites and adopts an arsenal of strategies to manipulate host immunity. Mucosal-associated invariant T (MAIT) cells are abundant innate-like T lymphocy…
View article: Mass spectrometry-based thermostability profiling of virus-derived MHC peptide complexes serves as an effective predictor of immunogenicity
Mass spectrometry-based thermostability profiling of virus-derived MHC peptide complexes serves as an effective predictor of immunogenicity Open
The major histocompatibility complex (MHC) encodes molecules that present peptides on the surface of cells to stimulate T-cell-mediated immune responses. The stability of peptide-MHC class I complexes (pMHCI) has been postulated to influen…
View article: A quantitative approach to poxvirus infection reveals general correlates of antigen presentation and immunogenicity for viral CD8<sup>+</sup>T cell epitopes
A quantitative approach to poxvirus infection reveals general correlates of antigen presentation and immunogenicity for viral CD8<sup>+</sup>T cell epitopes Open
CD8 + T cells are essential effectors in antiviral immunity that kill infected cells displaying viral peptide epitopes on MHC class I. The pathways underpinning antigen presentation on MHC I are well known but we lack a general understandi…
View article: Lytic promoter activity during herpes simplex virus latency is dependent on genome location
Lytic promoter activity during herpes simplex virus latency is dependent on genome location Open
Herpes simplex virus 1 (HSV-1) is a significant pathogen that establishes lifelong latent infections with intermittent episodes of resumed disease. In mouse models of HSV infection, sporadic low-level lytic gene expression has been detecte…
View article: The Cheshire Clown
The Cheshire Clown Open
Tässä teoksessa tarkastellaan huumorin käsitettä ja sen suhdetta ihmisen käyttäytymiseen. Kirjan luvut kattavat laajan ajanjakson ulottuen 1500-luvulta nykypäivään. Niissä syvennytään erilaisiin kulttuurisiin konteksteihin, sosiaalisten no…
View article: Moral Dimensions of Humour
Moral Dimensions of Humour Open
This volume explores the concept of humour and its relationship with human behaviour. The interdisciplinary essays in this book cover a wide range of time, from the sixteenth century to the present day. They delve into various cultural con…
View article: GPR41 and GPR43 regulate CD8+ T cell priming during herpes simplex virus type 1 infection
GPR41 and GPR43 regulate CD8+ T cell priming during herpes simplex virus type 1 infection Open
Naïve CD8 + T cells need to undergo a complex and coordinated differentiation program to gain the capacity to control virus infections. This not only involves the acquisition of effector functions, but also regulates the development of a s…
View article: DOCK2 Deficiency Causes Defects in Antiviral T-Cell Responses and Impaired Control of Herpes Simplex Virus Infection
DOCK2 Deficiency Causes Defects in Antiviral T-Cell Responses and Impaired Control of Herpes Simplex Virus Infection Open
The expanding number of rare immunodeficiency syndromes offers an opportunity to understand key genes that support immune defense against infectious diseases. However, analysis of these in patients is complicated by their treatments and co…
View article: Multi-targeted loss of the antigen presentation molecule MR1 during HSV-1 and HSV-2 infection
Multi-targeted loss of the antigen presentation molecule MR1 during HSV-1 and HSV-2 infection Open
View article: Genomic location dictates lytic promoter activity during herpes simplex virus latency
Genomic location dictates lytic promoter activity during herpes simplex virus latency Open
Herpes simplex virus 1 (HSV-1) is a significant pathogen that establishes life-long latent infections with intermittent episodes of resumed disease. In mouse models of HSV infection, persistent low-level lytic gene expression has been dete…
View article: The expression and function of HSV ICP47 and its promoter in mice
The expression and function of HSV ICP47 and its promoter in mice Open
Herpes simplex virus (HSV) protein immediate early-infected cell protein (ICP)47 inhibits the transporter associated with antigen presentation, thereby concealing infected cells from the CD8 + T-cell response in humans. By contrast, in mou…
View article: Need to know which MHCs protect against COVID? There's an App for that!
Need to know which MHCs protect against COVID? There's an App for that! Open
In this article, we discuss the recent observation by Augusto et al. made using a novel mobile phone application-based COVID-19 Citizen Science Study that an HLA genetic variant, HLA-B*15:01, is associated with asymptomatic SARS-CoV-2 infe…
View article: DOCK2-deficiency causes defects in anti-viral T cell responses and poor control of herpes simplex virus infection
DOCK2-deficiency causes defects in anti-viral T cell responses and poor control of herpes simplex virus infection Open
The expanding number of rare immunodeficiency syndromes offers an opportunity to understand key genes that support immune defence against infectious diseases. However, patients with these diseases are by definition rare. In addition, any a…
View article: BMX-A and BMX-S: Accessible cell-free methods to estimate peptide-MHC-I affinity and stability
BMX-A and BMX-S: Accessible cell-free methods to estimate peptide-MHC-I affinity and stability Open
The affinity and stability of peptide binding to Major Histocompatibility Complex Class I (MHC-I) molecules are fundamental parameters that underpin the specificity and magnitude of CD8+ T cell responses. These parameters can be…
View article: CTLA4 protects against maladaptive cytotoxicity during the differentiation of effector and follicular CD4+ T cells
CTLA4 protects against maladaptive cytotoxicity during the differentiation of effector and follicular CD4+ T cells Open
View article: Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”
Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse” Open
We, members of the Australasian Virology Society, agree with and support the statement entitled “Virology under the Microscope—a Call for Rational Discourse” (1). Like virologists everywhere, we have worked with scientist and clinician col…
View article: Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”
Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse” Open
We, members of the Australasian Virology Society, agree with and support the statement entitled “Virology under the Microscope—a Call for Rational Discourse” (1). Like virologists everywhere, we have worked with scientist and clinician col…
View article: Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”
Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse” Open
We, members of the Australasian Virology Society, agree with and support the statement entitled “Virology under the Microscope—a Call for Rational Discourse” (1). Like virologists everywhere, we have worked with scientist and clinician col…
View article: Supplementary Figure 6 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting
Supplementary Figure 6 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting Open
Cytokines present in serum of ACTIV-treated mice.
View article: Data from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting
Data from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting Open
Purpose: While adoptive transfer of T cells bearing a chimeric antigen receptor (CAR) can eliminate substantial burdens of some leukemias, the ultimate challenge remains the eradication of large solid tumors for most cancers. We aim…
View article: Supplementary Figure 6 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting
Supplementary Figure 6 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting Open
Cytokines present in serum of ACTIV-treated mice.
View article: Supplementary Figure 3 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting
Supplementary Figure 3 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting Open
CAR T cells lacking the pMEL TCR are less effective than CARaMEL T cells at inhibiting tumor growth.
View article: Supplementary Figure 1 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting
Supplementary Figure 1 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting Open
Dual-specific T cells respond against both gp100 and Her2.
View article: Supplementary Figure 5 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting
Supplementary Figure 5 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting Open
CARaMEL T cells persist in long term surviving mice.
View article: Supplementary Figure 2 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting
Supplementary Figure 2 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting Open
High dose IL-2 enables durable tumor regression and proliferation of T cells.
View article: Supplementary Figure 3 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting
Supplementary Figure 3 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting Open
CAR T cells lacking the pMEL TCR are less effective than CARaMEL T cells at inhibiting tumor growth.
View article: Supplementary Figure 5 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting
Supplementary Figure 5 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting Open
CARaMEL T cells persist in long term surviving mice.
View article: Supplementary Figure 2 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting
Supplementary Figure 2 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting Open
High dose IL-2 enables durable tumor regression and proliferation of T cells.
View article: Supplementary Figure 1 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting
Supplementary Figure 1 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting Open
Dual-specific T cells respond against both gp100 and Her2.
View article: Supplementary Figure 4 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting
Supplementary Figure 4 from Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting Open
ACTIV therapy induces cytokine secretion and apoptosis of tumor cells.