Yu‐Chieh Chen
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View article: High-resolution single-cell analyses reveal evolutionary constraints and evolvability of sexual circuits in <i>Drosophila</i>
High-resolution single-cell analyses reveal evolutionary constraints and evolvability of sexual circuits in <i>Drosophila</i> Open
Understanding how the cellular and molecular composition of neural circuits evolves to generate species-specific behaviors remains a major challenge in evolutionary biology and neuroscience. The remarkable diversity of male sexual behavior…
View article: Efficacy Evaluation of an E2 Subunit Vaccine Against Highly Virulent Classical Swine Fever Virus Strain
Efficacy Evaluation of an E2 Subunit Vaccine Against Highly Virulent Classical Swine Fever Virus Strain Open
Background/Objectives: Classical swine fever (CSF) is listed by the World Organisation for Animal Health as a highly devastating and contagious pig disease, causing severe economic losses to the swine industry. In spite of the successful e…
View article: Development of an Effective Single-Dose PCV2/CSFV Bivalent Subunit Vaccine Against Classical Swine Fever Virus and Porcine Circovirus Type 2
Development of an Effective Single-Dose PCV2/CSFV Bivalent Subunit Vaccine Against Classical Swine Fever Virus and Porcine Circovirus Type 2 Open
Background/Objectives: Porcine Circovirus Type 2 (PCV2) impairs pigs’ immune systems and increases susceptibility to co-infections, including Classical Swine Fever (CSF), a highly contagious disease listed by the World Organisation for Ani…
View article: Deciphering the combinatorial expression pattern and genetic regulatory mechanisms of Beats and Sides in the olfactory circuits of <i>Drosophila</i>
Deciphering the combinatorial expression pattern and genetic regulatory mechanisms of Beats and Sides in the olfactory circuits of <i>Drosophila</i> Open
Over the past decades, many critical molecular players have been uncovered to control distinct steps in olfactory circuit assembly in Drosophila. Among these, multi-member gene families of cell surface proteins are of interest because they…
View article: A library of lineage-specific driver lines connects developing neuronal circuits to behavior in the Drosophila ventral nerve cord
A library of lineage-specific driver lines connects developing neuronal circuits to behavior in the Drosophila ventral nerve cord Open
Understanding developmental changes in neuronal lineages is crucial to elucidate how they assemble into functional neural networks. Studies investigating nervous system development in model systems have only focused on select regions of th…
View article: A library of lineage-specific driver lines connects developing neuronal circuits to behavior in the Drosophila Ventral Nerve Cord
A library of lineage-specific driver lines connects developing neuronal circuits to behavior in the Drosophila Ventral Nerve Cord Open
Understanding developmental changes in neuronal lineages is crucial to elucidate how they assemble into functional neural networks. Studies investigating nervous system development in model systems have only focused on select regions of th…
View article: High-resolution comparative single-cell transcriptomics of doublesex-expressing neurons reveals evolutionary conservation and diversity of sexual circuits in Drosophila
High-resolution comparative single-cell transcriptomics of doublesex-expressing neurons reveals evolutionary conservation and diversity of sexual circuits in Drosophila Open
Understanding how the cellular and molecular composition of neural circuits change during evolution is essential for deciphering how behavior evolves. Male sexual behaviors in Drosophila species are remarkably diverse, and the underlying s…
View article: A library of lineage-specific driver lines connects developing neuronal circuits to behavior in the Drosophila ventral nerve cord
A library of lineage-specific driver lines connects developing neuronal circuits to behavior in the Drosophila ventral nerve cord Open
Understanding developmental changes in neuronal lineages is crucial to elucidate how they assemble into functional neural networks. Studies investigating nervous system development in model systems have only focused on select regions of th…
View article: A library of lineage-specific driver lines connects developing neuronal circuits to behavior in the Drosophila Ventral Nerve Cord
A library of lineage-specific driver lines connects developing neuronal circuits to behavior in the Drosophila Ventral Nerve Cord Open
Understanding the developmental changes in neuronal lineages is crucial to elucidate how they assemble into functional neural networks. Studies investigating nervous system development in model systems have focused on only on a few regions…
View article: Decoding neuronal wiring by joint inference of cell identity and synaptic connectivity
Decoding neuronal wiring by joint inference of cell identity and synaptic connectivity Open
Animal behaviors are executed by motor neurons (MNs), which receive information from complex pre-motor neuron (preMN) circuits and output commands to muscles. How motor circuits are established during development remains an important unsol…
View article: Temporal and Notch identity determine layer targeting and synapse location of medulla neurons
Temporal and Notch identity determine layer targeting and synapse location of medulla neurons Open
How specification mechanisms that generate neural diversity translate into specific neuronal targeting, connectivity, and function in the adult brain is not understood. In the medulla region of the Drosophila optic lobe, neural progenitors…
View article: A library of lineage-specific driver lines connects developing neuronal circuits to behavior in the <i>Drosophila</i> Ventral Nerve Cord
A library of lineage-specific driver lines connects developing neuronal circuits to behavior in the <i>Drosophila</i> Ventral Nerve Cord Open
Understanding developmental changes in neuronal lineages is crucial to elucidate how they assemble into functional neural networks. Studies investigating nervous system development in model systems have only focused on select regions of th…
View article: Correction: Adenosine A2A Receptor Up-Regulates Retinal Wave Frequency via Starburst Amacrine Cells in the Developing Rat Retina
Correction: Adenosine A2A Receptor Up-Regulates Retinal Wave Frequency via Starburst Amacrine Cells in the Developing Rat Retina Open
[This corrects the article DOI: 10.1371/journal.pone.0095090.].
View article: Blinatumomab in Children with MRD-Positive B-Cell Precursor Acute Lymphoblastic Leukemia: A Report of 11 Cases
Blinatumomab in Children with MRD-Positive B-Cell Precursor Acute Lymphoblastic Leukemia: A Report of 11 Cases Open
Background/Objectives: Relapsed B-cell acute lymphoblastic leukemia (B-ALL) remains an unresolved matter of concern regarding adverse outcomes. This case study aimed to evaluate the effectiveness of blinatumomab, with or without door lymph…
View article: Biased cell adhesion organizes a circuit for visual motion integration
Biased cell adhesion organizes a circuit for visual motion integration Open
Layer specific computations in the brain rely on neuronal processes establishing synaptic connections with specific partners in distinct laminae. In the Drosophila lobula plate neuropile, the axons of the four subtypes of T4 and T5 visual …
View article: Protocol for replacing coding intronic MiMIC and CRIMIC lines with T2A-split-GAL4 lines in Drosophila using genetic crosses
Protocol for replacing coding intronic MiMIC and CRIMIC lines with T2A-split-GAL4 lines in Drosophila using genetic crosses Open
Here, we present a protocol for generating gene-specific split-GAL4 drivers from coding intronic Minos-mediated integration cassette/CRISPR-mediated integration cassette (MiMIC/CRIMIC) lines in Drosophila. We describe steps for four rounds…
View article: Using single-cell RNA sequencing to generate predictive cell-type-specific split-GAL4 reagents throughout development
Using single-cell RNA sequencing to generate predictive cell-type-specific split-GAL4 reagents throughout development Open
Cell-type-specific tools facilitate the identification and functional characterization of the distinct cell types that form the complexity of neuronal circuits. A large collection of existing genetic tools in Drosophila relies on enhancer …
View article: Bistable scattering of nano-silicon for super-linear super-resolution imaging
Bistable scattering of nano-silicon for super-linear super-resolution imaging Open
Optical bistability is fundamental for all-optical switches, but typically requires high-Q cavities with micrometer sizes. Through boosting nonlinearity with photo-thermo-optical effects, we achieve bistability in a silicon Mie resonator w…
View article: Using single-cell RNA sequencing to generate cell-type-specific split-GAL4 reagents throughout development
Using single-cell RNA sequencing to generate cell-type-specific split-GAL4 reagents throughout development Open
Cell-type-specific tools facilitate the identification and functional characterization of distinct cell types, which underly the complexity of neuronal circuits. A large collection of existing genetic tools in Drosophila relies on enhancer…
View article: Clinical Characteristics and Prognostic Factors of Non-Infectious Cerebral Venous Sinus Thrombosis
Clinical Characteristics and Prognostic Factors of Non-Infectious Cerebral Venous Sinus Thrombosis Open
Non-infectious cerebral venous thrombosis (CVT) is an uncommon type of cerebrovascular disease that usually affects young patients. It occurs frequently in female patients, probably due to the association of sex-specific risk factors for c…
View article: Altered gut microbiota correlates with behavioral problems but not gastrointestinal symptoms in individuals with autism
Altered gut microbiota correlates with behavioral problems but not gastrointestinal symptoms in individuals with autism Open
Our findings suggest that altered microbiota are associated with behavioral phenotypes but not GI symptoms in ASD. The function of the identified microbial profiles mainly involves the immune pathway, supporting the hypothesis of a complex…
View article: Headline Diagnosis: Manipulation of Content Farm Headlines
Headline Diagnosis: Manipulation of Content Farm Headlines Open
As technology grows faster, the news spreads through social media. In order to attract more readers and acquire additional profit, some news agencies reproduce massive news in a more appealing manner. Therefore, it is essential to accurate…