Yin Cai
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View article: Involvement of the <scp>miR</scp>‐128‐3p/<scp>KDM3A</scp>/<scp>NLRP3</scp> Axis in High Glucose‐Induced Inflammatory Injury in Retinal Endothelial Cells
Involvement of the <span>miR</span>‐128‐3p/<span>KDM3A</span>/<span>NLRP3</span> Axis in High Glucose‐Induced Inflammatory Injury in Retinal Endothelial Cells Open
This study explores the regulatory mechanism of the miR‐128‐3p in diabetic retinopathy (DR)‐associated inflammatory injury. A cellular model of DR was established by inducing immortalized human retinal endothelial cells (IM‐HRECs) with hig…
View article: Endoplasmic reticulum-associated degradation mitigates atherosclerosis by maintaining cellular homeostasis
Endoplasmic reticulum-associated degradation mitigates atherosclerosis by maintaining cellular homeostasis Open
Atherosclerosis (AS) is a fatal cardiovascular disease (CVD) that threatens human health. Although there are some treatments for AS in clinical practice, cardiovascular complications such as myocardial ischemia and hypoxia, heart failure, …
View article: Impact of biomarkers on carotid artery disease and stroke
Impact of biomarkers on carotid artery disease and stroke Open
Stroke poses a significant public health challenge, especially in China, where geographical disparities in incidence rates suggest environmental, genetic, and lifestyle influences on stroke risk. Traditional diagnostic methods, while effec…
View article: Editorial: Function and regulation of non-neuronal cells in the nervous system
Editorial: Function and regulation of non-neuronal cells in the nervous system Open
202507 bcch
View article: Ferroptosis and its Potential Determinant Role in Myocardial Susceptibility to Ischemia/Reperfusion Injury in Diabetes
Ferroptosis and its Potential Determinant Role in Myocardial Susceptibility to Ischemia/Reperfusion Injury in Diabetes Open
Myocardial ischemia/reperfusion injury (MIRI) is a major cause of cardiac death particularly in patients with diabetes. When the coronary artery is partially or completely blocked, restoration of blood perfusion can normally be achieved wi…
View article: Editorial: The complex phenotype of diabetic cardiomyopathy: clinical indicators and novel treatment targets
Editorial: The complex phenotype of diabetic cardiomyopathy: clinical indicators and novel treatment targets Open
202503 bcch
View article: Salvianolic acids and its potential for cardio-protection against myocardial ischemic reperfusion injury in diabetes
Salvianolic acids and its potential for cardio-protection against myocardial ischemic reperfusion injury in diabetes Open
The incidence of diabetes and related mortality rate increase yearly in modern cities. Additionally, elevated glucose levels can result in an increase of reactive oxygen species (ROS), ferroptosis, and the disruption of protective pathways…
View article: Connexin43 overexpression promoted ferroptosis and increased myocardial vulnerability to ischemia-reperfusion injury in type 1 diabetic mice
Connexin43 overexpression promoted ferroptosis and increased myocardial vulnerability to ischemia-reperfusion injury in type 1 diabetic mice Open
Enhancement of Connexin43 (Cx43) and ferroptosis are respectively associated with the exacerbation of myocardial ischemia-reperfusion injury (MIRI) in diabetes. Myocardial vulnerability to ischemic insult has been shown to vary during earl…
View article: Propofol and salvianolic acid A synergistically attenuated cardiac ischemia–reperfusion injury in diabetic mice via modulating the CD36/AMPK pathway
Propofol and salvianolic acid A synergistically attenuated cardiac ischemia–reperfusion injury in diabetic mice via modulating the CD36/AMPK pathway Open
Background Prevention of diabetic heart myocardial ischemia–reperfusion (IR) injury (MIRI) is challenging. Propofol attenuates MIRI through its reactive oxygen species scavenging property at high doses, while its use at high doses causes h…
View article: [Mechanism of propofol-induced apoptosis in neonatal rat oligodendrocytes].
[Mechanism of propofol-induced apoptosis in neonatal rat oligodendrocytes]. Open
Propofol induces apoptosis in oligodendrocytes by activating the caspase family protein members involved in triggering cell apoptosis and inhibiting the anti-apoptosis mechanism.
View article: KIAA1429 REGULATES HIPPO‐YAP PATHWAY TO MAINTAIN THE TUMORIGENICITY OF DIFFUSE LARGE B‐CELL LYMPHOMA VIA AN M6A‐DEPENDENT MANNER
KIAA1429 REGULATES HIPPO‐YAP PATHWAY TO MAINTAIN THE TUMORIGENICITY OF DIFFUSE LARGE B‐CELL LYMPHOMA VIA AN M6A‐DEPENDENT MANNER Open
Introduction: N6-methyladenosine (m6A) is the most abundant form of chemical modification in eukaryotes. m6A methylation is dynamically modulated by diverse types of regulators, including methyltransferases ('writers'), RNA binding protein…
View article: PTGDS PROMOTES TUMORIGENESIS OF PERIPHERAL T CELL LYMPHOMA THROUGH REGULATING IRON METABOLISM
PTGDS PROMOTES TUMORIGENESIS OF PERIPHERAL T CELL LYMPHOMA THROUGH REGULATING IRON METABOLISM Open
Introduction: Accumulating evidence indicates that ferroptosis, an iron-dependent cell death, is involved in the development of tumors, and targeting ferroptosis offers great potential in tumor therapy. However, the regulatory networks of …
View article: THE RNA M6A READER YTHDF2 REGULATES ACER2‐CERAMIDE METABOLIC AXIS TO PROMOTE TUMORIGENESIS OF DIFFUSE LARGE B‐CELL LYMPHOMA
THE RNA M6A READER YTHDF2 REGULATES ACER2‐CERAMIDE METABOLIC AXIS TO PROMOTE TUMORIGENESIS OF DIFFUSE LARGE B‐CELL LYMPHOMA Open
Introduction: N6-methyladenosine (m6A) is the most abundant modification in eukaryotes and plays an important biological function in human diseases. YTHDF2 is an important m6A reading protein, which could specifically bind to m6A-modified …
View article: Alpha‐ketoglutarate Suppresses Tumor Growth of Diffuse Large B‐cell Lymphoma by Inducing Ferroptosis
Alpha‐ketoglutarate Suppresses Tumor Growth of Diffuse Large B‐cell Lymphoma by Inducing Ferroptosis Open
Background: Metabolic reprogramming is one of the vital characteristics of cancers. Glutamine metabolism is an essential metabolic pathway in tumorigenesis, which provides a ready carbon and nitrogen source to support tumor biosynthesis, e…
View article: NAT10 REGULATES THE AMPK SIGNALING PATHWAY TO PROMOTE DLBCL PROGRESSION VIA AC4C ACETYLATION OF SLC30A9 MRNA
NAT10 REGULATES THE AMPK SIGNALING PATHWAY TO PROMOTE DLBCL PROGRESSION VIA AC4C ACETYLATION OF SLC30A9 MRNA Open
Introduction: N-acetyltransferase 10 (NAT10) is the only confirmed regulator to mediate the N4-acetylcytidine (ac4C) modification of mRNA and is crucial for mRNA stability and translation efficiency. However, its role in diffuse large B-ce…
View article: IDENTIFYING A NOVEL DEFINED PYROPTOSIS‐ASSOCIATED SIGNATURE CONTRIBUTES TO PREDICTING PROGNOSIS AND TUMOR MICROENVIRONMENT OF DIFFUSE LARGE B‐CELL LYMPHOMA
IDENTIFYING A NOVEL DEFINED PYROPTOSIS‐ASSOCIATED SIGNATURE CONTRIBUTES TO PREDICTING PROGNOSIS AND TUMOR MICROENVIRONMENT OF DIFFUSE LARGE B‐CELL LYMPHOMA Open
Emerging evidence shows that pyroptosis plays a crucial role in the development and progression of multiple types of cancer. However, there is a limited understanding of the role of pyroptosis in DLBCL. The study aimed to identify pyroptos…
View article: Ionizable drug delivery systems for efficient and selective gene therapy
Ionizable drug delivery systems for efficient and selective gene therapy Open
Gene therapy has shown great potential to treat various diseases by repairing the abnormal gene function. However, a great challenge in bringing the nucleic acid formulations to the market is the safe and effective delivery to the specific…
View article: Editorial: Natural products targeting oxidative stress and cell death: Treatment potential in metabolic and cardiovascular diseases
Editorial: Natural products targeting oxidative stress and cell death: Treatment potential in metabolic and cardiovascular diseases Open
EDITORIAL article Front. Pharmacol., 01 February 2023Sec. Ethnopharmacology Volume 14 - 2023 | https://doi.org/10.3389/fphar.2023.1141878
View article: FGF21–Sirtuin 3 Axis Confers the Protective Effects of Exercise Against Diabetic Cardiomyopathy by Governing Mitochondrial Integrity
FGF21–Sirtuin 3 Axis Confers the Protective Effects of Exercise Against Diabetic Cardiomyopathy by Governing Mitochondrial Integrity Open
Background: Exercise is an effective nonpharmacological strategy to alleviate diabetic cardiomyopathy (DCM) through poorly defined mechanisms. FGF21 (fibroblast growth factor 21), a peptide hormone with pleiotropic benefits on cardiometabo…
View article: Effects of targeted-edited oncogenic insulin-like growth factor-1 receptor with specific-sgRNA on biological behaviors of HepG2 cells
Effects of targeted-edited oncogenic insulin-like growth factor-1 receptor with specific-sgRNA on biological behaviors of HepG2 cells Open
Edited oncogenic IGF-1R was useful to inhibit biological behaviors of HepG2 cells.