David Chirio
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View article: To Switch or not to Switch to Long-acting Injectable Cabotegravir/Rilpivirine in PWH With Past Hepatitis B Virus (HBV) Coinfection: Which HBV Markers to Manage Risk of HBV Reactivation?
To Switch or not to Switch to Long-acting Injectable Cabotegravir/Rilpivirine in PWH With Past Hepatitis B Virus (HBV) Coinfection: Which HBV Markers to Manage Risk of HBV Reactivation? Open
We report the occurrence of low-level hepatitis B virus (HBV) viremia in people with HIV with controlled CD4 counts and isolated core antibody reactivity switched to long-acting injectable cabotegravir/rilpivirine. This series raises quest…
View article: Immunosenescence markers in T- and NK-cells according to the CD4/CD8 ratio in successfully treated people living with HIV
Immunosenescence markers in T- and NK-cells according to the CD4/CD8 ratio in successfully treated people living with HIV Open
Introduction The CD4/CD8 ratio has emerged as a useful indicator of immune dysfunction and comorbid conditions in people living with HIV (PLWH). However, its optimal cut-off value is unclear. We explored the correlation between the CD4/CD8…
View article: Psychiatric outcomes in outpatients affected by long COVID: A link between mental health and persistence of olfactory complaint
Psychiatric outcomes in outpatients affected by long COVID: A link between mental health and persistence of olfactory complaint Open
BACKGROUND Anosmia was one of the main symptoms of coronavirus disease 2019 (COVID-19). A psychiatric history (i.e., depression) may be an independent contributor to the risk of COVID-19 diagnosis, and COVID-19 survivors appear to have an …
View article: Olfactory Training in Post-COVID-19 Persistent Olfactory Disorders: Value Normalization for Threshold but Not Identification
Olfactory Training in Post-COVID-19 Persistent Olfactory Disorders: Value Normalization for Threshold but Not Identification Open
(1) Background: Persistent post-viral olfactory disorders (PPVOD) are estimated at 30% of patients one year after COVID-19 infection. No treatment is, to date, significantly effective on PPVOD with the exception of olfactory training (OT).…
View article: Correlations between Persistent Olfactory and Semantic Memory Disorders after SARS-CoV-2 Infection
Correlations between Persistent Olfactory and Semantic Memory Disorders after SARS-CoV-2 Infection Open
Background: One of the main symptoms of COVID-19 is hyposmia or even anosmia. Olfactory identification is most often affected. In addition, some cognitive disorders tend to appear following the infection, particularly regarding executive f…
View article: OLFACTORY TRAINING EFFICIENCY IN POST-COVID-19 PERSISTENT OLFACTORY DISORDERS
OLFACTORY TRAINING EFFICIENCY IN POST-COVID-19 PERSISTENT OLFACTORY DISORDERS Open
Background Persistent post-viral olfactory disorders (PPVOD) are widely reported after a COVID-19 and estimate to 30% one year after infection. Parosmias are the main qualitative dysosmia associated with olfaction recovery. No treatment is…
View article: WHAT ABOUT USING SNIFFIN’ STICKS 12 SCREENING TEST TO IDENTIFY POST-COVID-19 OLFACTORY DISORDERS?
WHAT ABOUT USING SNIFFIN’ STICKS 12 SCREENING TEST TO IDENTIFY POST-COVID-19 OLFACTORY DISORDERS? Open
Background Olfactory impairment is a major sequela of SARS-CoV-2 infection and has a negative impact on daily life quality. Olfactory loss can be assessed in many ways but seems to be little realized in a daily clinical practice. The sniff…
View article: Spread of the SARS-CoV-2 UK-variant in the South East of France: impact on COVID-19 patients’ age, comorbidity profiles and clinical presentation
Spread of the SARS-CoV-2 UK-variant in the South East of France: impact on COVID-19 patients’ age, comorbidity profiles and clinical presentation Open
Objectives The variant 20I/501Y.V1, associated to a higher risk of transmissibility, emerged in Nice city (South East of France, French Riviera) during January 2021. The pandemic has resumed late December 2020 in this aera. A high incidenc…
View article: Persistent olfactory complaints after COVID-19: a new interpretation of the psychophysical olfactory scores
Persistent olfactory complaints after COVID-19: a new interpretation of the psychophysical olfactory scores Open
Background: Sudden olfactory loss is a major symptom of SARS-CoV-2 infection and has a negative impact on daily life quality. Almost 80% of disorders regress spontaneously. No precise characterization of the medium- and long-term olfactory…
View article: Spread of the SARS-CoV-2 UK-variant in the South East of France: impact on COVID-19 patients age, comorbidity profiles and clinical presentation
Spread of the SARS-CoV-2 UK-variant in the South East of France: impact on COVID-19 patients age, comorbidity profiles and clinical presentation Open
Objectives: The variant 20I/501Y.V1, associated to a higher risk of transmissibility, emerged in Nice city (South East of France, French Riviera) during January 2021. The pandemic has resumed late December 2020 in this aera. A high inciden…
View article: Heterogeneous NLRP3 inflammasome signature in circulating myeloid cells as a biomarker of COVID-19 severity
Heterogeneous NLRP3 inflammasome signature in circulating myeloid cells as a biomarker of COVID-19 severity Open
Dysregulated immune response is the key factor leading to unfavorable coronavirus disease 2019 (COVID-19) outcome. Depending on the pathogen-associated molecular pattern, the NLRP3 inflammasome can play a crucial role during innate immunit…
View article: A Population Pharmacokinetic Analysis of Continuous Infusion of Cloxacillin during <i>Staphylococcus aureus</i> Bone and Joint Infections
A Population Pharmacokinetic Analysis of Continuous Infusion of Cloxacillin during <i>Staphylococcus aureus</i> Bone and Joint Infections Open
Intravenous administration of antibiotics is recommended during the early phase of methicillin-susceptible S. aureus (MSSA) bone and joint infection (BJI). We sought to compare the plasma concentrations of cloxacillin administered alternat…
View article: High Prevalence of Acquired Thrombophilia Without Prognosis Value in Patients With Coronavirus Disease 2019
High Prevalence of Acquired Thrombophilia Without Prognosis Value in Patients With Coronavirus Disease 2019 Open
Background Recent literature reports a strong thrombotic tendency in patients hospitalized for a coronavirus disease 2019 (COVID‐19) infection. This characteristic is unusual and seems specific to COVID‐19 infections, especially in their s…
View article: Hepatitis Rebound after Infection with Yellow Fever Virus
Hepatitis Rebound after Infection with Yellow Fever Virus Open
In 2018, yellow fever with hepatitis was diagnosed for 2 unvaccinated travelers returning to France from Brazil. Hepatitis persisted for >6 months; liver enzyme levels again increased 2 months after disease onset with no detection of yello…
View article: Impact de l’ouverture H24 du laboratoire du C.H.U. de Nice sur la prise en charge des bactériémies
Impact de l’ouverture H24 du laboratoire du C.H.U. de Nice sur la prise en charge des bactériémies Open
Background: Rapid microbial identification is pivotal in order to adapt antibiotic treatment and ensure its efficacy in bloodstream infections. We aimed to evaluate the clinical impact of an uninterrupted around the clock processing of blo…