Choon Hyuck David Kwon
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View article: A behavioral assay for measuring acute itch in mice v1
A behavioral assay for measuring acute itch in mice v1 Open
Here we present a protocol for measuring mouse behavioral responses to acute itch stimuli. The experimenter injects mice intradermally with a pruritogen, then allows them to move freely within an enclosure. Behavior is recorded with HD vid…
View article: Circulating Tumor DNA in Primary and Secondary Liver Cancers: A Comprehensive Review
Circulating Tumor DNA in Primary and Secondary Liver Cancers: A Comprehensive Review Open
Similar to many other cancer types, liver malignancies pose the common challenges of late detection of primary tumors and recurrences. Liquid biopsies, which assess the presence of circulating tumor DNA, have emerged as a novel, non-invasi…
View article: Nutrient-gene therapy as a strategy to enhance CAR T cell function and overcome barriers in the tumor microenvironment
Nutrient-gene therapy as a strategy to enhance CAR T cell function and overcome barriers in the tumor microenvironment Open
Cancer immunotherapy is transforming the treatment landscape of both hematological and solid cancers. Although T-cell-based adoptive cell transfer (ACT) therapies have demonstrated initial success, several recurrent obstacles limit their l…
View article: Targeting DNA helicase CMG complex and NFκB2-driven drug-resistant transcriptional axis to effectively treat KRASG12D-mutated pancreatic cancer
Targeting DNA helicase CMG complex and NFκB2-driven drug-resistant transcriptional axis to effectively treat KRASG12D-mutated pancreatic cancer Open
View article: Transforming Transplant Oversight: Enhancing Combined Cardiothoracic Surgery and Liver Transplantation With Normothermic Machine Perfusion
Transforming Transplant Oversight: Enhancing Combined Cardiothoracic Surgery and Liver Transplantation With Normothermic Machine Perfusion Open
Background. Simultaneous cardiothoracic surgery and liver transplantation (LT) is a high-risk procedure associated with high mortality and morbidity rates. The use of normothermic machine perfusion (NMP) allows graft quality enhancement, a…
View article: Discovery and Characterization of Small Molecule Inhibitors Targeting Exonuclease 1 for Homologous Recombination-Deficient Cancer Therapy
Discovery and Characterization of Small Molecule Inhibitors Targeting Exonuclease 1 for Homologous Recombination-Deficient Cancer Therapy Open
Human exonuclease 1 (EXO1), a member of the structure-specific nuclease family, plays a critical role in maintaining genome stability by processing DNA double-strand breaks (DSBs), nicks, and replication intermediates during DNA replicatio…
View article: Recipient 3-Hepatic Vein Technique with Graft Venoplasty to Maximize Venous Outflow in Left Lobe Living Donor Liver Transplantation
Recipient 3-Hepatic Vein Technique with Graft Venoplasty to Maximize Venous Outflow in Left Lobe Living Donor Liver Transplantation Open
Background. Augmentation of hepatic venous outflow is crucial in living donor liver transplantation (LDLT) to maximize functional graft size and prevent venous complications. We present details of our outflow augmentation technique for lef…
View article: The first international experience with histotripsy: a safety analysis of 230 cases
The first international experience with histotripsy: a safety analysis of 230 cases Open
To the best of our knowledge, this is the first study to report on the real-world therapeutic use of histotripsy for liver tumors. Histotripsy was well tolerated, with few overall complications and rare serious complications, indicating a …
View article: Effect of Stage Coupling on Optimal Launch Angle in Multi-Stage Projectile Trajectories
Effect of Stage Coupling on Optimal Launch Angle in Multi-Stage Projectile Trajectories Open
A practical question is raised when designing Rube Goldberg-style launch system that traditional single-stage projectile formulas fail to answer well. How would the initial launch angle be selected when the flight is broken into many segme…
View article: Encapsulation and Delivery of the Kinase Inhibitor PIK-75 by Organic Core High-Density Lipoprotein-Like Nanoparticles Targeting Scavenger Receptor Class B Type 1
Encapsulation and Delivery of the Kinase Inhibitor PIK-75 by Organic Core High-Density Lipoprotein-Like Nanoparticles Targeting Scavenger Receptor Class B Type 1 Open
PIK-75 (F7) is a potent multikinase inhibitor that targets p110α, DNA-PK, and p38γ. PIK-75 has shown potential as a therapy in preclinical cancer models, but it has not been used in the clinic, at least in part, due to limited solubility. …
View article: Uterine manipulator simulation: a simple universal uterine model to allow placement and simulation of any uterine manipulator
Uterine manipulator simulation: a simple universal uterine model to allow placement and simulation of any uterine manipulator Open
View article: Circulating Tumor DNA Profiling in Liver Transplant for Hepatocellular Carcinoma, Cholangiocarcinoma, and Colorectal Liver Metastases: A Programmatic Proof of Concept
Circulating Tumor DNA Profiling in Liver Transplant for Hepatocellular Carcinoma, Cholangiocarcinoma, and Colorectal Liver Metastases: A Programmatic Proof of Concept Open
Introduction: Circulating tumor DNA (ctDNA) is emerging as a promising, non-invasive diagnostic and surveillance biomarker in solid organ malignancy. However, its utility before and after liver transplant (LT) for patients with primary and…
View article: Risk assessment in liver transplantation for hepatocellular carcinoma: long-term follow-up of a two-centre experience
Risk assessment in liver transplantation for hepatocellular carcinoma: long-term follow-up of a two-centre experience Open
Background: Liver transplantation (LT) is a well-established treatment for hepatocellular carcinoma (HCC), but there are ongoing debates regarding outcomes and selection. This study examines the experience of LT for HCC at a high-volume ce…
View article: Pharmacological profiling of a berbamine derivative for lymphoma treatment
Pharmacological profiling of a berbamine derivative for lymphoma treatment Open
Ca2+/calmodulin-dependent protein kinase II γ (CAMKIIγ) has been identified as a potential target for treating cancer. Based on our previous study of berbamine (BBM) as a CAMKIIγ inhibitor, we have synthesized a new BBM derivative termed P…
View article: Long-term mortality of living liver donors: a systematic review and meta-analysis
Long-term mortality of living liver donors: a systematic review and meta-analysis Open
Background: Although the outcome of living donor liver transplantation (LDLT) recipients has been developed, concerns remain about donor safety and moral issues.The safety of the living donor is the top priority when performing a living li…
View article: Risk factors associated with surgical morbidities of laparoscopic living liver donors
Risk factors associated with surgical morbidities of laparoscopic living liver donors Open
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View article: Minimally Invasive Versus Open Liver Resections for Hepatocellular Carcinoma in Patients With Metabolic Syndrome
Minimally Invasive Versus Open Liver Resections for Hepatocellular Carcinoma in Patients With Metabolic Syndrome Open
Objective: To compare minimally invasive (MILR) and open liver resections (OLRs) for hepatocellular carcinoma (HCC) in patients with metabolic syndrome (MS). Background: Liver resections for HCC on MS are associated with high perioperative…
View article: Response to Comment on “Living Donor Liver Transplantation With Augmented Venous Outflow and Splenectomy: A Promised Land for Small Left Lobe Grafts”
Response to Comment on “Living Donor Liver Transplantation With Augmented Venous Outflow and Splenectomy: A Promised Land for Small Left Lobe Grafts” Open
We appreciate the comments of Ng et al.1 with regard to our recent study. The authors concluded that our series of living donor liver transplantation (LDLT), especially left lobe graft (LLG)-LDLT was highly selective based on recipient dem…
View article: The High Incidence of Occult Carcinoma in Total Hepatectomy Specimens of Patients Treated for Unresectable Colorectal Liver Metastases With Liver Transplant
The High Incidence of Occult Carcinoma in Total Hepatectomy Specimens of Patients Treated for Unresectable Colorectal Liver Metastases With Liver Transplant Open
Objective: To describe the rate of occult carcinoma deposits in total hepatectomy specimens from patients treated with liver transplant (LT) for colorectal liver metastases (CRLM). Background: Previous studies have shown that patients with…
View article: Model to predict major complications following liver resection for HCC in patients with metabolic syndrome
Model to predict major complications following liver resection for HCC in patients with metabolic syndrome Open
Background: Metabolic syndrome (MS) is rapidly growing as risk factor for HCC. Liver resection for HCC in patients with MS is associated with increased postoperative risks. There are no data on factors associated with postoperative complic…
View article: Initiation of Liver Transplant in Nepal: A Milestone
Initiation of Liver Transplant in Nepal: A Milestone Open
Background. The incidence of chronic liver disease is increasing in the Nepalese population. Liver transplantation (LT) is the best option for patients with end-stage liver disease (ESLD). Nepal’s first liver transplant was performed in 20…
View article: Positive autoantibodies in living liver donors
Positive autoantibodies in living liver donors Open
Isolated pre-transplant autoantibody positivity is not correlated to worse post-transplant outcomes in living liver donor transplants.
View article: Influence of surgical technique in donor hepatectomy on immediate and short‐term living donor outcomes – A systematic review of the literature, meta‐analysis, and expert panel recommendations
Influence of surgical technique in donor hepatectomy on immediate and short‐term living donor outcomes – A systematic review of the literature, meta‐analysis, and expert panel recommendations Open
Background There are currently no guidelines pertaining to ERAS pathways in living donor hepatectomy. Objectives The aim of this study was to identify whether surgical technique influences immediate and short‐term outcomes after living liv…
View article: Recipient and Donor Outcomes After Living-Donor Liver Transplant for Unresectable Colorectal Liver Metastases
Recipient and Donor Outcomes After Living-Donor Liver Transplant for Unresectable Colorectal Liver Metastases Open
Importance Colorectal cancer is a leading cause of cancer-related death, and nearly 70% of patients with this cancer have unresectable colorectal cancer liver metastases (CRLMs). Compared with chemotherapy, liver transplant has been report…
View article: Hepatectomy outcomes in patients with hepatitis C virus-related hepatocellular carcinoma with or without cirrhosis
Hepatectomy outcomes in patients with hepatitis C virus-related hepatocellular carcinoma with or without cirrhosis Open
The cirrhotic group showed poor prognosis due to poor liver function after LR compared to the non-cirrhotic group, but this was not sustained in multivariate analysis. The factors influencing HCC recurrence and death were different in the …
View article: Laparoscopic living donor hepatectomy using the left liver
- pushing the limits further
Laparoscopic living donor hepatectomy using the left liver
- pushing the limits further Open
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View article: Laparoscopic isolated caudate lobectomy for HCC
Laparoscopic isolated caudate lobectomy for HCC Open
Hepatoma Research is an open access journal and focuses on all topics related to hepatoma. The following articles are especially welcome: pathogenesis, clinical examination and early diagnosis of hepatoma, complications of hepatoma, and th…
View article: Safety and Feasibility of Laparoscopic Major Hepatectomy after Portal Vein Embolization
Safety and Feasibility of Laparoscopic Major Hepatectomy after Portal Vein Embolization Open
Background and Aim: The operative safety and feasibility of laparoscopic major hepatectomy in patients after portal vein embolization is unknown, prompting our investigation of its safety and feasibility in patients at our center.
Metho…
View article: Purely laparoscopic extended posterior hepatectomy for large right hepatic mass
Purely laparoscopic extended posterior hepatectomy for large right hepatic mass Open
View article: Realization of improved outcomes following liver resection in hepatocellular carcinoma patients aged 75 years and older
Realization of improved outcomes following liver resection in hepatocellular carcinoma patients aged 75 years and older Open
LR in elderly HCC patients has been frequently performed recently, and the outcomes have improved significantly compared to the past.