Chun‐Wei Chen
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View article: Supplementary Figures S1-S12 from Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia
Supplementary Figures S1-S12 from Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia Open
Supplementary Figure 1. NPM1c degradation leads to differentiation of OCI-AML3 cells.Supplementary Figure 2. NPM1c chromatin targets identified in OCI-AML3-NPM1c-FKBP12 cells and validated by targeted degradation.Supplementary Figure 3. Mo…
View article: Supplementary Tables S1-S14 from Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia
Supplementary Tables S1-S14 from Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia Open
Table S1. Read normalized ratios of ChIPseq signal of untreated versus dTAG-13 treated OCI-AML3-NPM1c-FKBP12 cells.Table S2. Summary of NPM1c and NPM1 Chromatin Binding Targets.Table S3. Patient info for patient derived xenograft (PDX) mod…
View article: Editor’s Note: Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia
Editor’s Note: Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia Open
View article: Nuclear Phase Separation Drives NPM1-mutant Acute Myeloid Leukemia
Nuclear Phase Separation Drives NPM1-mutant Acute Myeloid Leukemia Open
During cancer development, mutations promote gene expression changes that cause transformation. Leukemia is frequently associated with aberrant HOXA expression driven by translocations in nucleoporin genes or KMT2A, and mutations in NPM1. …
View article: A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma
A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma Open
Diffuse midline glioma (DMG) is a fatal childhood brain tumor characterized primarily by mutant histone H3 (H3K27M). H3K27M causes a global reduction in Polycomb repressive complex 2 (PRC2)-mediated H3K27 trimethylation (H3K27me3). Paradox…
View article: m6A/IGF2BP3-driven serine biosynthesis fuels AML stemness and metabolic vulnerability
m6A/IGF2BP3-driven serine biosynthesis fuels AML stemness and metabolic vulnerability Open
View article: Risk Factors and Awareness of Bone Fragility in Inflammatory Bowel Disease in Taiwan: A Cross-Sectional Study
Risk Factors and Awareness of Bone Fragility in Inflammatory Bowel Disease in Taiwan: A Cross-Sectional Study Open
Background/Objectives: Patients with inflammatory bowel disease (IBD) are at a higher risk of developing bone disorders. Awareness and understanding of the disease are crucial for prevention and early diagnosis. Currently, there is no rese…
View article: Nuclear Control of Mitochondrial Homeostasis and Venetoclax Efficacy in AML via COX4I1
Nuclear Control of Mitochondrial Homeostasis and Venetoclax Efficacy in AML via COX4I1 Open
Cell signaling pathways are enriched for biological processes crucial for cellular communication, response to external stimuli, and metabolism. Here, a cell signaling‐focused CRISPR screen identified cytochrome c oxidase subunit 4 isoform …
View article: Protein capture performance of microfluidic system: effects of a super hydrophilic coating
Protein capture performance of microfluidic system: effects of a super hydrophilic coating Open
This paper outlines the coating of polymethylmethacrylate (PMMA) with a 316 stainless-steel (SS) thin film to create a super hydrophilic microfluidic system for the capture of hydrophilic bovine serum albumin (BSA) protein. Scanning electr…
View article: Dynamic-SUPERB Phase-2: A Collaboratively Expanding Benchmark for Measuring the Capabilities of Spoken Language Models with 180 Tasks
Dynamic-SUPERB Phase-2: A Collaboratively Expanding Benchmark for Measuring the Capabilities of Spoken Language Models with 180 Tasks Open
Multimodal foundation models, such as Gemini and ChatGPT, have revolutionized human-machine interactions by seamlessly integrating various forms of data. Developing a universal spoken language model that comprehends a wide range of natural…
View article: Remodelling of the glycome of B-cell precursor acute lymphoblastic leukemia cells developing drug-tolerance
Remodelling of the glycome of B-cell precursor acute lymphoblastic leukemia cells developing drug-tolerance Open
Reduced responsiveness of precursor B-acute lymphoblastic leukemia (BCP-ALL) to chemotherapy can be first detected in the form of minimal residual disease leukemia cells that persist after 28 days of initial treatment. The ability of these…
View article: Hematologic DNMT3A reduction and high-fat diet synergize to promote weight gain and tissue inflammation
Hematologic DNMT3A reduction and high-fat diet synergize to promote weight gain and tissue inflammation Open
View article: Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size
Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size Open
View article: Therapeutic targeting Tudor domains in leukemia via CRISPR-Scan Assisted Drug Discovery
Therapeutic targeting Tudor domains in leukemia via CRISPR-Scan Assisted Drug Discovery Open
Epigenetic dysregulation has been reported in multiple cancers including leukemias. Nonetheless, the roles of the epigenetic reader Tudor domains in leukemia progression and therapy remain unexplored. Here, we conducted a Tudor domain–focu…
View article: Hematologic DNMT3A reduction and high-fat diet synergize to promote weight gain and tissue inflammation
Hematologic DNMT3A reduction and high-fat diet synergize to promote weight gain and tissue inflammation Open
During aging, blood cell production becomes dominated by a limited number of variant hematopoietic stem cell (HSC) clones. Differentiated progeny of variant HSCs are thought to mediate the detrimental effects of such clonal hematopoiesis o…
View article: A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens
A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens Open
View article: METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation
METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation Open
View article: SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation
SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation Open
View article: Relationship between plasma atherogenic index of plasma (AIP) and Klotho protein: A cross-sectional study
Relationship between plasma atherogenic index of plasma (AIP) and Klotho protein: A cross-sectional study Open
Background : The plasma atherogenic index of plasma (AIP) is an indicator that measures the degree of lipid abnormalities and the risk of atherosclerosis, while Klotho protein is a protein with anti-aging biological functions. However, the…
View article: Specific cPRC1 complexes are co-opted to mediate oncogenic gene repression in diffuse midline glioma
Specific cPRC1 complexes are co-opted to mediate oncogenic gene repression in diffuse midline glioma Open
Diffuse midline glioma (DMG) is a fatal childhood brain tumour characterised primarily by mutant histone H3 (H3K27M). H3K27M causes a global reduction in Polycomb Repressive Complex 2 (PRC2)-mediated H3K27me3 by inhibiting PRC2 enzymatic a…
View article: The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG
The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG Open
View article: TP63 fusions drive multicomplex enhancer rewiring, lymphomagenesis, and EZH2 dependence
TP63 fusions drive multicomplex enhancer rewiring, lymphomagenesis, and EZH2 dependence Open
Gene fusions involving tumor protein p63 gene (TP63) occur in multiple T and B cell lymphomas and portend a dismal prognosis for patients. The function and mechanisms of TP63 fusions remain unclear, and there is no target therapy for patie…
View article: Diverse Roles of Protein Palmitoylation in Cancer Progression, Immunity, Stemness, and Beyond
Diverse Roles of Protein Palmitoylation in Cancer Progression, Immunity, Stemness, and Beyond Open
Protein S-palmitoylation, a type of post-translational modification, refers to the reversible process of attachment of a fatty acyl chain—a 16-carbon palmitate acid—to the specific cysteine residues on target proteins. By adding the lipid …
View article: Bioenergetic alteration in gastrointestinal cancers: The good, the bad and the ugly
Bioenergetic alteration in gastrointestinal cancers: The good, the bad and the ugly Open
Tumor necrosis factor-α (TNF-α) antagonists, the first biologics approved for treating patients with inflammatory bowel disease (IBD), are effective for the induction and maintenance of remission and significantly improving prognosis. Howe…
View article: MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer
MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer Open
Mutations in genes encoding components of chromatin modifying and remodeling complexes are among the most frequently observed somatic events in human cancers. For example, missense and nonsense mutations targeting the mixed lineage leukemi…
View article: MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer
MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer Open
Mutations in genes encoding components of chromatin modifying and remodeling complexes are among the most frequently observed somatic events in human cancers. For example, missense and nonsense mutations targeting the mixed lineage leukemi…
View article: Author response: MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer
Author response: MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer Open
View article: Intrinsic suppression of type I interferon production underlies the therapeutic efficacy of IL-15-producing natural killer cells in B-cell acute lymphoblastic leukemia
Intrinsic suppression of type I interferon production underlies the therapeutic efficacy of IL-15-producing natural killer cells in B-cell acute lymphoblastic leukemia Open
Background Type I interferons (IFN-Is), secreted by hematopoietic cells, drive immune surveillance of solid tumors. However, the mechanisms of suppression of IFN-I-driven immune responses in hematopoietic malignancies including B-cell acut…
View article: Chimeric Human Papillomavirus-16 Virus-like Particles Presenting HIV-1 P18I10 Peptide: Expression, Purification, Bio-Physical Properties and Immunogenicity in BALB/c Mice
Chimeric Human Papillomavirus-16 Virus-like Particles Presenting HIV-1 P18I10 Peptide: Expression, Purification, Bio-Physical Properties and Immunogenicity in BALB/c Mice Open
Human papillomavirus (HPV) vaccines based on HPV L1 virus-like particles (VLPs) are already licensed but not accessible worldwide. About 38.0 million people were living with HIV in 2020 and there is no HIV vaccine yet. Therefore, safe, eff…
View article: Menin inhibitor ziftomenib (KO-539) synergizes with drugs targeting chromatin regulation or apoptosis and sensitizes acute myeloid leukemia with <i>MLL</i> rearrangement or <i>NPM1</i> mutation to venetoclax
Menin inhibitor ziftomenib (KO-539) synergizes with drugs targeting chromatin regulation or apoptosis and sensitizes acute myeloid leukemia with <i>MLL</i> rearrangement or <i>NPM1</i> mutation to venetoclax Open
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