David L. Cochran
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View article: The National Dental Practice-Based Research Network Dental Implant Restoration Registry: A Protocol for a Prospective Observational Study of Dental Implant Outcomes in Community Practice Settings (Preprint)
The National Dental Practice-Based Research Network Dental Implant Restoration Registry: A Protocol for a Prospective Observational Study of Dental Implant Outcomes in Community Practice Settings (Preprint) Open
BACKGROUND Dental implants are a widely used therapeutic option for tooth replacement; however, biological and prosthetic complications may compromise implant success. While prior research has largely focused on academic or specialty sett…
View article: Peri‐implantitis induction and resolution around zirconia versus titanium implants
Peri‐implantitis induction and resolution around zirconia versus titanium implants Open
Background This study compared titanium and zirconia implant ligature‐induced peri‐implant defect progression and response to regenerative surgical intervention. Methods Eight tissue‐level endosseous implants were placed in 6 mixed‐breed f…
View article: Recruitment strategies and retention rates for five National Dental PBRN studies
Recruitment strategies and retention rates for five National Dental PBRN studies Open
Background: We describe a retrospective assessment of practitioner and patient recruitment strategies, patient retention strategies, and rates for five clinical studies conducted in the National Dental Practice-Based Research Network betwe…
View article: Osteoimmune regulation underlies oral implant osseointegration and its perturbation
Osteoimmune regulation underlies oral implant osseointegration and its perturbation Open
In the field of biomaterials, an endosseous implant is now recognized as an osteoimmunomodulatory but not bioinert biomaterial. Scientific advances in bone cell biology and in immunology have revealed a close relationship between the bone …
View article: Implications of considering peri‐implant bone loss a disease, a narrative review
Implications of considering peri‐implant bone loss a disease, a narrative review Open
Background Peri‐implantitis has been suggested to cause significant increasing proportions of implant failure with increasing time. Purpose To assess whether implant failure rates in long term studies are matching the supposed high prevale…
View article: Structure, function, and productivity from the National Dental Practice-Based Research Network
Structure, function, and productivity from the National Dental Practice-Based Research Network Open
Introduction: Following inception in 2005 as a multiregional practice-based research network (PBRN), the “National Dental PBRN” expanded nationwide in 2012, and in 2019 implemented additional organizational changes. The objectives are to: …
View article: Additional file 2 of Risk assessment of labial bone perforation in the anterior mandibular region: a virtual immediate implant placement study
Additional file 2 of Risk assessment of labial bone perforation in the anterior mandibular region: a virtual immediate implant placement study Open
Additional file 2.
View article: Preclinical evaluation of a 3D-printed hydroxyapatite/poly(lactic-co-glycolic acid) scaffold for ridge augmentation
Preclinical evaluation of a 3D-printed hydroxyapatite/poly(lactic-co-glycolic acid) scaffold for ridge augmentation Open
The 3DP HA/PLGA scaffold maintains supracrestal space and demonstrates osteoconductivity to facilitate SRA.
View article: Practitioner Engagement in Activities of the National Dental Practice-Based Research Network (PBRN): 7-Year Results
Practitioner Engagement in Activities of the National Dental Practice-Based Research Network (PBRN): 7-Year Results Open
This Network used a broad range of activities to engage community practitioners. These activities were successful in sustaining a high level of practitioner engagement in clinical research and its relevance to everyday clinical practice.
View article: Bone glue - The final frontier for fracture repair and implantable device stabilization
Bone glue - The final frontier for fracture repair and implantable device stabilization Open
The need for a bone adhesive is a challenge that has remained unmet. The concept of a "bone glue" to repair simple and comminuted fractures, as well as to glue orthopaedic devices in place, is considered a holy grail. Today such a product …
View article: Compression-Resistant Polymer/Ceramic Composite Scaffolds Augmented with rhBMP-2 Promote New Bone Formation in a Nonhuman Primate Mandibular Ridge Augmentation Model
Compression-Resistant Polymer/Ceramic Composite Scaffolds Augmented with rhBMP-2 Promote New Bone Formation in a Nonhuman Primate Mandibular Ridge Augmentation Model Open
CR scaffolds augmented with a clinically relevant dose of rhBMP-2 (1.5 mg/mL) promoted significant new bone formation. These results suggest that a CR PEUR/ceramic composite scaffold without a protective membrane may be a potential new rhB…
View article: Impact of Er:YAG laser on wound healing following nonsurgical therapy: A pilot study
Impact of Er:YAG laser on wound healing following nonsurgical therapy: A pilot study Open
The purpose is to examine early wound healing through histological analysis by characterizing connective tissue distribution and organization in the treated periodontium following nonsurgical therapy. Periodontal disease is a multifactoria…
View article: Practitioner Participation in National Dental Practice-based Research Network (PBRN) Studies: 12-Year Results
Practitioner Participation in National Dental Practice-based Research Network (PBRN) Studies: 12-Year Results Open
The network engaged practitioners in its research activities with relatively high participation rates over a 12-year period. Strategies employed by the network to engage practitioners may serve as a model for PBRN networks for other allied…
View article: Prescription Drug Monitoring Program Use: National Dental PBRN Results
Prescription Drug Monitoring Program Use: National Dental PBRN Results Open
Introduction: The American Dental Association recommends that dentists use a prescription drug monitoring program (PDMP) prior to prescribing an opioid for acute pain management. Objective: The objective of this study was to examine dentis…
View article: Group 4 ITI Consensus Report: Risks and biologic complications associated with implant dentistry
Group 4 ITI Consensus Report: Risks and biologic complications associated with implant dentistry Open
Objectives The aim of Working Group 4 was to address topics related to biologic risks and complications associated with implant dentistry. Focused questions on (a) diagnosis of peri‐implantitis, (b) complications associated with implants i…
View article: Human osteoblasts exhibit sexual dimorphism in their response to estrogen on microstructured titanium surfaces
Human osteoblasts exhibit sexual dimorphism in their response to estrogen on microstructured titanium surfaces Open
Male and female human osteoblasts respond similarly to microstructure and 1α,25(OH)2D3 but exhibit sexual dimorphism in substrate-dependent responses to E2. E2 affected female osteoblasts, suggesting that signaling is sex-specific and surf…
View article: Peri‐implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions
Peri‐implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions Open
A classification for peri‐implant diseases and conditions was presented. Focused questions on the characteristics of peri‐implant health, peri‐implant mucositis, peri‐implantitis, and soft‐ and hard‐tissue deficiencies were addressed. Peri…
View article: Peri‐implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions
Peri‐implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions Open
A classification for peri‐implant diseases and conditions was presented. Focused questions on the characteristics of peri‐implant health, peri‐implant mucositis, peri‐implantitis, and soft‐ and hard‐tissue deficiencies were addressed. Peri…
View article: Injectable, compression‐resistant polymer/ceramic composite bone grafts promote lateral ridge augmentation without protective mesh in a canine model
Injectable, compression‐resistant polymer/ceramic composite bone grafts promote lateral ridge augmentation without protective mesh in a canine model Open
Objective The objective of this study was to test the hypothesis that a compression‐resistant bone graft augmented with recombinant human morphogenetic protein‐2 (rhBMP‐2) will promote lateral ridge augmentation without the use of protecti…
View article: Assessment of Gingival Biotype and Keratinized Gingival Width of Maxillary Anterior Region in Individuals with Different Types of Malocclusion
Assessment of Gingival Biotype and Keratinized Gingival Width of Maxillary Anterior Region in Individuals with Different Types of Malocclusion Open
Although it is thought that there is a relationship between gingival thickness, width of keratinized gingiva, and Angle classification with regard to malaligned teeth, this cross-sectional evaluation of 181 patients failed to show a signif…
View article: Exploring Women’s Support Needs After Breast Reconstruction Surgery
Exploring Women’s Support Needs After Breast Reconstruction Surgery Open
Background The procedures for breast reconstruction (BR) after mastectomy frequently initiate a difficult recovery period. A better understanding of women’s support needs after surgery would improve patient care. Objective The aim of this …
View article: Patient Information Needs and Breast Reconstruction After Mastectomy
Patient Information Needs and Breast Reconstruction After Mastectomy Open
Background Although many women benefit from breast reconstruction after mastectomy, several studies report women's dissatisfaction with the level of information they were provided with before reconstruction. Objective The present meta-synt…
View article: Optimizing stadium evacuation by integrating geocomputation and affordance theory
Optimizing stadium evacuation by integrating geocomputation and affordance theory Open
Football is culturally and economically important in the United States, and football stadiums are part of the country's critical infrastructure, thus receiving government protection against hazard events. In this project, an agent-based ev…
View article: Emerging Regenerative Approaches for Periodontal Reconstruction: A Systematic Review From the AAP Regeneration Workshop
Emerging Regenerative Approaches for Periodontal Reconstruction: A Systematic Review From the AAP Regeneration Workshop Open
More than 30 years have passed since the first successful application of regenerative therapy for treatment of periodontal diseases. Despite being feasible, periodontal regeneration still faces numerous challenges, and complete restoration…