David Colquhoun
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View article: Tabletop Role Playing Games as a Way Forward with Structurally Marginalized Youth: A Narrative Review
Tabletop Role Playing Games as a Way Forward with Structurally Marginalized Youth: A Narrative Review Open
View article: Asia–Pacific Real-World Evolocumab Use, LDL-C Reduction, Physician Goals, and Patient Perceptions: HALES Observational Study
Asia–Pacific Real-World Evolocumab Use, LDL-C Reduction, Physician Goals, and Patient Perceptions: HALES Observational Study Open
View article: Using artificial intelligence (AI) to assess the prevalence of false or misleading health-related claims
Using artificial intelligence (AI) to assess the prevalence of false or misleading health-related claims Open
Complementary healthcare in the United Kingdom is subject to voluntary, publicly funded regulation. Many such practices include pseudoscience. There are concerns that regulated practitioners make misleading health claims. This study used a…
View article: The affinity–efficacy problem: an essential part of pharmacology education
The affinity–efficacy problem: an essential part of pharmacology education Open
A fundamental mistake in receptor theory has led to an enduring misunderstanding of how to estimate the affinity and efficacy of an agonist. These properties are inextricably linked and cannot be easily separated in any case where the bind…
View article: Absence of Pericarditis Recurrence in Rilonacept-Treated Patients With COVID-19 and SARS-CoV-2 Vaccination: Results From the RHAPSODY Long-term Extension
Absence of Pericarditis Recurrence in Rilonacept-Treated Patients With COVID-19 and SARS-CoV-2 Vaccination: Results From the RHAPSODY Long-term Extension Open
View article: The affinity-efficacy problem: an essential part of pharmacology education
The affinity-efficacy problem: an essential part of pharmacology education Open
A fundamental mistake in receptor theory has led to an enduring misunderstanding of how to estimate the affinity and efficacy of an agonist. These properties are inextricably linked and cannot be easily separated in any case where the bind…
View article: Safety and Immunogenicity of Bivalent RSVpreF Vaccine Coadministered With Seasonal Inactivated Influenza Vaccine in Older Adults
Safety and Immunogenicity of Bivalent RSVpreF Vaccine Coadministered With Seasonal Inactivated Influenza Vaccine in Older Adults Open
Background Respiratory syncytial virus (RSV) and influenza are both typically seasonal diseases, with winter peaks in temperate climates. Coadministration of an RSV vaccine and influenza vaccine could be a benefit, requiring 1 rather than …
View article: A Clinical Guide for Assessment and Prescription of Exercise and Physical Activity in Cardiac Rehabilitation. A CSANZ Position Statement
A Clinical Guide for Assessment and Prescription of Exercise and Physical Activity in Cardiac Rehabilitation. A CSANZ Position Statement Open
View article: This abstract has been withdrawn
This abstract has been withdrawn Open
View article: Efficacy and Safety of Inclisiran According to Age: A Pooled Analysis of Phase III Studies (ORION 9, 10 and 11)
Efficacy and Safety of Inclisiran According to Age: A Pooled Analysis of Phase III Studies (ORION 9, 10 and 11) Open
View article: Pericardial late gadolinium enhancement and time to recurrence: a substudy from RHAPSODY, a phase 3 clinical trial of rilonacept in recurrent pericarditis
Pericardial late gadolinium enhancement and time to recurrence: a substudy from RHAPSODY, a phase 3 clinical trial of rilonacept in recurrent pericarditis Open
Aims In this protocol-predefined substudy of the RHAPSODY trial, the primary aim was to assess whether pericardial late gadolinium enhancement (LGE) was associated with time to pericarditis recurrence. Methods and results RHAPSODY was a Ph…
View article: Management of depression in patients with coronary artery disease: A systematic review
Management of depression in patients with coronary artery disease: A systematic review Open
Depression is an independent risk factor for coronary artery disease (CAD). Both illnesses contribute significantly to the global burden of disease. This systematic literature review examines treatment interventions for CAD patients with c…
View article: Interleukin‐1 Trap Rilonacept Improved Health‐Related Quality of Life and Sleep in Patients With Recurrent Pericarditis: Results From the Phase 3 Clinical Trial RHAPSODY
Interleukin‐1 Trap Rilonacept Improved Health‐Related Quality of Life and Sleep in Patients With Recurrent Pericarditis: Results From the Phase 3 Clinical Trial RHAPSODY Open
Background Recurrent pericarditis is characterized by painful flares and inflammation, which negatively impact health‐related quality of life. RHAPSODY (rilonacept inhibition of interleukin‐1 alpha and beta for recurrent pericarditis: a pi…
View article: Investigation of C-reactive protein and AIM2 methylation as a marker for PTSD in Australian Vietnam veterans
Investigation of C-reactive protein and AIM2 methylation as a marker for PTSD in Australian Vietnam veterans Open
View article: Synopsis of an integrated guidance for enhancing the care of familial hypercholesterolaemia: an Australian perspective
Synopsis of an integrated guidance for enhancing the care of familial hypercholesterolaemia: an Australian perspective Open
These recommendations need to be utilised using judicious clinical judgement and shared decision making with patients and families. Models of care need to be adapted to both local and regional needs and resources. In Australia new governme…
View article: Referee report. For: FDRestimation: Flexible False Discovery Rate Computation in R [version 2; peer review: 2 approved]
Referee report. For: FDRestimation: Flexible False Discovery Rate Computation in R [version 2; peer review: 2 approved] Open
View article: Integrated Guidance for Enhancing the Care of Familial Hypercholesterolaemia in Australia
Integrated Guidance for Enhancing the Care of Familial Hypercholesterolaemia in Australia Open
Familial hypercholesterolaemia (FH) is a dominant and highly penetrant monogenic disorder present from birth that markedly elevates plasma low-density lipoprotein (LDL)-cholesterol concentration and, if untreated, leads to premature athero…
View article: Clinical Outcomes and Response to Vericiguat According to Index Heart Failure Event
Clinical Outcomes and Response to Vericiguat According to Index Heart Failure Event Open
ClinicalTrials.gov Identifier: NCT02861534.
View article: Optimising Secondary Prevention and Cardiac Rehabilitation for Atherosclerotic Cardiovascular Disease During the COVID-19 Pandemic: A Position Statement From the Cardiac Society of Australia and New Zealand (CSANZ)
Optimising Secondary Prevention and Cardiac Rehabilitation for Atherosclerotic Cardiovascular Disease During the COVID-19 Pandemic: A Position Statement From the Cardiac Society of Australia and New Zealand (CSANZ) Open
View article: A response to critiques of ‘The reproducibility of research and the misinterpretation of <i>p</i> -values’
A response to critiques of ‘The reproducibility of research and the misinterpretation of <i>p</i> -values’ Open
I proposed (8, 1, 3) that p values should be supplemented by an estimate of\nthe false positive risk (FPR). FPR was defined as the probability that, if you\nclaim that there is a real effect on the basis of p value from a single\nunbiased …
View article: John Henry Gaddum’s 1940 guidance on controlled clinical trials
John Henry Gaddum’s 1940 guidance on controlled clinical trials Open
View article: A response to O. Arandjelovic's critique of "The reproducibility of research and the misinterpretation of p-values"
A response to O. Arandjelovic's critique of "The reproducibility of research and the misinterpretation of p-values" Open
The main criticism of my piece in ref (2) seems to be that my calculations rely on testing a point null hypothesis, i.e. the hypothesis that the true effect size is zero. He objects to my contention that the true effect size can be zero, j…
View article: Comparison of Sleep Patterns in Vietnam Veterans With and Without Posttraumatic Stress Disorder Using Wrist Actigraphy
Comparison of Sleep Patterns in Vietnam Veterans With and Without Posttraumatic Stress Disorder Using Wrist Actigraphy Open
View article: Obesity is Only a Risk Number for Secondary Prevention – Failure of Randomised Weight Loss Trials
Obesity is Only a Risk Number for Secondary Prevention – Failure of Randomised Weight Loss Trials Open
View article: The False Positive Risk: A Proposal Concerning What to Do About <i>p</i>-Values
The False Positive Risk: A Proposal Concerning What to Do About <i>p</i>-Values Open
It is widely acknowledged that the biomedical literature suffers from a surfeit of false positive results. Part of the reason for this is the persistence of the myth that observation of p < 0.05 is sufficient justification to claim …
View article: Precision Cost Effectiveness of Lipid Therapies in Real World Individual Response Analysis – a Paradigm Shift
Precision Cost Effectiveness of Lipid Therapies in Real World Individual Response Analysis – a Paradigm Shift Open
View article: Effect of lorcaserin on prevention and remission of type 2 diabetes in overweight and obese patients (CAMELLIA-TIMI 61): a randomised, placebo-controlled trial
Effect of lorcaserin on prevention and remission of type 2 diabetes in overweight and obese patients (CAMELLIA-TIMI 61): a randomised, placebo-controlled trial Open
View article: Detailed Polysomnography in Australian Vietnam Veterans With and Without Posttraumatic Stress Disorder
Detailed Polysomnography in Australian Vietnam Veterans With and Without Posttraumatic Stress Disorder Open
View article: Peer Review #3 of "Effectiveness and adequacy of blinding in the moderation of pain outcomes: Systematic review and meta-analyses of dry needling trials (v0.2)"
Peer Review #3 of "Effectiveness and adequacy of blinding in the moderation of pain outcomes: Systematic review and meta-analyses of dry needling trials (v0.2)" Open
Background: Blinding is critical to clinical trials because it allows for separation of specific intervention effects from bias, by equalising all factors between groups except for the proposed mechanism of action.Absent or inadequate blin…
View article: Peer Review #3 of "Effectiveness and adequacy of blinding in the moderation of pain outcomes: Systematic review and meta-analyses of dry needling trials (v0.1)"
Peer Review #3 of "Effectiveness and adequacy of blinding in the moderation of pain outcomes: Systematic review and meta-analyses of dry needling trials (v0.1)" Open
Background: Blinding is critical to clinical trials because it allows for separation of specific intervention effects from bias, by equalising all factors between groups except for the proposed mechanism of action.Absent or inadequate blin…