David J. Neep
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View article: Evaluating the stability of synthetic cathinones in liquid urine and dried urine spots: impact of pH and storage conditions
Evaluating the stability of synthetic cathinones in liquid urine and dried urine spots: impact of pH and storage conditions Open
Synthetic cathinones comprise a class of new psychoactive substances associated with significant morbidity and mortality. Their detection in biological samples is complicated by their instability, which can compromise quantification or int…
View article: Multimodal 3D-printed passive samplers to monitor, model and prioritise <i>in situ</i> pharmaceutical and pesticide pollution risks to an aquatic freshwater invertebrate, <i>Gammarus pulex</i>
Multimodal 3D-printed passive samplers to monitor, model and prioritise <i>in situ</i> pharmaceutical and pesticide pollution risks to an aquatic freshwater invertebrate, <i>Gammarus pulex</i> Open
Multimodal 3D-printed passive sampler devices (3D-PSDs) were used to monitor contaminants of emerging concern (CECs) in freshwater and to estimate chemical toxic and effect units in a benthic invertebrate.
View article: The Potential of Paper Spray-Mass Spectrometry for the Analysis of NPS in Emergency Department
The Potential of Paper Spray-Mass Spectrometry for the Analysis of NPS in Emergency Department Open
Ambient ionisation has recently become an attractive addition to toxicology workflows, as it provides rapid analysis of drugs of abuse compared with traditional chromatographic techniques such as LC-MS. Based on electrospray ionisation mec…
View article: Routine application of SFC‐MS in doping control: Analysis of 3 × 1000 urine samples using three different SFC‐MS instruments
Routine application of SFC‐MS in doping control: Analysis of 3 × 1000 urine samples using three different SFC‐MS instruments Open
Supercritical fluid chromatography‐mass spectrometry (SFC‐MS) has proved to be a beneficial tool for sample analysis for a wide variety of compounds and, as such, has recently gained the attention of the anti‐doping community. We have test…
View article: Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients
Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients Open
The IMPACC cohort, composed of >1,000 hospitalized COVID-19 participants, contains five illness trajectory groups (TGs) during acute infection (first 28 days), ranging from milder (TG1-3) to more severe disease course (TG4) and death (TG5)…
View article: TREM2+ and interstitial-like macrophages orchestrate airway inflammation in SARS-CoV-2 infection in rhesus macaques
TREM2+ and interstitial-like macrophages orchestrate airway inflammation in SARS-CoV-2 infection in rhesus macaques Open
The immunopathological mechanisms driving the development of severe COVID-19 remain poorly defined. Here, we utilize a rhesus macaque model of acute SARS-CoV-2 infection to delineate perturbations in the innate immune system. SARS-CoV-2 in…
View article: Analysis of doping control samples using supercritical fluid chromatography‐tandem mass spectrometry: Ready for routine use
Analysis of doping control samples using supercritical fluid chromatography‐tandem mass spectrometry: Ready for routine use Open
Supercritical fluid chromatography is proving to be a good separation and sample preparation tool for various analytical applications and, as such, has gained the attention of the anti‐doping community. Here, the applicability of supercrit…
View article: Quantification of insulin‐like growth factor‐I by liquid chromatography–mass spectrometry
Quantification of insulin‐like growth factor‐I by liquid chromatography–mass spectrometry Open
We describe three methods of sample preparation for the liquid chromatography coupled with mass spectrometric measurement of insulin‐like growth factor‐I concentration in blood. One method involves trypsin digestion, the second involves in…
View article: Index
Index Open
Effective Communication for Lawyers is an essential guide to communicating in the radically and rapidly changing environment of professional law today. Offering a deep dive into understanding communication as behaviour, as well as practica…
View article: Dialogue and law - new horizons
Dialogue and law - new horizons Open
The need for more effective communication by lawyers is examined. Changes in culture, and revolutionary technology, is disrupting the legal profession and lawyers can no longer afford to ignore the need to change the way they communicate. …
View article: A Targeted Liquid Chromatography–Tandem Mass Spectrometry Method for Simultaneous Quantification of Peptides from the Carboxyl-terminal Region of Type III Procollagen, Biomarkers of Collagen Turnover
A Targeted Liquid Chromatography–Tandem Mass Spectrometry Method for Simultaneous Quantification of Peptides from the Carboxyl-terminal Region of Type III Procollagen, Biomarkers of Collagen Turnover Open
Background The development of analytical approaches to help reduce the risk of growth hormone (GH) doping is important to fair competition and the health of athletes. However, the reliable detection of GH use remains challenging. The ident…
View article: Combined statistical decision limits based on two GH-2000 scores for the detection of growth hormone misuse
Combined statistical decision limits based on two GH-2000 scores for the detection of growth hormone misuse Open
The growth hormone-2000 biomarker method, based on the measurements of insulin-like growth factor-I and the amino-terminal pro-peptide of type III collagen, has been developed as a powerful technique for the detection of growth hormone mis…
View article: Stability of drugs of abuse in synthetic oral fluid investigated using a simple “dilute and inject” method of analysis
Stability of drugs of abuse in synthetic oral fluid investigated using a simple “dilute and inject” method of analysis Open
Human oral fluid is well established as a matrix for drug screening, particularly in the workplace. The need to synthesise synthetic oral fluid (SOF) has been recognised in order to overcome human oral fluid's composition variability. We h…
View article: Advances in the detection of growth hormone releasing hormone synthetic analogs
Advances in the detection of growth hormone releasing hormone synthetic analogs Open
The administration of growth hormone releasing hormone (GHRH) and its synthetic analogs is prohibited by the World Anti‐Doping Agency (WADA). Although there is evidence of their use, based on admissions and intelligence, they do not appear…
View article: TREM2+ and interstitial macrophages orchestrate airway inflammation in SARS-CoV-2 infection in rhesus macaques
TREM2+ and interstitial macrophages orchestrate airway inflammation in SARS-CoV-2 infection in rhesus macaques Open
The COVID-19 pandemic remains a global health crisis, yet, the immunopathological mechanisms driving the development of severe disease remain poorly defined. Here, we utilize a rhesus macaque (RM) model of SARS-CoV-2 infection to delineate…
View article: Towards Identifying Nicomorphine Administration in Doping Control: Synthesis of Metabolites
Towards Identifying Nicomorphine Administration in Doping Control: Synthesis of Metabolites Open
Aim: Nicomorphine is rapidly metabolized mainly to the biologically active 6-nicotinoyl morphine and morphine. In sport, morphine and nicomorphine use is prohibited whereas codeine use is permitted. Accredited laboratories routinely test f…
View article: Procollagen type III amino‐terminal propeptide and insulin‐like growth factor I as biomarkers of growth hormone administration
Procollagen type III amino‐terminal propeptide and insulin‐like growth factor I as biomarkers of growth hormone administration Open
The acceptance in 2012 by the World Anti‐Doping Agency (WADA) of the biomarker test for human growth hormone (hGH) based on procollagen type III amino‐terminal propeptide (P‐III‐NP) and insulin‐like growth factor I (IGF‐I) was perhaps the …
View article: Ambient ionization mass spectrometry applied to new psychoactive substance analysis
Ambient ionization mass spectrometry applied to new psychoactive substance analysis Open
In the past decade a plethora of drugs with similar effects to controlled psychoactive drugs, like cannabis, amfetamine (amphetamine), or lysergic acid diethylamide, have been synthesized. These drugs can collectively be classified under t…
View article: CCR2-dependent monocyte-derived cells restrict SARS-CoV-2 infection
CCR2-dependent monocyte-derived cells restrict SARS-CoV-2 infection Open
SARS-CoV-2 has caused a historic pandemic of respiratory disease (COVID-19) and current evidence suggests severe disease is associated with dysregulated immunity within the respiratory tract. However, the innate immune mechanisms that medi…
View article: Rapid direct analysis of river water and machine learning assisted suspect screening of emerging contaminants in passive sampler extracts
Rapid direct analysis of river water and machine learning assisted suspect screening of emerging contaminants in passive sampler extracts Open
Machine-learning assisted suspect screening in passive sampler extracts and rapid direct injection LC-MS/MS of river water from the River Thames, London, UK in 2018/9.
View article: Artificial oral fluid characterisation: Potential for use as a reference matrix in drug testing
Artificial oral fluid characterisation: Potential for use as a reference matrix in drug testing Open
Quality assurance schemes for drug‐screening programmes require access to large quantities of biological matrices for reference or control samples. This presents problems when the availability of a matrix, such as oral fluid (OF) for scree…
View article: Online Educational Tools for Caregivers of People with Dementia: A Scoping Literature Review (Preprint)
Online Educational Tools for Caregivers of People with Dementia: A Scoping Literature Review (Preprint) Open
BACKGROUND Over one million Canadians are affected directly or indirectly by dementia. Informal caregivers (CGs) of people with dementia (PwD) provide the majority of health-based care to PwD. Providing this care requires knowledge and ac…
View article: Inter-Laboratory Agreement of Insulin-like Growth Factor 1 Concentrations Measured Intact by Mass Spectrometry
Inter-Laboratory Agreement of Insulin-like Growth Factor 1 Concentrations Measured Intact by Mass Spectrometry Open
Background Insulin-like growth factor-I (IGF-1) is measured mainly by immunoassay for the diagnosis and treatment of growth hormone (GH) disorders, and to detect misuse of GH in sport. Immunoassays often have insufficient inter-laboratory …
View article: Anti-doping: Two Scientists’ Points of View
Anti-doping: Two Scientists’ Points of View Open
As we get close to the start of the Olympic and Paralympic Games taking place next summer in Tokyo, Japan, athletes are preparing for selection by their host nation. This preparation, like most activities, is governed by the rules of sport…
View article: Race, Breast Cancer Subtypes, and Survival in the Carolina Breast Cancer Study
Race, Breast Cancer Subtypes, and Survival in the Carolina Breast Cancer Study Open
Context: Gene expression analysis has identified several breast cancer subtypes, including basal-like, human epidermal growth factor receptor-2 positive/estrogen receptor negative (HER2+/ER–), luminal A, and luminal B. Objectives: To deter…