David Dailler
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Switching Residues: A Platform for the Synthesis of Fidaxomicin Antibiotics Open
Peripheral modification is often the main approach to optimize natural products for improved biological activity or desired physicochemical properties. This procedure inevitably increases molecular weight, often accompanied by undesired in…
Carbonylative N-Heterocyclization via Nitrogen-Directed C–C Bond Activation of Nonactivated Cyclopropanes Open
Under Rh-catalyzed conditions, secondary amines and anilines function as directing groups to facilitate regioselective C-C bond activation of nonactivated cyclopropanes. The resulting amino-stabilized rhodacycles undergo carbonylative C-N …
Novel Fidaxomicin Antibiotics through Site-Selective Catalysis Open
Fidaxomicin (FDX) is a marketed antibiotic for the treatment Clostridium difficile infections (CDI). Although showing interesting antibacterial properties against many Gram-positive bacteria, the application of this antibiotic is currently…
Novel Fidaxomicin Antibiotics through Site-Selective Catalysis Open
Fidaxomicin (FDX) is a marketed antibiotic for the treatment Clostridium difficile infections (CDI). Although showing interesting antibacterial properties against many Gram-positive bacteria, the application of this antibiotic is currently…
A Four-Step Synthesis of (±)-γ-Lycorane via Pd<sup>0</sup>-Catalyzed Double C(sp<sup>2</sup>)–H/C(sp<sup>3</sup>)–H Arylation Open
An expedient synthesis of lycorine alkaloids is reported using a palladium(0)-catalyzed double C-X/C-H arylation as the key step. The selectivity of this reaction was controlled through the judicious choice of the two halogen atoms, and it…
CCDC 1850396: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
Synthesis of β‐Lactams by Palladium(0)‐Catalyzed C(sp<sup>3</sup>)−H Carbamoylation Open
A general and user‐friendly synthesis of β‐lactams is reported that makes use of Pd 0 ‐catalyzed carbamoylation of C(sp 3 )−H bonds, and operates under stoichiometric carbon monoxide in a two‐chamber reactor. This reaction is compatible wi…
Development and applications of palladium(0)-catalyzed-C(sp3)-H activation Open
Over the last decade, the transition metal-catalyzed intramolecular activation of unactivated CH \nbonds has emerged as a powerful method to transform otherwise inert entities allowing access \nto molecular complexity in an atom- and step-…
Synthesis of Strained γ‐Lactams by Palladium(0)‐Catalyzed C(sp<sup>3</sup>)−H Alkenylation and Application to Alkaloid Synthesis Open
A variety of strained α‐alkylidene‐γ‐lactams were synthesized by palladium(0)‐catalyzed intramolecular C(sp 3 )−H alkenylation from easily accessible acyclic and monocyclic bromoalkene precursors. These lactams are valuable intermediates f…