David W. Johnson
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View article: Body roundness index and mortality risk in patients with chronic kidney disease: moving beyond the obesity paradox
Body roundness index and mortality risk in patients with chronic kidney disease: moving beyond the obesity paradox Open
Background Body roundness index (BRI), an emerging anthropometric measure, has been shown to outperform body mass index (BMI) in predicting mortality risk in the general population. However, its prognostic value among patients with chronic…
View article: #937 Goals of frail older people living with chronic kidney disease
#937 Goals of frail older people living with chronic kidney disease Open
Background and Aims Frail older adults with chronic kidney disease (CKD) have complex care needs, and their priorities may differ from those assumed by healthcare providers. Understanding their goals is crucial to delivering person-centred…
View article: From Clonidine Withdrawal to Posterior Reversible Encephalopathy Syndrome: Imaging and Cerebrospinal Fluid Clues in a Case of Hypertensive Emergency
From Clonidine Withdrawal to Posterior Reversible Encephalopathy Syndrome: Imaging and Cerebrospinal Fluid Clues in a Case of Hypertensive Emergency Open
We report the case of a 33-year-old man who developed posterior reversible encephalopathy syndrome (PRES) after clonidine withdrawal, which led to a hypertensive crisis. The patient presented with rapid neurologic decline, including vision…
View article: Impacts of Community Pediatric Asthma Education Program on Asthma Outcomes in Alberta, Canada
Impacts of Community Pediatric Asthma Education Program on Asthma Outcomes in Alberta, Canada Open
Objective Asthma affects about 10% of Canadian children, with significant impacts on the healthcare system. This study describes a cohort of children with asthma, exploring outcomes of targeted asthma education through a Community Pediatri…
View article: Association of autosomal dominant polycystic kidney disease (ADPKD) with cardiovascular disease and mortality in patients with treated kidney failure
Association of autosomal dominant polycystic kidney disease (ADPKD) with cardiovascular disease and mortality in patients with treated kidney failure Open
Introduction Autosomal dominant polycystic kidney disease (ADPKD) is a multisystem syndrome associated with significant morbidity and mortality, particularly kidney failure. This study sought to evaluate mortality and transplant outcomes i…
View article: Implementation of Metformin Therapy to Ease Decline of Kidney Function in Polycystic Kidney Disease (IMPEDE-PKD): study protocol for a phase III, multi-centre, randomized, placebo-controlled trial evaluating the long-term efficacy of metformin in slowing the rate of kidney function decline in patients with autosomal dominant polycystic kidney disease
Implementation of Metformin Therapy to Ease Decline of Kidney Function in Polycystic Kidney Disease (IMPEDE-PKD): study protocol for a phase III, multi-centre, randomized, placebo-controlled trial evaluating the long-term efficacy of metformin in slowing the rate of kidney function decline in patients with autosomal dominant polycystic kidney disease Open
CLINICALTRIALS: gov NCT04939935. Registered on 25 June 2021.
View article: Australian pharmacists' experiences and perspectives in implementing a chronic kidney disease screening service in community pharmacies: A qualitative study
Australian pharmacists' experiences and perspectives in implementing a chronic kidney disease screening service in community pharmacies: A qualitative study Open
Australian community pharmacists generally reported positive experiences in implementing the QUM-CKD trial. To ensure the service's success and sustainability, we recommend adequate pharmacy staffing, appropriate pharmacist remuneration, a…
View article: Collapse of Lipid Membranes into Distended Lipidic Cubic Phases at High Solvent Levels, Membrane Remodelling, and Self-Repair
Collapse of Lipid Membranes into Distended Lipidic Cubic Phases at High Solvent Levels, Membrane Remodelling, and Self-Repair Open
Performance plastics, such as poly(methyl methacrylate), underpin the modern economy. Global manufacturing of plastic precursors relies on fossil carbon sources, and the urgently needed shift toward renewable carbon use through biofermenta…
View article: Development and validation of novel scales to measure trust and confidence in using telephone and video consultation scales in people with chronic kidney disease
Development and validation of novel scales to measure trust and confidence in using telephone and video consultation scales in people with chronic kidney disease Open
Aim Patients’ trust and confidence in telehealth are core components of its adoption, effectiveness and sustained use. This study aimed to develop and validate scales to measure trust and confidence in using telephone and video consultatio…
View article: A methodology for determining dosing recommendations for anticancer drugs in patients with reduced kidney function
A methodology for determining dosing recommendations for anticancer drugs in patients with reduced kidney function Open
Development of the ADDIKD guideline is funded by the Cancer Institute NSW as part of the NSW Government and received no funding from external commercial sources.
View article: Operative and nonoperative management of acute cholecystitis in patients on chronic kidney replacement therapy
Operative and nonoperative management of acute cholecystitis in patients on chronic kidney replacement therapy Open
Background Patients with kidney failure receiving chronic kidney replacement therapy (KRT: dialysis or kidney transplantation) have increased risks of postoperative mortality and morbidity. This study assesses the outcomes of acute cholecy…
View article: Comprehensive geriatric assessment for frail older people with chronic kidney disease to increase attainment of patient-identified goals: Statistical analysis plan for a cluster-randomised controlled trial
Comprehensive geriatric assessment for frail older people with chronic kidney disease to increase attainment of patient-identified goals: Statistical analysis plan for a cluster-randomised controlled trial Open
ClinicalTrials.govNCT04538157.
View article: Goals of Frail Older People Living With Chronic Kidney Disease: A Mixed Methods Study
Goals of Frail Older People Living With Chronic Kidney Disease: A Mixed Methods Study Open
Background Frail older adults with chronic kidney disease (CKD) have complex care needs, and their priorities may differ from those assumed by healthcare providers. Understanding their goals is crucial to delivering person‐centred care. Th…
View article: Global availability of medications and health technologies for kidney care: A multinational study from the ISN-GKHA
Global availability of medications and health technologies for kidney care: A multinational study from the ISN-GKHA Open
A core feature of universal health coverage is equitable access to affordable care not exposing people to financial hardship. This study aims to provide a global overview on availability and access to medications and health technologies fo…
View article: Disparities in kidney care in vulnerable populations: A multinational study from the ISN-GKHA
Disparities in kidney care in vulnerable populations: A multinational study from the ISN-GKHA Open
Vulnerable populations, such as the elderly, children, displaced people, and refugees, often encounter challenges in accessing healthcare. In this study, we used data from the third iteration of the International Society of Nephrology Glob…
View article: Regional hotspots for chronic kidney disease: A multinational study from the ISN-GKHA
Regional hotspots for chronic kidney disease: A multinational study from the ISN-GKHA Open
Chronic kidney disease (CKD) disproportionately affects certain populations as demonstrated by well-established subnational geographic hotspots of CKD in Central America and South Asia. Using data from the third iteration of the Internatio…
View article: Landscape of kidney replacement therapy provision in low- and lower-middle income countries: A multinational study from the ISN-GKHA
Landscape of kidney replacement therapy provision in low- and lower-middle income countries: A multinational study from the ISN-GKHA Open
In low- and lower-middle-income countries (LLMICs), delivering equitable kidney care presents substantial challenges, resulting in significant disparities in disease management and treatment outcomes for people with kidney failure. This co…
View article: Global Policy and Advocacy Initiatives for Improving Kidney Care
Global Policy and Advocacy Initiatives for Improving Kidney Care Open
Key Points Inclusion and prioritization of CKD and kidney failure within national health strategies are generally lacking. Countries with CKD-specific strategies tend to include and fund a broader spectrum of kidney disease populations and…
View article: Establishing a peritoneal dialysis technique survival core outcome measure: A standardised outcomes in nephrology-peritoneal dialysis consensus workshop report
Establishing a peritoneal dialysis technique survival core outcome measure: A standardised outcomes in nephrology-peritoneal dialysis consensus workshop report Open
Background Technique survival, also reported with negative connotations as technique failure or transfer from peritoneal dialysis to haemodialysis, has been identified by patients, caregivers and health professionals as a critically import…
View article: Baseline Characteristics of Frailty and Disease Stage in Older People Living With CKD
Baseline Characteristics of Frailty and Disease Stage in Older People Living With CKD Open
This cohort demonstrated poorer quality-of-life scores in those with more severe frailty and more advanced CKD.