David Dodwell
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View article: A core outcome set for locoregional treatment reporting in neoadjuvant systemic breast cancer treatment trials
A core outcome set for locoregional treatment reporting in neoadjuvant systemic breast cancer treatment trials Open
Accurate information about locoregional breast cancer treatments following neoadjuvant systemic therapy (NST) is essential for meaningful interpretation of oncological outcomes but reporting is currently poor. We developed a core outcome s…
View article: A randomised SWAT assessing the impact of an enhanced patient information leaflet on recruitment in a trial of axillary treatment for early-stage breast cancer
A randomised SWAT assessing the impact of an enhanced patient information leaflet on recruitment in a trial of axillary treatment for early-stage breast cancer Open
Background A study within a trial (SWAT) can be used to compare the effectiveness of various recruitment aids. In this SWAT, we assessed the impact of incorporating a pictorial aid into an enhanced Patient Information Leaflet (PIL) versus …
View article: Correction: The unexploited potential of data systems tracking medicines utilization: an opportunity to improve access to oncology combination therapies
Correction: The unexploited potential of data systems tracking medicines utilization: an opportunity to improve access to oncology combination therapies Open
[This corrects the article DOI: 10.3389/fphar.2025.1532022.].
View article: Histological types of invasive breast cancer in 830,000 women diagnosed in England during 1988–2016
Histological types of invasive breast cancer in 830,000 women diagnosed in England during 1988–2016 Open
Breast cancer can be categorised into a number of histological types, based on microscopic appearances. There is some evidence that the different breast cancer histological types are associated with different patient and tumour characteris…
View article: Second cancers in 475 000 women with early invasive breast cancer diagnosed in England during 1993-2016: population based observational cohort study
Second cancers in 475 000 women with early invasive breast cancer diagnosed in England during 1993-2016: population based observational cohort study Open
Objective To describe long term risks of second non-breast primary cancers and contralateral breast cancers among women with early invasive breast cancer after primary surgery. Design Population based observational cohort study. Setting Ro…
View article: Patients need information on the risk of second cancer after early breast cancer
Patients need information on the risk of second cancer after early breast cancer Open
View article: The unexploited potential of data systems tracking medicines utilization: an opportunity to improve access to oncology combination therapies
The unexploited potential of data systems tracking medicines utilization: an opportunity to improve access to oncology combination therapies Open
Background While progress has been made in oncology treatments, including the introduction of combination therapies, barriers affect patient access. There are approaches that could improve access including combination-specific pricing that…
View article: Safe and transparent introduction and evaluation of targeted axillary dissection in patients with node-positive breast cancer undergoing primary surgery: international consensus process
Safe and transparent introduction and evaluation of targeted axillary dissection in patients with node-positive breast cancer undergoing primary surgery: international consensus process Open
Background Axillary node clearance is the current standard of care in patients with node-positive breast cancer undergoing primary surgery, despite a lack of evidence to demonstrate survival benefit and high rates of life-changing morbidit…
View article: Extending the duration of endocrine treatment for early breast cancer: patient-level meta-analysis of 12 randomised trials of aromatase inhibitors in 22 031 postmenopausal women already treated with at least 5 years of endocrine therapy
Extending the duration of endocrine treatment for early breast cancer: patient-level meta-analysis of 12 randomised trials of aromatase inhibitors in 22 031 postmenopausal women already treated with at least 5 years of endocrine therapy Open
View article: Optimising mastectomy with a focus on skin and nipple-sparing approaches: a multidisciplinary point of view
Optimising mastectomy with a focus on skin and nipple-sparing approaches: a multidisciplinary point of view Open
View article: Understanding global variation in breast cancer mortality
Understanding global variation in breast cancer mortality Open
Breast cancer is an important global health challenge. Among women, it is the most commonly diagnosed cancer and the leading cause of cancer-related mortality. There are significant variations in the incidence and mortality rates globally …
View article: Corrigendum to “Risk of secondary myelodysplastic syndromes and acute myeloid leukaemia following poly(ADP-ribose) polymerase inhibitor treatment for advanced-stage ovarian cancer: A retrospective cohort study” [Eur J Cancer 222 (2025) 115472]
Corrigendum to “Risk of secondary myelodysplastic syndromes and acute myeloid leukaemia following poly(ADP-ribose) polymerase inhibitor treatment for advanced-stage ovarian cancer: A retrospective cohort study” [Eur J Cancer 222 (2025) 115472] Open
View article: Time to adjuvant chemotherapy and overall survival in advanced-stage ovarian cancer patients in England: a population-based retrospective cohort study
Time to adjuvant chemotherapy and overall survival in advanced-stage ovarian cancer patients in England: a population-based retrospective cohort study Open
Background and purpose: In advanced ovarian cancer, delayed time to chemotherapy (TTC) has been associated with poorer survival outcomes; evidence is conflicting, however. This study investigated the impact of patient demographic factors o…
View article: Mapping the current landscape of locoregional therapy de-escalation trials in early breast cancer: a systematic review
Mapping the current landscape of locoregional therapy de-escalation trials in early breast cancer: a systematic review Open
A systematic review undertaken to map the current landscape of locoregional de-escalation trials to inform future research. Online databases and trial registries were searched to identify ongoing, recently completed or published studies de…
View article: The impact of the COVID-19 pandemic on the use of systemic therapy for patients diagnosed with cancer in England: A population-based study with a focus on breast and lung cancer
The impact of the COVID-19 pandemic on the use of systemic therapy for patients diagnosed with cancer in England: A population-based study with a focus on breast and lung cancer Open
Changes in the delivery of SACT were largely driven by a reduction in the number of patients who were diagnosed with cancer in 2020. An increased proportion of breast cancer patients treated with SACT likely reflects the increased proporti…
View article: The Impact of Body Mass Index (BMI) on Clinical Outcomes for Patients Receiving Systemic Anti-Cancer Therapies for Advanced Clear Cell Renal Carcinoma
The Impact of Body Mass Index (BMI) on Clinical Outcomes for Patients Receiving Systemic Anti-Cancer Therapies for Advanced Clear Cell Renal Carcinoma Open
Introduction Obesity is a risk factor for the development of renal cell carcinoma (RCC), however observational studies have suggested patients with RCC receiving systemic anti-cancer therapy (SACT) and BMI ≥25 kg/m 2 may have a better prog…
View article: The Assisi think tank focus review on postoperative radiation for lobular breast cancer
The Assisi think tank focus review on postoperative radiation for lobular breast cancer Open
View article: Survival following adjuvant trastuzumab-based treatment among older patients with HER2-positive early invasive breast cancer: A national population-based cohort study using routine data
Survival following adjuvant trastuzumab-based treatment among older patients with HER2-positive early invasive breast cancer: A national population-based cohort study using routine data Open
In this national dataset, adjuvant trastuzumab was associated with improvements in survival, with an OS effect size similar to RCT evidence. The effect size was not found to vary by patient age or fitness. Chronological age and fitness alo…
View article: Locoregional recurrence in studies of primary systemic therapy in early invasive breast cancer
Locoregional recurrence in studies of primary systemic therapy in early invasive breast cancer Open
View article: Exploring locoregional treatment reporting in neoadjuvant systemic breast cancer treatment studies: A systematic review
Exploring locoregional treatment reporting in neoadjuvant systemic breast cancer treatment studies: A systematic review Open
Accurate information about locoregional treatments in breast cancer neoadjuvant systemic therapy (NST) trials is vital to support surgical decision-making and allow meaningful interpretation of long-term oncological outcomes. This systemat…
View article: Survival outcomes after breast cancer surgery among older women with early invasive breast cancer in England: population-based cohort study
Survival outcomes after breast cancer surgery among older women with early invasive breast cancer in England: population-based cohort study Open
Background This study assessed the influence of age, co-morbidity and frailty on 5-year survival outcomes after breast conservation surgery (BCS) with radiotherapy (RT) versus mastectomy (with or without RT) in women with early invasive br…
View article: Estimated Doses to the Heart, Lungs and Oesophagus and Risks From Typical UK Radiotherapy for Early Breast Cancer During 2015–2023
Estimated Doses to the Heart, Lungs and Oesophagus and Risks From Typical UK Radiotherapy for Early Breast Cancer During 2015–2023 Open
View article: The Lancet Breast Cancer Commission
The Lancet Breast Cancer Commission Open
View article: Which real indications remain for mastectomy?
Which real indications remain for mastectomy? Open
View article: Protocol for the development of a core outcome set and reporting guidelines for locoregional treatment in neoadjuvant systemic breast cancer treatment trials: the PRECEDENT project
Protocol for the development of a core outcome set and reporting guidelines for locoregional treatment in neoadjuvant systemic breast cancer treatment trials: the PRECEDENT project Open
Introduction Neoadjuvant systemic anticancer therapy (neoSACT) is increasingly used in the treatment of early breast cancer. Response to therapy is prognostic and allows locoregional and adjuvant systemic treatments to be tailored to minim…
View article: BoHFAB. The impact of adjuvant zoledronate therapy on bone health in postmenopausal patients with early breast cancer
BoHFAB. The impact of adjuvant zoledronate therapy on bone health in postmenopausal patients with early breast cancer Open
View article: Invasive breast cancer and breast cancer death after non-screen detected ductal carcinoma in situ from 1990 to 2018 in England: population based cohort study
Invasive breast cancer and breast cancer death after non-screen detected ductal carcinoma in situ from 1990 to 2018 in England: population based cohort study Open
Objectives To evaluate the long term risks of invasive breast cancer and death related to breast cancer after non-screen detected ductal carcinoma in situ. Risks for women in the general population and for women diagnosed with ductal carci…
View article: Prolonged bone health benefits for breast cancer patients following adjuvant bisphosphonate therapy: the BoHFAB study
Prolonged bone health benefits for breast cancer patients following adjuvant bisphosphonate therapy: the BoHFAB study Open
Adjuvant bisphosphonates are often recommended in postmenopausal women with early breast cancer at intermediate-to-high risk of disease recurrence, but the magnitude and duration of their effects on bone mineral density (BMD) and bone turn…
View article: Mastectomy patterns among older women with early invasive breast cancer in England and Wales: A population-based cohort study
Mastectomy patterns among older women with early invasive breast cancer in England and Wales: A population-based cohort study Open
Older women with EIBC are more commonly treated with mastectomy. This could not be explained by tumour characteristics or physical fitness, raising questions about whether surgical decision-making inconsistently incorporates information on…
View article: Radiotherapy to regional nodes in early breast cancer: an individual patient data meta-analysis of 14 324 women in 16 trials
Radiotherapy to regional nodes in early breast cancer: an individual patient data meta-analysis of 14 324 women in 16 trials Open