David A. Rubenstein
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View article: Exposure to Secondhand Smoke Extract Increases Cisplatin Resistance in Head and Neck Cancer Cells
Exposure to Secondhand Smoke Extract Increases Cisplatin Resistance in Head and Neck Cancer Cells Open
Chemotherapy and radiotherapy resistance are major obstacles in the long-term efficacy of head and neck squamous cell carcinoma (HNSCC) treatment. Secondhand smoke (SHS) exposure is common and has been proposed as an independent predictor …
View article: Complement component C1q initiates extrinsic coagulation via the receptor for the globular head of C1q in adventitial fibroblasts and vascular smooth muscle cells
Complement component C1q initiates extrinsic coagulation via the receptor for the globular head of C1q in adventitial fibroblasts and vascular smooth muscle cells Open
Background Vascular diseases are highly associated with inflammation and thrombosis. Elucidating links between these two processes may provide a clearer understanding of these diseases, allowing for the design of more effective treatments.…
View article: Dermal Safety of Tapinarof Cream 1%: Results From 4 Phase 1 Trials
Dermal Safety of Tapinarof Cream 1%: Results From 4 Phase 1 Trials Open
IND 104601 J Drugs Dermatol. 2022;21(10):1084-1090. doi:10.36849/JDD.6627R1.
View article: SARS-CoV-2 Exacerbates COVID-19 Pathology Through Activation of the Complement and Kinin Systems
SARS-CoV-2 Exacerbates COVID-19 Pathology Through Activation of the Complement and Kinin Systems Open
Infection with SARS-CoV-2 triggers the simultaneous activation of innate inflammatory pathways including the complement system and the kallikrein-kinin system (KKS) generating in the process potent vasoactive peptides that contribute to se…
View article: Keratinocyte Adherens Junctions Initiate Nuclear Signaling byTranslocation of Plakoglobin from the Membrane to the Nucleus
Keratinocyte Adherens Junctions Initiate Nuclear Signaling byTranslocation of Plakoglobin from the Membrane to the Nucleus Open
Because changes in cell-cell adhesion have profound effects on cellular behavior, we hypothesized a link between the adhesion and signaling functions of plakoglobin and beta-catenin. To investigate the existence of adherens-junction-mediat…
View article: Development of 3D Printed Electrospun Scaffolds for the Fabrication of Porous Scaffolds for Vascular Applications
Development of 3D Printed Electrospun Scaffolds for the Fabrication of Porous Scaffolds for Vascular Applications Open
Over the past two decades, electrospinning has emerged as a common technique to produce biomedical scaffolds composed of ultrafine fibers formed from many natural and synthetic polymers. A major advantage of this technique is the ability t…
View article: Inflammatory, Thrombotic, and Diabetic Responses in Human Arterial Fibroblasts and Endothelial Cells are Regulated by SARS‐CoV‐2 Structural Proteins
Inflammatory, Thrombotic, and Diabetic Responses in Human Arterial Fibroblasts and Endothelial Cells are Regulated by SARS‐CoV‐2 Structural Proteins Open
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is responsible for many pathological processes, such as altered vascular disease development, dysfunctional thrombosis, and a heightened inflammatory state. Although many clinica…
View article: Reliability and Convergent Validity of Two Outcome Instruments for Pemphigus
Reliability and Convergent Validity of Two Outcome Instruments for Pemphigus Open
A major obstacle in performing multicenter controlled trials for pemphigus is the lack of a validated disease activity scoring system. Here we assess the reliability and convergent validity of the PDAI (pemphigus disease area index). A gro…
View article: Definitions and outcome measures for bullous pemphigoid: Recommendations by an international panel of experts
Definitions and outcome measures for bullous pemphigoid: Recommendations by an international panel of experts Open
Our scientific knowledge of bullous pemphigoid (BP) has dramatically progressed in recent years. However, despite the availability of various therapeutic options for the treatment of inflammatory diseases, only a few multicenter controlled…
View article: Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus
Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus Open
Our scientific knowledge of pemphigus has dramatically progressed in recent years. However, despite the availability of various therapeutic options for the treatment of inflammatory diseases, only a few multicenter controlled trials have h…
View article: Advances in pemphigus and its endemic pemphigus foliaceus (Fogo Selvagem) phenotype: A paradigm of human autoimmunity
Advances in pemphigus and its endemic pemphigus foliaceus (Fogo Selvagem) phenotype: A paradigm of human autoimmunity Open
Pemphigus encompasses a group of organ specific, antibody mediated autoimmune diseases of the skin characterized by keratinocyte detachment that leads to the development of blisters and erosions, which can become life-threatening. The path…
View article: Neutrophil elastase cleaves the murine hemidesmosomal protein BP180/type XVII collagen and generates degradation products that modulate experimental bullous pemphigoid
Neutrophil elastase cleaves the murine hemidesmosomal protein BP180/type XVII collagen and generates degradation products that modulate experimental bullous pemphigoid Open
Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease associated with autoantibodies against the hemidesmosomal proteins BP180 and BP230. In the IgG passive transfer model of BP, blister formation is triggered by anti-BP…
View article: A Fluid–Structure Interaction Model of the Left Coronary Artery
A Fluid–Structure Interaction Model of the Left Coronary Artery Open
A fluid–structure interaction (FSI) model of a left anterior descending (LAD) coronary artery was developed, incorporating transient blood flow, cyclic bending motion of the artery, and myocardial contraction. The three-dimensional (3D) ge…
View article: Electronic cigarette aerosols suppress cellular antioxidant defenses and induce significant oxidative DNA damage
Electronic cigarette aerosols suppress cellular antioxidant defenses and induce significant oxidative DNA damage Open
Exposure to EC aerosol extracts suppressed the cellular antioxidant defenses and led to significant DNA damage. These findings emphasize the urgent need to investigate the potential long-term cancer risk of exposure to EC aerosol for vaper…