Jonathan R. Clark
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View article: Micro-Costing of Dental Prosthetics in Jaw Reconstruction
Micro-Costing of Dental Prosthetics in Jaw Reconstruction Open
Introduction Dental rehabilitation has a significant impact on health-related quality of life (HRQOL) for patients undergoing microvascular reconstruction of the jaw. Virtual surgical planning (VSP) and computer-aided design and computer-a…
View article: Integration of Whole-Genome Sequencing Analysis with Unique Patient-Derived Models Reveals Clinically Relevant Drug Targets in <i>TFCP2</i> Fusion–Defined Rhabdomyosarcoma
Integration of Whole-Genome Sequencing Analysis with Unique Patient-Derived Models Reveals Clinically Relevant Drug Targets in <i>TFCP2</i> Fusion–Defined Rhabdomyosarcoma Open
Precision medicine is a likely future for all cancer treatment but may have its greatest impact on less common, high-mortality, and molecularly heterogeneous cancers. TFCP2-rearranged rhabdomyosarcoma (RMS) is a rare, aggressive cancer wit…
View article: In Silico Modeling of Safe Force Limits for Trismus Therapy Following Jaw Reconstruction
In Silico Modeling of Safe Force Limits for Trismus Therapy Following Jaw Reconstruction Open
Background and Objective Restricted mouth opening (trismus) is a common complication following segmental mandibulectomy and autologous bone reconstruction. However, the biomechanical limits of reconstructed mandibles, particularly in cases…
View article: CTCF Binding Site Mutations: Linking Topologically Associated Domains Dysregulation to Cutaneous Squamous Cell Carcinoma Progression
CTCF Binding Site Mutations: Linking Topologically Associated Domains Dysregulation to Cutaneous Squamous Cell Carcinoma Progression Open
Background Cutaneous squamous cell carcinoma (cSCC) is the most common lethal malignancy with metastatic potential. The high mutational burden in cSCC has made it difficult to understand the significance of variants in the noncoding and re…
View article: Improving genetic diagnostic yield in familial and sporadic cerebral cavernous malformations: detection of copy number and deep Intronic variants
Improving genetic diagnostic yield in familial and sporadic cerebral cavernous malformations: detection of copy number and deep Intronic variants Open
Cerebral cavernous malformations (CCMs) are intracranial vascular lesions associated with risk of haemorrhages and seizures. While the majority are sporadic and often associated with somatic variants in PIK3CA and MAP3K3, around 20% are fa…
View article: Traffic Light Coding System for Engaging With <scp>AI</scp> in Surgery
Traffic Light Coding System for Engaging With <span>AI</span> in Surgery Open
Artificial Intelligence (AI) is generally defined as the development of computer systems or machines that can perform tasks typically requiring human intelligence and is increasingly being used in modern healthcare. While, various AI syste…
View article: Determinants of surgical department research success
Determinants of surgical department research success Open
View article: Surgical approach to model facial nerve paralysis in an ovine model for in vivo testing of a novel intervention
Surgical approach to model facial nerve paralysis in an ovine model for in vivo testing of a novel intervention Open
Facial nerve paralysis (FNP) disrupts neural inputs to the facial muscles, the most significant being those responsible for blinking. This loss often results in discomfort, corneal exposure, and if improperly treated, vision loss. FNP typi…
View article: Mechanobiologically-optimized non-resorbable artificial bone – a new paradigm in patient-matched scaffold-guided bone regeneration
Mechanobiologically-optimized non-resorbable artificial bone – a new paradigm in patient-matched scaffold-guided bone regeneration Open
Patient-matched scaffold guided bone regeneration (SGBR) has been poised to revolutionize the management of critical-sized bone defects due to trauma, tumors, infection, and congenital deformities. However, translation has been hampered by…
View article: Evaluation of osseointegration of plasma treated polyaryletherketone maxillofacial implants
Evaluation of osseointegration of plasma treated polyaryletherketone maxillofacial implants Open
View article: A comparison of the accuracy and feasibility of a low‐cost mobile application versus higher‐cost handheld <scp>3D</scp> scanner for digital ear prosthetics
A comparison of the accuracy and feasibility of a low‐cost mobile application versus higher‐cost handheld <span>3D</span> scanner for digital ear prosthetics Open
Background Facial prosthetics are an important means to rehabilitate patients with congenital or acquired facial defects. However, with a time‐consuming manual workflow and workforce shortage, access to facial prosthetics is limited in Aus…
View article: Finite element analysis of biomechanical alterations in the temporomandibular joint following mandibular reconstruction
Finite element analysis of biomechanical alterations in the temporomandibular joint following mandibular reconstruction Open
View article: The Impact of Preoperative Facial Nerve Weakness and Facial Nerve Outcomes in the Management of Patients With Parotid Metastases of Cutaneous Squamous Cell Carcinoma
The Impact of Preoperative Facial Nerve Weakness and Facial Nerve Outcomes in the Management of Patients With Parotid Metastases of Cutaneous Squamous Cell Carcinoma Open
Background Cutaneous squamous cell carcinomas (cSCC) metastasizing to the parotid gland can cause facial nerve (FN) dysfunction secondary to direct invasion, perineural spread, or surgical ablation. This study aims to characterize the prev…
View article: Predictors of accidental parathyroidectomy and hypoparathyroidism in thyroid surgery
Predictors of accidental parathyroidectomy and hypoparathyroidism in thyroid surgery Open
View article: Exploring Trismus Management in Australia: A Mixed Methods Evaluation of Surveys and Interviews With Health Professionals
Exploring Trismus Management in Australia: A Mixed Methods Evaluation of Surveys and Interviews With Health Professionals Open
Objective This study evaluates how health care professionals manage trismus in Australia and identifies facilitators and barriers experienced by clinicians in routine patient care. Methods A mixed‐methods approach was used to evaluate the …
View article: Trismus following facial nerve sacrifice and reanimation surgery: Incidence and management
Trismus following facial nerve sacrifice and reanimation surgery: Incidence and management Open
View article: Botulinum toxin application to the buccinator muscle in the treatment of facial synkinesis: a prospective cohort study
Botulinum toxin application to the buccinator muscle in the treatment of facial synkinesis: a prospective cohort study Open
Background: Synkinesis may develop following facial nerve palsy, impacting quality of life. Botulinum toxin treatment for synkinesis is commonly used, but buccinator muscle injection is less common. We aim to investigate buccinator botulin…
View article: The prevalence and predictors of discharge opioid overprescribing in opioid-naïve patients after breast, gynecologic, and head and neck cancer surgery: a prospective cohort study
The prevalence and predictors of discharge opioid overprescribing in opioid-naïve patients after breast, gynecologic, and head and neck cancer surgery: a prospective cohort study Open
View article: Predictors of distant metastatic recurrence in head and neck cutaneous squamous cell carcinoma with lymph node metastases treated with curative intent: A multicenter study
Predictors of distant metastatic recurrence in head and neck cutaneous squamous cell carcinoma with lymph node metastases treated with curative intent: A multicenter study Open
Background We aimed to identify predictors of distant metastatic recurrence (DMR) in patients with head and neck cutaneous squamous cell carcinoma (HNcSCC) with nodal metastases treated with curative intent. Methods Predictors of DMR were …
View article: A qualitative exploration of the pathway to diagnosis and treatment of cutaneous squamous cell carcinoma of the head and neck with perineural spread
A qualitative exploration of the pathway to diagnosis and treatment of cutaneous squamous cell carcinoma of the head and neck with perineural spread Open
Background Perineural spread (PNS) is associated with a poor prognosis in cutaneous squamous cell carcinoma of the head and neck (cSCCHN). Hence, investigating facilitators and barriers of early diagnosis and treatment of PNS in cSCCHN may…
View article: Models of survivorship care in patients with head and neck cancer in regional, rural, and remote areas: a systematic review
Models of survivorship care in patients with head and neck cancer in regional, rural, and remote areas: a systematic review Open
Purpose Rural people with head and neck cancers (HNC) are likely to experience poorer health outcomes due to limited access to health services, so many benefit from models of care that account for rurality. The aim of this review was to sy…
View article: Association between Swallowing Outcomes and Dose to Critical Swallow Structures in Patients Undergoing Transoral Robotic Surgery and Post-Operative Radiation Therapy
Association between Swallowing Outcomes and Dose to Critical Swallow Structures in Patients Undergoing Transoral Robotic Surgery and Post-Operative Radiation Therapy Open
Background The radiation dose to dysphagia and aspiration-related structures (DARS) for patients undergoing transoral robotic surgery (TORS) and post-operative radiation therapy (PORT) for primary oropharyngeal carcinoma is unknown. Method…
View article: Quality of life outcomes in patients receiving dental implants in vascularised bone flaps for mandibular reconstruction
Quality of life outcomes in patients receiving dental implants in vascularised bone flaps for mandibular reconstruction Open
Resection, reconstruction, and rehabilitation of the mandible impact function and health related quality of life (HRQOL). In this study, we aimed to understand the impact of delayed versus immediate dental implant placement. A cross-sectio…
View article: On effect of residual stress on fracture behavior of mandibular reconstruction plates
On effect of residual stress on fracture behavior of mandibular reconstruction plates Open
Titanium reconstruction plates are often used to bridge mandibulectomy defects in load bearing scenarios when bone grafts are not well integrated to the host bone. The residual stress within a standard reconstruction plate is generated whe…
View article: Exercise adherence for patients with trismus after head and neck cancer treatment
Exercise adherence for patients with trismus after head and neck cancer treatment Open
Background Head and neck cancer treatment often leads to trismus, a condition characterized by limited mouth opening. Exercise‐based therapy is the most common intervention but there are no clear guidelines as to the optimal exercise regim…
View article: Spatial mapping reveals unique cellular interactions and enhanced tertiary lymphoid structures in responders to anti-PD-1 therapy in mucosal head and neck cancers
Spatial mapping reveals unique cellular interactions and enhanced tertiary lymphoid structures in responders to anti-PD-1 therapy in mucosal head and neck cancers Open
Survival in recurrent/metastatic head and neck mucosal squamous cell carcinoma (HNmSCC) remains poor. Anti-programmed death (PD)-1 therapies have demonstrated improved survival with lower toxicity when compared to standard chemotherapy. Ho…
View article: Restorabite™: Phase <scp>II</scp> trial of jaw stretching exercises using a novel device for patients with trismus following head and neck cancer
Restorabite™: Phase <span>II</span> trial of jaw stretching exercises using a novel device for patients with trismus following head and neck cancer Open
Patients treated for oral cancer, may experience restricted mouth opening (trismus). Barriers such as cost have limited the utilization of traditional jaw stretching devices, and consequently, patients experience problems with swallowing, …
View article: Chondrocyte harvest viability of auricular and nasal septal cartilage in a sheep model
Chondrocyte harvest viability of auricular and nasal septal cartilage in a sheep model Open
Introduction: Autologous techniques for reconstruction of cartilaginous structures of the head and neck are limited by donor cartilage volume, donor site morbidity and inconsistent results. Bioprinting combines “bioinks” consisting of livi…
View article: Functional and aesthetic outcomes of dermofat graft reconstruction in limited parotidectomy defects: a cross-sectional study
Functional and aesthetic outcomes of dermofat graft reconstruction in limited parotidectomy defects: a cross-sectional study Open
Background: To mitigate the cosmetic defect associated with parotidectomy, dermofat grafts have been utilized to restore the contour of the face and reduce complications such as salivary leak and Frey's syndrome. This study aimed to invest…
View article: Dynamic optimisation for graded tissue scaffolds using machine learning techniques
Dynamic optimisation for graded tissue scaffolds using machine learning techniques Open
Tissue scaffolds have emerged as a promising solution for treatment of critical size bone defects, offering significant advantages over conventional strategies. One of the key functionalities of bone scaffolds is their ability to promote l…