David W. Dyer
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View article: Age, sex, and mitochondrial-haplotype influence gut microbiome composition and metabolites in a genetically diverse rat model
Age, sex, and mitochondrial-haplotype influence gut microbiome composition and metabolites in a genetically diverse rat model Open
We evaluated the impact of sex and mitochondrial-haplotype on the age-related changes in the fecal gut microbiome of the genetically heterogeneous rodent model, the OKC-HETB/W rat. The age-related changes in the microbiome diffe…
View article: Age, sex, and mitochondrial-haplotype influence gut microbiome composition and metabolites in a genetically diverse rat model
Age, sex, and mitochondrial-haplotype influence gut microbiome composition and metabolites in a genetically diverse rat model Open
We evaluated the impact of sex and mitochondrial-haplotype on the age-related changes in the fecal gut microbiome of the genetically heterogeneous rodent model, the OKC-HET B/W rat. Alpha-diversity, measuring richness and evenness of gut m…
View article: Western diet-induced shifts in the maternal microbiome are associated with altered microRNA expression in baboon placenta and fetal liver
Western diet-induced shifts in the maternal microbiome are associated with altered microRNA expression in baboon placenta and fetal liver Open
Maternal consumption of a high-fat, Western-style diet (WD) disrupts the maternal/infant microbiome and contributes to developmental programming of the immune system and nonalcoholic fatty liver disease (NAFLD) in the offspring. Epigenetic…
View article: Western diet-induced shifts in the maternal microbiome are associated with altered microRNA expression in baboon placenta and fetal liver
Western diet-induced shifts in the maternal microbiome are associated with altered microRNA expression in baboon placenta and fetal liver Open
Maternal consumption of a high-fat, Western-style diet (WD) disrupts the maternal/infant microbiome and contributes to developmental programming of the immune system and nonalcoholic fatty liver disease (NAFLD) in the offspring. Epigenetic…
View article: Hyaluronic Acid 35 kDa Protects against a Hyperosmotic, Formula Feeding Model of Necrotizing Enterocolitis
Hyaluronic Acid 35 kDa Protects against a Hyperosmotic, Formula Feeding Model of Necrotizing Enterocolitis Open
Necrotizing enterocolitis (NEC), an inflammatory disease of the intestine, is a common gastrointestinal emergency among preterm infants. Intestinal barrier dysfunction, hyperactivation of the premature immune system, and dysbiosis are thou…
View article: Early Antibiotic Exposure Alters Intestinal Development and Increases Susceptibility to Necrotizing Enterocolitis: A Mechanistic Study
Early Antibiotic Exposure Alters Intestinal Development and Increases Susceptibility to Necrotizing Enterocolitis: A Mechanistic Study Open
Increasing evidence suggests that prolonged antibiotic therapy in preterm infants is associated with increased mortality and morbidities, such as necrotizing enterocolitis (NEC), a devastating gastrointestinal pathology characterized by in…
View article: Antibacterial efficacy of non-thermal atmospheric plasma against Streptococcus mutans biofilm grown on the surfaces of restorative resin composites
Antibacterial efficacy of non-thermal atmospheric plasma against Streptococcus mutans biofilm grown on the surfaces of restorative resin composites Open
View article: OCT4 and YY1 transcription factors regulate gene expression of an adenoviral ocular pathogen
OCT4 and YY1 transcription factors regulate gene expression of an adenoviral ocular pathogen Open
View article: Acceleration of Small Intestine Development and Remodeling of the Microbiome Following Hyaluronan 35 kDa Treatment in Neonatal Mice
Acceleration of Small Intestine Development and Remodeling of the Microbiome Following Hyaluronan 35 kDa Treatment in Neonatal Mice Open
The beneficial effects of human milk suppressing the development of intestinal pathologies such as necrotizing enterocolitis in preterm infants are widely known. Human milk (HM) is rich in a multitude of bioactive factors that play major r…
View article: Identification and purification of a hemoglobin-binding outer membrane protein from Neisseria gonorrhoeae.
Identification and purification of a hemoglobin-binding outer membrane protein from Neisseria gonorrhoeae. Open
The majority of in vitro-grown Neisseria gonorrhoeae strains were unable to use hemoglobin as the sole source of iron for growth (Hgb-), but a minor population was able to do so (Hgb+). The ability of Hgb+ gonococci to utilize hemoglobin a…
View article: Loss of transferrin receptor activity in Neisseria meningitidis correlates with inability to use transferrin as an iron source.
Loss of transferrin receptor activity in Neisseria meningitidis correlates with inability to use transferrin as an iron source. Open
Although Neisseria meningitidis does not produce siderophores, it is able to obtain iron from human transferrin. We observed saturable specific binding of 125I-labeled human transferrin to meningococci. Human lactoferrin and mouse transfer…
View article: Human immune response to iron-repressible outer membrane proteins of Neisseria meningitidis.
Human immune response to iron-repressible outer membrane proteins of Neisseria meningitidis. Open
Neisseria meningitidis grown under iron-limiting conditions in vitro expresses additional iron-repressible outer membrane proteins (FeRPs). To see which FeRPs were expressed and immunogenic in human infection, we examined purified membrane…
View article: Effects of serum carrier proteins on the growth of pathogenic neisseriae with heme-bound iron.
Effects of serum carrier proteins on the growth of pathogenic neisseriae with heme-bound iron. Open
The pathogenic neisseriae can use free heme and hemoglobin as an essential source of iron (Fe) for growth in vitro, but it is unknown whether they can utilize heme bound to human hemopexin or to human serum albumin, or hemoglobin bound to …
View article: Genomics‐based re‐examination of the taxonomy and phylogeny of <i>human</i> and <i>simian Mastadenoviruses</i>: an evolving whole genomes approach, revealing putative zoonosis, anthroponosis, and amphizoonosis
Genomics‐based re‐examination of the taxonomy and phylogeny of <i>human</i> and <i>simian Mastadenoviruses</i>: an evolving whole genomes approach, revealing putative zoonosis, anthroponosis, and amphizoonosis Open
With the advent of high‐resolution and cost‐effective genomics and bioinformatics tools and methods contributing to a large database of both human (HAdV) and simian (SAdV) adenoviruses, a genomics‐based re‐evaluation of their taxonomy is w…
View article: Small Particle Aerosol Exposure of African Green Monkeys to MERS-CoV as a Model for Highly Pathogenic Coronavirus Infection
Small Particle Aerosol Exposure of African Green Monkeys to MERS-CoV as a Model for Highly Pathogenic Coronavirus Infection Open
Emerging highly pathogenic coronaviruses (CoV) are a global public health threat due to the potential for person-to-person transmission and higher mortality rates than common seasonal respiratory pathogens. Middle East respiratory syndrome…
View article: Small Particle Aerosol Exposure of African Green Monkeys to MERS-CoV as a Model for Highly Pathogenic Coronavirus Infection
Small Particle Aerosol Exposure of African Green Monkeys to MERS-CoV as a Model for Highly Pathogenic Coronavirus Infection Open
Emerging highly pathogenic coronaviruses (CoV) are a global public health threat due to the potential for person-to-person transmission and higher mortality rates than common seasonal respiratory pathogens. Middle East respiratory syndrome…
View article: Genomic foundations of evolution and ocular pathogenesis in human adenovirus species D
Genomic foundations of evolution and ocular pathogenesis in human adenovirus species D Open
Human adenovirus commonly causes infections of respiratory, gastrointestinal, genitourinary, and ocular surface mucosae. Although most adenovirus eye infections are mild and self‐limited, specific viruses within human adenovirus species D …
View article: A Zoonotic Adenoviral Human Pathogen Emerged through Genomic Recombination among Human and Nonhuman Simian Hosts
A Zoonotic Adenoviral Human Pathogen Emerged through Genomic Recombination among Human and Nonhuman Simian Hosts Open
An emergent adenoviral human pathogen, HAdV-B76, associated with a fatality in 1965, shows a remarkable degree of genome identity with two recently isolated simian adenoviruses that contain cross-species genome recombination events from th…
View article: Divergent Evolution of E1A CR3 in Human Adenovirus Species D
Divergent Evolution of E1A CR3 in Human Adenovirus Species D Open
Adenovirus E1A is the first viral protein expressed during infection. E1A controls critical aspects of downstream viral gene expression and cell cycle deregulation, and its function is thought to be highly conserved among adenoviruses. Var…
View article: Draft Genome Sequence of Pediatric Otitis Media Isolate Streptococcus pneumoniae Strain EF3030, Which Forms <i>In Vitro</i> Biofilms That Closely Mimic <i>In Vivo</i> Biofilms
Draft Genome Sequence of Pediatric Otitis Media Isolate Streptococcus pneumoniae Strain EF3030, Which Forms <i>In Vitro</i> Biofilms That Closely Mimic <i>In Vivo</i> Biofilms Open
Here, we report the draft genome sequence of Streptococcus pneumoniae EF3030, a pediatric otitis media isolate active in biofilm assays of epithelial colonization. The final draft assembly included 2,209,198 bp; the annotation predicted 2,…
View article: Corrigendum: Adenoviromics: Mining the Human Adenovirus Species D Genome
Corrigendum: Adenoviromics: Mining the Human Adenovirus Species D Genome Open
[This corrects the article DOI: 10.3389/fmicb.2018.02178.].
View article: Author Correction: Genomic analysis of a large set of currently—and historically—important human adenovirus pathogens
Author Correction: Genomic analysis of a large set of currently—and historically—important human adenovirus pathogens Open
The original publication of this article [1] was missing the below author that made contributions to the research and the published article.
View article: Adenoviromics: Mining the Human Adenovirus Species D Genome
Adenoviromics: Mining the Human Adenovirus Species D Genome Open
Human adenovirus (HAdV) infections cause disease world-wide. Whole genome sequencing has now distinguished 90 distinct genotypes in 7 species (A-G). Over half of these 90 HAdVs fall within species D, with essentially all of the HAdV-D whol…
View article: Bacterial RecA Protein Promotes Adenoviral Recombination during <i>In Vitro</i> Infection
Bacterial RecA Protein Promotes Adenoviral Recombination during <i>In Vitro</i> Infection Open
Adenoviruses are common human mucosal pathogens of the gastrointestinal, respiratory, and genitourinary tracts and ocular surface. Here, we report finding Chi-like sequences in adenovirus recombination hot spots. Adenovirus coinfection in …
View article: Genomic analysis of a large set of currently—and historically—important human adenovirus pathogens
Genomic analysis of a large set of currently—and historically—important human adenovirus pathogens Open
Human adenoviruses (HAdVs) are uniquely important "model organisms" as they have been used to elucidate fundamental biological processes, are recognized as complex pathogens, and are used as remedies for human health. As pathogens, HAdVs m…
View article: Route of infection alters virulence of neonatal septicemia Escherichia coli clinical isolates
Route of infection alters virulence of neonatal septicemia Escherichia coli clinical isolates Open
Escherichia coli is the leading cause of Gram-negative neonatal septicemia in the United States. Invasion and passage across the neonatal gut after ingestion of maternal E. coli strains produce bacteremia. In this study, we compared the vi…
View article: Bacteria-driven evolution of human adenoviruses
Bacteria-driven evolution of human adenoviruses Open
View article: Iron-regulated small RNA expression as Neisseria gonorrhoeae FA 1090 transitions into stationary phase growth
Iron-regulated small RNA expression as Neisseria gonorrhoeae FA 1090 transitions into stationary phase growth Open
Here we report the temporal expression of Fe-regulated sRNAs in N. gonorrhoeae FA 1090 with several appearing to be controlled by the Fe-repressible sRNA NrrF. Temporal regulation of these sRNAs suggests a regulatory role in controlling fu…
View article: The 5′UTR in human adenoviruses: leader diversity in late gene expression
The 5′UTR in human adenoviruses: leader diversity in late gene expression Open
View article: Additional file 8: Table S4. of Iron-regulated small RNA expression as Neisseria gonorrhoeae FA 1090 transitions into stationary phase growth
Additional file 8: Table S4. of Iron-regulated small RNA expression as Neisseria gonorrhoeae FA 1090 transitions into stationary phase growth Open
Lists of 451 Neisseriaceae complete and draft genomes; blastn results of the homology search in 345 Neisseria sp. for Nrs and Nrf sRNAs; list of the Neisseria sp. genomes used for cluster analysis. (XLSX 353 kb)