Explanipedia

Author Correction: Reciprocal signalling by Notch–Collagen V–CALCR retains muscle stem cells in their niche Open

Meryem B. Baghdadi, David Castel, Léo Machado, So‐ichiro Fukada, David E. Birk , et al. · 2025

Collagen V Influences Homeostatic Maintenance of Patellar Tendon Failure Properties in Mature Female Mice Open

Ryan J. Leiphart, Jeremy D. Eekhoff, Stephanie N. Weiss, R. P. Betts, Jaclyn A. Carlson , et al. · 2025

The collagenous matrix of tendon provides mechanical integrity, allowing the tissue to withstand large tensile forces. While collagen I‐containing fibrils provide the major backbone of the tendon matrix, interactions with other collagen ty…

Structure, Mechanics, and Mechanobiology of Fibrocartilage Pericellular Matrix Mediated by Type V Collagen (Adv. Sci. 32/2025) Open

Chao Wang, Mingyue Fan, Su‐Jin Heo, Sheila M. Adams, Thomas Li , et al. · 2025

Structure, Mechanics, and Mechanobiology of Fibrocartilage Pericellular Matrix Mediated by Type V Collagen Open

Chao Wang, Mingyue Fan, Su‐Jin Heo, Sheila M. Adams, Thomas Li , et al. · 2025

The pericellular matrix (PCM) is the immediate microniche surrounding cells in various tissues, regulating matrix turnover, cell‐matrix interactions, and disease. This study elucidates the structure‐mechanical properties and mechanobiology…

Decorin and/or biglycan knockdown in aged mouse patellar tendon impacts fibril morphology, scar area, and mechanical properties Open

Joseph B. Newton, Stephanie N. Weiss, Courtney A. Nuss, Christelle Darrieutort‐Laffite, Jeremy D. Eekhoff , et al. · 2024

Small leucine‐rich proteoglycans, such as decorin and biglycan, play pivotal roles in collagen fibrillogenesis during development, healing, and aging in tendon. Previous work has shown that the absence of decorin and biglycan affects fibri…

Structure-Mechanics Principles and Mechanobiology of Fibrocartilage Pericellular Matrix: A Pivotal Role of Type V Collagen Open

Chao Wang, Mingyue Fan, Su-Jin Heo, Sheila M. Adams, Thomas Li , et al. · 2024

The pericellular matrix (PCM) is the immediate microniche surrounding resident cells in various tissue types, regulating matrix turnover, cell-matrix cross-talk and disease initiation. This study elucidated the structure-mechanical propert…

Collagen V haploinsufficiency in female murine patellar tendons results in altered matrix engagement and cellular density, demonstrating decreased healing Open

Jaclyn A. Carlson, Snehal S. Shetye, Mei Sun, Stephanie N. Weiss, David E. Birk , et al. · 2023

Collagen V (Col5) is a quantitatively minor component of collagen fibrils comprising tendon, however, plays a crucial role in regulation of development and dynamic healing processes. Clinically, patients with COL5a1 haploinsufficiency, kno…

Ablation of collagen XII disturbs joint extracellular matrix organization and causes patellar subluxation Open

Mengjie Zhu, Fabian Metzen, Mark Hopkinson, Janina Betz, Juliane Heilig , et al. · 2023

Collagen XII, belonging to the fibril-associated collagens, is a homotrimeric secreted extracellular matrix (ECM) protein encoded by the COL12A1 gene. Mutations in the human COL12A1 gene cause an Ehlers-Danlos/myopathy overla…

Collagen XII mediated cellular and extracellular mechanisms in development, regeneration, and disease Open

Yayoi Izu, David E. Birk · 2023

Collagen XII, a fibril-associated collagen with interrupted triple helices (FACIT), influences fibrillogenesis in numerous tissues. In addition to this extracellular function, collagen XII also directly regulates cellular function. Collage…

Targeted conditional collagen XII deletion alters tendon function Open

Ashley K. Fung, Mei Sun, Louis J. Soslowsky, David E. Birk · 2022

Decorin knockdown is beneficial for aged tendons in the presence of biglycan expression Open

Zakary M. Beach, Mihir S. Dekhne, Ashley B. Rodriguez, Stephanie N. Weiss, Thomas H. Adams , et al. · 2022

Decorin and biglycan are two major small leucine-rich proteoglycans (SLRPs) present in the tendon extracellular matrix that facilitate collagen fibrillogenesis, tissue turnover, and cell signal transduction. Previously, we demonstrated tha…

Biglycan has a major role in maintenance of mature tendon mechanics Open

Zakary M. Beach, Kelsey A. Bonilla, Mihir S. Dekhne, Mei Sun, Thomas H. Adams , et al. · 2022

Decorin and biglycan are two small leucine‐rich proteoglycans (SLRPs) that regulate collagen fibrillogenesis and extracellular matrix assembly in tendon. The objective of this study was to determine the individual roles of these molecules …

Ablation of the FACIT collagen XII disturbs musculoskeletal ECM organization and causes patella dislocation and myopathy Open

Mengjie Zhu, Fabian Metzen, Janina Betz, Mark Hopkinson, Juliane Heilig , et al. · 2021

Collagen XII, belonging to the fibril-associated collagens with interrupted triple helix (FACIT) family, assembles from three identical α-chains encoded by the COL12A1 gene. The trimeric molecule consists of three N-terminal noncollagenous…

Coordinate roles for collagen VI and biglycan in regulating tendon collagen fibril structure and function Open

Ryan J. Leiphart, Hai Thanh Pham, Tyler Harvey, Taishi Komori, Tina M. Kilts , et al. · 2021

Tendon is a vital musculoskeletal tissue that is prone to degeneration. Proper tendon maintenance requires complex interactions between extracellular matrix components that remain poorly understood. Collagen VI and biglycan are two matrix …

Collagen Dysregulation in the Dermis of the Sagg/+ Mouse: A Loose Skin Model Open

Paul J. Christner, Julieta Gentiletti, Josephine Peters, Simon Ball, Mitsuo Yamauchi , et al. · 2021

The Sagg/+ mouse is an ethylnitrosourea-derived mutant with a dermal phenotype similar to some of the subtypes of Ehlers-Danlos syndrome (EDS) and cutis laxa. The dermis of the Sagg/+ mouse has less dense and more disorganized collagen fib…

Type V collagen regulates the structure and biomechanics of TMJ condylar cartilage: A fibrous-hyaline hybrid Open

Prashant Chandrasekaran, Bryan Kwok, Biao Han, Sheila M. Adams, Chao Wang , et al. · 2021

Differentiated activities of decorin and biglycan in the progression of post-traumatic osteoarthritis Open

Biao Han, Q. Li, C. Wang, Prashant Chandrasekaran, Ying Zhou , et al. · 2021

Decorin regulates cartilage pericellular matrix micromechanobiology Open

Daphney R. Chery, Biao Han, Ying Zhou, Chao Wang, Sheila M. Adams , et al. · 2020

Collagen XII mediated cellular and extracellular mechanisms regulate establishment of tendon structure and function Open

Yayoi Izu, Sheila M. Adams, Brianne K. Connizzo, David P. Beason, Louis J. Soslowsky , et al. · 2020

Collagen XI regulates the acquisition of collagen fibril structure, organization and functional properties in tendon Open

Mei Sun, Eric Y. Luo, Sheila M. Adams, Thomas H. Adams, Yaping Ye , et al. · 2020

Collagen XI is a fibril-forming collagen that regulates collagen fibrillogenesis. Collagen XI is normally associated with collagen II-containing tissues such as cartilage, but it also is expressed broadly during development in collagen I-c…

Composition, structure and function of the corneal stroma Open

Edgar M. Espana, David E. Birk · 2020

Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury Open

Tomohiro Yokota, Jackie L. McCourt, Feiyang Ma, Shuxun Ren, Shen Li , et al. · 2020

Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity Open

Chang Yeop Han, Inkyung Kang, Ingrid A. Harten, John A. Gebe, Christina K. Chan , et al. · 2020

Collagen XII Is a Regulator of Corneal Stroma Structure and Function Open

Mei Sun, Nabeel Zafrullah, Floriane Devaux, Chinda Hemmavanh, Sheila M. Adams , et al. · 2020

Collagen XII plays a major role in establishing and maintaining stromal structure and function. In the absence of collagen XII, the corneal stroma showed significant abnormalities, including decreased interfibrillar space, disrupted lamell…

Endothelial–Stromal Communication in Murine and Human Corneas Open

Lauren J. Jeang, J. Byeong, David E. Birk, Edgar M. Espana · 2020

The purpose of this study is to identify and characterize interactions of corneal endothelial cells with the posterior stroma. Corneal endothelial–stromal interactions were examined in developing postnatal day 3 (P3) and mature postnatal d…

Mediation of Cartilage Matrix Degeneration and Fibrillation by Decorin in Post‐traumatic Osteoarthritis Open

Qing Li, Biao Han, Chao Wang, Wei Tong, Yulong Wei , et al. · 2020

Objective To elucidate the role of decorin, a small leucine‐rich proteoglycan, in the degradation of cartilage matrix during the progression of post‐traumatic osteoarthritis ( OA ). Methods Three‐month–old decorin‐null (Dcn −/− ) and induc…

Decorin Regulates the Aggrecan Network Integrity and Biomechanical Functions of Cartilage Extracellular Matrix Open

Biao Han, Qing Li, Chao Wang, Pavan Patel, Sheila M. Adams , et al. · 2019

Joint biomechanical functions rely on the integrity of cartilage extracellular matrix. Understanding the molecular activities that govern cartilage matrix assembly is critical for developing effective cartilage regeneration strategies. Thi…

Collagen XII Regulates Corneal Stroma Stiffness and Myofibroblast Differentiation Open

Edgar M. Espana, Mei Sun, David E. Birk · 2019

Limb- and tendon-specific Adamtsl2 deletion identifies a role for ADAMTSL2 in tendon growth in a mouse model for geleophysic dysplasia Open

Dirk Hubmacher, Nandaraj Taye, Zerina Balic, Stetson Thacker, Sheila M. Adams , et al. · 2019

Therapeutic efficacy of mesenchymal stem cells for the treatment of congenital and acquired corneal opacity. Open

Mindy K. Call, Mohamed Elzarka, Mary Kunesh, Nanki Hura, David E. Birk , et al. · 2019

UMSC transplantation was successful in recovering some corneal transparency in injured corneas of wild-type, Col5a1^f/f and Col5a1^∆st/∆st mice. The production of collagen V by transplanted UMSCs may accou…

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