David E. Bruns
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View article: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus
Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus Open
BACKGROUND Numerous laboratory tests are used in the diagnosis and management of diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially. APPROACH An expert committee compiled evide…
View article: Executive Summary: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus
Executive Summary: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus Open
Background Numerous laboratory tests are used in the diagnosis and management of patients with diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially. An expert committee compiled …
View article: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus
Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus Open
BACKGROUND Numerous laboratory tests are used in the diagnosis and management of diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially. APPROACH An expert committee compiled evide…
View article: Executive Summary: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus
Executive Summary: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus Open
BACKGROUND Numerous laboratory tests are used in the diagnosis and management of patients with diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially. An expert committee compiled …
View article: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus
Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus Open
BACKGROUND Numerous laboratory tests are used in the diagnosis and management of diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially. APPROACH An expert committee compiled evide…
View article: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus
Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus Open
Background Numerous laboratory tests are used in the diagnosis and management of diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially. Approach An expert committee compiled evide…
STARD 2015 guidelines for reporting diagnostic accuracy studies: explanation and elaboration Open
Diagnostic accuracy studies are, like other clinical studies, at risk of bias due to shortcomings in design and conduct, and the results of a diagnostic accuracy study may not apply to other patient groups and settings. Readers of study re…
View article: Milliarcsecond Astrometry for the Galilean Moons Using Stellar Occultations
Milliarcsecond Astrometry for the Galilean Moons Using Stellar Occultations Open
A stellar occultation occurs when a Solar System object passes in front of a star for an observer. This technique allows the sizes and shapes of the occulting body to be determined with kilometer precision. In addition, this technique cons…
STARD 2015 guidelines for reporting diagnostic accuracy studies: explanation and elaboration. Translation to Russian Open
Diagnostic accuracy studies are, like other clinical studies, at risk of bias due to shortcomings in design and conduct, and the results of a diagnostic accuracy study may not apply to other patient groups and settings. Readers of study re…
RECOVER-E – a mobile app for patients undergoing total knee or hip replacement: study protocol Open
Background Total knee replacement (TKR) or total hip replacement (THR) are common and effective procedures in patients with osteoarthritis (OA) to restore physical function and reduce joint related pain. Patient education plays an importan…
View article: Inadequate Reporting of Analytical Characteristics of Biomarkers Used in Clinical Research: A Threat to Interpretation and Replication of Study Findings
Inadequate Reporting of Analytical Characteristics of Biomarkers Used in Clinical Research: A Threat to Interpretation and Replication of Study Findings Open
BACKGROUND Analytical characteristics of methods to measure biomarkers determine how well the methods measure what they claim to measure. Transparent reporting of analytical characteristics allows readers to assess the validity and general…
Streamlining Quality Review of Mass Spectrometry Data in the Clinical Laboratory by Use of Machine Learning Open
Context.— Turnaround time and productivity of clinical mass spectrometric (MS) testing are hampered by time-consuming manual review of the analytical quality of MS data before release of patient results. Objective.— To determine whether a …
Prevalence of Rare Hemoglobin Variants Identified During Measurements of Hb A1c by Capillary Electrophoresis Open
To the Editor: Hemoglobin (Hb)1 variants represent a challenge to the validity of measurements of Hb A1c. Hb variants can falsely increase or decrease reported Hb A1c results, depending on the measurement procedure used (1, 2). Moreover, H…
Decrease of Serum IGF-I following Transsphenoidal Pituitary Surgery for Acromegaly Open
BACKGROUND In the immediate postoperative period following resection of growth hormone (GH)-secreting pituitary tumors, serum concentrations of GH have limited ability to predict remission of acromegaly. Since many actions of GH actions ar…
STARD 2015 guidelines for reporting diagnostic accuracy studies: explanation and elaboration Open
Diagnostic accuracy studies are, like other clinical studies, at risk of bias due to shortcomings in design and conduct, and the results of a diagnostic accuracy study may not apply to other patient groups and settings. Readers of study re…
Undetectable Urine Calcium in a Gastric Bypass Patient Open
A 62-year-old woman with osteoporosis was noted to have undetectable urine calcium (Table 1). The patient had undergone Roux-en-Y surgery for weight loss 10 years earlier. Her medications included zoledronic acid, calcitriol, and calcium s…
Updating standards for reporting diagnostic accuracy: the development of STARD 2015 Open
After a systematic updating process, STARD 2015 provides an updated list of 30 essential items for reporting diagnostic accuracy studies.
Smartphones Can Monitor Medical Center Pneumatic Tube Systems Open
To the Editor: The pneumatic tube system (PTS) has become a common means of transportation of specimens in medical centers. Although the PTS provides convenience and speed of transport, hemolysis of blood specimens and preanalytical variat…
Undetectable Alanine Aminotransferase during Hospitalization Open
A 58-year-old man with chronic systolic heart failure and type 2 diabetes mellitus presented with bacteremia, acute exacerbation of chronic heart failure, and acute renal failure.He described poor appetite and drinking beer for several day…