David E. Elder
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View article: Generating Seamless Virtual Immunohistochemical Whole Slide Images with Content and Color Consistency
Generating Seamless Virtual Immunohistochemical Whole Slide Images with Content and Color Consistency Open
Immunohistochemical (IHC) stains play a vital role in a pathologist's analysis of medical images, providing crucial diagnostic information for various diseases. Virtual staining from hematoxylin and eosin (H&E)-stained whole slide images (…
View article: MPATH-Dx version 2.0 schema for melanocytic lesions: A robust tool for standardized diagnostic reporting
MPATH-Dx version 2.0 schema for melanocytic lesions: A robust tool for standardized diagnostic reporting Open
The new revised MPATH-Dx (version 2.0) reporting schema for melanocytic lesions is presented. Principal changes include the simplification of the previous five-class version 1.0 to a four-class hierarchy of melanocytic lesions to improve d…
View article: BRAF Mutated and Morphologically Spitzoid Tumors, a Subgroup of Melanocytic Neoplasms Difficult to Distinguish From True Spitz Neoplasms
BRAF Mutated and Morphologically Spitzoid Tumors, a Subgroup of Melanocytic Neoplasms Difficult to Distinguish From True Spitz Neoplasms Open
Drivers of Spitz neoplasms include activating point mutations in HRAS and Spitz-associated genomic fusions. It has become evident that some BRAF -mutated melanocytic neoplasms can morphologically mimic Spitz tumors (STs). These have been t…
View article: Immunohistochemistry for Diagnosing Melanoma in Older Adults
Immunohistochemistry for Diagnosing Melanoma in Older Adults Open
Importance Pathologic assessment to diagnose skin biopsies, especially for cutaneous melanoma, can be challenging, and immunohistochemistry (IHC) staining has the potential to aid decision-making. Currently, the temporal trends regarding t…
View article: Supplementary Fig. S1 from Increased cyclin D1 expression can mediate BRAF inhibitor resistance in <i>BRAF</i> V600E–mutated melanomas
Supplementary Fig. S1 from Increased cyclin D1 expression can mediate BRAF inhibitor resistance in <i>BRAF</i> V600E–mutated melanomas Open
Supplementary Fig. S1 from Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E–mutated melanomas
View article: Data from Increased cyclin D1 expression can mediate BRAF inhibitor resistance in <i>BRAF</i> V600E–mutated melanomas
Data from Increased cyclin D1 expression can mediate BRAF inhibitor resistance in <i>BRAF</i> V600E–mutated melanomas Open
Recent studies have shown that there is a considerable heterogeneity in the response of melanoma cell lines to MEK and BRAF inhibitors. In the current study, we address whether dysregulation of cyclin-dependent kinase 4 (CDK4) and/or cycli…
View article: Data from Increased cyclin D1 expression can mediate BRAF inhibitor resistance in <i>BRAF</i> V600E–mutated melanomas
Data from Increased cyclin D1 expression can mediate BRAF inhibitor resistance in <i>BRAF</i> V600E–mutated melanomas Open
Recent studies have shown that there is a considerable heterogeneity in the response of melanoma cell lines to MEK and BRAF inhibitors. In the current study, we address whether dysregulation of cyclin-dependent kinase 4 (CDK4) and/or cycli…
View article: Supplementary Fig. S1 from Increased cyclin D1 expression can mediate BRAF inhibitor resistance in <i>BRAF</i> V600E–mutated melanomas
Supplementary Fig. S1 from Increased cyclin D1 expression can mediate BRAF inhibitor resistance in <i>BRAF</i> V600E–mutated melanomas Open
Supplementary Fig. S1 from Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E–mutated melanomas
View article: Histopathological diagnosis of cutaneous melanocytic lesions: blinded and nonblinded second opinions offer similar improvement in diagnostic accuracy
Histopathological diagnosis of cutaneous melanocytic lesions: blinded and nonblinded second opinions offer similar improvement in diagnostic accuracy Open
We found that both blinded and nonblinded second reviewers offered a similar modest improvement in diagnostic accuracy compared with single reviewers. Obtaining second opinions with knowledge of previous reviews tends to generate agreement…
View article: Histopathologic synoptic reporting of invasive melanoma: How reliable are the data?
Histopathologic synoptic reporting of invasive melanoma: How reliable are the data? Open
Background Synoptic reporting is recommended by many guideline committees to encourage the thorough histologic documentation necessary for optimal management of patients with melanoma. Methods One hundred fifty‐one pathologists from 40 US …
View article: The Impact of Longitudinal Surveillance on Tumor Thickness for Melanoma-Prone Families with and without Pathogenic Germline Variants of <i>CDKN2A</i> and <i>CDK4</i>
The Impact of Longitudinal Surveillance on Tumor Thickness for Melanoma-Prone Families with and without Pathogenic Germline Variants of <i>CDKN2A</i> and <i>CDK4</i> Open
Background: Skin cancer screening is routinely performed for members of melanoma-prone families, but longitudinal studies evaluating the efficacy of surveillance in this high-risk population are lacking. Methods: We evaluated thickness for…
View article: Terminology for melanocytic skin lesions and the <scp>MPATH‐Dx</scp> classification schema: A survey of dermatopathologists
Terminology for melanocytic skin lesions and the <span>MPATH‐Dx</span> classification schema: A survey of dermatopathologists Open
Background Diagnostic terms used in histopathology reports of cutaneous melanocytic lesions are not standardized. We describe dermatopathologists' views regarding diverse diagnostic terminology and the utility of the Melanocytic Pathology …
View article: Clinical Validity of a Gene Expression Signature in Diagnostically Uncertain Neoplasms
Clinical Validity of a Gene Expression Signature in Diagnostically Uncertain Neoplasms Open
Aim: Evaluate the accuracy of a 23-gene expression signature in differentiating benign nevi from melanoma by comparing test results with clinical outcomes. Materials & methods: Seven dermatopathologists blinded to gene expression test resu…
View article: Malpractice and Patient Safety Concerns
Malpractice and Patient Safety Concerns Open
Objectives “Assurance behaviors,” a type of defensive medicine, involve physicians’ utilization of additional patient services to avoid adverse legal outcomes. We aim to compare the use of clinical behaviors (such as ordering additional te…
View article: Factors associated with use of immunohistochemical markers in the histopathological diagnosis of cutaneous melanocytic lesions
Factors associated with use of immunohistochemical markers in the histopathological diagnosis of cutaneous melanocytic lesions Open
Background Melanocytic tumors are often challenging and constitute almost one in four skin biopsies. Immunohistochemical (IHC) studies may assist diagnosis; however, indications for their use are not standardized. Methods A test set of 240…
View article: A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma
A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma Open
Therapy of advanced melanoma is changing dramatically. Following mutational and biological subclassification of this heterogeneous cancer, several targeted and immune therapies were approved and increased survival significantly. To facilit…
View article: Dermatopathologists’ Experience With and Perceptions of Patient Online Access to Pathologic Test Result Reports
Dermatopathologists’ Experience With and Perceptions of Patient Online Access to Pathologic Test Result Reports Open
Dermatopathologists in this survey study perceived both positive and negative consequences of patient online access to pathologic test result reports written by the respondents. Most participants believe that making pathologic test result …
View article: Assessment of Second-Opinion Strategies for Diagnoses of Cutaneous Melanocytic Lesions
Assessment of Second-Opinion Strategies for Diagnoses of Cutaneous Melanocytic Lesions Open
The results of this study suggest that second opinions rendered by dermatopathologists improve reliability of melanocytic lesion diagnosis. However, discordance among pathologists remained high.
View article: Draining dorsal hand pustules, nodules, and ulcers in a patient with immunosuppression
Draining dorsal hand pustules, nodules, and ulcers in a patient with immunosuppression Open
A man in his 70s with type 2 diabetes mellitus and chronic obstructive pulmonary disease taking 10 mg prednisone daily presented with 2 months of right dorsal hand pustules with purulent drainage (Fig 1) after peripheral intravenous infilt…
View article: Associations of pigmentary and naevus phenotype with melanoma risk in two populations with comparable ancestry but contrasting levels of ambient sun exposure
Associations of pigmentary and naevus phenotype with melanoma risk in two populations with comparable ancestry but contrasting levels of ambient sun exposure Open
Background People at high risk of developing melanoma are usually identified by pigmentary and naevus phenotypes. Objective We examined whether associations of these phenotypes with melanoma risk differed by ambient sun exposure or partici…