David E. Fleck
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View article: Changes in ventral prefrontal-subcortical network connectivity during the course of remission from bipolar mania
Changes in ventral prefrontal-subcortical network connectivity during the course of remission from bipolar mania Open
View article: 414 Post-stroke Cognitive deficits are associated with reduced cognitive conflict evoked mid-frontal EEG theta oscillations and can be potentially improved with prefrontal transcranial electrical stimulation
414 Post-stroke Cognitive deficits are associated with reduced cognitive conflict evoked mid-frontal EEG theta oscillations and can be potentially improved with prefrontal transcranial electrical stimulation Open
OBJECTIVES/GOALS: Cognitive dysfunction and/or depressionfollowing ischemic stroke results in loss of independence in daily functioning. The objective of this work is to assess neural correlates of post-stroke cognitive deficits and the ef…
View article: Effect of non-invasive spinal cord stimulation in unmedicated adults with major depressive disorder: a pilot randomized controlled trial and induced current flow pattern
Effect of non-invasive spinal cord stimulation in unmedicated adults with major depressive disorder: a pilot randomized controlled trial and induced current flow pattern Open
Converging theoretical frameworks suggest a role and a therapeutic potential for spinal interoceptive pathways in major depressive disorder (MDD). Here, we aimed to evaluate the antidepressant effects and tolerability of transcutaneous spi…
View article: Cortical and subcortical structural differences in psychostimulant-free ADHD youth with and without a family history of bipolar I disorder: a cross-sectional morphometric comparison
Cortical and subcortical structural differences in psychostimulant-free ADHD youth with and without a family history of bipolar I disorder: a cross-sectional morphometric comparison Open
Although attention-deficit/hyperactivity disorder (ADHD) and a family history of bipolar I disorder (BD) are associated with increased risk for developing BD, their neuroanatomical substrates remain poorly understood. This study compared c…
View article: Brain network structural connectome abnormalities among youth with attention-deficit/hyperactivity disorder at varying risk for bipolar I disorder: a cross-sectional graph-based magnetic resonance imaging study
Brain network structural connectome abnormalities among youth with attention-deficit/hyperactivity disorder at varying risk for bipolar I disorder: a cross-sectional graph-based magnetic resonance imaging study Open
Background: Attention-deficit/hyperactivity disorder (ADHD) is highly prevalent among youth with or at familial risk for bipolar-I disorder (BD-I), and ADHD symptoms commonly precede and may increase the risk for BD-I; however, associated …
View article: Morphological abnormalities in youth with bipolar disorder and their relationship to clinical characteristics
Morphological abnormalities in youth with bipolar disorder and their relationship to clinical characteristics Open
View article: Effect of Non-invasive Spinal Cord Stimulation in Unmedicated Adults with Major Depressive Disorder: A Pilot Randomized Controlled Trial and Induced Current Flow Pattern
Effect of Non-invasive Spinal Cord Stimulation in Unmedicated Adults with Major Depressive Disorder: A Pilot Randomized Controlled Trial and Induced Current Flow Pattern Open
Background Converging theoretical frameworks suggest a role and a therapeutic potential for spinal interoceptive pathways in major depressive disorder (MDD). We aimed to evaluate the antidepressant effects and tolerability of transcutaneou…
View article: Regional microstructural differences in ADHD youth with and without a family history of bipolar I disorder
Regional microstructural differences in ADHD youth with and without a family history of bipolar I disorder Open
View article: Cortical and Subcortical Structural Differences in Psychostimulant-Free ADHD Youth With and Without a Family History of Bipolar I Disorder: A Cross-Sectional Morphometric Comparison
Cortical and Subcortical Structural Differences in Psychostimulant-Free ADHD Youth With and Without a Family History of Bipolar I Disorder: A Cross-Sectional Morphometric Comparison Open
Although attention-deficit/hyperactivity disorder (ADHD) and a family history of bipolar I disorder (BD) both increase the risk for developing BD, associated neuroanatomical substrates remain poorly understood. This study compared cortical…
View article: Neurocognitive predictors of adherence to an online pain self-management program adjunct to long-term opioid therapy
Neurocognitive predictors of adherence to an online pain self-management program adjunct to long-term opioid therapy Open
NCT03309188.
View article: Brain functional activation and first mood episode in youth at risk for bipolar disorder
Brain functional activation and first mood episode in youth at risk for bipolar disorder Open
View article: Effects of short-term quetiapine and lithium therapy for acute manic or mixed episodes on the limbic system and emotion regulation circuitry in youth with bipolar disorder
Effects of short-term quetiapine and lithium therapy for acute manic or mixed episodes on the limbic system and emotion regulation circuitry in youth with bipolar disorder Open
View article: Changes in the structural brain connectome over the course of a nonrandomized clinical trial for acute mania
Changes in the structural brain connectome over the course of a nonrandomized clinical trial for acute mania Open
View article: Sparser and Less Efficient Hippocampal-Prefrontal Projections account for Developmental Network Dysfunction in a Model of Psychiatric Risk Mediated by Gene-Environment Interaction
Sparser and Less Efficient Hippocampal-Prefrontal Projections account for Developmental Network Dysfunction in a Model of Psychiatric Risk Mediated by Gene-Environment Interaction Open
Precise information flow from the hippocampus (HP) to prefrontal cortex (PFC) emerges during early development and accounts for cognitive processing throughout life. On flip side, this flow is selectively impaired in mental illness. In mou…
View article: Pretreatment Alterations and Acute Medication Treatment Effects on Brain Task–Related Functional Connectivity in Youth With Bipolar Disorder: A Neuroimaging Randomized Clinical Trial
Pretreatment Alterations and Acute Medication Treatment Effects on Brain Task–Related Functional Connectivity in Youth With Bipolar Disorder: A Neuroimaging Randomized Clinical Trial Open
View article: Changes in the brain structural connectome after a prospective randomized clinical trial of lithium and quetiapine treatment in youth with bipolar disorder
Changes in the brain structural connectome after a prospective randomized clinical trial of lithium and quetiapine treatment in youth with bipolar disorder Open
The goals of the current study were to determine whether topological organization of brain structural networks is altered in youth with bipolar disorder, whether such alterations predict treatment outcomes, and whether they are normalized …
View article: Predicting Post-Concussion Symptom Recovery in Adolescents Using a Novel Artificial Intelligence
Predicting Post-Concussion Symptom Recovery in Adolescents Using a Novel Artificial Intelligence Open
This pilot study explores the possibility of predicting post-concussion symptom recovery at one week post-injury using only objective diffusion tensor imaging (DTI) data inputs to a novel artificial intelligence (AI) system composed of Gen…
View article: Variation in rostral anterior cingulate functional connectivity with amygdala and caudate during first manic episode distinguish bipolar young adults who do not remit following treatment
Variation in rostral anterior cingulate functional connectivity with amygdala and caudate during first manic episode distinguish bipolar young adults who do not remit following treatment Open
Objectives Altered activity in the ventrolateral prefrontal and anterior cingulate cortices, as well as subcortical and amygdala projection sites, was previously reported during a first manic episode in youth with bipolar disorder and obse…
View article: Frontolimbic brain volume abnormalities in bipolar disorder with suicide attempts
Frontolimbic brain volume abnormalities in bipolar disorder with suicide attempts Open
Over 2.3 million people in the United States live with bipolar disorder. Sixty percent of those with a bipolar disorder diagnosis attempt suicide at least once in their lifetime, and up to 19% die by suicide. However, the neurobiology of s…
View article: The Generalized Anxiety Disorder 7-Item Scale in Adolescents with Generalized Anxiety Disorder: Signal Detection and Validation
The Generalized Anxiety Disorder 7-Item Scale in Adolescents with Generalized Anxiety Disorder: Signal Detection and Validation Open
Background In pediatric patients with anxiety disorders, existing symptom inventories are either not freely available or require extensive time and effort to administer. We sought to evaluate a brief self-report scale— the Generalized Anxi…
View article: Prediction of lithium response in first‐episode mania using the LITHium Intelligent Agent (<scp>LITHIA</scp>): Pilot data and proof‐of‐concept
Prediction of lithium response in first‐episode mania using the LITHium Intelligent Agent (<span>LITHIA</span>): Pilot data and proof‐of‐concept Open
Objectives Individualized treatment for bipolar disorder based on neuroimaging treatment targets remains elusive. To address this shortcoming, we developed a linguistic machine learning system based on a cascading genetic fuzzy tree ( GFT …
View article: Percutaneous biopsies in the era of precision medicine: causes of inadequate sampling
Percutaneous biopsies in the era of precision medicine: causes of inadequate sampling Open
View article: fMRI brain activation changes following treatment of a first bipolar manic episode
fMRI brain activation changes following treatment of a first bipolar manic episode Open
Objectives We tested the hypothesis that, with treatment, functional magnetic resonance imaging (fMRI) regional brain activation in first‐episode mania would normalize – i.e., that differences from healthy subjects would diminish over time…
View article: Impact of functional magnetic resonance imaging (fMRI) scanner noise on affective state and attentional performance
Impact of functional magnetic resonance imaging (fMRI) scanner noise on affective state and attentional performance Open
The results of the present study suggest that the acoustic qualities of MRI enhance frustration effects on an affective attentional task and that scanner noise may influence mood during similar functional magnetic resonance imaging (fMRI) …
View article: Placebo effect of medication cost in Parkinson disease
Placebo effect of medication cost in Parkinson disease Open
This study provides Class III evidence that perception of cost is capable of influencing motor function and brain activation in Parkinson disease.