David E. Freeman
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View article: Endothelial glycocalyx damage is associated with small intestinal disease in horses
Endothelial glycocalyx damage is associated with small intestinal disease in horses Open
Objective To determine if blood and peritoneal fluid levels of syndecan-1, heparan sulfate, and hyaluronan are elevated in horses with small intestinal disease compared to healthy counterparts. Methods 61 horses were categorized into contr…
View article: Risk factors for equine strangulating lipoma colic: An international, case–control study
Risk factors for equine strangulating lipoma colic: An international, case–control study Open
Background Obstruction by strangulating lipoma (SLO) is one of the most common causes of small intestinal strangulation in horses and is fatal without surgery. Current knowledge of risk factors for SLO is limited to horse signalment featur…
View article: Risk factors for strangulating lipoma obstruction and lipomata in horses
Risk factors for strangulating lipoma obstruction and lipomata in horses Open
Background Strangulating lipoma obstruction ( SLO ) is the most common cause of equine small intestinal strangulation and is fatal without surgery. Currently, epidemiological information is primarily limited to signalment‐related risk fact…
View article: Comparison of end‐to‐side versus side‐to‐side jejunocecostomy in horses
Comparison of end‐to‐side versus side‐to‐side jejunocecostomy in horses Open
Objectives To compare end‐to‐side (ES) and side‐to‐side (SS) jejunocecostomy (JC) in healthy horses. Study design Experimental study in vivo. Animals A total of 14 healthy adult horses underwent ventral midline celiotomy, a resection, and …
View article: Multi-centre post-mortem study on the use of coronary inflammation in CCTA to improve the diagnosis of the coronary related cause of death with histopathology validation
Multi-centre post-mortem study on the use of coronary inflammation in CCTA to improve the diagnosis of the coronary related cause of death with histopathology validation Open
Background/Introduction A limitation of post-mortem computed tomography (PMCT) is the diagnostic accuracy of coronary related death, which constitute majority of investigations. Measurements using coronary inflammation with fat attenuation…
View article: Inhibition of mast cell degranulation by novel small molecule MRGPRX2 antagonists
Inhibition of mast cell degranulation by novel small molecule MRGPRX2 antagonists Open
MRGPRX2 small molecule antagonists potently inhibited agonist-induced mast cell degranulation in vitro and in vivo as well as ex vivo in human skin, supporting potential therapeutic utility as a novel treatment for multiple human diseases …
View article: Nonsteroidal antiinflammatory drugs reduce anion secretion and increase apoptosis in equine colonic mucosa ex vivo
Nonsteroidal antiinflammatory drugs reduce anion secretion and increase apoptosis in equine colonic mucosa ex vivo Open
OBJECTIVE Right dorsal colitis causes chronic colic associated with long-term treatment with nonsteroidal antiinflammatory drugs (NSAIDs). This study was designed to determine if NSAIDs could inhibit anion transporters that protect against…
View article: Endoscope‐assisted three‐wire technique for extensive nasal septum resection in horses
Endoscope‐assisted three‐wire technique for extensive nasal septum resection in horses Open
Objective To describe a 3‐wire method with endoscopic guidance for extensive nasal septum resection. Study design Retrospective study. Sample population Thirteen horses with nasal septum diseases. Methods In anesthetized horses in left lat…
View article: "Real Attackers Don't Compute Gradients": Bridging the Gap Between Adversarial ML Research and Practice
"Real Attackers Don't Compute Gradients": Bridging the Gap Between Adversarial ML Research and Practice Open
Recent years have seen a proliferation of research on adversarial machine learning. Numerous papers demonstrate powerful algorithmic attacks against a wide variety of machine learning (ML) models, and numerous other papers propose defenses…
View article: Propagation effects in high-harmonic generation from dielectric thin films
Propagation effects in high-harmonic generation from dielectric thin films Open
Theoretical investigation is conducted of high-order harmonic generation (HHG) in silicon thin films to elucidate the effect of light propagation in reflected and transmitted waves. The first-principles simulations are performed of the pro…
View article: P20 Technical advances in imaging guided minimally invasive post-mortem CT angiography
P20 Technical advances in imaging guided minimally invasive post-mortem CT angiography Open
Objective Post-mortem computed tomography (PMCT) is widely used to reduce the requirement for invasive autopsy. The angiographic aspect of the PMCT has been described in centres in England and Europe using different techniques. This study …
View article: Quantum Mechanics for Closure of Dynamical Systems
Quantum Mechanics for Closure of Dynamical Systems Open
We propose a scheme for data-driven parameterization of unresolved dimensions of dynamical systems based on the mathematical framework of quantum mechanics and Koopman operator theory. Given a system in which some components of the state a…
View article: Mechanisms of bicarbonate secretion in the equine colon ex vivo
Mechanisms of bicarbonate secretion in the equine colon ex vivo Open
OBJECTIVE To examine bicarbonate (HCO 3 − ) secretion ex vivo in the equine large colon to determine any differences between the right dorsal colon (RDC) and right ventral colon (RVC). The effect of phenylbutazone (PBZ) on HCO 3 − secretio…
View article: Hypothesis on the pathophysiology of small intestinal strangulation by a pedunculated lipoma
Hypothesis on the pathophysiology of small intestinal strangulation by a pedunculated lipoma Open
Summary The current hypothesis proposed for strangulation of small intestine by a pedunculated lipoma in horses involves movement of the lipoma around the small intestine until it loops through its own pedicle. This mechanism is difficult …
View article: Effect of Feed Intake on Water Consumption in Horses: Relevance to Maintenance Fluid Therapy
Effect of Feed Intake on Water Consumption in Horses: Relevance to Maintenance Fluid Therapy Open
Maintenance fluid therapy is challenging in horses that cannot drink or are denied feed and water because of concerns about gastrointestinal tract function and patency. Intravenous fluid delivery to meet water needs based on current recomm…
View article: Participation Of Experienced Students In Introducing Freshman Students To Engineering Experimentation
Participation Of Experienced Students In Introducing Freshman Students To Engineering Experimentation Open
NOTE: The first page of text has been automatically extracted and included below in lieu of an abstract Session 1326 Participation of Experienced Students in Introducing Freshman Students to Engineering Experimentation Devdas Pai1, Rommel …
View article: Prevention and Treatment of Postoperative Complications in Equines
Prevention and Treatment of Postoperative Complications in Equines Open
Colic surgery is one of the most expensive procedures in equine clinics throughout the world. Although costs of surgery and anesthesia can be standardized to some extent, the cost of aftercare is less predictable. It can be altered conside…
View article: Appropriate Use of Transesophageal Echocardiogram for Infective Endocarditis: A Single Center Experience
Appropriate Use of Transesophageal Echocardiogram for Infective Endocarditis: A Single Center Experience Open
Background . Transesophageal echocardiogram (TEE) is a valuable tool in healthcare today with its ease of use, ability to visualize important structures not seen on transthoracic echocardiogram (TTE), and the relatively lower cost of TEE, …
View article: Post‐operative reflux – a surgeon's perspective
Post‐operative reflux – a surgeon's perspective Open
Summary Post‐operative ileus ( POI ) is a well‐recognised complication of colic surgery that accounts for a high proportion of post‐operative deaths. Although much has been written about the pathophysiology and management of POI in horses,…
View article: Effects of ischemia and reperfusion on eosinophilic accumulation and distribution in mucosa of equine jejunum and colon
Effects of ischemia and reperfusion on eosinophilic accumulation and distribution in mucosa of equine jejunum and colon Open
OBJECTIVE To evaluate the eosinophilic response in intestinal mucosa of horses with intestinal ischemia and reperfusion or with strangulation of the jejunum or colon. SAMPLE Mucosal samples from horses with naturally occurring strangulatio…