David E. Holt
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View article: Preclinical Evaluation of Novel SGLT2-Targeted Near-Infrared Optical Imaging Agent for Early-Stage Pulmonary Adenocarcinoma
Preclinical Evaluation of Novel SGLT2-Targeted Near-Infrared Optical Imaging Agent for Early-Stage Pulmonary Adenocarcinoma Open
Purpose Lung cancer is increasingly diagnosed at early stages, but intraoperative localization of early lesions remains challenging. Intraoperative molecular imaging (IMI) aids in localization of tumors during surgery; however, no optical …
View article: Clinical and histological characterization of 19 chondro-osseous respiratory epithelial adenomatoid hamartomas and 2 respiratory epithelial adenomatoid hamartomas in dogs
Clinical and histological characterization of 19 chondro-osseous respiratory epithelial adenomatoid hamartomas and 2 respiratory epithelial adenomatoid hamartomas in dogs Open
Nasal biopsies from 21 dogs diagnosed with chondro-osseous respiratory epithelial adenomatoid hamartomas or respiratory epithelial adenomatoid hamartomas were reviewed. Associated lesions included angiomatous tissue (4/21), seromucinous gl…
View article: A combination of pre‐ and intraoperative techniques identifies sentinel lymph nodes in dogs with thyroid carcinoma: A pilot study
A combination of pre‐ and intraoperative techniques identifies sentinel lymph nodes in dogs with thyroid carcinoma: A pilot study Open
Objective The aim of this study was to develop and describe pre‐ and intra‐operative sentinel lymph node (SLN) mapping techniques in dogs with thyroid carcinoma. Study design A prospective, pilot clinical trial was performed. Animals Six c…
View article: Comparison of bacteria cultured during a total ear canal ablation and subsequent incisional dehiscence in 12 dogs
Comparison of bacteria cultured during a total ear canal ablation and subsequent incisional dehiscence in 12 dogs Open
Objective To compare bacteria cultured at the time of total ear canal ablation (TECA) to bacteria cultured from post‐TECA incisional dehiscence. Study design Multicenter retrospective case series. Animal population Dogs ( n = 12) with inci…
View article: Feline eosinophilic sclerosing fibroplasia of the duodenum treated with gastrojejunostomy in a domestic shorthair cat
Feline eosinophilic sclerosing fibroplasia of the duodenum treated with gastrojejunostomy in a domestic shorthair cat Open
Case summary A 2-year-old female spayed domestic shorthair cat was presented for evaluation of severe thickening of the proximal duodenum identified on abdominal ultrasound after a 1-year history of vomiting. At surgery, a proximal duodena…
View article: Evaluating preoperative coagulation panels in dogs undergoing liver lobectomy for primary liver tumors: A multi‐institutional retrospective study
Evaluating preoperative coagulation panels in dogs undergoing liver lobectomy for primary liver tumors: A multi‐institutional retrospective study Open
Background The objectives of this study were to: (i) Determine whether operable primary liver tumors were associated with prolongations in prothrombin time (PT) and activated partial thromboplastin time (aPTT) and (ii) determine if these s…
View article: Non-Small Cell Lung Cancer Imaging Using a Phospholipase A2 Activatable Fluorophore
Non-Small Cell Lung Cancer Imaging Using a Phospholipase A2 Activatable Fluorophore Open
Lung cancer, the most common cause of cancer-related death in the United States, requires advanced intraoperative detection methods to improve evaluation of surgical margins. In this study we employed DDAO-arachidonate (DDAO-A), a phosphol…
View article: Computed tomographic diagnosis of a common bile duct abscess and secondary extrahepatic biliary duct obstruction in a potbelly pig
Computed tomographic diagnosis of a common bile duct abscess and secondary extrahepatic biliary duct obstruction in a potbelly pig Open
A potbelly pig was evaluated for anorexia and icterus. Clinicopathologic abnormalities suggested an active inflammatory hepatobiliary process. Ultrasound and CT of the abdomen revealed an extrahepatic biliary obstruction of the common bile…
View article: Supplementary Data from A Cathepsin-Targeted Quenched Activity–Based Probe Facilitates Enhanced Detection of Human Tumors during Resection
Supplementary Data from A Cathepsin-Targeted Quenched Activity–Based Probe Facilitates Enhanced Detection of Human Tumors during Resection Open
Supplementary Data from A Cathepsin-Targeted Quenched Activity–Based Probe Facilitates Enhanced Detection of Human Tumors during Resection
View article: Data from A Cathepsin-Targeted Quenched Activity–Based Probe Facilitates Enhanced Detection of Human Tumors during Resection
Data from A Cathepsin-Targeted Quenched Activity–Based Probe Facilitates Enhanced Detection of Human Tumors during Resection Open
Purpose:Fluorescence-guided surgery using tumor-targeted contrast agents has been developed to improve the completeness of oncologic resections. Quenched activity–based probes that fluoresce after covalently binding to tumor-specific enzym…
View article: Supplementary Data from A Cathepsin-Targeted Quenched Activity–Based Probe Facilitates Enhanced Detection of Human Tumors during Resection
Supplementary Data from A Cathepsin-Targeted Quenched Activity–Based Probe Facilitates Enhanced Detection of Human Tumors during Resection Open
Supplementary Data from A Cathepsin-Targeted Quenched Activity–Based Probe Facilitates Enhanced Detection of Human Tumors during Resection
View article: Data from A Cathepsin-Targeted Quenched Activity–Based Probe Facilitates Enhanced Detection of Human Tumors during Resection
Data from A Cathepsin-Targeted Quenched Activity–Based Probe Facilitates Enhanced Detection of Human Tumors during Resection Open
Purpose:Fluorescence-guided surgery using tumor-targeted contrast agents has been developed to improve the completeness of oncologic resections. Quenched activity–based probes that fluoresce after covalently binding to tumor-specific enzym…
View article: A Cathepsin-Targeted Quenched Activity–Based Probe Facilitates Enhanced Detection of Human Tumors during Resection
A Cathepsin-Targeted Quenched Activity–Based Probe Facilitates Enhanced Detection of Human Tumors during Resection Open
Purpose: Fluorescence-guided surgery using tumor-targeted contrast agents has been developed to improve the completeness of oncologic resections. Quenched activity–based probes that fluoresce after covalently binding to tumor-specific enzy…
View article: A veterinary and nursing collaboration to increase access to healthcare
A veterinary and nursing collaboration to increase access to healthcare Open
Hypertension is associated with almost 25% of US deaths. Philadelphia has the highest prevalence of hypertension of the 6 largest cities in the US, predominantly in non-Hispanic Black communities. Social determinants of health (SDOH) contr…
View article: Surgical treatment of a double aortic arch in a dog.
Surgical treatment of a double aortic arch in a dog. Open
An 8-month-old spayed female Labrador retriever dog was evaluated for regurgitation 6 months after surgery for a suspected vascular ring anomaly. The dog had a history of regurgitation and slow development as a puppy. An initial left-sided…
View article: Intraoperative near-infrared imaging can identify canine mammary tumors, a spontaneously occurring, large animal model of human breast cancer
Intraoperative near-infrared imaging can identify canine mammary tumors, a spontaneously occurring, large animal model of human breast cancer Open
Systemic ICG accumulates reliably in malignant canine mammary tumors > 2 cm. Although no tumor margins fluoresced, a wider margin of normal tissue is removed in canine mastectomy, making direct comparisons with breast conserving surgery di…
View article: Echocardiographic Pulmonary to Left Atrial Ratio (ePLAR): A Comparison Study between Ironman Athletes, Age Matched Controls and A General Community Cohort
Echocardiographic Pulmonary to Left Atrial Ratio (ePLAR): A Comparison Study between Ironman Athletes, Age Matched Controls and A General Community Cohort Open
Background: During exercise there is a proportionally lower rise in systemic and pulmonary pressures compared to cardiac output due to reduced vascular resistance. Invasive exercise data suggest that systemic vascular resistance reduces mo…
View article: Near‐infrared imaging and optical coherence tomography for intraoperative visualization of tumors
Near‐infrared imaging and optical coherence tomography for intraoperative visualization of tumors Open
Surgical excision is the foundation of treatment for early‐stage solid tumors in man and companion animals. Complete excision with appropriate margins of surrounding tumor‐free tissue is crucial to survival. Intraoperative imaging allows r…
View article: Clinical findings, diagnostic test results, and treatment outcome in cats with hiatal hernia: 31 cases (1995‐2018)
Clinical findings, diagnostic test results, and treatment outcome in cats with hiatal hernia: 31 cases (1995‐2018) Open
Background Information regarding clinical signs, assessment, treatment, and outcome in cats with hiatal hernia (HH) is limited. Objectives To characterize the clinical presentation of HH and medical and surgical outcomes in a cohort of aff…
View article: Evaluation of Aminolevulinic Acid-Derived Tumor Fluorescence Yields Disparate Results in Murine and Spontaneous Large Animal Models of Lung Cancer
Evaluation of Aminolevulinic Acid-Derived Tumor Fluorescence Yields Disparate Results in Murine and Spontaneous Large Animal Models of Lung Cancer Open
Fluorescence guided surgery is an emerging technology that may improve accuracy of pulmonary resection for non-small cell lung cancer (NSCLC). Herein we explore optical imaging for NSCLC surgery using the well-studied protoporphyrin IX (PP…
View article: Folate Receptor Overexpression in Human and Canine Meningiomas—Immunohistochemistry and Case Report of Intraoperative Molecular Imaging
Folate Receptor Overexpression in Human and Canine Meningiomas—Immunohistochemistry and Case Report of Intraoperative Molecular Imaging Open
BACKGROUND Meningiomas are well-encapsulated benign brain tumors and surgical resection is often curative. Nevertheless, this is not always possible due to the difficulty of identifying residual disease intraoperatively. We hypothesized th…
View article: Effect of Prophylactic Calcitriol Administration on Serum Ionized Calcium Concentrations after Parathyroidectomy: 78 Cases (2005–2015)
Effect of Prophylactic Calcitriol Administration on Serum Ionized Calcium Concentrations after Parathyroidectomy: 78 Cases (2005–2015) Open
Background Prophylactic administration of calcitriol has been suggested to mitigate the risk of hypocalcemia after parathyroidectomy. The effect of calcitriol on postoperative serum ionized calcium concentrations has not been evaluated in …
View article: Colonoscopic and histologic features of rectal masses in dogs: 82 cases (1995–2012)
Colonoscopic and histologic features of rectal masses in dogs: 82 cases (1995–2012) Open
OBJECTIVE To evaluate colonoscopic and histologic features of rectal masses in dogs. DESIGN Retrospective case series. ANIMALS 82 client-owned dogs with rectal masses that underwent colonoscopy. PROCEDURES Medical records of dogs with rect…
View article: Intraoperative near‐infrared fluorescence imaging targeting folate receptors identifies lung cancer in a large‐animal model
Intraoperative near‐infrared fluorescence imaging targeting folate receptors identifies lung cancer in a large‐animal model Open
BACKGROUND Complete tumor resection is the most important predictor of patient survival with non–small cell lung cancer. Methods for intraoperative margin assessment after lung cancer excision are lacking. This study evaluated near‐infrare…
View article: Intraoperative imaging identifies thymoma margins following neoadjuvant chemotherapy
Intraoperative imaging identifies thymoma margins following neoadjuvant chemotherapy Open
Near infrared (NIR) molecular imaging is useful to identify tumor margins during surgery; however, the value of this technology has not been evaluated for tumors that have been pre-treated with chemotherapy. We hypothesized that NIR molecu…
View article: Intraoperative near-infrared fluorescence imaging and spectroscopy identifies residual tumor cells in wounds
Intraoperative near-infrared fluorescence imaging and spectroscopy identifies residual tumor cells in wounds Open
Surgery is the most effective method to cure patients with solid tumors, and 50% of all cancer patients undergo resection. Local recurrences are due to tumor cells remaining in the wound, thus we explore near-infrared (NIR) fluorescence sp…