David E. Kandzari
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View article: Underrepresented patient populations in cardiovascular device trials: A transatlantic expert narrative on sex, age, demographic groups, and geographical background
Underrepresented patient populations in cardiovascular device trials: A transatlantic expert narrative on sex, age, demographic groups, and geographical background Open
External validity of clinical research can be optimized by an adequate representation of all patient groups within a disease spectrum. This emphasizes the need of enrolling patient groups who have been historically underrepresented on the …
View article: Long-term outcomes following radiofrequency renal denervation: meta-analysis of 18 reports
Long-term outcomes following radiofrequency renal denervation: meta-analysis of 18 reports Open
Aims Radiofrequency (RF) renal denervation (RDN) safely lowers office and 24-h blood pressure (BP). This meta-analysis examined the long-term durability of RF RDN based on randomized trials and observational studies. Methods and results Pa…
View article: Clinical Experience With a Novel Perfusion Balloon Catheter in Patients With Coronary Artery Perforation: Primary Results From the Ringer Clinical Study
Clinical Experience With a Novel Perfusion Balloon Catheter in Patients With Coronary Artery Perforation: Primary Results From the Ringer Clinical Study Open
Treatment of CAP with a novel perfusion balloon catheter achieved favorable rates of deliverability and reduction in hemorrhage while maintaining antegrade flow. These results demonstrate that the Ringer perfusion catheter is a safe and ef…
View article: Renal denervation for managing hypertension: Key elements in selecting and referring patients
Renal denervation for managing hypertension: Key elements in selecting and referring patients Open
Renal denervation (RDN) is an innovative procedure with regulatory approval for treating patients whose blood pressure remains uncontrolled despite lifestyle changes and the prescription of antihypertensive medications. It is important to …
View article: Long-Term Safety and Efficacy of Renal Denervation: 24-Month Results From the SPYRAL HTN-ON MED Trial
Long-Term Safety and Efficacy of Renal Denervation: 24-Month Results From the SPYRAL HTN-ON MED Trial Open
BACKGROUND: Six-month results from the SPYRAL HTN-ON MED trial (SPYRAL HTN-ON MED Study of Renal Denervation With the Symplicity Spyral Multi-Electrode Renal Denervation System) demonstrated that renal denervation (RDN) reduced office bloo…
View article: Two-year nighttime blood pressure changes after radiofrequency renal denervation: pooled results from the SPYRAL HTN trials
Two-year nighttime blood pressure changes after radiofrequency renal denervation: pooled results from the SPYRAL HTN trials Open
Elevated nighttime blood pressure (BP) and abnormal circadian dipping patterns are associated with advanced age and coexisting illnesses and are attributed to autonomic dysfunction. Radiofrequency renal denervation (RF RDN) effectively low…
View article: Impacto de la tortuosidad de las arterias coronarias en los resultados del implante de stent farmacoactivo de nueva generación: un análisis de los estudios aleatorizados BIOFLOW
Impacto de la tortuosidad de las arterias coronarias en los resultados del implante de stent farmacoactivo de nueva generación: un análisis de los estudios aleatorizados BIOFLOW Open
View article: Long-Term, Patient-Level Analysis of Radiofrequency Renal Denervation in the SYMPLICITY Clinical Trial Program
Long-Term, Patient-Level Analysis of Radiofrequency Renal Denervation in the SYMPLICITY Clinical Trial Program Open
View article: Rationale and design of the prevail global trial program evaluating the prevail drug-coated balloon in patients with in-stent restenosis and de novo small vessel disease
Rationale and design of the prevail global trial program evaluating the prevail drug-coated balloon in patients with in-stent restenosis and de novo small vessel disease Open
Prevail Global, NCT06535854, is registered at https://clinicaltrials.gov/study/NCT06535854.
View article: Impact of coronary artery tortuosity on outcomes following stenting with newer-generation drug-eluting stents. An analysis of the randomized BIOFLOW trials
Impact of coronary artery tortuosity on outcomes following stenting with newer-generation drug-eluting stents. An analysis of the randomized BIOFLOW trials Open
Clinicaltrials.gov NCT01356888, NCT01939249, NCT02389946.
View article: Underrepresented Patient Populations in Cardiovascular Device Trials: Transatlantic Consensus Recommendations on Sex, Age, Demographic Groups, and Geographical Background
Underrepresented Patient Populations in Cardiovascular Device Trials: Transatlantic Consensus Recommendations on Sex, Age, Demographic Groups, and Geographical Background Open
View article: Comparison of Ridaforolimus‐Eluting and Zotarolimus‐Eluting Coronary Stents: 5‐Year Outcomes From the BIONICS and NIREUS Trials
Comparison of Ridaforolimus‐Eluting and Zotarolimus‐Eluting Coronary Stents: 5‐Year Outcomes From the BIONICS and NIREUS Trials Open
Background The BIONICS (BioNIR Ridaforolimus‐Eluting Coronary Stent System in Coronary Stenosis) and the NIREUS (BioNIR Ridaforolimus Eluting Coronary Stent System [BioNIR] European Angiography Study) randomized clinical trials showed noni…
View article: Novel approaches to define responders to interventional treatment in hypertension: insights from the SPYRAL HTN-OFF and HTN-ON MED trials
Novel approaches to define responders to interventional treatment in hypertension: insights from the SPYRAL HTN-OFF and HTN-ON MED trials Open
View article: Renal Denervation Lowers Nighttime Blood Pressure in True Resistant Hypertension
Renal Denervation Lowers Nighttime Blood Pressure in True Resistant Hypertension Open
View article: Impact of expected blood pressure reduction on patient preferences for pharmaceutical and renal denervation treatment
Impact of expected blood pressure reduction on patient preferences for pharmaceutical and renal denervation treatment Open
Background: Effective patient-centered care requires an adequate understanding of patient preferences for different therapeutic options. We modelled patient preference for blood pressure (BP) management by pharmaceutical or interventional …
View article: Randomized Trials of Renal Denervation for Uncontrolled Hypertension: An Updated Meta‐Analysis
Randomized Trials of Renal Denervation for Uncontrolled Hypertension: An Updated Meta‐Analysis Open
Background Despite optimal medical therapy, a significant proportion of patients' blood pressure remains uncontrolled. Catheter‐based renal denervation (RDN) has been proposed as a potential intervention for uncontrolled hypertension. We c…
View article: Catheter-Based Radiofrequency Renal Denervation in the United States: A Cost-Effectiveness Analysis Based on Contemporary Evidence
Catheter-Based Radiofrequency Renal Denervation in the United States: A Cost-Effectiveness Analysis Based on Contemporary Evidence Open
Based on a lifetime projection, catheter-based RF RDN is a cost-effective, high-value intervention for hypertensive patients with uncontrolled hypertension.
View article: Paclitaxel‐coated versus sirolimus‐coated balloon angioplasty for coronary artery disease: A systematic review and meta‐analysis
Paclitaxel‐coated versus sirolimus‐coated balloon angioplasty for coronary artery disease: A systematic review and meta‐analysis Open
Background Although use of sirolimus‐based analogs has shown superiority over paclitaxel in drug‐eluting stents, the relative efficacy of these two agents released from drug‐coated balloons (DCB) is unclear. The present meta‐analysis is ai…
View article: One-Month Dual Antiplatelet Therapy in High Bleeding Risk Asian Patients Undergoing Percutaneous Coronary Intervention ― Onyx ONE Clear 2-Year Results ―
One-Month Dual Antiplatelet Therapy in High Bleeding Risk Asian Patients Undergoing Percutaneous Coronary Intervention ― Onyx ONE Clear 2-Year Results ― Open
After propensity score matching, HBR patients from Asian countries undergoing PCI treated with 1-month DAPT had similar ischemic outcomes but fewer bleeding events between 1 month and 2 years compared with patients from non-Asian countries.
View article: Effects of catheter-based renal denervation in hypertension: a systematic review and meta-analysis
Effects of catheter-based renal denervation in hypertension: a systematic review and meta-analysis Open
Background Several sham-controlled trials have investigated the efficacy and safety of catheter-based renal denervation (RDN) with mixed outcomes. Aim To perform a comprehensive meta-analysis of all randomized, sham-controlled trials inves…
View article: Global Consensus Recommendations on Improving the Safety of Chronic Total Occlusion Interventions
Global Consensus Recommendations on Improving the Safety of Chronic Total Occlusion Interventions Open
View article: F-5 | Long-term Outcomes Following Radiofrequency Renal Denervation: Meta-analysis of 18 Reports with Patient Level Data from the Global Symplicity Registry DEFINE
F-5 | Long-term Outcomes Following Radiofrequency Renal Denervation: Meta-analysis of 18 Reports with Patient Level Data from the Global Symplicity Registry DEFINE Open
Radiofrequency renal denervation (RF RDN) safely reduces office and 24-hour blood pressure (BP) in patients with uncontrolled hypertension. We performed a meta-analysis to assess long-term durability of RF RDN to at least 3 years based on …
View article: Ultrathin-strut versus thin-strut stent healing and outcomes in preclinical and clinical subjects
Ultrathin-strut versus thin-strut stent healing and outcomes in preclinical and clinical subjects Open
Ultrathin-strut and thin-strut BP-SES demonstrate similar early arterial healing profiles and 30-day and 1-year clinical outcomes.
View article: D-55 | Use of plaque modification microcatheters in chronic total occlusion percutaneous coronary interventions for: Insights from the PROGRESS-CTO registry
D-55 | Use of plaque modification microcatheters in chronic total occlusion percutaneous coronary interventions for: Insights from the PROGRESS-CTO registry Open
There is limited information on the use of plaque modification microcatheters (Tornus [Asahi Medical] and Turnpike Gold [Teleflex]) in contemporary chronic total occlusion (CTO) percutaneous coronary artery intervention (PCI). We evaluated…
View article: A novel, proof-of-concept radiofrequency renal denervation strategy to improve procedural efficiency: 12-month results from the SPYRAL DYSTAL pilot study
A novel, proof-of-concept radiofrequency renal denervation strategy to improve procedural efficiency: 12-month results from the SPYRAL DYSTAL pilot study Open
In this pilot study, focusing ablation treatment on the distal main and proximal branch renal arteries was performed, resulting in fewer RF lesions, and reduced contrast volume and procedure time. Whether BP reductions are similar between …
View article: Effect of Alcohol-Mediated Renal Denervation on Blood Pressure in the Presence of Antihypertensive Medications: Primary Results From the TARGET BP I Randomized Clinical Trial
Effect of Alcohol-Mediated Renal Denervation on Blood Pressure in the Presence of Antihypertensive Medications: Primary Results From the TARGET BP I Randomized Clinical Trial Open
BACKGROUND: Renal denervation (RDN) has demonstrated clinically relevant reductions in blood pressure (BP) among individuals with uncontrolled hypertension despite lifestyle intervention and medications. The safety and effectiveness of alc…
View article: Renal denervation in the management of hypertension
Renal denervation in the management of hypertension Open
Arterial hypertension is a global leading cause of cardiovascular, cerebrovascular, and renal disease, as well as mortality. Although pharmacotherapy is safe and effective in lowering blood pressure (BP) and cardiovascular disease risk, BP…
View article: Impact of Antihypertensive Medication Changes After Renal Denervation Among Different Patient Groups: SPYRAL HTN-ON MED
Impact of Antihypertensive Medication Changes After Renal Denervation Among Different Patient Groups: SPYRAL HTN-ON MED Open
BACKGROUND: The SPYRAL HTN-ON MED (Global Clinical Study of Renal Denervation With the Symplicity Spyral Multi-electrode Renal Denervation System in Patients With Uncontrolled Hypertension in the Absence of Antihypertensive Medications)tri…
View article: Cost-effectiveness of catheter-based radiofrequency renal denervation for the treatment of uncontrolled hypertension: an analysis for the UK based on recent clinical evidence
Cost-effectiveness of catheter-based radiofrequency renal denervation for the treatment of uncontrolled hypertension: an analysis for the UK based on recent clinical evidence Open
Aims Catheter-based radiofrequency renal denervation (RF RDN) has recently been approved for clinical use in the European Society of Hypertension guidelines and by the US Food and Drug Administration. This study evaluated the lifetime cost…
View article: Clinical Experience of a Novel Optical Coherence Tomography-Guided Coronary Chronic Total Occlusion Re-Entry Device
Clinical Experience of a Novel Optical Coherence Tomography-Guided Coronary Chronic Total Occlusion Re-Entry Device Open
We demonstrated a first-in-human case of successful antegrade dissection and re-entry using an image-guided re-entry catheter that enables real-time high-resolution visualization with graphical augmentation, and precision steering and adva…