David E. Korenchan
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View article: Optimization of CEST MRI Reporter Protein Design Using Cation‐Pi Networks
Optimization of CEST MRI Reporter Protein Design Using Cation‐Pi Networks Open
Nucleic acid‐based therapeutics, such as oncolytic virotherapy or gene therapy, would benefit greatly from a reporter gene that induces endogenous production of a protein biomarker to noninvasively track the delivery, persistence, and spre…
View article: Influence of Magnesium Ion Binding on the Adenosine Diphosphate Structure and Dynamics, Investigated by <sup>31</sup>P NMR and Molecular Dynamics Simulations
Influence of Magnesium Ion Binding on the Adenosine Diphosphate Structure and Dynamics, Investigated by <sup>31</sup>P NMR and Molecular Dynamics Simulations Open
Magnesium (Mg2+) is the most abundant divalent cation in the cell and is essential to nearly every biochemical reaction involving adenosine triphosphate (ATP) and its lower energy counterpart, adenosine diphosphate (ADP). In this work, we …
View article: Clinically Translatable Hyperpolarized <sup>13</sup>C Bicarbonate pH Imaging Method for Use in Prostate Cancer
Clinically Translatable Hyperpolarized <sup>13</sup>C Bicarbonate pH Imaging Method for Use in Prostate Cancer Open
Solid tumors such as prostate cancer (PCa) commonly develop an acidic microenvironment with pH 6.5-7.2, owing to heterogeneous perfusion, high metabolic activity, and rapid cell proliferation. In preclinical prostate cancer models, disease…
View article: Computational peptide discovery with a genetic programming approach
Computational peptide discovery with a genetic programming approach Open
Background The development of peptides for therapeutic targets or biomarkers for disease diagnosis is a challenging task in protein engineering. Current approaches are tedious, often time-consuming and require complex laboratory data due t…
View article: Development of a synthetic biosensor for chemical exchange MRI utilizing in silico optimized peptides
Development of a synthetic biosensor for chemical exchange MRI utilizing in silico optimized peptides Open
Chemical exchange saturation transfer (CEST) MRI has been identified as a novel alternative to classical diagnostic imaging. Over the last several decades, many studies have been conducted to determine possible CEST agents, such as endogen…
View article: Development of a Synthetic Biosensor for Chemical Exchange MRI Utilizing<i>In Silico</i>Optimized Peptides
Development of a Synthetic Biosensor for Chemical Exchange MRI Utilizing<i>In Silico</i>Optimized Peptides Open
1 Abstract Chemical Exchange Saturation Transfer (CEST) magnetic resonance imaging (MRI) has been identified as a novel alternative to classical diagnostic imaging. Over the last several decades, many studies have been conducted to determi…
View article: Limits of the quantum cognition hypothesis: 31P singlet order lifetimes of pyrophosphate from experiment and simulation
Limits of the quantum cognition hypothesis: 31P singlet order lifetimes of pyrophosphate from experiment and simulation Open
A proposal of quantum cognition advances the hypothesis that quantum entanglement between 31P nuclei could serve as a means of information storage in the brain. Testing this hypothesis requires an understanding of how long-lived these quan…
View article: Limits of the quantum cognition hypothesis: 31P singlet order lifetimes of pyrophosphate from experiment and simulation
Limits of the quantum cognition hypothesis: 31P singlet order lifetimes of pyrophosphate from experiment and simulation Open
A proposal of quantum cognition advances the hypothesis that quantum entanglement between 31P nuclei could serve as a means of information storage in the brain. Testing this hypothesis requires an understanding of how long-lived these quan…
View article: <sup>31</sup>P nuclear spin singlet lifetimes in a system with switchable magnetic inequivalence: experiment and simulation
<sup>31</sup>P nuclear spin singlet lifetimes in a system with switchable magnetic inequivalence: experiment and simulation Open
31 P NMR nuclear spin singlet order is reported for the first time. Experiments and molecular dynamics simulations indicate that the singlet order relaxes primarily via chemical shift anisotropy at high magnetic field strengths.
View article: 68Ga-PSMA-11 PET/MRI: determining ideal acquisition times to reduce noise and increase image quality
68Ga-PSMA-11 PET/MRI: determining ideal acquisition times to reduce noise and increase image quality Open
Background In this study, we investigate the impact of increased PET acquisition time per bed position on lesion detectability, standard uptake value, and image noise in 68 Ga-PSMA-11 PET/MRI scans. Methods Scans of twenty patients were an…
View article: Tensor image enhancement and optimal multichannel receiver combination analyses for human hyperpolarized <sup>13</sup>C MRSI
Tensor image enhancement and optimal multichannel receiver combination analyses for human hyperpolarized <sup>13</sup>C MRSI Open
Purpose With the initiation of human hyperpolarized 13 C (HP‐ 13 C) trials at multiple sites and the development of improved acquisition methods, there is an imminent need to maximally extract diagnostic information to facilitate clinical …
View article: Hyperpolarized <i>in vivo</i> pH imaging reveals grade-dependent acidification in prostate cancer
Hyperpolarized <i>in vivo</i> pH imaging reveals grade-dependent acidification in prostate cancer Open
There is an unmet clinical need for new and robust imaging biomarkers to distinguish indolent from aggressive prostate cancer. Hallmarks of aggressive tumors such as a decrease in extracellular pH (pHe) can potentially be used to identify …
View article: Amino Acid‐Derived Sensors for Specific Zn<sup>2+</sup> Detection Using Hyperpolarized <sup>13</sup>C Magnetic Resonance Spectroscopy
Amino Acid‐Derived Sensors for Specific Zn<sup>2+</sup> Detection Using Hyperpolarized <sup>13</sup>C Magnetic Resonance Spectroscopy Open
Alterations in Zn 2+ concentration are seen in normal tissues and in disease states, and for this reason imaging of Zn 2+ is an area of active investigation. Herein, enriched [1‐ 13 C]cysteine and [1‐ 13 C 2 ]iminodiacetic acid were develo…
View article: Spatiotemporal pH Heterogeneity as a Promoter of Cancer Progression and Therapeutic Resistance
Spatiotemporal pH Heterogeneity as a Promoter of Cancer Progression and Therapeutic Resistance Open
Dysregulation of pH in solid tumors is a hallmark of cancer. In recent years, the role of altered pH heterogeneity in space, between benign and aggressive tissues, between individual cancer cells, and between subcellular compartments, has …
View article: Using bidirectional chemical exchange for improved hyperpolarized [<sup>13</sup>C]bicarbonate pH imaging
Using bidirectional chemical exchange for improved hyperpolarized [<sup>13</sup>C]bicarbonate pH imaging Open
Purpose Rapid chemical exchange can affect SNR and pH measurement accuracy for hyperpolarized pH imaging with [ 13 C]bicarbonate. The purpose of this work was to investigate chemical exchange effects on hyperpolarized imaging sequences to …
View article: The Role of Lactate Metabolism in Prostate Cancer Progression and Metastases Revealed by Dual-Agent Hyperpolarized 13C MRSI
The Role of Lactate Metabolism in Prostate Cancer Progression and Metastases Revealed by Dual-Agent Hyperpolarized 13C MRSI Open
This study applied a dual-agent, 13C-pyruvate and 13C-urea, hyperpolarized 13C magnetic resonance spectroscopic imaging (MRSI) and multi-parametric (mp) 1H magnetic resonance imaging (MRI) approach in the transgenic adenocarcinoma of mouse…
View article: Detection of Bacteria-Specific Metabolism Using Hyperpolarized [2-<sup>13</sup>C]Pyruvate
Detection of Bacteria-Specific Metabolism Using Hyperpolarized [2-<sup>13</sup>C]Pyruvate Open
The differentiation of bacterial infection from other causes of inflammation is difficult in clinical practice and is critical where patient outcomes rely heavily on early interventions. In addition to physical exam and laboratory markers,…
View article: Late-stage deuteration of<sup>13</sup>C-enriched substrates for<i>T</i><sub>1</sub>prolongation in hyperpolarized<sup>13</sup>C MRI
Late-stage deuteration of<sup>13</sup>C-enriched substrates for<i>T</i><sub>1</sub>prolongation in hyperpolarized<sup>13</sup>C MRI Open
Deuteration on13C-enriched substrates led to increases inT1, yielding improvements in imaging parameters.
View article: Scatter Artifact with Ga-68-PSMA-11 PET: Severity Reduced With Furosemide Diuresis and Improved Scatter Correction
Scatter Artifact with Ga-68-PSMA-11 PET: Severity Reduced With Furosemide Diuresis and Improved Scatter Correction Open
Purpose: To assess the utility of furosemide diuresis and the role of an improved scatter correction algorithm in reducing scatter artifact severity on Ga-68- Prostate-specific membrane antigen (PSMA)-11 positron emission tomography (PET).…
View article: Dicarboxylic acids as pH sensors for hyperpolarized<sup>13</sup>C magnetic resonance spectroscopic imaging
Dicarboxylic acids as pH sensors for hyperpolarized<sup>13</sup>C magnetic resonance spectroscopic imaging Open
Hyperpolarized [2-13C,D10]diethylmalonic acid demonstrates long-lived signal enhancements for high-accuracy pH imagingvia13C MR spectroscopic imaging.
View article: Dynamic nuclear polarization of biocompatible<sup>13</sup>C-enriched carbonates for in vivo pH imaging
Dynamic nuclear polarization of biocompatible<sup>13</sup>C-enriched carbonates for in vivo pH imaging Open
High concentrations of hyperpolarized13C-bicarbonate are generatedviarapid hydrolysis of highly polarizable, low-toxicity carbonate precursors.