David E. Koser
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View article: Predicting local tissue mechanics using immunohistochemistry
Predicting local tissue mechanics using immunohistochemistry Open
Local tissue stiffness provides an important signal to which cells respond in vivo. However, assessing tissue mechanics is currently challenging and requires sophisticated technology. We here developed a model quantitatively predicting ner…
View article: The soft mechanical signature of glial scars in the central nervous system
The soft mechanical signature of glial scars in the central nervous system Open
View article: The soft mechanical signature of glial scars in the central nervous system
The soft mechanical signature of glial scars in the central nervous system Open
Injury to the central nervous system (CNS) alters the molecular and cellular composition of neural tissue and leads to glial scarring, which inhibits the regrowth of damaged axons. Mammalian glial scars supposedly form a chemical and mecha…
View article: Mechanosensing is critical for axon growth in the developing brain
Mechanosensing is critical for axon growth in the developing brain Open
View article: CNS Cell Distribution and Axon Orientation Determine Local Spinal Cord Mechanical Properties
CNS Cell Distribution and Axon Orientation Determine Local Spinal Cord Mechanical Properties Open
Mechanical signaling plays an important role in cell physiology and pathology. Many cell types, including neurons and glial cells, respond to the mechanical properties of their environment. Yet, for spinal cord tissue, data on tissue stiff…