David E. Krantz
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View article: MDMA for treatment of PTSD and neurorehabilitation in military populations
MDMA for treatment of PTSD and neurorehabilitation in military populations Open
BACKGROUND: Neurorehabilitation in military populations is complicated by higher rates of PTSD and unique characteristics of military institutions. These factors can adversely impact the patient-therapist therapeutic alliance and engagemen…
View article: Heterogeneity in the projections and excitability of tyraminergic/octopaminergic neurons that innervate the Drosophila reproductive tract
Heterogeneity in the projections and excitability of tyraminergic/octopaminergic neurons that innervate the Drosophila reproductive tract Open
Aminergic nuclei in mammals are generally composed of relatively small numbers of cells with broad projection patterns. Despite the gross similarity of many individual neurons, recent transcriptomic, anatomic and behavioral studies suggest…
View article: Constitutive and Conditional Epitope Tagging of Endogenous G-Protein–Coupled Receptors in <i>Drosophila</i>
Constitutive and Conditional Epitope Tagging of Endogenous G-Protein–Coupled Receptors in <i>Drosophila</i> Open
To visualize the cellular and subcellular localization of neuromodulatory G-protein–coupled receptors in Drosophila , we implement a molecular strategy recently used to add epitope tags to ionotropic receptors at their endogenous loci. Lev…
View article: The effect of older age on outcomes of rTMS treatment for treatment-resistant depression
The effect of older age on outcomes of rTMS treatment for treatment-resistant depression Open
Clinical outcomes of repetitive transcranial magnetic stimulation (rTMS) for treatment of treatment-resistant depression (TRD) vary widely and there is no mood rating scale that is standard for assessing rTMS outcome. It remains unclear wh…
View article: Expression and potential regulatory functions of <i>Drosophila</i> octopamine receptors in the female reproductive tract
Expression and potential regulatory functions of <i>Drosophila</i> octopamine receptors in the female reproductive tract Open
Aminergic signaling is known to play a critical role in regulating female reproductive processes in both mammals and insects. In Drosophila, the ortholog of noradrenaline, octopamine, is required for ovulation as well as several other fema…
View article: Constitutive and conditional epitope-tagging of endogenous G protein coupled receptors in<i>Drosophila</i>
Constitutive and conditional epitope-tagging of endogenous G protein coupled receptors in<i>Drosophila</i> Open
To visualize the cellular and subcellular localization of neuromodulatory G-protein coupled receptors (GPCRs) in Drosophila , we implement a molecular strategy recently used to add epitope tags to ionotropic receptors at their endogenous l…
View article: Pretreatment pupillary reactivity is associated with differential early response to 10 Hz and intermittent theta-burst repetitive transcranial magnetic stimulation (rTMS) treatment of major depressive disorder (MDD)
Pretreatment pupillary reactivity is associated with differential early response to 10 Hz and intermittent theta-burst repetitive transcranial magnetic stimulation (rTMS) treatment of major depressive disorder (MDD) Open
Background: Repetitive Transcranial Magnetic Stimulation (rTMS) is an effective treatment for Major Depressive Disorder (MDD). Two common rTMS protocols, 10 Hz and intermittent theta burst stimulation (iTBS), have comparable rates of effic…
View article: Right lateral orbitofrontal cortex inhibitory transcranial magnetic stimulation for treatment of refractory mood and depression
Right lateral orbitofrontal cortex inhibitory transcranial magnetic stimulation for treatment of refractory mood and depression Open
High-frequency repetitive Transcranial Magnetic Stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC) is an effective treatment for Major Depressive Disorder (MDD), but up to half of patients can have significant residual d…
View article: Low frequency transcranial magnetic stimulation for cognitive recovery after traumatic brain injury: A case report
Low frequency transcranial magnetic stimulation for cognitive recovery after traumatic brain injury: A case report Open
: Repetitive Transcranial Magnetic Stimulation (rTMS) shows promise for treating sequelae of traumatic brain injury (TBI) including headache and depression. The few studies examining rTMS for cognitive recovery after TBI have reported mixe…
View article: Pretreatment pupillary reactivity is associated with outcome of Repetitive Transcranial Magnetic Stimulation (rTMS) treatment of Major Depressive Disorder (MDD)
Pretreatment pupillary reactivity is associated with outcome of Repetitive Transcranial Magnetic Stimulation (rTMS) treatment of Major Depressive Disorder (MDD) Open
BackgroundPre-treatment biomarkers for outcome of repetitive Transcranial Magnetic Stimulation (rTMS) treatment of Major Depressive Disorder (MDD) have proven elusive. One promising family of biomarkers involves the autonomic nervous syste…
View article: Transcriptional changes in specific subsets of Drosophila neurons following inhibition of the serotonin transporter
Transcriptional changes in specific subsets of Drosophila neurons following inhibition of the serotonin transporter Open
The transcriptional effects of SSRIs and other serotonergic drugs remain unclear, in part due to the heterogeneity of postsynaptic cells, which may respond differently to changes in serotonergic signaling. Relatively simple model systems s…
View article: <i>Drosophila</i>cells that express octopamine receptors can either inhibit or promote oviposition
<i>Drosophila</i>cells that express octopamine receptors can either inhibit or promote oviposition Open
Adrenergic signaling is known to play a critical role in regulating female reproductive processes in both mammals and insects. In Drosophila , the ortholog of noradrenaline, octopamine (Oa), is required for ovulation as well as several oth…
View article: Transcriptional changes in specific subsets of Drosophila neurons following inhibition of the serotonin transporter
Transcriptional changes in specific subsets of Drosophila neurons following inhibition of the serotonin transporter Open
The transcriptional effects of SSRIs and other serotonergic drugs remain unclear, in part due to the heterogeneity of postsynaptic cells, which may respond differently to changes in serotonergic signaling. Relatively simple model systems s…
View article: Agreeing to disagree: inter-subject variability of mood rating scales during rtms treatment of depression
Agreeing to disagree: inter-subject variability of mood rating scales during rtms treatment of depression Open
Background: Outcomes of repetitive Transcranial Magnetic Stimulation (rTMS) for treatment-resistant depression vary widely across published studies. Several different mood rating scales have been used to assess response and remission. Obje…
View article: Mutation of the Drosophila melanogaster serotonin transporter dSERT impacts sleep, courtship, and feeding behaviors
Mutation of the Drosophila melanogaster serotonin transporter dSERT impacts sleep, courtship, and feeding behaviors Open
The Serotonin Transporter (SERT) regulates extracellular serotonin levels and is the target of most current drugs used to treat depression. The mechanisms by which inhibition of SERT activity influences behavior are poorly understood. To a…
View article: Mutation of the<i>Drosophila</i>serotonin transporter dSERT disrupts courtship and feeding and increases both daytime and nighttime sleep
Mutation of the<i>Drosophila</i>serotonin transporter dSERT disrupts courtship and feeding and increases both daytime and nighttime sleep Open
The Serotonin Transporter (SERT) regulates extracellular serotonin levels and is the target of most current drugs used to treat depression. The mechanisms by which inhibition of SERT activity influences behavior are poorly understood. To a…
View article: Sequential Prefrontal and Temporoparietal Repetitive Transcranial Magnetic Stimulation (rTMS) for Treatment of Tinnitus With and Without Comorbid Depression: A Case Series and Systematic Review
Sequential Prefrontal and Temporoparietal Repetitive Transcranial Magnetic Stimulation (rTMS) for Treatment of Tinnitus With and Without Comorbid Depression: A Case Series and Systematic Review Open
Background Tinnitus distress is related to both the loudness and intrusiveness of the tinnitus percept. Treatment approaches targeting both attentional/limbic and auditory systems may better alleviate tinnitus distress than approaches targ…
View article: Treatment of Spider Phobia Using Repeated Exposures and Adjunctive Repetitive Transcranial Magnetic Stimulation: A Proof-of-Concept Study
Treatment of Spider Phobia Using Repeated Exposures and Adjunctive Repetitive Transcranial Magnetic Stimulation: A Proof-of-Concept Study Open
Background Specific phobias represent the largest category of anxiety disorders. Previous work demonstrated that stimulating the ventromedial prefrontal cortex (vmPFC) with repetitive Transcranial Magnetic Stimulation (rTMS) may improve re…
View article: Multi-target repetitive transcranial magnetic stimulation (rTMS) protocol for the treatment of comorbid depression and chronic pain
Multi-target repetitive transcranial magnetic stimulation (rTMS) protocol for the treatment of comorbid depression and chronic pain Open
Background: Major Depressive Disorder (MDD) and chronic pain are frequently co-occurring, and the onset of either condition can either precede or follow the onset of the other. Notably, clinical outcome for pharmacological and rTMS treatme…
View article: Subthreshold stimulation intensity is associated with greater clinical efficacy of intermittent theta-burst stimulation priming for Major Depressive Disorder
Subthreshold stimulation intensity is associated with greater clinical efficacy of intermittent theta-burst stimulation priming for Major Depressive Disorder Open
Subthreshold intensity iTBS-P was associated with greater clinical improvement than suprathreshold stimulation. This finding is consistent with iTBS-P acting through homeostatic plasticity mechanisms.
View article: Repetitive transcranial magnetic stimulation treatment of major depressive disorder and comorbid chronic pain: response rates and neurophysiologic biomarkers
Repetitive transcranial magnetic stimulation treatment of major depressive disorder and comorbid chronic pain: response rates and neurophysiologic biomarkers Open
Background Major depressive disorder (MDD) and chronic pain are highly comorbid, and pain symptoms are associated with a poorer response to antidepressant medication treatment. It is unclear whether comorbid pain also is associated with a …
View article: Serotonergic modulation of visual neurons in Drosophila melanogaster
Serotonergic modulation of visual neurons in Drosophila melanogaster Open
Sensory systems rely on neuromodulators, such as serotonin, to provide flexibility for information processing as stimuli vary, such as light intensity throughout the day. Serotonergic neurons broadly innervate the optic ganglia of Drosophi…