David E. Moorman
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View article: Impact of chronic alcohol and stress on mid-life cognition and locus coeruleus integrity
Impact of chronic alcohol and stress on mid-life cognition and locus coeruleus integrity Open
Background Excessive alcohol consumption and stress are associated with structural and functional alterations in the brain and impaired cognition. However, the persistence of long-term neural impacts after alcohol and stress are less under…
View article: Functional Connectivity: Continuous-Time Latent Factor Models for Neural Spike Trains
Functional Connectivity: Continuous-Time Latent Factor Models for Neural Spike Trains Open
Modelling the dynamics of interactions in a neuronal ensemble is an important problem in functional connectivity research. One popular framework is latent factor models (LFMs), which have achieved notable success in decoding neuronal popul…
View article: Chemogenetic Inactivation of Orbitofrontal Cortex Decreases Cue‐induced Reinstatement of Ethanol and Sucrose Seeking in Male and Female Wistar Rats
Chemogenetic Inactivation of Orbitofrontal Cortex Decreases Cue‐induced Reinstatement of Ethanol and Sucrose Seeking in Male and Female Wistar Rats Open
Background The orbitofrontal cortex (OFC) encodes internal representations of outcomes and subjective value to facilitate flexible reward seeking. OFC activation is associated with drug seeking in both human subjects and animal models. OFC…
View article: Orbitofrontal Cortex Encodes Preference for Alcohol
Orbitofrontal Cortex Encodes Preference for Alcohol Open
Orbitofrontal cortex (OFC) plays a key role in representation and regulation of reward value, preference, and seeking. OFC function is disrupted in drug use and dependence, but its specific role in alcohol use disorders has not been thorou…
View article: Differential Effects of Dorsal and Ventral Medial Prefrontal Cortex Inactivation during Natural Reward Seeking, Extinction, and Cue-Induced Reinstatement
Differential Effects of Dorsal and Ventral Medial Prefrontal Cortex Inactivation during Natural Reward Seeking, Extinction, and Cue-Induced Reinstatement Open
Rodent dorsal medial prefrontal cortex (mPFC), typically prelimbic cortex, is often described as promoting actions such as reward seeking, whereas ventral mPFC, typically infralimbic cortex, is thought to promote response inhibition. Howev…
View article: Optogenetic Dissection of Temporal Dynamics of Amygdala-Striatal Interplay during Risk/Reward Decision Making
Optogenetic Dissection of Temporal Dynamics of Amygdala-Striatal Interplay during Risk/Reward Decision Making Open
Decision making often requires weighing costs and benefits of different options that vary in terms of reward magnitude and uncertainty. Previous studies using pharmacological inactivations have shown that the basolateral amygdala (BLA) to …
View article: Phasic locus coeruleus activity regulates cortical encoding of salience information
Phasic locus coeruleus activity regulates cortical encoding of salience information Open
Significance Locus coeruleus (LC) function has been associated with focused attention across species. LC neurons fire tonically or with short phasic bursts. We found that phasic, but not tonic, LC activity produced attentional signals acro…
View article: Stress Facilitates the Development of Cognitive Dysfunction After Chronic Ethanol Exposure
Stress Facilitates the Development of Cognitive Dysfunction After Chronic Ethanol Exposure Open
Together, these findings show that interactions between EtOH and stress exposure rapidly lead to disruptions in signaling across cognitive networks and impairments in PFC-dependent cognitive function.
View article: Orexin/hypocretin neuron activation is correlated with alcohol seeking and preference in a topographically specific manner
Orexin/hypocretin neuron activation is correlated with alcohol seeking and preference in a topographically specific manner Open
Orexin ( ORX ) (also known as hypocretin) neurons are located exclusively in the posterior hypothalamus, and are involved in a wide range of behaviours, including motivation for drugs of abuse such as alcohol. Hypothalamic subregions conta…
View article: A Dynamic Bayesian Model for Characterizing Cross-Neuronal Interactions During Decision-Making
A Dynamic Bayesian Model for Characterizing Cross-Neuronal Interactions During Decision-Making Open
The goal of this article is to develop a novel statistical model for studying cross-neuronal spike train interactions during decision-making. For an individual to successfully complete the task of decision-making, a number of temporally or…