David E. Stec
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View article: Role of Liver-Derived Ketones, Hepatokines, and Metabolites in the Regulation of Renal Function
Role of Liver-Derived Ketones, Hepatokines, and Metabolites in the Regulation of Renal Function Open
Alteration in renal function has long been known to be a consequence of liver disease. However, the mechanisms by which the liver can regulate kidney function under basal conditions and in response to liver disease have yet to be fully und…
View article: RETRACTED: Shen et al. Cold-Pressed Nigella Sativa Oil Standardized to 3% Thymoquinone Potentiates Omega-3 Protection against Obesity-Induced Oxidative Stress, Inflammation, and Markers of Insulin Resistance Accompanied with Conversion of White to Beige Fat in Mice. Antioxidants 2020, 9, 489
RETRACTED: Shen et al. Cold-Pressed Nigella Sativa Oil Standardized to 3% Thymoquinone Potentiates Omega-3 Protection against Obesity-Induced Oxidative Stress, Inflammation, and Markers of Insulin Resistance Accompanied with Conversion of White to Beige Fat in Mice. Antioxidants 2020, 9, 489 Open
The journal retracts the article “Cold-Pressed Nigella Sativa Oil Standardized to 3% Thymoquinone Potentiates Omega-3 Protection against Obesity-Induced Oxidative Stress, Inflammation, and Markers of Insulin Resistance Accompanied with Con…
View article: Abstract 1850 Stress hormone receptors remodel the hepatic lipidome, increasing cell migration and fatty acid metabolism pathways
Abstract 1850 Stress hormone receptors remodel the hepatic lipidome, increasing cell migration and fatty acid metabolism pathways Open
View article: Abstract 2307 The Loss of Bilirubin's Hormonal Function Drives Metabolic Dysfunction-Associated Steatotic Liver Disease and Adiposity
Abstract 2307 The Loss of Bilirubin's Hormonal Function Drives Metabolic Dysfunction-Associated Steatotic Liver Disease and Adiposity Open
View article: Heme oxygenase, biliverdin reductase, and bilirubin pathways regulate oxidative stress and insulin resistance: a focus on diabetes and therapeutics
Heme oxygenase, biliverdin reductase, and bilirubin pathways regulate oxidative stress and insulin resistance: a focus on diabetes and therapeutics Open
Metabolic and insulin-resistant diseases, such as type 2 diabetes mellitus (T2DM), have become major health issues worldwide. The prevalence of insulin resistance in the general population ranges from 15.5% to 44.6%. Shockingly, the global…
View article: Contribution of Sex Differences to Development of Cardiovascular Disease in Metabolic-Associated Steatotic Liver Disease (MASLD)
Contribution of Sex Differences to Development of Cardiovascular Disease in Metabolic-Associated Steatotic Liver Disease (MASLD) Open
Sex differences are a complex and crucial variable in developing and progressing metabolic and cardiovascular disease pathophysiology and clinical outcomes. The female sex, compared to the male sex, is protected from metabolic disturbances…
View article: The Role of Renal Medullary Bilirubin and Biliverdin Reductase in Angiotensin II-Dependent Hypertension
The Role of Renal Medullary Bilirubin and Biliverdin Reductase in Angiotensin II-Dependent Hypertension Open
BACKGROUND Increased circulating bilirubin attenuates angiotensin (Ang) II-induced hypertension and improves renal hemodynamics. However, the intrarenal mechanisms that mediate these effects are not known. The goal of the present study was…
View article: Bilirubin bioconversion to urobilin in the gut-liver-kidney axis: A biomarker for insulin resistance in the Cardiovascular-Kidney-Metabolic (CKM) Syndrome
Bilirubin bioconversion to urobilin in the gut-liver-kidney axis: A biomarker for insulin resistance in the Cardiovascular-Kidney-Metabolic (CKM) Syndrome Open
The rising rates of obesity worldwide have increased the incidence of cardiovascular disease (CVD), making it the number one cause of death. Higher plasma bilirubin levels have been shown to prevent metabolic dysfunction and CVD. However, …
View article: On the Therapeutic Potential of Heme Oxygenase-1 and Its Metabolites
On the Therapeutic Potential of Heme Oxygenase-1 and Its Metabolites Open
Over the past 55 years, the heme oxygenase (HO) system has emerged as a pivotal player in a myriad of cellular, tissue, and integrative physiological processes [...]
View article: Mice lacking ASIC2 and βENaC are protected from high-fat-diet-induced metabolic syndrome
Mice lacking ASIC2 and βENaC are protected from high-fat-diet-induced metabolic syndrome Open
Introduction Degenerin proteins, such as βENaC and ASIC2, have been implicated in cardiovascular function. However, their role in metabolic syndrome have not been studied. To begin to assess this interaction, we evaluated the impact of a h…
View article: Cardiac lipotoxicity and fibrosis underlie impaired contractility in a mouse model of metabolic dysfunction‐associated steatotic liver disease
Cardiac lipotoxicity and fibrosis underlie impaired contractility in a mouse model of metabolic dysfunction‐associated steatotic liver disease Open
The leading cause of death among patients with metabolic dysfunction‐associated steatotic liver disease (MASLD) is cardiovascular disease. A significant percentage of MASLD patients develop heart failure driven by functional and structural…
View article: Abstract 1501 The reduction of adiposity and hepatic lipid accumulation by bilirubin is dependent on its hormonal function
Abstract 1501 The reduction of adiposity and hepatic lipid accumulation by bilirubin is dependent on its hormonal function Open
The global prevalence of obesity and its related comorbidities, including diabetes and metabolic dysfunction associated fatty liver disease (MAFLD), are on the rise. For unknown reasons, serum bilirubin levels are negatively correlated wit…
View article: Abstract 1506 The Glucocorticoid Receptor β (GRβ) induces glucocorticoid resistance and PPARγ activation to increase eicosanoid and monoacylglyceride synthesis which leads to hepatic lipid accumulation
Abstract 1506 The Glucocorticoid Receptor β (GRβ) induces glucocorticoid resistance and PPARγ activation to increase eicosanoid and monoacylglyceride synthesis which leads to hepatic lipid accumulation Open
A diet that is high in fat can lead to obesity and various other metabolic issues, like type II diabetes, cardiovascular disease, and non-alcoholic fatty liver disease. Interestingly, a diet high in fat can also induce issues like glucocor…
View article: Loss of hepatic PPARα in mice causes hypertension and cardiovascular disease
Loss of hepatic PPARα in mice causes hypertension and cardiovascular disease Open
The leading cause of death in patients with nonalcoholic fatty liver disease (NAFLD) is cardiovascular disease (CVD). However, the mechanisms are unknown. Mice deficient in hepatocyte proliferator-activated receptor-α (PPARα) ( Ppara HepKO…
View article: Mechanisms Linking Metabolic-Associated Fatty Liver Disease (MAFLD) to Cardiovascular Disease
Mechanisms Linking Metabolic-Associated Fatty Liver Disease (MAFLD) to Cardiovascular Disease Open
View article: Editorial: Insights in drug metabolism and transport: 2021
Editorial: Insights in drug metabolism and transport: 2021 Open
EDITORIAL article Front. Pharmacol., 09 May 2023Sec. Drug Metabolism and Transport Volume 14 - 2023 | https://doi.org/10.3389/fphar.2023.1198598
View article: The physiology of bilirubin: health and disease equilibrium
The physiology of bilirubin: health and disease equilibrium Open
View article: Bilirubin Nanoparticle Treatment in Obese Mice Inhibits Hepatic Ceramide Production and Remodels Liver Fat Content
Bilirubin Nanoparticle Treatment in Obese Mice Inhibits Hepatic Ceramide Production and Remodels Liver Fat Content Open
Studies have indicated that increasing plasma bilirubin levels might be useful for preventing and treating hepatic lipid accumulation that occurs with metabolic diseases such as obesity and diabetes. We have previously demonstrated that mi…
View article: Suppressing Hepatic UGT1A1 Increases Plasma Bilirubin, Lowers Plasma Urobilin, Reorganizes Kinase Signaling Pathways and Lipid Species and Improves Fatty Liver Disease
Suppressing Hepatic UGT1A1 Increases Plasma Bilirubin, Lowers Plasma Urobilin, Reorganizes Kinase Signaling Pathways and Lipid Species and Improves Fatty Liver Disease Open
Several population studies have observed lower serum bilirubin levels in patients with non-alcoholic fatty liver disease (NAFLD). Yet, treatments to target this metabolic phenotype have not been explored. Therefore, we designed an N-Acetyl…
View article: Sex and molecular differences in cardiovascular parameters at peak influenza disease in mice
Sex and molecular differences in cardiovascular parameters at peak influenza disease in mice Open
This study performed longitudinal cardiovascular measurements of influenza viral infection and identified sex difference in both physiological and molecular markers at peak disease.
View article: Cutting edge concepts: Does bilirubin enhance exercise performance?
Cutting edge concepts: Does bilirubin enhance exercise performance? Open
Exercise performance is dependent on many factors, such as muscular strength and endurance, cardiovascular capacity, liver health, and metabolic flexibility. Recent studies show that plasma levels of bilirubin, which has classically been v…
View article: Powering the powerhouse: Heme oxygenase‐1 regulates mitochondrial function in non‐alcoholic fatty liver disease (NAFLD)
Powering the powerhouse: Heme oxygenase‐1 regulates mitochondrial function in non‐alcoholic fatty liver disease (NAFLD) Open
In this issue, Li et al.1 advanced our understanding of heme oxygenase-1 (HO-1) in non-alcoholic fatty liver disease (NAFLD). They developed hepatocyte-specific HO-1 knockout (KO) mice (HO-1HEPKO) and used LO-2 human hepatocytes with HO-1 …
View article: Badmus et al. kinome data and reports.
Badmus et al. kinome data and reports. Open
Supplemental Tables, Full Kinome Reports, Log2 Fold Change of Family and Individual Kinases, and Raw Data Files
View article: Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways
Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways Open
The metabolic-associated fatty liver disease (MAFLD) is a condition of fat accumulation in the liver in combination with metabolic dysfunction in the form of overweight or obesity and insulin resistance. It is also associated with an incre…
View article: Novel Function for Bilirubin as a Metabolic Signaling Molecule: Implications for Kidney Diseases
Novel Function for Bilirubin as a Metabolic Signaling Molecule: Implications for Kidney Diseases Open
Bilirubin is the end product of the catabolism of heme via the heme oxygenase pathway. Heme oxygenase generates carbon monoxide (CO) and biliverdin from the breakdown of heme, and biliverdin is rapidly reduced to bilirubin by the enzyme bi…
View article: βENaC and ASIC2 associate in VSMCs to mediate pressure-induced constriction in the renal afferent arteriole
βENaC and ASIC2 associate in VSMCs to mediate pressure-induced constriction in the renal afferent arteriole Open
Transmission of systemic blood pressure to delicate renal microvessels is a primary determinant of vascular injury in chronic kidney disease progression to end-stage renal disease. Here, we identified two degenerin family members, with an …
View article: Reactive Oxygen Species (ROS) and Antioxidants as Immunomodulators in Exercise: Implications for Heme Oxygenase and Bilirubin
Reactive Oxygen Species (ROS) and Antioxidants as Immunomodulators in Exercise: Implications for Heme Oxygenase and Bilirubin Open
Exercise is commonly prescribed as a lifestyle treatment for chronic metabolic diseases as it functions as an insulin sensitizer, cardio-protectant, and essential lifestyle tool for effective weight maintenance. Exercise boosts the product…
View article: Adipose-Specific PPARα Knockout Mice Have Increased Lipogenesis by PASK–SREBP1 Signaling and a Polarity Shift to Inflammatory Macrophages in White Adipose Tissue
Adipose-Specific PPARα Knockout Mice Have Increased Lipogenesis by PASK–SREBP1 Signaling and a Polarity Shift to Inflammatory Macrophages in White Adipose Tissue Open
The nuclear receptor PPARα is associated with reducing adiposity, especially in the liver, where it transactivates genes for β-oxidation. Contrarily, the function of PPARα in extrahepatic tissues is less known. Therefore, we established th…
View article: Editorial: Oxidative Stress, Antioxidants, Transcription Factors, and Assimilation of Signal Transduction Pathways in Obesity-Related Disorders
Editorial: Oxidative Stress, Antioxidants, Transcription Factors, and Assimilation of Signal Transduction Pathways in Obesity-Related Disorders Open
EDITORIAL article Front. Pharmacol., 07 September 2021 | https://doi.org/10.3389/fphar.2021.759468
View article: Heme-oxygenase and lipid mediators in obesity and associated cardiometabolic diseases: Therapeutic implications
Heme-oxygenase and lipid mediators in obesity and associated cardiometabolic diseases: Therapeutic implications Open