David E. Wentworth
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View article: Influenza mRNA vaccine reduces pathogenicity and transmission of A(H5N1) virus in a ferret model
Influenza mRNA vaccine reduces pathogenicity and transmission of A(H5N1) virus in a ferret model Open
The global spread of highly pathogenic avian influenza A(H5N1) viruses poses a serious pandemic threat. While sustained human-to-human transmission has not occurred, widespread circulation in birds, increased detection in mammals, and occa…
View article: The XBB.1.5 COVID-19 vaccine elicits a durable antibody response to ancestral and XBB.1.5 SARS-CoV-2 spike proteins
The XBB.1.5 COVID-19 vaccine elicits a durable antibody response to ancestral and XBB.1.5 SARS-CoV-2 spike proteins Open
The rapid emergence of divergent SARS-CoV-2 variants led to a 2023–2024 update of the COVID-19 mRNA vaccine to a monovalent version containing the XBB.1.5 SARS-CoV-2 spike antigen. To determine the durability and breadth of the antibody re…
View article: An influenza mRNA vaccine protects ferrets from lethal infection with highly pathogenic avian influenza A(H5N1) virus
An influenza mRNA vaccine protects ferrets from lethal infection with highly pathogenic avian influenza A(H5N1) virus Open
The global spread of the highly pathogenic avian influenza (HPAI) A(H5N1) virus poses a serious pandemic threat, necessitating the swift development of effective vaccines. The success of messenger RNA (mRNA) vaccine technology in the COVID…
View article: Interferon as an immunoadjuvant to enhance antibodies following influenza B infection and vaccination in ferrets
Interferon as an immunoadjuvant to enhance antibodies following influenza B infection and vaccination in ferrets Open
View article: Discriminating North American Swine Influenza Viruses with a Portable, One-Step, Triplex Real-Time RT-PCR Assay, and Portable Sequencing
Discriminating North American Swine Influenza Viruses with a Portable, One-Step, Triplex Real-Time RT-PCR Assay, and Portable Sequencing Open
Swine harbors a genetically diverse population of swine influenza A viruses (IAV-S), with demonstrated potential to transmit to the human population, causing outbreaks and pandemics. Here, we describe the development of a one-step, triplex…
View article: Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States
Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States Open
Influenza viruses continually evolve new antigenic variants, through mutations in epitopes of their major surface proteins, hemagglutinin (HA) and neuraminidase (NA). Antigenic drift potentiates the reinfection of previously infected indiv…
View article: Author response: Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States
Author response: Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States Open
View article: Author response: Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States
Author response: Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States Open
Influenza viruses continually evolve new antigenic variants, through mutations in epitopes of their major surface proteins, hemagglutinin (HA) and neuraminidase (NA). Antigenic drift potentiates the reinfection of previously infected indiv…
View article: Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States
Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States Open
Influenza viruses continually evolve new antigenic variants, through mutations in epitopes of their major surface proteins, hemagglutinin (HA) and neuraminidase (NA). Antigenic drift potentiates the reinfection of previously infected indiv…
View article: H19 influenza A virus exhibits species-specific MHC class II receptor usage
H19 influenza A virus exhibits species-specific MHC class II receptor usage Open
View article: Antigenic Characterization of Circulating and Emerging SARS-CoV-2 Variants in the U.S. throughout the Delta to Omicron Waves
Antigenic Characterization of Circulating and Emerging SARS-CoV-2 Variants in the U.S. throughout the Delta to Omicron Waves Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved into numerous lineages with unique spike mutations and caused multiple epidemics domestically and globally. Although COVID-19 vaccines are available, new variants wit…
View article: Novel influenza A viruses in pigs with zoonotic potential, Chile
Novel influenza A viruses in pigs with zoonotic potential, Chile Open
Novel H1N2 and H3N2 swine influenza A viruses (IAVs) have recently been identified in Chile. The objective of this study was to evaluate their zoonotic potential. We perform phylogenetic analyses to determine the genetic origin and evoluti…
View article: Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States
Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States Open
Influenza viruses continually evolve new antigenic variants, through mutations in epitopes of their major surface proteins, hemagglutinin (HA) and neuraminidase (NA). Antigenic drift potentiates the reinfection of previously infected indiv…
View article: Reviewer #2 (Public Review): Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States
Reviewer #2 (Public Review): Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States Open
Influenza viruses continually evolve new antigenic variants, through mutations in epitopes of their major surface proteins, hemagglutinin (HA) and neuraminidase (NA). Antigenic drift potentiates the reinfection of previously infected indiv…
View article: Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States
Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States Open
Influenza viruses continually evolve new antigenic variants, through mutations in epitopes of their major surface proteins, hemagglutinin (HA) and neuraminidase (NA). Antigenic drift potentiates the reinfection of previously infected indiv…
View article: Reviewer #1 (Public Review): Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States
Reviewer #1 (Public Review): Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States Open
Influenza viruses continually evolve new antigenic variants, through mutations in epitopes of their major surface proteins, hemagglutinin (HA) and neuraminidase (NA). Antigenic drift potentiates the reinfection of previously infected indiv…
View article: Reviewer #3 (Public Review): Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States
Reviewer #3 (Public Review): Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States Open
Influenza viruses continually evolve new antigenic variants, through mutations in epitopes of their major surface proteins, hemagglutinin (HA) and neuraminidase (NA). Antigenic drift potentiates the reinfection of previously infected indiv…
View article: Differential interferon responses to influenza A and B viruses in primary ferret respiratory epithelial cells
Differential interferon responses to influenza A and B viruses in primary ferret respiratory epithelial cells Open
Influenza B viruses (IBV) cocirculate with influenza A viruses (IAV) and cause periodic epidemics of disease, yet antibody and cellular responses following IBV infection are less well understood. Using the ferret model for antisera generat…
View article: In‐field detection and characterization of B/Victoria lineage deletion variant viruses causing early influenza activity and an outbreak in Louisiana, 2019
In‐field detection and characterization of B/Victoria lineage deletion variant viruses causing early influenza activity and an outbreak in Louisiana, 2019 Open
Background In 2019, the Louisiana Department of Health reported an early influenza B/Victoria (B/VIC) virus outbreak. Method As it was an atypically large outbreak, we deployed to Louisiana to investigate it using genomics and a triplex re…
View article: Targeted amplification and genetic sequencing of the severe acute respiratory syndrome coronavirus 2 surface glycoprotein
Targeted amplification and genetic sequencing of the severe acute respiratory syndrome coronavirus 2 surface glycoprotein Open
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is a highly immunogenic and mutable protein that is the target of vaccine prevention and antibody therapeutics. This makes the encoding S-gene an important sequ…
View article: Strengthening influenza surveillance capacity in the Eastern Mediterranean Region: Nearly two decades of direct support from the United States Centers for Disease Control and Prevention
Strengthening influenza surveillance capacity in the Eastern Mediterranean Region: Nearly two decades of direct support from the United States Centers for Disease Control and Prevention Open
Since 2004, the US Centers for Disease Control and Prevention (CDC) Influenza Division (ID) has supported seven countries in the Eastern Mediterranean region and the World Health Organization Regional Office for the Eastern Mediterranean t…
View article: In-field detection and characterization of B/Victoria lineage deletion variant viruses causing early influenza activity and an outbreak in Louisiana, 2019
In-field detection and characterization of B/Victoria lineage deletion variant viruses causing early influenza activity and an outbreak in Louisiana, 2019 Open
In 2019, the Louisiana Department of Health reported an early influenza B/Victoria (B/VIC) virus outbreak. As it was an atypically large outbreak, we deployed to Louisiana to investigate it using genomics and a triplex real-time RT-PCR ass…
View article: Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States
Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States Open
Influenza viruses continually evolve new antigenic variants, through mutations in epitopes of their major surface proteins, hemagglutinin (HA) and neuraminidase (NA). Antigenic drift potentiates the reinfection of previously infected indiv…
View article: Structural basis of the American mink ACE2 binding by Y453F trimeric spike glycoproteins of SARS‐CoV‐2
Structural basis of the American mink ACE2 binding by Y453F trimeric spike glycoproteins of SARS‐CoV‐2 Open
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) enters the host cell by binding to angiotensin‐converting enzyme 2 (ACE2). While evolutionarily conserved, ACE2 receptors differ across various species and differential interacti…
View article: New insights into the neuraminidase-mediated hemagglutination activity of influenza A(H3N2) viruses
New insights into the neuraminidase-mediated hemagglutination activity of influenza A(H3N2) viruses Open
Influenza virus neuraminidase (NA) can act as a receptor-binding protein, a role commonly attributed to hemagglutinin (HA). In influenza A(H3N2) viruses, three NA amino acid residues have previously been associated with NA-mediated hemaggl…
View article: Strengthening influenza surveillance capacity in the Eastern Mediterranean Region: nearly two decades of direct support from the United States Centers for Disease Control and Prevention
Strengthening influenza surveillance capacity in the Eastern Mediterranean Region: nearly two decades of direct support from the United States Centers for Disease Control and Prevention Open
Since 2004, the U.S. Centers for Disease Control and Prevention (CDC) Influenza Division (ID) has supported seven countries in the Eastern Mediterranean region and the World Health Organization Regional Office for the Eastern Mediterranean…
View article: Targeted Amplification and Genetic Sequencing of the Severe Acute Respiratory Syndrome Coronavirus 2 Surface Glycoprotein
Targeted Amplification and Genetic Sequencing of the Severe Acute Respiratory Syndrome Coronavirus 2 Surface Glycoprotein Open
The SARS-CoV-2 spike protein is a highly immunogenic and mutable protein that is the target of vaccine prevention and antibody therapeutics. This makes the encoding S-gene an important sequencing target. The SARS-CoV-2 sequencing community…
View article: Structural basis of the American mink ACE2 binding by Y453F trimeric spike glycoproteins of SARS-CoV-2
Structural basis of the American mink ACE2 binding by Y453F trimeric spike glycoproteins of SARS-CoV-2 Open
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) enters the host cell by binding to angiotensin-converting enzyme 2 (ACE2). While evolutionarily conserved, ACE2 glycoproteins differ across various species and differential inter…
View article: Antiviral susceptibility of clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) viruses isolated from birds and mammals in the United States, 2022
Antiviral susceptibility of clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) viruses isolated from birds and mammals in the United States, 2022 Open
View article: Reported Global Avian Influenza Detections Among Humans and Animals During 2013-2022: Comprehensive Review and Analysis of Available Surveillance Data
Reported Global Avian Influenza Detections Among Humans and Animals During 2013-2022: Comprehensive Review and Analysis of Available Surveillance Data Open
Background Avian influenza (AI) virus detections occurred frequently in 2022 and continue to pose a health, economic, and food security risk. The most recent global analysis of official reports of animal outbreaks and human infections with…