David E. Wheatley
YOU?
Author Swipe
View article: In pursuit of larger lipophilicity enhancement: an investigation of sugar deoxychlorination
In pursuit of larger lipophilicity enhancement: an investigation of sugar deoxychlorination Open
Carbohydrate deoxychlorination is shown to be a powerful tool to significantly increase sugar lipophilicities compared to analogous deoxyfluorinated monosaccharides.
View article: Obtaining Pure <sup>1</sup>H NMR Spectra of Individual Pyranose and Furanose Anomers of Reducing Deoxyfluorinated Sugars
Obtaining Pure <sup>1</sup>H NMR Spectra of Individual Pyranose and Furanose Anomers of Reducing Deoxyfluorinated Sugars Open
Due to tautomeric equilibria, NMR spectra of reducing sugars can be complex with many overlapping resonances. This hampers coupling constant determination, which is required for conformational analysis and configurational assignment of sub…
View article: A ‘glyco-fluorine’ code revealing differential recognition by glycan binding partners
A ‘glyco-fluorine’ code revealing differential recognition by glycan binding partners Open
Biosensing or diagnostics using glycan sequences as targets is limited by glycan cross-reactivities. As binding sites of different proteins that all recognise a given glycan will not be identical, we introduce application of a library of s…
View article: Reverse thiophosphorylase activity of a glycoside phosphorylase in the synthesis of an unnatural Manβ1,4GlcNAc library
Reverse thiophosphorylase activity of a glycoside phosphorylase in the synthesis of an unnatural Manβ1,4GlcNAc library Open
A carbohydrate phosphorylase is utilised in the synthesis of unnatural Manβ1,4-GlcNAc and longer β-mannan like glycans, including formation of phosphorolysis-stable thioglycoside linkages via novel "reverse thiophosphorylase" enzymatic act…
View article: Introducing affinity and selectivity into galectin-targeting nanoparticles with fluorinated glycan ligands
Introducing affinity and selectivity into galectin-targeting nanoparticles with fluorinated glycan ligands Open
A chemo-enzymatic site-specific fluorination strategy is employed to obtain glyco-nanoparticles with tuneable selectivity towards galectins.