David Ebeid
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View article: Surface Lin28A expression consistent with cellular stress parallels indicators of senescence
Surface Lin28A expression consistent with cellular stress parallels indicators of senescence Open
Aims Declining cellular functional capacity resulting from stress or ageing is a primary contributor to impairment of myocardial performance. Molecular pathway regulation of biological processes in cardiac interstitial cells (CICs) is pivo…
View article: PIM1 Promotes Survival of Cardiomyocytes by Upregulating c-Kit Protein Expression
PIM1 Promotes Survival of Cardiomyocytes by Upregulating c-Kit Protein Expression Open
Enhancing cardiomyocyte survival is crucial to blunt deterioration of myocardial structure and function following pathological damage. PIM1 (Proviral Insertion site in Murine leukemia virus (PIM) kinase 1) is a cardioprotective serine thre…
Pim1 maintains telomere length in mouse cardiomyocytes by inhibiting TGFβ signalling Open
Aims Telomere attrition in cardiomyocytes is associated with decreased contractility, cellular senescence, and up-regulation of proapoptotic transcription factors. Pim1 is a cardioprotective kinase that antagonizes the aging phenotype of c…
View article: Cardiomyocyte cell cycle dynamics and proliferation revealed through cardiac-specific transgenesis of fluorescent ubiquitinated cell cycle indicator (FUCCI)
Cardiomyocyte cell cycle dynamics and proliferation revealed through cardiac-specific transgenesis of fluorescent ubiquitinated cell cycle indicator (FUCCI) Open
Cardiomyocyte-specific expression of Fluorescence Ubiquitination-based Cell Cycle Indicators (FUCCI) reveals previously unappreciated aspects of cardiomyocyte cell cycle arrest and biological activity in postnatal development and in respon…
View article: Cardiac c-Kit Biology Revealed by Inducible Transgenesis
Cardiac c-Kit Biology Revealed by Inducible Transgenesis Open
Rationale: Biological significance of c-Kit as a cardiac stem cell marker and role(s) of c-Kit+ cells in myocardial development or response to pathological injury remain unresolved because of varied and discrepant findings. Alternative exp…