David E. Ong
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View article: Monocyte-endothelial interactions as a targetable node in clonal hematopoiesis-mediated cardiovascular disease
Monocyte-endothelial interactions as a targetable node in clonal hematopoiesis-mediated cardiovascular disease Open
Background Clonal hematopoiesis of indeterminate potential (CHIP) increases risk of cardiovascular disease yet the molecular mechanisms driving this association remain incompletely understood. We hypothesized that aberrant monocyte-endothe…
View article: Monocyte-endothelial interactions as a targetable node in clonal hematopoiesis-mediated cardiovascular disease
Monocyte-endothelial interactions as a targetable node in clonal hematopoiesis-mediated cardiovascular disease Open
Background Clonal hematopoiesis of indeterminate potential (CHIP) increases risk of cardiovascular disease yet the molecular mechanisms driving this association remain incompletely understood. We hypothesized that aberrant monocyte-endothe…
View article: Accurate and reliable detection of clonal hematopoiesis in plasma cell-free DNA
Accurate and reliable detection of clonal hematopoiesis in plasma cell-free DNA Open
View article: Closing the loop: Teaching single-cell foundation models to learn from perturbations
Closing the loop: Teaching single-cell foundation models to learn from perturbations Open
The application of transfer learning models to large scale single-cell datasets has enabled the development of single-cell foundation models (scFMs) that can predict cellular responses to perturbations in silico. Although these predictions…
View article: Epigenome-wide DNA methylation association study of CHIP provides insight into perturbed gene regulation
Epigenome-wide DNA methylation association study of CHIP provides insight into perturbed gene regulation Open
With age, hematopoietic stem cells can acquire somatic mutations in leukemogenic genes that confer a proliferative advantage in a phenomenon termed CHIP. How these mutations result in increased risk for numerous age-related diseases remain…
View article: Epigenome-wide DNA Methylation Association Study of CHIP Provides Insight into Perturbed Gene Regulation
Epigenome-wide DNA Methylation Association Study of CHIP Provides Insight into Perturbed Gene Regulation Open
With age, hematopoietic stem cells can acquire somatic mutations in leukemogenic genes that confer a proliferative advantage in a phenomenon termed “clonal hematopoiesis of indeterminate potential” (CHIP). How these mutations confer a prol…
View article: Supplementary Table S2 from The Retinoic Acid Synthesis Gene <i>ALDH1a2</i> Is a Candidate Tumor Suppressor in Prostate Cancer
Supplementary Table S2 from The Retinoic Acid Synthesis Gene <i>ALDH1a2</i> Is a Candidate Tumor Suppressor in Prostate Cancer Open
Supplementary Table S2 from The Retinoic Acid Synthesis Gene ALDH1a2 Is a Candidate Tumor Suppressor in Prostate Cancer
View article: Data from The Retinoic Acid Synthesis Gene <i>ALDH1a2</i> Is a Candidate Tumor Suppressor in Prostate Cancer
Data from The Retinoic Acid Synthesis Gene <i>ALDH1a2</i> Is a Candidate Tumor Suppressor in Prostate Cancer Open
Prostate cancer is the most common cancer among men in the United States, and aberrant DNA methylation is known to be an early molecular event in its development. Here, we have used expression profiling to identify novel hypermethylated ge…
View article: Supplementary Table S1 from The Retinoic Acid Synthesis Gene <i>ALDH1a2</i> Is a Candidate Tumor Suppressor in Prostate Cancer
Supplementary Table S1 from The Retinoic Acid Synthesis Gene <i>ALDH1a2</i> Is a Candidate Tumor Suppressor in Prostate Cancer Open
Supplementary Table S1 from The Retinoic Acid Synthesis Gene ALDH1a2 Is a Candidate Tumor Suppressor in Prostate Cancer
View article: Data from The Retinoic Acid Synthesis Gene <i>ALDH1a2</i> Is a Candidate Tumor Suppressor in Prostate Cancer
Data from The Retinoic Acid Synthesis Gene <i>ALDH1a2</i> Is a Candidate Tumor Suppressor in Prostate Cancer Open
Prostate cancer is the most common cancer among men in the United States, and aberrant DNA methylation is known to be an early molecular event in its development. Here, we have used expression profiling to identify novel hypermethylated ge…
View article: Supplementary Table S1 from The Retinoic Acid Synthesis Gene <i>ALDH1a2</i> Is a Candidate Tumor Suppressor in Prostate Cancer
Supplementary Table S1 from The Retinoic Acid Synthesis Gene <i>ALDH1a2</i> Is a Candidate Tumor Suppressor in Prostate Cancer Open
Supplementary Table S1 from The Retinoic Acid Synthesis Gene ALDH1a2 Is a Candidate Tumor Suppressor in Prostate Cancer
View article: Supplementary Table S2 from The Retinoic Acid Synthesis Gene <i>ALDH1a2</i> Is a Candidate Tumor Suppressor in Prostate Cancer
Supplementary Table S2 from The Retinoic Acid Synthesis Gene <i>ALDH1a2</i> Is a Candidate Tumor Suppressor in Prostate Cancer Open
Supplementary Table S2 from The Retinoic Acid Synthesis Gene ALDH1a2 Is a Candidate Tumor Suppressor in Prostate Cancer
View article: Estrogen regulates the expression of retinoic acid synthesis enzymes and binding proteins in mouse skin
Estrogen regulates the expression of retinoic acid synthesis enzymes and binding proteins in mouse skin Open
View article: Issue Information
Issue Information Open