David Engblom
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View article: Role of microglia reactivity and sex on the cognitive decline linked to sporadic hypercholesterolemia
Role of microglia reactivity and sex on the cognitive decline linked to sporadic hypercholesterolemia Open
Background High blood cholesterol levels are recognized as an important risk factor for dementia, including Alzheimer's disease (AD). Although the mechanisms linking high cholesterol to cognitive decline remain unclear, blood‐brain barrier…
View article: Sex-specific gene expression and weighted co-expression network analysis suggest distinct sex-specific molecular signatures in acutely suicidal MDD-patients without somatic comorbidities
Sex-specific gene expression and weighted co-expression network analysis suggest distinct sex-specific molecular signatures in acutely suicidal MDD-patients without somatic comorbidities Open
Introduction Major depressive disorder (MDD) is a debilitating psychiatric disorder and is strongly associated with suicidal ideation and acute suicidality. While sex differences are evident across nearly all stages of depression, sex-spec…
View article: Minocycline Ameliorates Cognitive Impairments Without Modulate Microglial Reactivity in Sporadic Hypercholesterolemia: A Sex-Specific Analysis in Mice
Minocycline Ameliorates Cognitive Impairments Without Modulate Microglial Reactivity in Sporadic Hypercholesterolemia: A Sex-Specific Analysis in Mice Open
High blood cholesterol levels have been progressively recognized as an important risk factor for dementia, yet the underlying mechanisms remain poorly understood. Emerging evidence indicates that blood-brain barrier (BBB) dysfunction and m…
View article: Reconceptualizing rehabilitation research via an enactive framework and a radically interdisciplinary cross-analysis: a study protocol on fatigue in post COVID-19 condition (PCC)
Reconceptualizing rehabilitation research via an enactive framework and a radically interdisciplinary cross-analysis: a study protocol on fatigue in post COVID-19 condition (PCC) Open
Objective: To present a radically interdisciplinary research approach to ill-defined symptoms, with a focus on fatigue as a major symptom of post COVID-19 condition, where multiple and, to date, rarely combined approaches may yield a fulle…
View article: Nicotinic α7 receptors on cholinergic neurons in the striatum mediate cocaine-reinforcement, but not food reward
Nicotinic α7 receptors on cholinergic neurons in the striatum mediate cocaine-reinforcement, but not food reward Open
The neurotransmitter acetylcholine has since long been implicated in reward learning and drug addiction. However, the role of specific cholinergic receptor subtypes on different neuronal populations remain elusive. Here, we studied the fun…
View article: Unraveling the role of Microglia in triggering High Fat Diet‐Induced Cognitive Decline
Unraveling the role of Microglia in triggering High Fat Diet‐Induced Cognitive Decline Open
Background Excessive dietary fat is not only a risk factor for metabolic disorders but also for premature cognitive decline and Alzheimer’s disease. Recent findings from our study revealed that even a few days of a high‐fat diet (HFD) are …
View article: Social transmission of inflammation in mice
Social transmission of inflammation in mice Open
The ability to detect and respond to sickness in others promotes survival. Here we show that mouse dams respond to immune challenged pups by mirroring their inflammatory response. Dams with pups subjected to immune challenge displayed a ma…
View article: Melanocortin 4 receptor-expressing neurons in the lateral stripe of the striatum are involved in affect regulation and motor control
Melanocortin 4 receptor-expressing neurons in the lateral stripe of the striatum are involved in affect regulation and motor control Open
The dopaminergic system is crucial for affect regulation. Melanocortin 4 receptors (MC4R) in the ventral striatum have been shown to be necessary for establishing aversive states. Here, we set out to functionally characterize MC4R-expressi…
View article: Social transmission of inflammation in mice
Social transmission of inflammation in mice Open
The ability to detect and respond to sickness in others promotes survival. Here we show that mouse dams respond to immune challenged pups by mirroring their inflammatory response. Thus, dams with pups subjected to immune challenge displaye…
View article: Microglia contribute to cognitive decline in hypercholesterolemic <scp>LDLr</scp><sup>−/−</sup> mice
Microglia contribute to cognitive decline in hypercholesterolemic <span>LDLr</span><sup>−/−</sup> mice Open
Familial hypercholesterolemia (FH) is caused by mutations in the gene that encodes the low‐density lipoprotein (LDL) receptor, which leads to an excessive increase in plasma LDL cholesterol levels. Previous studies have shown that FH is as…
View article: Glial cell reactivity drives cognitive decline in LDLr‐/‐ mice: experimental evidences
Glial cell reactivity drives cognitive decline in LDLr‐/‐ mice: experimental evidences Open
Background Familial hypercholesterolemia (FH) is a clinical condition characterized by increased plasma cholesterol levels, due to a mutation in the gene encoding the low‐density lipoprotein receptor (LDLr) in cells [Brown and Goldstein, 1…
View article: Resistance training reduced luteinising hormone levels in postmenopausal women in a substudy of a randomised controlled clinical trial: A clue to how resistance training reduced vasomotor symptoms
Resistance training reduced luteinising hormone levels in postmenopausal women in a substudy of a randomised controlled clinical trial: A clue to how resistance training reduced vasomotor symptoms Open
Background Vasomotor symptoms (VMS) are common around menopause. Menopausal hormone therapy is the most effective treatment for VMS. Physical exercise has been proposed as an alternative treatment since physically active women have previou…
View article: Hippocampal Function Is Impaired by a Short-Term High-Fat Diet in Mice: Increased Blood–Brain Barrier Permeability and Neuroinflammation as Triggering Events
Hippocampal Function Is Impaired by a Short-Term High-Fat Diet in Mice: Increased Blood–Brain Barrier Permeability and Neuroinflammation as Triggering Events Open
Graphical Abstract An illustrative scheme summarizing the main outcomes in Swiss mice fed high-fat diet (HFD), with their exact time of onset of changes in the hippocampus. An increase in the expression of proinflammatory cytokines, togeth…
View article: Fever During Localized Inflammation in Mice Is Elicited by a Humoral Pathway and Depends on Brain Endothelial Interleukin-1 and Interleukin-6 Signaling and Central EP<sub>3</sub> Receptors
Fever During Localized Inflammation in Mice Is Elicited by a Humoral Pathway and Depends on Brain Endothelial Interleukin-1 and Interleukin-6 Signaling and Central EP<sub>3</sub> Receptors Open
We examined the signaling route for fever during localized inflammation in male and female mice, elicited by casein injection into a preformed air pouch. The localized inflammation gave rise to high concentrations of prostaglandins of the …
View article: Calcitonin Gene Related Peptide Α Is Dispensable for Many Danger-related Motivational Responses
Calcitonin Gene Related Peptide Α Is Dispensable for Many Danger-related Motivational Responses Open
Calcitonin gene related peptide (CGRP) expressing neurons in the parabrachial nucleus have been shown to encode danger. Through projections to the amygdala and other forebrain structures, they regulate food intake and trigger adaptive beha…
View article: NF-κB signaling in tanycytes mediates inflammation-induced anorexia
NF-κB signaling in tanycytes mediates inflammation-induced anorexia Open
Tanycytes form the brain barrier that mediates the anorexic effect of systemic inflammation in the hypothalamus.
View article: The generation of immune‐induced fever and emotional stress‐induced hyperthermia in mice does not involve brown adipose tissue thermogenesis
The generation of immune‐induced fever and emotional stress‐induced hyperthermia in mice does not involve brown adipose tissue thermogenesis Open
We examined the role of brown adipose tissue (BAT) for fever and emotional stress‐induced hyperthermia. Wild‐type and uncoupling protein‐1 (UCP‐1) knockout mice were injected with lipopolysaccharide intraperitoneally or intravenously, or s…
View article: Immune-mediated febrile response in female rats: Role of central hypothalamic mediators
Immune-mediated febrile response in female rats: Role of central hypothalamic mediators Open
Lipopolysaccharide (LPS) induces fever through cytokines like receptor-activator of nuclear factor κB ligand (RANKL), triggering mediators like prostaglandins (PG), endothelin-1 (ET-1), corticotrophin-releasing factor (CRF), substance P (S…
View article: CGRP Is Critical for Hot Flushes in Ovariectomized Mice
CGRP Is Critical for Hot Flushes in Ovariectomized Mice Open
Hot flushes are common and troublesome symptoms of menopause. The neuropeptide calcitonin gene-related peptide (CGRP) is increased in plasma during hot flushes but it has not been clear if CGRP is causally involved in the mechanism underpi…
View article: Motivational valence is determined by striatal melanocortin 4 receptors
Motivational valence is determined by striatal melanocortin 4 receptors Open
It is critical for survival to assign positive or negative valence to salient stimuli in a correct manner. Accordingly, harmful stimuli and internal states characterized by perturbed homeostasis are accompanied by discomfort, unease, and a…
View article: The antipyretic effect of paracetamol occurs independent of transient receptor potential ankyrin 1‐mediated hypothermia and is associated with prostaglandin inhibition in the brain
The antipyretic effect of paracetamol occurs independent of transient receptor potential ankyrin 1‐mediated hypothermia and is associated with prostaglandin inhibition in the brain Open
The mode of action of paracetamol (acetaminophen), which is widely used for treating pain and fever, has remained obscure, but may involve several distinct mechanisms, including cyclooxygenase inhibition and transient receptor potential an…
View article: Muscarinic M4 Receptors on Cholinergic and Dopamine D1 Receptor-Expressing Neurons Have Opposing Functionality for Positive Reinforcement and Influence Impulsivity
Muscarinic M4 Receptors on Cholinergic and Dopamine D1 Receptor-Expressing Neurons Have Opposing Functionality for Positive Reinforcement and Influence Impulsivity Open
The neurotransmitter acetylcholine has been implicated in reward learning and drug addiction. However, the roles of the various cholinergic receptor subtypes on different neuron populations remain elusive. Here we study the function of mus…