David Fabre
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View article: Is the transition to unsteadiness in the wake of slender bodies an artefact of boundary conditions ?
Is the transition to unsteadiness in the wake of slender bodies an artefact of boundary conditions ? Open
This work considers the transition to unsteadiness in the wake of 2D slender bodies, and questions the relevance of the generally accepted scenario involving a region of absolute instability within the near wake. The case of a thin plate a…
View article: Population Pharmacokinetic and Pharmacodynamic Modeling for the Prediction of the Extended Amlitelimab Phase 3 Dosing Regimen in Atopic Dermatitis
Population Pharmacokinetic and Pharmacodynamic Modeling for the Prediction of the Extended Amlitelimab Phase 3 Dosing Regimen in Atopic Dermatitis Open
Amlitelimab is a fully human, nondepleting, anti‐OX40 ligand monoclonal antibody being investigated for the treatment of moderate‐to‐severe atopic dermatitis (AD) in adults and adolescents. Population pharmacokinetic (PopPK) and pharmacoki…
View article: Two-way perturbative coupling of plasma–fluid interactions
Two-way perturbative coupling of plasma–fluid interactions Open
This contribution focuses on the modeling of ionic wind generated by a stationary corona discharge (CD) within a steady imposed external flow. The electro-drift velocity of unipolar charges in air is generally of a few hundred meters per s…
View article: Covariate Model Selection Approaches for Population Pharmacokinetics: A Systematic Review of Existing Methods, From SCM to AI
Covariate Model Selection Approaches for Population Pharmacokinetics: A Systematic Review of Existing Methods, From SCM to AI Open
A growing number of covariate modeling methods have been proposed in the field of popPK modeling, but limited information exists on how they all compare. The objective of this study was to perform a systematic review of all popPK covariate…
View article: Numerical Simulations of Ionic Wind Induced by Positive DC-Corona Discharges
Numerical Simulations of Ionic Wind Induced by Positive DC-Corona Discharges Open
This paper analyzes ionic wind production and propulsive force in various electrode configurations under atmospheric conditions. By considering the aerodynamic forces in addition to previously considered electric ones, new predictions for …
View article: Path instability of deformable bubbles rising in Newtonian liquids: a linear study
Path instability of deformable bubbles rising in Newtonian liquids: a linear study Open
The first stages of the path instability phenomenon affecting the buoyancy-driven motion of gas bubbles rising in weakly or moderately viscous liquids are examined using a recently developed numerical approach designed to assess the global…
View article: Identifying the active flow regions in acoustic-hydrodynamic feedback mechanisms
Identifying the active flow regions in acoustic-hydrodynamic feedback mechanisms Open
International audience
View article: Mode selection in concentric jets: the steady–steady 1 : 2 resonant mode interaction with O(2) symmetry
Mode selection in concentric jets: the steady–steady 1 : 2 resonant mode interaction with O(2) symmetry Open
The linear and nonlinear stability of two concentric jets separated by a duct wall is analysed by means of global linear stability and weakly nonlinear analysis. Three governing parameters are considered, the Reynolds number based on the i…
View article: Population Pharmacokinetic Modeling and Determination of Individual Exposure to Avalglucosidase Alfa in Adolescent and Adult Patients With Late-Onset Pompe Disease: Analysis of Pooled Data From Phase I to III Clinical Trials
Population Pharmacokinetic Modeling and Determination of Individual Exposure to Avalglucosidase Alfa in Adolescent and Adult Patients With Late-Onset Pompe Disease: Analysis of Pooled Data From Phase I to III Clinical Trials Open
Background: Pompe disease is a rare genetic disorder caused by a deficiency of a lysosomal enzyme called acid alpha-glucosidase and is classified into infantile and late-onset forms. Since 2006, an enzyme replacement therapy involving algl…
View article: An ALE method for instabilities in the wake of multiple freely-oscillating bodies
An ALE method for instabilities in the wake of multiple freely-oscillating bodies Open
International audience
View article: When, how, and why the path of an air bubble rising in pure water becomes unstable
When, how, and why the path of an air bubble rising in pure water becomes unstable Open
Recently, [Herrada, M. A. and Eggers, J. G., Proc. Natl. Acad. Sci. U.S.A. 120, e2216830120 (2023)] reported predictions for the onset of the path instability of an air bubble rising in water and put forward a physical scenario to explain …
View article: Mode selection in concentric jets. The steady-steady 1:2 resonant mode interaction with O(2) symmetry
Mode selection in concentric jets. The steady-steady 1:2 resonant mode interaction with O(2) symmetry Open
In this article, a thorough characterization of the configuration composed by two concentric jets at a low Reynolds number is presented. The analysis comprises a layout with a wide range for the velocity ratio between the inner and outer j…
View article: Dynamics of a gas bubble in a straining flow: Deformation, oscillations, self-propulsion
Dynamics of a gas bubble in a straining flow: Deformation, oscillations, self-propulsion Open
International audience
View article: Stability and dynamics of the flow past a bullet-shaped blunt body moving in a pipe
Stability and dynamics of the flow past a bullet-shaped blunt body moving in a pipe Open
The flow past a bullet-shaped blunt body moving in a pipe is investigated through global linear stability analysis (LSA) and direct numerical simulation. A cartography of the bifurcation curves is provided thanks to LSA, covering the range…
View article: Acoustic instability prediction of the flow through a circular aperture in a thick plate via an impedance criterion
Acoustic instability prediction of the flow through a circular aperture in a thick plate via an impedance criterion Open
We investigate the mechanisms leading to acoustic whistling for a jet passing through a circular hole in a thick plate connecting two domains. Two generic situations are considered. In the first one, the upstream domain is a closed cavity …
View article: Correction: Linear Theory and Experiments for Laminar Bias Flow Impedance: Orifice Shape Effect
Correction: Linear Theory and Experiments for Laminar Bias Flow Impedance: Orifice Shape Effect Open
Correction NoticeA leak in the experimental impedance-tube setup was found.In the Appendix of the original paper a calibration procedure using a relative pressure in the tube of = 112 Pa, was described for the Bronkhorst.A factor orf / set…
View article: Unveiling the competitive role of global modes in the pattern formation of rotating sphere flows
Unveiling the competitive role of global modes in the pattern formation of rotating sphere flows Open
The wake flow past a streamwise rotating sphere is a canonical model of numerous applications, such as particle-driven flows, sport aerodynamics and freely rising or falling bodies, where the changes in particles’ paths are related to the …
View article: Multi-inception patterns of emitter array/collector systems in DC corona discharge
Multi-inception patterns of emitter array/collector systems in DC corona discharge Open
Multiple emitters systems have been previously used so as to increase charge density in the drift region, many times without producing sensible increment neither in total current nor ionic wind. This contribution focuses on analyzing the d…
View article: Numerical study of ElectroAeroDynamic force and current resulting from ionic wind in emitter/collector systems
Numerical study of ElectroAeroDynamic force and current resulting from ionic wind in emitter/collector systems Open
ElectroAeroDynamic (EAD) propulsion has recently shown a growing interest with distinct propulsive capabilities and specific advantages. These experimental observations are, therefore, driving interest for numerical predictions of their pr…
View article: Bifurcation scenario in the two-dimensional laminar flow past a rotating cylinder
Bifurcation scenario in the two-dimensional laminar flow past a rotating cylinder Open
View article: Sound generation in a hole-tone configuration
Sound generation in a hole-tone configuration Open
International audience
View article: A comprehensive study on the instabilities arising in the wake of a rotating cylinder
A comprehensive study on the instabilities arising in the wake of a rotating cylinder Open
International audience
View article: Vortex-induced vibration prediction via an impedance criterion
Vortex-induced vibration prediction via an impedance criterion Open
The vortex-induced vibration of a spring-mounted, damped, rigid circular cylinder, immersed in a Newtonian viscous flow and capable of moving in the direction orthogonal to the unperturbed flow is investigated for Reynolds numbers in the v…
View article: Acoustic impedance and hydrodynamic instability of the flow through a circular aperture in a thick plate
Acoustic impedance and hydrodynamic instability of the flow through a circular aperture in a thick plate Open
International audience