David Fairman
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How translational modeling in oncology needs to get the mechanism just right Open
Translational model‐based approaches have played a role in increasing success in the development of novel anticancer treatments. However, despite this, significant translational uncertainty remains from animal models to patients. Optimizat…
View article: A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome
A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome Open
ClinicalTrials.gov, NCT01597635 . Registered on 26 January 2012.
View article: Why Has Model‐Informed Precision Dosing Not Yet Become Common Clinical Reality? Lessons From the Past and a Roadmap for the Future
Why Has Model‐Informed Precision Dosing Not Yet Become Common Clinical Reality? Lessons From the Past and a Roadmap for the Future Open
Patient groups prone to polypharmacy and special subpopulations are susceptible to suboptimal treatment. Refined dosing in special populations is imperative to improve therapeutic response and/or lowering the risk of toxicity. Model‐inform…