David Fällmar
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View article: Effects of intermittent theta- burst stimulation on emotion anticipation and processing in depression- investigating behavioral, electrodermal and neural activity
Effects of intermittent theta- burst stimulation on emotion anticipation and processing in depression- investigating behavioral, electrodermal and neural activity Open
Active, compared with sham, iTBS treatment does not affect behavioral, skin conductance or neural activity to emotion anticipation and processing in depression. However, across treatment groups, changes occur with time, perhaps reflecting …
View article: Developmental differences in reward-learning and its connection to resting-state functional connectivity modeled using a hierarchical Bayesian model
Developmental differences in reward-learning and its connection to resting-state functional connectivity modeled using a hierarchical Bayesian model Open
Adolescence is a period of heightened sensation-seeking, risk-taking, and reward sensitivity, characterized by structural and functional changes in the brain. Developmental changes in functional connectivity between cortical and subcortica…
View article: Radiation doses in ventriculoperitoneal shunt catheter imaging – Comparing traditional plain radiography with computed tomography and photon counting computed tomography
Radiation doses in ventriculoperitoneal shunt catheter imaging – Comparing traditional plain radiography with computed tomography and photon counting computed tomography Open
A transition from plain radiography to CT offers several benefits, such as decreased discomfort for the patient, shorter examination time, richer imaging data, and decreased radiation dose.
View article: Developmental differences in reward-learning and its connection to resting-state functional connectivity
Developmental differences in reward-learning and its connection to resting-state functional connectivity Open
Adolescence is a period of heightened sensation-seeking, risk-taking, and reward sensitivity, characterized by structural and functional changes in the brain. Developmental changes in functional connectivity between cortical and subcortica…
View article: Inhibitory neurotransmission in frontostriatal circuitry: implications for psychomotor and vegetative symptoms in depressive episodes
Inhibitory neurotransmission in frontostriatal circuitry: implications for psychomotor and vegetative symptoms in depressive episodes Open
Background Gamma-aminobutyric acid (GABA) dysfunction has been implicated in depression, although research findings remain inconsistent. This may indicate that distinct biological mechanisms underlie different symptom profiles in depressiv…
View article: Congruency between publicly available pictorial displays of medial temporal lobe atrophy
Congruency between publicly available pictorial displays of medial temporal lobe atrophy Open
The medial temporal lobe atrophy (MTA) score is used for visual assessment of MTA on radiological images in suspected neurodegenerative dementia. Although volumetric tools are available, many radiologists still use visual scoring and compa…
View article: Emotion anticipation and processing in depression: Behavioral, neural, and physiological reactivity
Emotion anticipation and processing in depression: Behavioral, neural, and physiological reactivity Open
Background Depression is characterized by disturbed emotion processing, with aberrant neural and physiological responses to emotional stimuli. Here, we applied an emotion anticipation and processing paradigm to investigate brain neural and…
View article: Comprehensive MRI assessment reveals subtle brain findings in non-hospitalized post-COVID patients with cognitive impairment
Comprehensive MRI assessment reveals subtle brain findings in non-hospitalized post-COVID patients with cognitive impairment Open
Background Impaired cognitive ability is one of the most frequently reported neuropsychiatric symptoms in the post-COVID phase among patients. It is unclear whether this condition is related to structural or functional brain changes. Purpo…
View article: An exploratory study of the damage markers NfL, GFAP, and t-Tau, in cerebrospinal fluid and other findings from a patient cohort enriched for suspected autoimmune psychiatric disease
An exploratory study of the damage markers NfL, GFAP, and t-Tau, in cerebrospinal fluid and other findings from a patient cohort enriched for suspected autoimmune psychiatric disease Open
There is growing evidence suggesting that immunological mechanisms play a significant role in the development of psychiatric symptoms in certain patient subgroups. However, the relationship between clinical red flags for suspected autoimmu…
View article: Assessing CT-based Volumetric Analysis via Transfer Learning with MRI and Manual Labels for Idiopathic Normal Pressure Hydrocephalus
Assessing CT-based Volumetric Analysis via Transfer Learning with MRI and Manual Labels for Idiopathic Normal Pressure Hydrocephalus Open
Background Brain computed tomography (CT) is an accessible and commonly utilized technique for assessing brain structure. In cases of idiopathic normal pressure hydrocephalus (iNPH), the presence of ventriculomegaly is often neuroradiologi…
View article: Clinical Impact of an AI Decision Support System for Detection of Intracranial Hemorrhage in CT Scans
Clinical Impact of an AI Decision Support System for Detection of Intracranial Hemorrhage in CT Scans Open
This study aimed to evaluate the predictive value and clinical impact of a clinically implemented artificial neural network software model. The software detects intracranial hemorrhage (ICH) from head computed tomography (CT) scans and art…
View article: Quantitative brain stem assessment in discriminating neurodegenerative disorders from normal pressure hydrocephalus
Quantitative brain stem assessment in discriminating neurodegenerative disorders from normal pressure hydrocephalus Open
Background and Purpose Differentiating idiopathic normal pressure hydrocephalus (iNPH) from neurodegenerative disorders such as progressive supranuclear palsy (PSP), Multiple System Atrophy—parkinsonian type (MSA‐P), and vascular dementia …
View article: The influence of anterior cingulate GABA+ and glutamate on emotion regulation and reactivity in adolescents and adults
The influence of anterior cingulate GABA+ and glutamate on emotion regulation and reactivity in adolescents and adults Open
During adolescence, emotion regulation and reactivity are still developing and are in many ways qualitatively different from adulthood. However, the neurobiological processes underpinning these differences remain poorly understood, includi…
View article: GABA<sub>A</sub> Receptor Availability in Relation to Cortical Excitability in Depressed and Healthy: A Positron Emission Tomography and Transcranial Magnetic Stimulation Study
GABA<sub>A</sub> Receptor Availability in Relation to Cortical Excitability in Depressed and Healthy: A Positron Emission Tomography and Transcranial Magnetic Stimulation Study Open
Introduction: Gamma-aminobutyric acid (GABA) deficiency is suggested in depressive disorders, along with alterations in cortical excitability. However, whether these excitability changes are related to GABAA receptor availability is largel…
View article: Damage markers in cerebrospinal fluid and other findings from a patient cohort enriched for suspected autoimmune psychiatric disease
Damage markers in cerebrospinal fluid and other findings from a patient cohort enriched for suspected autoimmune psychiatric disease Open
There is growing evidence suggesting that immunological mechanisms play a significant role in the development of psychiatric symptoms in certain patient subgroups. However, it is challenging to identify and classify these cases in this ear…
View article: Pupil dilation during negative prediction errors is related to brain choline concentration and depressive symptoms in adolescents
Pupil dilation during negative prediction errors is related to brain choline concentration and depressive symptoms in adolescents Open
Depressive symptoms are associated with altered pupillary responses during learning and reward prediction as well as with changes in neurometabolite levels, including brain concentrations of choline, glutamate and gamma-aminobutyric acid (…
View article: Protein Expression Profile of ACE2 in the Normal and COVID-19-Affected Human Brain
Protein Expression Profile of ACE2 in the Normal and COVID-19-Affected Human Brain Open
SARS-coronavirus 2 (SARS-CoV-2) that caused the coronavirus disease 2019 (COVID-19) pandemic has posed to be a global challenge. An increasing number of neurological symptoms have been linked to the COVID-19 disease, but the underlying mec…
View article: Can diffusion tensor imaging (DTI) outperform standard magnetic resonance imaging (MRI) investigations in post-COVID-19 autoimmune encephalitis?
Can diffusion tensor imaging (DTI) outperform standard magnetic resonance imaging (MRI) investigations in post-COVID-19 autoimmune encephalitis? Open
Background: Neurological and psychiatric manifestations related to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection are widely recognised. Standard magnetic resonance imaging (MRI) investigations are normal in 40–80% …
View article: Spotting the difference between pairs of nearly identical Perlin images: Influences of presentation formats
Spotting the difference between pairs of nearly identical Perlin images: Influences of presentation formats Open
We investigated human performance in speed and precision of detecting a deviating visual target embedded in one of two otherwise identical non-figurative Perlin-noise images (i.e. a spot-the-difference task). The image-pairs were presented…
View article: Higher levels of neurofilament light chain and total tau in CSF are associated with negative outcome after shunt surgery in patients with normal pressure hydrocephalus
Higher levels of neurofilament light chain and total tau in CSF are associated with negative outcome after shunt surgery in patients with normal pressure hydrocephalus Open
Background Lumbar punctures are a common examination in the work-up of patients with idiopathic normal pressure hydrocephalus (iNPH) and cerebrospinal fluid (CSF) biomarkers should therefore be available for use in selection of shunt candi…
View article: Suppressing visual hallucinations in an adolescent by occipital transcranial magnetic stimulation: A single-case experimental research design
Suppressing visual hallucinations in an adolescent by occipital transcranial magnetic stimulation: A single-case experimental research design Open
Visual hallucinations after central or peripheral impairment, commonly called Charles Bonnet syndrome, are often highly distressing and with few available treatment options. Here we report a case where an adolescent developed severely dist…