David E. Fisher
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View article: YAP1 drives aggressive and therapy resistant state in melanoma through reprogramming the chromatin and regulating immune evasive programs
YAP1 drives aggressive and therapy resistant state in melanoma through reprogramming the chromatin and regulating immune evasive programs Open
Despite promising initial results in targeting the RAF-MEK-ERK cascade, resistance to BRAF/MEK inhibitors remains a critical challenge in nearly 50% of melanoma patients. Our study demonstrates that robust YAP1 activation in metastatic mel…
View article: Distinct Examples of Immunologic Analysis in Molecular and Cellular Biology: Small Nuclear Ribonucleoproteins and the T Cell Receptor
Distinct Examples of Immunologic Analysis in Molecular and Cellular Biology: Small Nuclear Ribonucleoproteins and the T Cell Receptor Open
Since the discovery (Tan and Kunkel, 1966; Mattioli and Peichlin, 1971; Sharp, et al., 1972) of human SLE autoantibodies directed against RNA-protein complexes in eucaryotic nuclei, a great deal of interest has been generated regarding bot…
View article: Lysosomal reduced thiols are essential for mouse embryonic development
Lysosomal reduced thiols are essential for mouse embryonic development Open
While it has been appreciated for decades that lysosomes can import cysteine, its significance for whole-organism physiology has remained uncertain. Recent work identified MFSD12 as a transmembrane protein required for cysteine import into…
View article: Oncogenic specificity in nevus and melanoma formation
Oncogenic specificity in nevus and melanoma formation Open
There is striking clinical, histological, and molecular diversity observed across melanocytic tumors. Activating mutations in BRAF and NRAS are well-established initiators of benign melanocytic nevi and melanoma. However, accumulating evid…
View article: A novel approach to target skin photodamage: Topical application of salt inducible kinase inhibitors
A novel approach to target skin photodamage: Topical application of salt inducible kinase inhibitors Open
Background Ultraviolet (UV) radiation accelerates skin damage and photoageing, leading to visible signs such as wrinkles, loss of elasticity and uneven pigmentation. UV radiation causes direct DNA damage, primarily through the formation of…
View article: Emerging Therapies for Congenital Melanocytic Nevi
Emerging Therapies for Congenital Melanocytic Nevi Open
Congenital melanocytic nevi (CMN) are benign melanocytic neoplasms that vary in genetic drivers leading to the formation of pigmented lesions. Activation of Mitogen-Activated Protein Kinase (MAPK) pathway members through oncogenic mutation…
View article: Lysosomal reduced thiols are essential for mouse embryonic development
Lysosomal reduced thiols are essential for mouse embryonic development Open
While it has been appreciated for decades that lysosomes can import cysteine, its for organismal physiology is unclear. Recently, the MFSD12 transmembrane protein was shown to be necessary to import cysteine into lysosomes (and melanosomes…
View article: MITF regulates IDH1, NNT, and a transcriptional program protecting melanoma from reactive oxygen species
MITF regulates IDH1, NNT, and a transcriptional program protecting melanoma from reactive oxygen species Open
Microphthalmia-associated transcription factor (MITF) is a master regulator of melanocyte function, development and plays a significant role in melanoma pathogenesis. MITF genomic amplification promotes melanoma development, and it can fac…
View article: Finiteness of totally geodesic hypersurfaces
Finiteness of totally geodesic hypersurfaces Open
We prove that a closed negatively curved analytic Riemannian manifold that contains infinitely many totally geodesic hypersurfaces is isometric to an arithmetic hyperbolic manifold. Equivalently, any closed analytic Riemannian manifold wit…
View article: Association Between Natural Hair Color, Race, and Alopecia
Association Between Natural Hair Color, Race, and Alopecia Open
Darker hair colors may be associated with a higher risk of AA, lighter hair colors with a lower risk, and differences in hair color could contribute to previously noted racial variations in AA incidence, potentially influencing dermatologi…
View article: Correction: Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEGFR/PDGFR Combination Treatment
Correction: Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEGFR/PDGFR Combination Treatment Open
[This corrects the article DOI: 10.1371/journal.pone.0140310.].
View article: Are Higher Body Mass Index and Worse Metabolic Parameters Associated with More Aggressive Differentiated Thyroid Cancer? A Retrospective Cohort Study
Are Higher Body Mass Index and Worse Metabolic Parameters Associated with More Aggressive Differentiated Thyroid Cancer? A Retrospective Cohort Study Open
Obesity is a risk factor for differentiated thyroid cancer (DTC), but the association with DTC aggressiveness is controversial. To evaluate the association between preoperative body mass index (BMI)/other metabolic parameters and DTC aggre…
View article: Removal of hexavalent chromium from aqueous solutions by sorption with activated carbon. Review
Removal of hexavalent chromium from aqueous solutions by sorption with activated carbon. Review Open
The article considers sources of hexavalent chromium in the environment, its toxicity, methods of removal, main adsorbents used for Cr(VI) removal, obtaining of carbon sorbents using different raw materials. The interpretation of the mecha…
View article: MITF regulates IDH1 and NNT and drives a transcriptional program protecting cutaneous melanoma from reactive oxygen species
MITF regulates IDH1 and NNT and drives a transcriptional program protecting cutaneous melanoma from reactive oxygen species Open
Microphthalmia-associated transcription factor (MITF) plays pivotal roles in melanocyte development, function, and melanoma pathogenesis. MITF amplification occurs in melanoma and has been associated with resistance to targeted therapies. …
View article: DrugMap: A quantitative pan-cancer analysis of cysteine ligandability
DrugMap: A quantitative pan-cancer analysis of cysteine ligandability Open
Cysteine-focused chemical proteomic platforms have accelerated the clinical development of covalent inhibitors of a wide-range of targets in cancer. However, how different oncogenic contexts influence cysteine targeting remains unknown. To…
View article: A fibered Tukia theorem for nilpotent Lie groups
A fibered Tukia theorem for nilpotent Lie groups Open
We establish a Tukia-type theorem for uniform quasiconformal groups of a Carnot group. More generally we establish a fiber bundle version (or foliated version) of Tukia theorem for uniform quasiconformal groups of a nilpotent Lie group who…
View article: Greenberg-Shalom's Commensurator Hypothesis and Applications
Greenberg-Shalom's Commensurator Hypothesis and Applications Open
We discuss many surprising implications of a positive answer to a question raised in some cases by Greenberg in the $`70$s and more generally by Shalom in the early $2000$s. We refer to this positive answer as the Greenberg-Shalom hypothes…
View article: Gene-edited and -engineered stem cell platform drives immunotherapy for brain metastatic melanomas
Gene-edited and -engineered stem cell platform drives immunotherapy for brain metastatic melanomas Open
Oncolytic virus therapy has shown activity against primary melanomas; however, its efficacy in brain metastases remains challenging, mainly because of the delivery and immunosuppressive nature of tumors in the brain. To address this challe…
View article: Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions
Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions Open
Glucose is vital for life, serving as both a source of energy and carbon building block for growth. When glucose is limiting, alternative nutrients must be harnessed. To identify mechanisms by which cells can tolerate complete loss of gluc…
View article: A new proof of finiteness of maximal arithmetic reflection groups
A new proof of finiteness of maximal arithmetic reflection groups Open
We give a new proof of the finiteness of maximal arithmetic reflection groups. Our proof is novel in that it makes no use of trace formulas or other tools from the theory of automorphic forms and instead relies on the arithmetic Margulis l…