David Prieto‐Merino
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View article: #1387 Machine learning identifies variables associated with risk of hospitalisation in a national in-centre hemodialysis patient cohort
#1387 Machine learning identifies variables associated with risk of hospitalisation in a national in-centre hemodialysis patient cohort Open
Background and Aims Unplanned emergency hospitalisation is associated with a loss of quality of life and reduction in life expectancy for patients receiving hemodialysis treatment. Artificial intelligence tools including machine learning a…
View article: Implementing Federated Analysis Using DataSHIELD in the DREAM TO TREAT Atopic Dermatitis Registries Collaboration
Implementing Federated Analysis Using DataSHIELD in the DREAM TO TREAT Atopic Dermatitis Registries Collaboration Open
Many new biologic treatments and small-molecule agents are emerging and being approved for treating atopic dermatitis. Robust evidence, based on large sample sizes from real-world clinical settings, is needed to investigate the use of thes…
View article: Prepandemic levels of cytokines and immunoglobulins and risk of SARS-CoV-2 infection and COVID-19 in the general population of Barcelona
Prepandemic levels of cytokines and immunoglobulins and risk of SARS-CoV-2 infection and COVID-19 in the general population of Barcelona Open
Background From a public health perspective it is remarkable that there are yet no longitudinal studies in the general population investigating the influence of the basal immune state, measured before the pandemic, on the risk of SARS-CoV-…
View article: Enhanced Mitochondrial Dynamics and Reactive Oxygen Species Levels with Reduced Antioxidant Defenses in Human Epicardial Adipose Tissue
Enhanced Mitochondrial Dynamics and Reactive Oxygen Species Levels with Reduced Antioxidant Defenses in Human Epicardial Adipose Tissue Open
Background/Objectives: Epicardial adipose tissue (EAT) is metabolically active and is in dynamic crosstalk with the surrounding cardiomyocytes, modulating their function and metabolism. Oxidative stress is a key contributor to cell death a…
View article: Stability of cytokine and immunoglobulin concentrations in the general population: prepandemic basal concentrations and intraindividual changes until the COVID-19 pandemic
Stability of cytokine and immunoglobulin concentrations in the general population: prepandemic basal concentrations and intraindividual changes until the COVID-19 pandemic Open
While there is wide evidence on concentrations of cytokines in patients attending health care facilities, evidence is scant on physiological, basal concentrations of cytokines in the general population and across sociodemographic groups, a…
View article: Evidence‐Based Approaches to Quality Improvement: A Narrative Review of Integrating Bayesian Adaptive Trials Into Health Services
Evidence‐Based Approaches to Quality Improvement: A Narrative Review of Integrating Bayesian Adaptive Trials Into Health Services Open
Rationale Quality improvement (QI) in health service programmes aims to make small, incremental changes to increase reach and efficiency. Simple, low‐risk programmatic changes can improve services, particularly when supported by robust evi…
View article: Stability of cytokine and immunoglobulin concentrations in the general population: prepandemic basal concentrations and intraindividual changes until the COVID-19 pandemic
Stability of cytokine and immunoglobulin concentrations in the general population: prepandemic basal concentrations and intraindividual changes until the COVID-19 pandemic Open
Background While there is wide evidence on concentrations of cytokines in patients attending health care facilities, evidence is scant on physiological, basal concentrations of cytokines in the general population and across sociodemographi…
View article: P122 Conducting federated treatment effectiveness analyses for systemic therapies in atopic dermatitis across country borders: methodological considerations from the DREAM TO TREAT AD project
P122 Conducting federated treatment effectiveness analyses for systemic therapies in atopic dermatitis across country borders: methodological considerations from the DREAM TO TREAT AD project Open
There is a lack of evidence on treatment outcomes in patients with moderate-to-severe atopic dermatitis (AD) in the context of regular healthcare provision. While registers are a valuable tool for data collection in the context of regular …
View article: O06 Association between novel systemic immunomodulatory medications and achievement of super response in patients with moderate-to-severe atopic eczema: results from the UK–Irish Atopic Eczema Systemic Therapy Register (A-STAR)
O06 Association between novel systemic immunomodulatory medications and achievement of super response in patients with moderate-to-severe atopic eczema: results from the UK–Irish Atopic Eczema Systemic Therapy Register (A-STAR) Open
Previous post hoc analyses of randomized controlled trial data demonstrated that more patients with atopic eczema (AE) on Janus kinase (JAK) inhibitors achieve ‘super response’ (defined as total or nearly total clearance of AE) compared wi…
View article: Atopic dermatitis epidemiological research methodology: a global scoping review
Atopic dermatitis epidemiological research methodology: a global scoping review Open
Background Atopic dermatitis (AD) has the highest burden of all skin diseases globally. While numerous systematic reviews and meta-analyses have attempted to estimate the burden of AD at country, regional and global levels, the variability…
View article: Immunosuppressive Formulations for Immunological Defense against Traumatic Brain Injury
Immunosuppressive Formulations for Immunological Defense against Traumatic Brain Injury Open
Traumatic brain injury (TBI) and subsequent neurodegeneration is partially driven by chronic inflammation both locally and systemically. Yet, current clinical intervention strategies do not mitigate inflammation sequelae necessitating the …
View article: Living network meta-analysis to compare nemolizumab against other available targeted systemic treatments for atopic dermatitis
Living network meta-analysis to compare nemolizumab against other available targeted systemic treatments for atopic dermatitis Open
Nemolizumab is a new biologic approved to treat atopic dermatitis. In this perspective piece, we use results from our living systematic review and network meta-analysis to provide perspective on the relative efficacy of nemolizumab compare…
View article: Ambulatory parathyroid surgery, keep moving forward
Ambulatory parathyroid surgery, keep moving forward Open
Background Outpatient surgery remain still controversial regarding endocrine surgery. The objective of this study was to present the advances of our outpatient parathyroid surgery program in a reference hospital. Methods The patient select…
View article: Methotrexate and ciclosporin improve skin biomarkers in paediatric atopic dermatitis: results from the TREatment of severe Atopic eczema Trial
Methotrexate and ciclosporin improve skin biomarkers in paediatric atopic dermatitis: results from the TREatment of severe Atopic eczema Trial Open
Methotrexate (MTX) and ciclosporin (CyA) are the main conventional systemic treatments for severe atopic dermatitis (AD) globally. Despite the emergence of advanced targeted therapies for AD, the complex interaction of cutaneous immune bio…
View article: Hypertension and Carcinoid Heart Disease as Initial Manifestations of Ovarian Carcinoid Tumor
Hypertension and Carcinoid Heart Disease as Initial Manifestations of Ovarian Carcinoid Tumor Open
Ovarian carcinoid tumors (OCTs) are rare and may cause carcinoid syndrome (CS) even in the absence of liver metastases. Carcinoid heart disease (CHD), which develops in up to 50% of patients with CS, substantially affects morbidity and mor…
View article: Enhanced patient counselling and SMS reminder messages to improve access to community-based eye care services in Meru, Kenya: statistical analysis plan for a Bayesian adaptive trial
Enhanced patient counselling and SMS reminder messages to improve access to community-based eye care services in Meru, Kenya: statistical analysis plan for a Bayesian adaptive trial Open
Background Health service programmes frequently encounter challenges with patient adherence to care. A promising, low-risk approach to address this issue is providing patients with targeted information about the importance of adherence. In…
View article: Vaccines for immunological defense against traumatic brain injury
Vaccines for immunological defense against traumatic brain injury Open
Traumatic brain injury (TBI) and subsequent neurodegeneration is partially driven by chronic inflammation both locally and systemically. Yet, current clinical intervention strategies do not mitigate inflammation sequalae necessitating the …
View article: Prepandemic levels of cytokines and immunoglobulins and risk of SARS-CoV-2 infection and COVID-19 in the general population of Barcelona
Prepandemic levels of cytokines and immunoglobulins and risk of SARS-CoV-2 infection and COVID-19 in the general population of Barcelona Open
Background: There are yet no longitudinal studies investigating the influence of the basal immune state measured before the pandemic on the risk of SARS-CoV-2 infection and COVID-19. Objective: To investigate the specific and combined effe…
View article: Stability of cytokine and immunoglobulin concentrations in the general population: prepandemic basal concentrations and intraindividual changes until the COVID-19 pandemic
Stability of cytokine and immunoglobulin concentrations in the general population: prepandemic basal concentrations and intraindividual changes until the COVID-19 pandemic Open
Background: Evidence on physiological, basal concentrations of cytokines in the general population across sociodemographic groups, and their stability, is scant. No studies have analyzed intraindividual changes in such concentrations from …
View article: A prospective observational cohort study comparing the treatment effectiveness and safety of ciclosporin, dupilumab and methotrexate in adult and paediatric patients with atopic dermatitis: results from the UK–Irish A-STAR register
A prospective observational cohort study comparing the treatment effectiveness and safety of ciclosporin, dupilumab and methotrexate in adult and paediatric patients with atopic dermatitis: results from the UK–Irish A-STAR register Open
Background The main conventional systemic treatments for atopic dermatitis (AD) are methotrexate (MTX) and ciclosporin (CyA). Dupilumab was the first novel systemic agent to enter routine clinical practice. There are no head-to-head random…
View article: Systemic Immunomodulatory Treatments for Atopic Dermatitis
Systemic Immunomodulatory Treatments for Atopic Dermatitis Open
Importance There are multiple approved systemic treatments for atopic dermatitis. Lebrikizumab is a newly licensed biologic medication that has been compared to placebo in clinical trials but not to other systemic treatments. Objective To …
View article: Age of Introduction to Animal Source Foods and Its Association With Child Growth Indices in Low-Income Informal Settlements of Nairobi, Kenya
Age of Introduction to Animal Source Foods and Its Association With Child Growth Indices in Low-Income Informal Settlements of Nairobi, Kenya Open
Objectives: Animal-sourced foods (ASFs) contain essential nutrients for human growth, maintenance, and repair. This study quantifies the relationship between the age of ASF introduction and later child growth indices in low-income Kenya in…
View article: O03 Comparing the treatment effectiveness and safety of ciclosporin, dupilumab and methotrexate in adult and paediatric patients with atopic eczema: results from the UK-Irish A-STAR register
O03 Comparing the treatment effectiveness and safety of ciclosporin, dupilumab and methotrexate in adult and paediatric patients with atopic eczema: results from the UK-Irish A-STAR register Open
The main conventional systemic treatments for atopic eczema are methotrexate (MTX) and ciclosporin (CIC). Dupilumab was the first novel systemic agent to enter routine clinical practice. There are no head-to-head randomized controlled tria…
View article: P086 The UK-Irish Atopic Eczema Systemic TherApy Register (A-STAR): baseline characteristics of the cohort
P086 The UK-Irish Atopic Eczema Systemic TherApy Register (A-STAR): baseline characteristics of the cohort Open
A-STAR is a prospective register of UK and Irish patients with atopic eczema receiving systemic immunomodulatory therapies. The register is designed to assess the short- and long-term clinical and cost-effectiveness and safety of such trea…
View article: Correction: Clinical outcomes in a primary-level non-communicable disease programme for Syrian refugees and the host population in Jordan: A cohort analysis using routine data
Correction: Clinical outcomes in a primary-level non-communicable disease programme for Syrian refugees and the host population in Jordan: A cohort analysis using routine data Open
[This corrects the article DOI: 10.1371/journal.pmed.1003279.].