Clifton D. Fuller
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View article: Radiation-specific Automated Dosimetric dental, Mandible, and maxilla Annotation for Predicting Periodontal Problems (RADMAP): A semi-automated tool for dosimetric oral risk communication and osteoradionecrosis assessment
Radiation-specific Automated Dosimetric dental, Mandible, and maxilla Annotation for Predicting Periodontal Problems (RADMAP): A semi-automated tool for dosimetric oral risk communication and osteoradionecrosis assessment Open
Purpose/Objective(s) Osteoradionecrosis of the jaw (ORN) is a severe complication of head and neck cancer (HNC) radiotherapy (RT), significantly impacting patient quality of life. Current dose assessment relies on whole-mandible dosimetry,…
View article: Patient-reported outcomes after ipsilateral radiation therapy for N2b tonsillar squamous cell carcinoma
Patient-reported outcomes after ipsilateral radiation therapy for N2b tonsillar squamous cell carcinoma Open
Background Previous studies have reported excellent disease control and survival in patients with well-lateralized, American Joint Committee on Cancer (AJCC)-7 T1-2N2b tonsillar squamous cell carcinoma (SCC). The reduced treatment volume i…
View article: Perspective: Radiotherapy and Body Composition: Unmet Needs in Low- and Middle-Income Countries
Perspective: Radiotherapy and Body Composition: Unmet Needs in Low- and Middle-Income Countries Open
Radiotherapy plays a vital role in cancer treatment, yet its effects on patients' nutritional status can precipitate muscle loss, with significant implications for treatment tolerance and outcomes. Evidence from high-income countries incre…
View article: Generative Modeling for Interpretable Anomaly Detection in Medical Imaging: Applications in Failure Detection and Data Curation
Generative Modeling for Interpretable Anomaly Detection in Medical Imaging: Applications in Failure Detection and Data Curation Open
This work aims to leverage generative modeling-based anomaly detection to enhance interpretability in AI failure detection systems and to aid data curation for large repositories. For failure detection interpretability, this retrospective …
View article: A Generative Patient Digital Twin for Sequential Treatment of Oropharyngeal Squamous Carcinomas
A Generative Patient Digital Twin for Sequential Treatment of Oropharyngeal Squamous Carcinomas Open
Real-world testing of treatment strategies is often infeasible, emphasizing the need for robust simulation frameworks that can model diverse patient characteristics and predict treatment outcomes. In this study, we present a generative sim…
View article: Post-RT Head and Neck DCE-MRI: Association Between Mandibular Dose and ve
Post-RT Head and Neck DCE-MRI: Association Between Mandibular Dose and ve Open
Background: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a functional imaging modality that can quantify tissue permeability and blood flow. Due to vasculature changes resulting from radiation therapy (RT), DCE-MRI qua…
View article: Quantitative evaluation of apparent diffusion coefficient in a large multi-unit institution
Quantitative evaluation of apparent diffusion coefficient in a large multi-unit institution Open
A comprehensive analysis of institution-wide MRI scanners was conducted, motivating further work to utilize these results to implement a comprehensive quality assurance program and advanced scheduling system to better match similarly perfo…
View article: Evaluating Dimensionality Reduction for Patient-Reported Outcome–Based Survival Modeling in Patients With Head and Neck Cancer
Evaluating Dimensionality Reduction for Patient-Reported Outcome–Based Survival Modeling in Patients With Head and Neck Cancer Open
PURPOSE This study aims to improve survival modeling in head and neck cancer (HNC) by integrating patient-reported outcomes (PROs) using dimensionality reduction techniques. PROs capture symptom severity across the treatment timeline and o…
View article: Deep learning NTCP model for late dysphagia after radiotherapy for head and neck cancer patients based on 3D dose, CT and segmentations
Deep learning NTCP model for late dysphagia after radiotherapy for head and neck cancer patients based on 3D dose, CT and segmentations Open
DL NTCP models performed significantly better than the conventional NTCP model, suggesting the benefit of using 3D-input over the conventional discrete dose parameters. Attention maps highlighted relevant regions linked to dysphagia, suppo…
View article: Sleep-related symptoms are associated with survival in oropharyngeal cancer radiotherapy survivors: Temporal characterization of patient-reported outcomes in a large-scale prospective longitudinal cohort
Sleep-related symptoms are associated with survival in oropharyngeal cancer radiotherapy survivors: Temporal characterization of patient-reported outcomes in a large-scale prospective longitudinal cohort Open
Purpose Sleep-related symptom prevalence is not well-characterized and likely under-recognized in head and neck cancer. We investigated longitudinal symptom severity trajectory, prevalence of moderate/severe symptoms, and association betwe…
View article: Computed Tomography Orodental Sub-volume Imaging Annotation Dataset of Head and Neck Cancer Radiation Therapy Patients
Computed Tomography Orodental Sub-volume Imaging Annotation Dataset of Head and Neck Cancer Radiation Therapy Patients Open
Accurate delineation of orodental structures on computed tomography (CT) is critical for image-guided assessments of radiation-associated bone injury. This dataset comprises curated CT imaging and expert-defined segmentation masks for 60 p…
View article: Prevalence of Manifestations of Afferent Baroreflex Failure Among Long-Term Survivors of Oropharyngeal Cancer
Prevalence of Manifestations of Afferent Baroreflex Failure Among Long-Term Survivors of Oropharyngeal Cancer Open
Background Afferent baroreflex failure (ABF) is an underrecognized but debilitating complication among head and neck cancer survivors, especially in oropharyngeal cancer (OPC), a malignancy with excellent prognosis. ABF is mainly caused by…
View article: Hypoglossal Neuropathy in the Pathogenesis of Fibrosis‐Related Late‐Radiation Associated Dysphagia: A Correlative Analysis Utilizing Electromyography to Explore the Frequency of Clinical and Subclinical Neuropathy in a Pilot Dysphagia Trial
Hypoglossal Neuropathy in the Pathogenesis of Fibrosis‐Related Late‐Radiation Associated Dysphagia: A Correlative Analysis Utilizing Electromyography to Explore the Frequency of Clinical and Subclinical Neuropathy in a Pilot Dysphagia Trial Open
Background Late radiation‐associated dysphagia (late‐RAD) commonly presents in patients with signs of hypoglossal neuropathy, with hallmark clinical features including lingual atrophy, deviation, and fasciculation. Gold‐standard electromyo…
View article: A Multimodal and Multi-centric Head and Neck Cancer Dataset for Segmentation, Diagnosis and Outcome Prediction
A Multimodal and Multi-centric Head and Neck Cancer Dataset for Segmentation, Diagnosis and Outcome Prediction Open
We present a publicly available multimodal dataset for head and neck cancer research, comprising 1123 annotated Positron Emission Tomography/Computed Tomography (PET/CT) studies from patients with histologically confirmed disease, acquired…
View article: Comparative Accuracy of 18-Gauge versus 20-Gauge Ultrasound-Guided Fine-Needle Aspiration in the Detection of Persistent Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma after Chemoradiation
Comparative Accuracy of 18-Gauge versus 20-Gauge Ultrasound-Guided Fine-Needle Aspiration in the Detection of Persistent Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma after Chemoradiation Open
CRT＝chemoradiotherapy; FNA = fine needle aspiration; HNSCC＝ head & neck squamous cell carcinoma; HPV = human papillomavirus; NC = negative concordant; NPV = negative predictive value; PC = positive concordant; PPV = positive predictive val…
View article: Clinical and dosimetric dataset of time-to-event normal tissue complication probability for osteoradionecrosis
Clinical and dosimetric dataset of time-to-event normal tissue complication probability for osteoradionecrosis Open
Osteoradionecrosis of the jaw (ORNJ) is a radiation-induced late toxicity that can dramatically decrease patients’ quality of life. Recent increases in survival rates of head and neck cancers associated with human papillomavirus (HPV) infe…
View article: Supplementary Table S10 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
Supplementary Table S10 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade Open
Differentially expressed genes of CD4 clusters
View article: Supplementary Table S18 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
Supplementary Table S18 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade Open
Differentially expressed genes of FCGR3A-positive vs FCGR3A-negative NK cells
View article: Supplementary Table S14 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
Supplementary Table S14 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade Open
Differentially expressed genes of CD8 clusters
View article: Supplementary Figures S1-S18 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
Supplementary Figures S1-S18 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade Open
Fig. S1. Patient disposition and characteristics. Fig. S2. Timing of OI biopsy collection did not correlate with response. Fig. S3. Major cell types identified in the tumor immune microenvironment. Fig. S4. CD4+ T cells identified in the t…
View article: Supplementary Table S19 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
Supplementary Table S19 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade Open
Statistical test for association of lymphocyte cluster proportion with progression
View article: Supplementary Table S7 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
Supplementary Table S7 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade Open
Single-cell RNA and TCR sequencing information and metrics
View article: Supplementary Table S9 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
Supplementary Table S9 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade Open
Sample-level cell counts of CD4 clusters
View article: Supplementary Table S20 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
Supplementary Table S20 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade Open
Clinical and single-cell features used in multivariable regression models
View article: Supplementary Table S15 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
Supplementary Table S15 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade Open
Statistical test for proportions of CD8+ T cell clusters in the tumor immune microenvironment stratified by histological response and timepoint
View article: Supplementary Table S16 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
Supplementary Table S16 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade Open
CD8+ T-cell clonotypes with significant frequency changes in response to treatment
View article: Supplementary Table S12 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
Supplementary Table S12 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade Open
Differentially expressed genes of CD8+ T cells from MHRs vs non-MHRs at baseline
View article: Supplementary Table S8 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade
Supplementary Table S8 from Depletion of Effector Regulatory T Cells Associates with Major Response to Induction Dual Immune Checkpoint Blockade Open
Statistical test for proportions of cell types in the tumor immune microenvironment stratified by histological response and timepoint