Explanipedia

Prior Dual Antiplatelet Therapy and Mortality After Intracerebral Hemorrhage: A Danish Nationwide Cohort Study Open

Christian Ovesen, Luis A. Garcı́a Rodrı́guez, Jesper Hallas, Camilla Storm, Stine Munk Hald , et al. · 2025

Background Limited data support the link between dual antiplatelet therapy (DAPT) and adverse outcome among patients with intracerebral hemorrhage. This study aimed to investigate the association between prior use of DAPT and mortality aft…

The Effect of Remote Ischemic Conditioning in Patients Treated with Endovascular Therapy: A RESIST Trial Post Hoc Study Open

Rolf Ankerlund Blauenfeldt, David C. Hess, David Gaist, Boris Modrau, Jan Brink Valentin , et al. · 2025

Association of Prior Antithrombotic Drug Use with 90-Day Mortality After Intracerebral Hemorrhage Open

Christian Jørgensen, Nils Jensen Boe, Stine Munk Hald, Frederik Meyer-Kristensen, Mie Micheelsen Jensen , et al. · 2024

In this unselected cohort from a geographically defined Danish population, 90-day mortality after s-ICH was higher in patients with prior use of an OAC compared with no AT use or patients using a PA. Mortality was slightly lower for patien…

Artificial intelligence for MRI stroke detection: a systematic review and meta-analysis Open

Jonas Asgaard Bojsen, Mohammad Talal Elhakim, Ole Graumann, David Gaist, Mads Nielsen , et al. · 2024

Objectives This systematic review and meta-analysis aimed to assess the stroke detection performance of artificial intelligence (AI) in magnetic resonance imaging (MRI), and additionally to identify reporting insufficiencies. Methods PRISM…

Recurrent Ischemic Stroke in Patients With Atrial Fibrillation While Receiving Oral Anticoagulants Open

Mette Foldager Hindsholm, Luis A. Garcı́a Rodrı́guez, Axel Brandes, Jesper Hallas, Birgit Bjerre Høyer , et al. · 2024

Importance Patients with atrial fibrillation (AF) can have an ischemic stroke (IS) despite oral anticoagulant (OAC) treatment. Knowledge regarding the association between OAC discontinuation and the subsequent risk of recurrent IS in patie…

Association of Antithrombotic Drug Use With Incident Intracerebral Hemorrhage Location Open

Nils Jensen Boe, Stine Munk Hald, Alexandra Redzkina Kristensen, Sören Möller, Jonas Asgaard Bojsen , et al. · 2024

Antithrombotics were associated with higher risks of s-ICH, but the strength of the associations varied by s-ICH location and drug, which may reflect differences in the cerebral microangiopathies associated with lobar vs nonlobar hemorrhag…

Mental Health Conditions in Partners and Adult Children of Stroke Survivors Open

Nils Skajaa, Dóra Körmendiné Farkas, Kristina Laugesen, Cecilia Hvitfeldt Fuglsang, Victor W. Henderson , et al. · 2024

Importance Family caregiving after critical illness has been associated with several adverse health outcomes, including various aspects of mental health, but research focusing specifically on family members of stroke survivors is limited. …

Lipid‐Lowering Therapy and Hemorrhagic Stroke: A Never‐Ending Debate of Clinical Implications. Have We Found the Answer? Open

David Gaist, Magdy Selim · 2024

Risk of Stroke and Myocardial Infarction Among Initiators of Triptans Open

Christian Lund Petersen, Anders Hougaard, David Gaist, Jesper Hallas · 2024

Importance Triptans are contraindicated in patients with ischemic heart disease or previous myocardial infarction, and caution is advised when prescribing these drugs to patients with vascular risk factors. However, controlled observationa…

Carotid web as a cause of recurrent ischaemic strokes Open

Nadia Damholt Savino, Karen Ægidius, W Krone, David Gaist · 2024

This case report presents a 37-year-old woman with two episodes of temporary left-sided hemiparesis. Brain scans (CT and MRI) showed multiple ischaemic lesions in the right hemisphere. During the next two months, the patient had four addit…

Remote Ischemic Conditioning for Acute Stroke Open

Rolf Ankerlund Blauenfeldt, Niels Hjort, Jan Brink Valentin, Anne-Mette Homburg, Boris Modrau , et al. · 2023

Importance Despite some promising preclinical and clinical data, it remains uncertain whether remote ischemic conditioning (RIC) with transient cycles of limb ischemia and reperfusion is an effective treatment for acute stroke. Objective T…

Management and Prognosis of Acute Stroke in Atrial Fibrillation Open

Mette Foldager Hindsholm, Dorte Damgaard, M. Edip Gurol, David Gaist, Claus Z. Simonsen · 2023

Atrial fibrillation (AF) is an important risk factor for ischemic stroke (IS). Oral anticoagulation (OAC) significantly reduces the risk of IS in AF but also increases the risk of systemic bleeding, including intracerebral hemorrhage (ICH)…

Association of Statin Use With Risk of Stroke Recurrence After Intracerebral Hemorrhage Open

David Gaist, Luis A. Garcı́a Rodrı́guez, Jesper Hallas, Stine Munk Hald, Sören Möller , et al. · 2023

This study provides Class III evidence that statin use in patients with ICH is associated with a lower risk of any stroke and IS and not with increased risk of recurrent ICH.

Investigations of the subarachnoid space as a potential link between aura and headache in migraine: A case-control MRI study Open

Andreas Vinther Thomsen, Oula Puonti, David Gaist, Kirsten Ohm Kyvik, Kristoffer H. Madsen , et al. · 2023

Background The connection between migraine aura and headache is poorly understood. Some patients experience migraine aura without headache, and patients with migraine aura with headache commonly experience milder headaches with age. The di…

Major Cardiovascular Events After Spontaneous Intracerebral Hemorrhage by Hematoma Location Open

Nils Jensen Boe, Stine Munk Hald, Mie Micheelsen Jensen, Line Kristensen, Jonas Asgaard Bojsen , et al. · 2023

Importance Survivors of spontaneous (ie, nontraumatic and with no known structural cause) intracerebral hemorrhage (ICH) have an increased risk of major cardiovascular events (MACEs), including recurrent ICH, ischemic stroke (IS), and myoc…

Association Between Statin Use and Intracerebral Hemorrhage Location Open

Nils Jensen Boe, Stine Munk Hald, Mie Micheelsen Jensen, Jonas Asgaard Bojsen, Mohammad Talal Elhakim , et al. · 2022

We found that statin use was associated with a lower risk of ICH, particularly with longer treatment duration. This association did not vary by hematoma location.

Corrigendum: Sex-differences in oral anticoagulant-related intracerebral hemorrhage Open

Josefine Grundtvig, Christian Ovesen, Thorsten Steiner, Cheryl Carcel, David Gaist , et al. · 2022

[This corrects the article DOI: 10.3389/fneur.2022.832903.].

Association of Prior Intracerebral Hemorrhage With Major Adverse Cardiovascular Events Open

David Gaist, Stine Munk Hald, Luis A. Garcı́a Rodrı́guez, Anne Clausen, Sören Möller , et al. · 2022

Importance Patients with stroke due to nontraumatic (spontaneous) intracerebral hemorrhage (ICH) often harbor vascular risk factors and comorbidities, but it is unclear which major adverse cardiovascular events (MACEs) occur more frequentl…

Pre‐ and post‐stroke oral antithrombotics and mortality in patients with ischaemic stroke Open

Luis A. Garcı́a Rodrı́guez, David Gaist, Yanina Balabanova, Gunnar Brobert, Mike Sharma , et al. · 2022

Background Reducing stroke occurrence requires the effective management of cardiovascular and other stroke risk factors. Purpose To describe pre‐ and post‐stroke medication use, focusing on antithrombotic therapy and mortality risk, in ind…

COVID‐19 did not result in increased hospitalization for stroke and transient ischemic attack: A nationwide study Open

Claus Z. Simonsen, Rolf Ankerlund Blauenfeldt, Jakob Nebeling Hedegaard, Christina Kruuse, David Gaist , et al. · 2022

Background The risk of thrombosis increases in infectious diseases, yet observational studies from single centers have shown a decrease in admission of acute ischemic stroke patients during the COVID‐19 pandemic. To investigate unselected …

Sex-Differences in Oral Anticoagulant-Related Intracerebral Hemorrhage Open

Josefine Grundtvig, Christian Ovesen, Thorsten Steiner, Cheryl Carcel, David Gaist , et al. · 2022

Introduction and Aim Data remain limited on sex-differences in patients with oral anticoagulant (OAC)-related intracerebral hemorrhage (ICH). We aim to explore similarities and differences in risk factors, acute presentation, treatments, a…

Trends in the use of oral anticoagulants, antiplatelets and statins in four European countries: a population-based study Open

Luis A. Garcı́a Rodrı́guez, Lucía Cea Soriano, Francisco J. de Abajo, Francesca Valent, Jesper Hallas , et al. · 2021

Validity of Simple Algorithms to Identify Recurrence of Intracerebral Hemorrhage in Two Danish Nationwide Registries Open

Mie Micheelsen Jensen, Stine Munk Hald, Line Kristensen, Nils Jensen Boe, Frederik Severin Gråe Harbo , et al. · 2021

Simple algorithms accurately identified re-ICH in DSR and DNPR. Compared with DNPR, DSR achieved higher PPV and sensitivity with a shorter BP. The proposed algorithms could facilitate valid use of DSR and DNPR for studies of re-ICH.

Test‐retest and time dependent variation and diagnostic values of vibratory sensation determined by biothesiometer and the Rydel‐Seiffer tuning fork Open

Bolette Wittenberg, Toke K. Svendsen, Laura M. Gaist, Mustapha Itani, Sandra Sif Gylfadottir , et al. · 2021

Background and aims Polyneuropathy is a common neurological disorder with many potential causes. An essential part in screening, diagnosis, and follow‐up evaluation of polyneuropathy is testing of the sensory function including vibratory s…

Trends in Incidence of Intracerebral Hemorrhage and Association With Antithrombotic Drug Use in Denmark, 2005-2018 Open

Stine Munk Hald, Sören Möller, Luis A. Garcı́a Rodrı́guez, Rustam Al‐Shahi Salman, Mike Sharma , et al. · 2021

In Denmark from 2005 to 2018, use of antithrombotic drugs, especially VKAs, was associated with ICH. Although use of oral anticoagulation increased substantially during the study period, the incidence rate of ICH decreased.

Trends in incidence of oral anticoagulant-related intracerebral hemorrhage and sales of oral anticoagulants in Capital Region of Denmark 2010–2017 Open

Josefine Grundtvig, Christian Ovesen, Inger Havsteen, Thomas Christensen, David Gaist , et al. · 2021

Introduction Non-vitamin K-antagonist oral anticoagulants (NOAC) have become first choice oral anticoagulant (OAC) with decreasing use of vitamin K antagonists (VKA), partly due to lower risk of intracerebral hemorrhage (ICH). Aim: to iden…

Discontinuation of oral anticoagulation in atrial fibrillation and risk of ischaemic stroke Open

Luis A. Garcı́a Rodrı́guez, Lucía Cea Soriano, Stine Munk Hald, Jesper Hallas, Yanina Balabanova , et al. · 2020

Objective To evaluate associations between oral anticoagulant (OAC) discontinuation and risk of ischaemic stroke (IS) among patients with atrial fibrillation (AF). Methods We undertook a population-based cohort study with nested case–contr…

The Validity of Intracerebral Hemorrhage Diagnoses in the Danish Patient Registry and the Danish Stroke Registry Open

Hald SM, Kunhanam Lilly C., Mikkel Agger, Schelde-Olesen MT, Miriam Højholt Terkelsen , et al. · 2020

Stine Munk Hald,1,2 Christine Kring Sloth,1 Mikkel Agger,1 Maria Therese Schelde-Olesen,1 Miriam Højholt,1 Mette Hasle,1 Helle Bogetofte,1 Ida Olesrud,1 Stefanie Binzer,3 Charlotte Madsen,1 Willy Krone,4 Luis Alberto Garc&ia…

The Validity of Intracerebral Hemorrhage Diagnoses in the Danish Patient Registry and the Danish Stroke Registry Open

Stine Munk Hald, Christine Kring Sloth, Mikkel Agger, Maria Therese Schelde-Olesen, Miriam Højholt Terkelsen , et al. · 2020

The validity of a-ICH diagnoses is high in both registries. For s-ICH, PPV was higher in DSR, while sensitivity was higher in DNPR. The location of s-ICH was similar to distributions seen in other populations.

Prevalence of Congenital Hemolytic Disorders in Denmark, 2000–2016 Open

Dennis Lund Hansen, Andreas Glenthøj, Sören Möller, Bart J. Biemond, Kjeld Andersen , et al. · 2020

The prevalence of congenital RBC disorders in Denmark is increasing. The hemoglobinopathy traits now have prevalences as high as hereditary spherocytosis. These estimates of congenital hemolytic disorders in Denmark emphasize that inborn h…

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