David Gallagher
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View article: Outcomes Following Colorectal Cancer Resection in Elderly Patients
Outcomes Following Colorectal Cancer Resection in Elderly Patients Open
Background: Colorectal cancer (CRC) mainly affects older adults, yet elderly patients are underrepresented in outcomes research. Accurate risk stratification tools, such as the Charlson Comorbidity Index (CCI), are essential for guiding su…
View article: Selective antimicrobial photodynamic therapy of clinical isolates from patients with infected diabetic foot ulcers using a small cationic chlorin
Selective antimicrobial photodynamic therapy of clinical isolates from patients with infected diabetic foot ulcers using a small cationic chlorin Open
Diabetic foot ulcers (DFUs) are a major complication of diabetes mellitus and the principal factor contributing to lower limb amputations. Antimicrobial photodynamic therapy (aPDT) is a promising therapeutic strategy because it is not limi…
View article: Clinical Signs and Symptoms of Biofilm in Chronic Wounds. What Do Practitioners Think? Consensus Through an Electronic Delphi Survey
Clinical Signs and Symptoms of Biofilm in Chronic Wounds. What Do Practitioners Think? Consensus Through an Electronic Delphi Survey Open
This study aimed to gain clinician consensus on which signs/symptoms reported to be indicative of biofilm in chronic wounds are likely to be so. An international, two‐round eDelphi process including wound care clinicians ran from December …
View article: A Sternum-Worn, Non-Invasive Vibrotactile Device to Alleviate Symptoms in Parkinson’s: a Multi-Site Double-Blind Randomised Controlled Trial
A Sternum-Worn, Non-Invasive Vibrotactile Device to Alleviate Symptoms in Parkinson’s: a Multi-Site Double-Blind Randomised Controlled Trial Open
Background Effective, measurable, and non-invasive treatments for motor symptoms, gait and balance difficulties, and associated non-motor burden in Parkinson’s disease (PD) remain limited. We aimed to assess the usability, safety/tolerabil…
View article: Distribution of age at natural menopause, age at menarche, menstrual cycle length, height and BMI in BRCA1 and BRCA2 pathogenic variant carriers and non-carriers: results from EMBRACE
Distribution of age at natural menopause, age at menarche, menstrual cycle length, height and BMI in BRCA1 and BRCA2 pathogenic variant carriers and non-carriers: results from EMBRACE Open
Background Carriers of germline pathogenic variants (PVs) in the BRCA1 and BRCA2 genes are at higher risk of developing breast and ovarian cancer than the general population. It is unclear if these PVs influence other breast or ovarian can…
View article: A Flexible Individualised ExeRcise programme for cancer patients during ChEmotherapy (FIERCE): Protocol for a randomised controlled feasibility trial
A Flexible Individualised ExeRcise programme for cancer patients during ChEmotherapy (FIERCE): Protocol for a randomised controlled feasibility trial Open
The study is registered with ClinicalTrials.gov, registration number: NCT06280885.
View article: MRI-based radiomics nomogram to predict complete response to definitive chemoradiation in patients with anal cancer
MRI-based radiomics nomogram to predict complete response to definitive chemoradiation in patients with anal cancer Open
Objectives Treatment response to definitive chemoradiation (dCRT) in patients with anal cancer varies significantly, with a subset experiencing persistent or progressive disease despite therapy. Radiomics extracts quantitative features fro…
View article: Non-invasive device to alleviate symptoms in people living with Parkinson’s: study protocol for a multicentre phase II double-blind randomised controlled trial
Non-invasive device to alleviate symptoms in people living with Parkinson’s: study protocol for a multicentre phase II double-blind randomised controlled trial Open
Introduction Existing interventions for people with Parkinson’s disease (PwP) often fall short in addressing gait disturbances and falls, impacting their quality of life. The CUE1 non-invasive medical device, along with its updated version…
View article: Distribution of age at natural menopause, age at menarche, menstrual cycle length, height and BMI in BRCA1 and BRCA2 pathogenic variant carriers and non-carriers: Results from EMBRACE
Distribution of age at natural menopause, age at menarche, menstrual cycle length, height and BMI in BRCA1 and BRCA2 pathogenic variant carriers and non-carriers: Results from EMBRACE Open
Background Carriers of germline pathogenic variants (PVs) in the BRCA1 and BRCA2 genes are at higher risk of developing breast and ovarian cancer than the general population. It is unclear if these PVs influence other breast or ovarian can…
View article: P-1321. The Infectious Disease Needs of Adult Ukrainian Refugees in a Tertiary Centre in the West of Ireland
P-1321. The Infectious Disease Needs of Adult Ukrainian Refugees in a Tertiary Centre in the West of Ireland Open
Background Since February 2022 6.5 million have fled Ukraine; 104’ 870 to Ireland (2% of Irish population) [1, 2] The surge in those seeking temporary protection, coupled with infectious disease epidemiology in Ukraine; high prevalence of …
View article: Factors Influencing Outcomes and Survival in Anal Cancer
Factors Influencing Outcomes and Survival in Anal Cancer Open
Background: We aim to ascertain prognostic factors in the current management of anal cancer within this study. Methods: We reviewed the management and outcomes of anal cancer cases over a seven-year period, inclusive (2016–2023). The prima…
View article: The Optimal Approach to Surgical Management of Goblet Cell Carcinoid of the Appendix: A Systematic Review
The Optimal Approach to Surgical Management of Goblet Cell Carcinoid of the Appendix: A Systematic Review Open
Introduction: Goblet cell carcinoid (GCC) is a rare and poorly understood appendiceal neoplasm, exhibiting mixed histological and aggressive clinical features. Current guidelines recommend right hemicolectomy in all cases, although there i…
View article: Modifiable risk factors for cancer among people with lynch syndrome: an international, cross-sectional survey
Modifiable risk factors for cancer among people with lynch syndrome: an international, cross-sectional survey Open
Background Lynch syndrome is the most common cause of hereditary colorectal and endometrial cancer. Lifestyle modification may provide an opportunity for adjunctive cancer prevention. In this study, we aimed to characterise modifiable risk…
View article: Assessing Circulating Tumour DNA (ctDNA) as a Biomarker for Anal Cancer Management: A Systematic Review
Assessing Circulating Tumour DNA (ctDNA) as a Biomarker for Anal Cancer Management: A Systematic Review Open
This systematic review investigates the potential of circulating tumour DNA (ctDNA) as a predictive biomarker in the management and prognosis of squamous cell carcinoma of the anal canal (SCCA). PubMed, EMBASE, and Cochrane Central Registr…
View article: Whole-Body MRI Screening for Carriers of Germline TP53 Mutations—A Systematic Review and Meta-Analysis
Whole-Body MRI Screening for Carriers of Germline TP53 Mutations—A Systematic Review and Meta-Analysis Open
Purpose: This systematic review evaluated whole-body MRI (WB-MRI) as a cancer screening tool for individuals carrying germline TP53 mutations, a population known to be at a significantly elevated risk of malignancy. The primary objective i…
View article: O04 Reintroducing pen and leaving quin-alone: examining the impact of a penicillin allergy de-labelling project on antibiotic prescribing in a hospital setting
O04 Reintroducing pen and leaving quin-alone: examining the impact of a penicillin allergy de-labelling project on antibiotic prescribing in a hospital setting Open
Background The label of penicillin allergy is carried by between 8 and 25% of all patients (1). Alternative antibiotics may not be as efficacious, can be more expensive and lead to more adverse effects (2). Interrogation of a penicillin al…
View article: Epitope Engineered Human Haematopoietic Stem Cells are Shielded from CD123-targeted Immunotherapy
Epitope Engineered Human Haematopoietic Stem Cells are Shielded from CD123-targeted Immunotherapy Open
Summary Targeted eradication of transformed or otherwise dysregulated cells using monoclonal antibodies (mAb), antibody-drug conjugates (ADC), T cell engagers (TCE) or chimeric antigen receptor (CAR) cells is very effective for haematologi…
View article: Signs, symptoms and/or biomarkers reported to indicate biofilm in chronic wounds: an eDelphi consensus protocol
Signs, symptoms and/or biomarkers reported to indicate biofilm in chronic wounds: an eDelphi consensus protocol Open
Background Chronic wounds secondary to conditions, including venous insufficiency, diabetes or unrelieved friction/shear, are a significant burden to patients and healthcare systems. Biofilms are estimated to occupy 60–78% of these wounds.…
View article: The Essentials of Multiomics
The Essentials of Multiomics Open
Within the last decade, the science of molecular testing has evolved from single gene and single protein analysis to broad molecular profiling as a standard of care, quickly transitioning from research to practice. Terms such as genomics, …
View article: Breast and Prostate Cancer Risks for Male<i>BRCA1</i>and<i>BRCA2</i>Pathogenic Variant Carriers Using Polygenic Risk Scores
Breast and Prostate Cancer Risks for Male<i>BRCA1</i>and<i>BRCA2</i>Pathogenic Variant Carriers Using Polygenic Risk Scores Open
Background Recent population-based female breast cancer and prostate cancer polygenic risk scores (PRS) have been developed. We assessed the associations of these PRS with breast and prostate cancer risks for male BRCA1 and BRCA2 pathogeni…
View article: Insertion of an <scp>SVA</scp> element in <scp><i>MSH2</i></scp> as a novel cause of Lynch syndrome
Insertion of an <span>SVA</span> element in <span><i>MSH2</i></span> as a novel cause of Lynch syndrome Open
Germline mutations in the DNA mismatch repair (MMR) genes cause Lynch syndrome (LS). In this study, we identified and characterized a novel SINE‐VNTR‐Alu (SVA) insertion in exon 12 of MSH2 in an individual with early‐onset colorectal cance…
View article: Insertion of an SVA Element in MSH2 as a Novel Cause of Lynch Syndrome
Insertion of an SVA Element in MSH2 as a Novel Cause of Lynch Syndrome Open
Germline mutations in the DNA mismatch repair (MMR) genes cause Lynch syndrome (LS). Insertions of retrotransposons in MMR genes have been reported as a rare cause of LS. Here, we present a novel SINE-VNTR-Alu (SVA) insertion in exon 12 of…