David Geisel
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View article: Engineering a<i>Sinorhizobium meliloti</i>chassis with monopartite, single replicon genome configuration
Engineering a<i>Sinorhizobium meliloti</i>chassis with monopartite, single replicon genome configuration Open
Multipartite bacterial genomes pose challenges for genome engineering and establishment of additional replicons. We simplified the tripartite genome structure (3.65 Mbp chromosome, 1.35 Mbp megaplasmid pSymA, 1.68 Mbp chromid pSymB) of Sin…
View article: Machine learning classification of trajectories from molecular dynamics simulations of chromosome segregation
Machine learning classification of trajectories from molecular dynamics simulations of chromosome segregation Open
In contrast to the well characterized mitotic machinery in eukaryotes it seems as if there is no universal mechanism organizing chromosome segregation in all bacteria. Apparently, some bacteria even use combinations of different segregatio…
View article: Simple Ventilators for Emergency Use Based on Bag-Valve Pressing Systems: Lessons Learned and Future Steps
Simple Ventilators for Emergency Use Based on Bag-Valve Pressing Systems: Lessons Learned and Future Steps Open
As part of a plethora of global efforts to minimize the negative effects of the SARS-CoV2 (COVID-19) pandemic, we developed two different mechanisms that, after further development, could potentially be of use in the future in order to inc…
View article: Can CPAP machines be repurposed to solve the ventilator shortage?
Can CPAP machines be repurposed to solve the ventilator shortage? Open
The worldwide shortage of medical-grade ventilators is a well-known issue, that has become one of the central topics during the COVID-19 pandemic. Given that these machines are expensive and have long lead times, one approach is to vacate …
View article: Chromosome Segregation in Bacillus subtilis Follows an Overall Pattern of Linear Movement and Is Highly Robust against Cell Cycle Perturbations
Chromosome Segregation in Bacillus subtilis Follows an Overall Pattern of Linear Movement and Is Highly Robust against Cell Cycle Perturbations Open
We have followed the segregation of origin regions on the Bacillus subtilis chromosome in the fastest practically achievable temporal manner, for a large fraction of the cell cycle. We show that segregation occurred in highly variable patt…
View article: Simple ventilators for emergency use based on Bag-Valve pressing systems: Lessons learned and future steps
Simple ventilators for emergency use based on Bag-Valve pressing systems: Lessons learned and future steps Open
As part of a plethora of global efforts to minimize the negative effects of the SARS-CoV2 (COVID-19) pandemic, we developed two different mechanisms that, after further development, could potentially be of use in the future in order to inc…