David Goertsen
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View article: Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates
Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates Open
View article: Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral vectors
Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral vectors Open
The blood-brain barrier (BBB) presents a major challenge for delivering large molecules to study and treat the central nervous system. This is due in part to the scarcity of targets known to mediate BBB crossing. To identify novel targets,…
View article: Primate-conserved Carbonic Anhydrase IV and murine-restricted Ly6c1 are new targets for crossing the blood-brain barrier
Primate-conserved Carbonic Anhydrase IV and murine-restricted Ly6c1 are new targets for crossing the blood-brain barrier Open
The blood-brain barrier (BBB) presents a major challenge to delivering large molecules to study and treat the central nervous system (CNS). This is due in part to the scarcity of effective targets for BBB crossing, the identification of wh…
View article: Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates
Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates Open
Delivering genes to and across the brain vasculature efficiently and specifically across species remains a critical challenge for addressing neurological diseases. We have evolved adeno-associated virus (AAV9) capsids into vectors that tra…
View article: Targeting the lung epithelium after intravenous delivery by directed evolution of underexplored sites on the AAV capsid
Targeting the lung epithelium after intravenous delivery by directed evolution of underexplored sites on the AAV capsid Open
View article: Adeno-Associated Virus Toolkit to Target Diverse Brain Cells
Adeno-Associated Virus Toolkit to Target Diverse Brain Cells Open
Recombinant adeno-associated viruses (AAVs) are commonly used gene delivery vehicles for neuroscience research. They have two engineerable features: the capsid (outer protein shell) and cargo (encapsulated genome). These features can be mo…
View article: AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset
AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset Open
View article: Broad gene expression throughout the mouse and marmoset brain after intravenous delivery of engineered AAV capsids
Broad gene expression throughout the mouse and marmoset brain after intravenous delivery of engineered AAV capsids Open
Genetic intervention is increasingly explored as a therapeutic option for debilitating disorders of the central nervous system. The safety and efficacy of gene therapies relies upon expressing a transgene in affected cells while minimizing…
View article: An investigation into... AMS Food and Beverage : optimal modes of campus food delivery
An investigation into... AMS Food and Beverage : optimal modes of campus food delivery Open
The installation of the New Student Union Building (SUB) creates a vast opportunity for restaurants to take advantage of the food delivery system towards the students of UBC. Ryan Bissell, Executive Chef, and Collyn Chan, New SUB Sustainab…