Luke Vale
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View article: Subjective Evaluation of Female Adult Body Fat Distribution: A Scoping Review
Subjective Evaluation of Female Adult Body Fat Distribution: A Scoping Review Open
Body fat distribution is a key indicator of obesity‐related disease risk, often assessed through objective anthropometric measurements. However, objective implementation at scale is limited by measurement variability, cost, and anthropomet…
View article: Exploring Pregnant Women’s Perceptions and Experiences of Adiposity Measurements in Routine Antenatal Care: A Qualitative Study
Exploring Pregnant Women’s Perceptions and Experiences of Adiposity Measurements in Routine Antenatal Care: A Qualitative Study Open
Background/objectives: Maternal adiposity is a known risk factor for adverse pregnancy outcomes, yet routine antenatal care primarily relies on body mass index (BMI), which has limitations. This study aimed to explore the acceptability of …
View article: #1596 Stopping eculizumab treatment safely in atypical HUS: a multicentre, open-label, prospective, single-arm trial of the safety and impact of eculizumab withdrawal
#1596 Stopping eculizumab treatment safely in atypical HUS: a multicentre, open-label, prospective, single-arm trial of the safety and impact of eculizumab withdrawal Open
Background and Aims Atypical haemolytic uraemic syndrome (aHUS) is a rare disease which without treatment is associated with high morbidity and mortality. Eculizumab, a monoclonal complement inhibitor, is an effective treatment but the opt…
View article: Real-World Evaluation of AI-Driven Diabetic Retinopathy Screening in Public Health Settings: Validation and Implementation Study
Real-World Evaluation of AI-Driven Diabetic Retinopathy Screening in Public Health Settings: Validation and Implementation Study Open
Background Artificial intelligence (AI) algorithms offer an effective solution to alleviate the burden of diabetic retinopathy (DR) screening in public health settings. However, there are challenges in translating diagnostic performance an…
View article: A group intervention for parents and carers to recognise and understand restricted and repetitive behaviour in autistic children: a multisite RCT
A group intervention for parents and carers to recognise and understand restricted and repetitive behaviour in autistic children: a multisite RCT Open
Background Restricted and repetitive behaviours vary greatly between autistic people. Some are a source of pleasure or create opportunities for learning; however, others are functionally impactful and may cause harm. We have developed a pa…
View article: Cost-effectiveness of lifelong eculizumab versus disease monitoring of aHUS
Cost-effectiveness of lifelong eculizumab versus disease monitoring of aHUS Open
Background Atypical haemolytic uraemic syndrome (aHUS) is a rare but severe condition caused by complement dysregulation. Eculizumab prophylaxis prevents recurrence and improves survival, yet the benefits of lifelong treatment for patients…
View article: Eculizumab withdrawal and monitoring in atypical haemolytic uraemic syndrome (SETS aHUS): a multicentre, open label, prospective, single arm trial
Eculizumab withdrawal and monitoring in atypical haemolytic uraemic syndrome (SETS aHUS): a multicentre, open label, prospective, single arm trial Open
Background: Atypical Haemolytic Uraemic Syndrome is a rare disease, associated with high morbidity and mortality. Eculizumab, a monoclonal complement inhibitor, is an effective treatment but the optimal way to use this high-cost medication…
View article: A strategy of eculizumab treatment withdrawal with disease monitoring is cost-effective compared to lifelong treatment for eligible atypical haemolytic uraemic syndrome patients: an economic evaluation of the SETS aHUS trial
A strategy of eculizumab treatment withdrawal with disease monitoring is cost-effective compared to lifelong treatment for eligible atypical haemolytic uraemic syndrome patients: an economic evaluation of the SETS aHUS trial Open
Background and hypothesis Atypical haemolytic uraemic syndrome (aHUS) is a rare condition caused by compliment dysregulation. Eculizumab is an effective treatment for patients with aHUS, yet a lifelong treatment strategy is costly for heal…
View article: PROPRIOCEPTION AND MOTOR KINESTHESIA: REAL GAINS WITH THE INTENSIVE SPEECH THERAPY AT THERASUIT
PROPRIOCEPTION AND MOTOR KINESTHESIA: REAL GAINS WITH THE INTENSIVE SPEECH THERAPY AT THERASUIT Open
This article deals with important issues in the speech therapy treatment of children with communication problems due to significant global neuropsychomotor developmental disorders using the Intensive Speech Therapy at Therasuit (ISTT) prog…
View article: Understanding Repetitive Behaviours: A clinical and cost-effectiveness, multi-site randomised controlled trial of a group for parents and carers of young autistic children
Understanding Repetitive Behaviours: A clinical and cost-effectiveness, multi-site randomised controlled trial of a group for parents and carers of young autistic children Open
Restricted and repetitive behaviours vary greatly between autistic people. Some are a source of pleasure or create opportunities for learning; others may be detrimental in day-to-day life or cause harm. We have developed, in close collabor…
View article: Prostate Assessment using Comparative Interventions – Fast MRI and Image-fusion for Cancer (IP7-PACIFIC): A prospective, multi-centre, dual sequential randomised controlled trial
Prostate Assessment using Comparative Interventions – Fast MRI and Image-fusion for Cancer (IP7-PACIFIC): A prospective, multi-centre, dual sequential randomised controlled trial Open
IP7-PACIFIC aims to provide randomised comparative evidence for the clinical utility and cost-effectiveness of using bpMRI and image-fusion biopsy. The findings will inform guidelines. The sequential randomised co-enrolment design allows s…
View article: Barriers and Determinants of Referral Adherence in AI-Enabled Diabetic Retinopathy Screening for Older Adults in Northern India During the COVID-19 Pandemic: Mixed Methods Pilot Study
Barriers and Determinants of Referral Adherence in AI-Enabled Diabetic Retinopathy Screening for Older Adults in Northern India During the COVID-19 Pandemic: Mixed Methods Pilot Study Open
Background Diabetic retinopathy (DR) is a leading cause of blindness globally. DR has increasingly affected both individuals and health care systems as the population ages. Objective This study aims to explore factors and identify barriers…
View article: Gathering baseline data to assess household energy interventions’ impact on indoor air quality, occupant health, and wellbeing: In2Air a non-randomized experiment
Gathering baseline data to assess household energy interventions’ impact on indoor air quality, occupant health, and wellbeing: In2Air a non-randomized experiment Open
Background Tackling climate change, together with improving indoor air quality, offers a significant opportunity to improve residents’ health and well-being. This requires the evidence base to inform an energy-efficient retrofit design. Ob…
View article: Methods used in early value assessments for nice: a scoping review
Methods used in early value assessments for nice: a scoping review Open
Objectives The National Institute for Health and Care Excellence (NICE) in England introduced early value assessments (EVAs) as an evidence-based method of accelerating access to promising health technologies that could address unmet needs…
View article: Public Valuations of Managing Compromised Molars: A Discrete Choice Experiment
Public Valuations of Managing Compromised Molars: A Discrete Choice Experiment Open
There is limited evidence to support optimal patient-centered management for compromised first permanent molars (cFPM) in children. Based on an online discrete choice experiment (DCE), this study elicits UK adult general population prefere…
View article: P18.39.A SEIZURE PROPHYLAXIS IN GLIOMA SURGERY (SPRING): A MULTI-CENTRE, UNBLINDED, RANDOMISED TRIAL
P18.39.A SEIZURE PROPHYLAXIS IN GLIOMA SURGERY (SPRING): A MULTI-CENTRE, UNBLINDED, RANDOMISED TRIAL Open
BACKGROUND 50-80% of all glioma patients will suffer from seizures during their lifetime. Over half of these patients will have drug resistant seizures. Seizure risk is increased peri-operatively, at tumour progression, and shortly before …
View article: Longitudinal health-related quality of life in people with thoracic aortic aneurysms
Longitudinal health-related quality of life in people with thoracic aortic aneurysms Open
Background Surgical intervention for thoracic aortic aneurysms is high risk. Understanding changes in health-related quality of life before and after endovascular stent grafting and open surgical repair can aid treatment decision-making. M…
View article: Development and pilot implementation of a novel protocol to assess capacity and readiness of health systems to adopt HPV detection-based cervical cancer screening in Europe
Development and pilot implementation of a novel protocol to assess capacity and readiness of health systems to adopt HPV detection-based cervical cancer screening in Europe Open
Our study's novelty lies in the successful development of this capacity assessment methodology implementable within a relatively short time frame, proving its feasibility for use in various contexts and countries. The resulting set of mate…
View article: Feasibility and acceptability of autism adapted safety plans: an external pilot randomised controlled trial
Feasibility and acceptability of autism adapted safety plans: an external pilot randomised controlled trial Open
This study is funded by the NIHR [Public Health Research Programme (NIHR129196)].