David Y. Graham
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View article: Elastic Cytomatrix Dynamics Influences Metabolic Rate and Tumor Microenvironment Formation
Elastic Cytomatrix Dynamics Influences Metabolic Rate and Tumor Microenvironment Formation Open
In healthy cells, the cytomatrix mechanics utilize mitochondrial respiration to control cytosolic motion and fine-tune the chemical processes. In cancer, the cytosolic motion is energized by glycolytic fermentation (the Warburg effect), wh…
View article: <scp>FIGO</scp> committee opinion: Environmental drivers of obstetric health and early childhood development
<span>FIGO</span> committee opinion: Environmental drivers of obstetric health and early childhood development Open
Environmental exposures are increasingly recognized as critical, yet underappreciated, determinants of reproductive, perinatal, and early childhood health. Developed through a structured consensus process and grounded in systematic evidenc…
View article: <scp>FIGO</scp> committee opinion: Environmental drivers of gynecologic and reproductive health
<span>FIGO</span> committee opinion: Environmental drivers of gynecologic and reproductive health Open
This FIGO committee opinion paper addresses the growing body of evidence linking environmental exposures to common gynecologic and reproductive conditions across the life course. From adolescence through menopause, women are exposed to a w…
View article: Resilience of the Gut Microbiome to Short Proton Pump Inhibitor Therapy With or Without High‐Dosage <i>L. reuteri</i> in <i>H. pylori</i> ‐Infected Adults
Resilience of the Gut Microbiome to Short Proton Pump Inhibitor Therapy With or Without High‐Dosage <i>L. reuteri</i> in <i>H. pylori</i> ‐Infected Adults Open
Background Helicobacter pylori eradication therapy typically consists of a combination of antibiotics and an antisecretory drug. Probiotics may be added to reduce side effects and possibly improve outcomes. Materials and Methods We conduct…
View article: The social must be stabilised: How are the social needs of young people with social work involvement characterized in their mental health case notes?
The social must be stabilised: How are the social needs of young people with social work involvement characterized in their mental health case notes? Open
View article: 40 years after the discovery of <i>Helicobacter Pylori</i>: Performing optimized “subtraction” for clinical eradication
40 years after the discovery of <i>Helicobacter Pylori</i>: Performing optimized “subtraction” for clinical eradication Open
View article: Proton pump inhibitors and the risk of gastric cancer: a systematic review, evidence synthesis and life course epidemiology perspective
Proton pump inhibitors and the risk of gastric cancer: a systematic review, evidence synthesis and life course epidemiology perspective Open
Objectives Since proton pump inhibitors (PPI) have been introduced, many concerns were raised regarding potential gastric carcinogenicity. We aim to summarise and weigh the epidemiological evidence and address possible causality. Design Sy…
View article: Dairy Consumption and the Colonic Mucosa-Associated Gut Microbiota in Humans—A Preliminary Investigation
Dairy Consumption and the Colonic Mucosa-Associated Gut Microbiota in Humans—A Preliminary Investigation Open
Background: Dairy consumption has been associated with various health outcomes that may be mediated by changes in gut microbiota. Methods: This cross-sectional study investigated the association between the colonic mucosa-associated gut mi…
View article: Typological and cumulative approaches to risk and adversity in Child and Adolescent Mental Health Services (CAMHS): Retrospective cohort analysis in South London
Typological and cumulative approaches to risk and adversity in Child and Adolescent Mental Health Services (CAMHS): Retrospective cohort analysis in South London Open
Our findings suggest that typological and cumulative approaches to risk and adversity can produce unique insights about diagnostic practices and service activity. This work provides further evidence for the contribution of contextual facto…
View article: Lack of Detection of Norwalk Virus in Saliva Samples From a Controlled Human Infection Model
Lack of Detection of Norwalk Virus in Saliva Samples From a Controlled Human Infection Model Open
Following recent reports of norovirus replication in salivary gland cells, we examined whether the prototype norovirus strain, Norwalk virus (GI.1), could be detected in the saliva of 21 experimentally infected persons. Viral RNA was not d…
View article: 777. COMBINED OESOPHAGEAL AND AIRWAY STENTING FOR MALIGNANT OESOPHAGEAL STRICTURES: THE UK’S LARGEST TERTIARY CENTRE EXPERIENCE AND DEVELOPMENT OF A NOVEL ALGORITHM
777. COMBINED OESOPHAGEAL AND AIRWAY STENTING FOR MALIGNANT OESOPHAGEAL STRICTURES: THE UK’S LARGEST TERTIARY CENTRE EXPERIENCE AND DEVELOPMENT OF A NOVEL ALGORITHM Open
Background Malignant oesophageal strictures can cause airway compromise and fistula formation. Combined oesophageal and airway stenting is a potential treatment yet no guidelines exist. This study aims to describe the outcomes of same-sess…
View article: Randomized, Double-Blind, Placebo-Controlled Study of Anti-Mycobacterial Therapy (RHB-104) in Active Crohn’s Disease
Randomized, Double-Blind, Placebo-Controlled Study of Anti-Mycobacterial Therapy (RHB-104) in Active Crohn’s Disease Open
This study, conducted between 4 October 2013, and 30 November 2018, tested the hypothesis that triple antimicrobial therapy, targeting Mycobacterium avium subspecies paratuberculosis (MAP), long considered a putative cause, would favorably…
View article: Self‐Correcting Method for Highly Effective Office‐Based <i>Helicobacter pylori</i> Therapy Using Cumulative Test of Cure Data
Self‐Correcting Method for Highly Effective Office‐Based <i>Helicobacter pylori</i> Therapy Using Cumulative Test of Cure Data Open
Background and Aim Helicobacter pylori infections have become resistant to many previously highly effective antimicrobial regimens resulting in clarithromycin, metronidazole, or fluoroquinolone‐containing therapies becoming unsuccessful. P…
View article: Social Workers’ Perceptions of the Nature of Child Neglect: A Systematic Literature Review
Social Workers’ Perceptions of the Nature of Child Neglect: A Systematic Literature Review Open
Neglect is the most common form of child maltreatment in the UK and the USA. This article reviews research about how child neglect is perceived by social workers. We conducted a systematic review and identified fifty relevant studies, usin…
View article: Impact of Artificial Intelligence on Advertising: A Bibliometric Analysis
Impact of Artificial Intelligence on Advertising: A Bibliometric Analysis Open
This paper presents a bibliometric analysis examining the impact of Artificial Intelligence (AI) on advertising. Using data from the Web of Science Core Collection spanning 2014 to 2024, the study investigates citation patterns, prolific a…
View article: Typological and cumulative approaches to risk and adversity in Child and Adolescent Mental Health Services (CAMHS): retrospective cohort analysis in South London
Typological and cumulative approaches to risk and adversity in Child and Adolescent Mental Health Services (CAMHS): retrospective cohort analysis in South London Open
Background: Childhood adversity is robustly associated with mental ill-health. Yet questions remain about how different conceptualisations of adversity relate to psychiatric diagnoses and service activity. This research aims to examine ass…
View article: Risk rates and profiles at intake in child and adolescent mental health services: A cohort and latent class analyses of 21,688 young people in South London
Risk rates and profiles at intake in child and adolescent mental health services: A cohort and latent class analyses of 21,688 young people in South London Open
Background Children and young people (CYP) seen by child and adolescent mental health services (CAMHS) often experience safeguarding issues. Yet little is known about the volume and nature of these risks, including how different adversitie…
View article: Mental Health Needs of Children and Young People in England, 2016-2021: An Epidemiological Study, and Comparison of Young People Who Have Received Protective and Care Interventions and Their Peers
Mental Health Needs of Children and Young People in England, 2016-2021: An Epidemiological Study, and Comparison of Young People Who Have Received Protective and Care Interventions and Their Peers Open
Aims: In England, around 18% of children and young people (CYP) experience clinical levels of mental health difficulties. CYP who receive protective (child protection plans; CPP) and care interventions (children looked after; CLA) may be p…
View article: Best Practices for <i>Helicobacter pylori</i> Management.
Best Practices for <i>Helicobacter pylori</i> Management. Open
For decades, antimicrobial therapy for Helicobacter pylori infection has been given empirically, and the results of therapy (success or failure) have either not been confirmed or when confirmed have not been used to modify prescribi…
View article: RE.GA.IN.: the Real-world Gastritis Initiative–updating the updates
RE.GA.IN.: the Real-world Gastritis Initiative–updating the updates Open
At the end of the last century, a far-sighted ‘working party’ held in Sydney, Australia addressed the clinicopathological issues related to gastric inflammatory diseases. A few years later, an international conference held in Houston, Texa…
View article: Crises in Antimicrobial Stewardship: Misuse of Clarithromycin for Helicobacter pylori Therapy
Crises in Antimicrobial Stewardship: Misuse of Clarithromycin for Helicobacter pylori Therapy Open
Helicobacter pylori is a class I carcinogen that infects more than 100 million individuals in the United States. Antimicrobial therapy for H. pylori has typically been prescribed empirically rather than based on susceptibility testing. Unt…
View article: Typological and Cumulative Approaches to Risk and Adversity in Child and Adolescent Mental Health Services (Camhs): Retrospective Cohort Analysis in South London
Typological and Cumulative Approaches to Risk and Adversity in Child and Adolescent Mental Health Services (Camhs): Retrospective Cohort Analysis in South London Open
View article: Management of Helicobacter pylori treatment failures: A large population-based study (HP treatment failures trial)
Management of Helicobacter pylori treatment failures: A large population-based study (HP treatment failures trial) Open
Background Helicobacter pylori treatment failure remains a challenging problem. This study aimed to identify predictive factors for successful eradication in patients following treatment failures. Methods This was a retrospective cohort st…
View article: Risk rates and profiles at intake in Child and Adolescent Mental Health Services (CAMHS): A cohort and latent class analyses of 21,688 young people in South London
Risk rates and profiles at intake in Child and Adolescent Mental Health Services (CAMHS): A cohort and latent class analyses of 21,688 young people in South London Open
Background Children and young people (CYP) seen by child and adolescent mental health services (CAMHS) often experience safeguarding issues. Yet little is known about the volume and nature of these risks, including how different adversitie…
View article: Toward Quantification of H pylori-associated Gastric Cancer Risk: Further Evidence Supporting Development of Population-based Strategies for H pylori Eradication
Toward Quantification of H pylori-associated Gastric Cancer Risk: Further Evidence Supporting Development of Population-based Strategies for H pylori Eradication Open
View article: Pilot studies of vonoprazan‐containing <i>Helicobacter pylori</i> eradication therapy suggest Thailand may be more similar to the <scp>US</scp> than Japan
Pilot studies of vonoprazan‐containing <i>Helicobacter pylori</i> eradication therapy suggest Thailand may be more similar to the <span>US</span> than Japan Open
Background Vonoprazan‐containing Helicobacter pylori eradication is reliably effective in Japan. Its effectiveness in other countries remains unclear. Here, we examined vonoprazan‐ H. pylori therapies in Thailand. Materials and Methods Thi…
View article: Controversies regarding management of Helicobacter pylori infections
Controversies regarding management of Helicobacter pylori infections Open
Purpose of review The recognition that Helicobacter pylori should be considered and treated as an infectious disease has yet to fundamentally change diagnostic and treatment practices and has resulted in many controversies. Recent findings…
View article: Effect of Norovirus Inoculum Dose on Virus Kinetics, Shedding, and Symptoms
Effect of Norovirus Inoculum Dose on Virus Kinetics, Shedding, and Symptoms Open
The effect of norovirus dose on outcomes such as virus shedding and symptoms after initial infection is not well understood. We performed a secondary analysis of a human challenge study by using Bayesian mixed-effects models. As the dose i…
View article: Intra- and Inter-host Evolution of Human Norovirus in Healthy Adults
Intra- and Inter-host Evolution of Human Norovirus in Healthy Adults Open
Background Human noroviruses are a leading cause of acute and sporadic gastroenteritis worldwide. The evolution of human noroviruses in immunocompromised persons has been evaluated in many studies. Much less is known about the evolutionary…
View article: <i>Helicobacter pylori</i>attachment-blocking antibodies protect against duodenal ulcer disease
<i>Helicobacter pylori</i>attachment-blocking antibodies protect against duodenal ulcer disease Open
SUMMARY The majority of the world population carry the gastric pathogen Helicobacter pylori . Fortunately, most individuals experience only low-grade or no symptoms, but in many cases the chronic inflammatory infection develops into severe…