David Granton
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View article: Corticosteroids for treating sepsis in children and adults
Corticosteroids for treating sepsis in children and adults Open
Moderate-certainty evidence indicates that corticosteroids probably reduce 28-day, 90-day and hospital mortality amongst patients with sepsis. Corticosteroids may shorten ICU and hospital length of stay (low-certainty evidence). There may …
View article: Nosocomial meningitis diagnostic test characteristics: a systematic review
Nosocomial meningitis diagnostic test characteristics: a systematic review Open
There were insufficient data to evaluate the diagnostic accuracy of lumbar puncture in nosocomial meningitis in patients without preceding neurosurgery or head trauma. Very low certainty evidence indicates the incidence of nosocomial menin…
View article: Sex and gender-based analysis and diversity metric reporting in acute care trials published in high-impact journals: a systematic review
Sex and gender-based analysis and diversity metric reporting in acute care trials published in high-impact journals: a systematic review Open
Objective To characterise sex and gender-based analysis (SGBA) and diversity metric reporting, representation of female/women participants in acute care trials and temporal changes in reporting before and after publication of the 2016 Sex …
View article: Efficacy and safety of corticosteroids in cardiac arrest: a systematic review, meta-analysis and trial sequential analysis of randomized control trials
Efficacy and safety of corticosteroids in cardiac arrest: a systematic review, meta-analysis and trial sequential analysis of randomized control trials Open
Background Post-cardiac arrest, outcomes for most patients are poor, regardless of setting. Many patients who do achieve spontaneous return of circulation require vasopressor therapy to maintain organ perfusion. There is some evidence to s…
View article: Efficacy and Safety of Corticosteroids in Cardiac Arrest: A Systematic Review, Meta- Analysis and Trial Sequential Analysis of Randomized Control Trials
Efficacy and Safety of Corticosteroids in Cardiac Arrest: A Systematic Review, Meta- Analysis and Trial Sequential Analysis of Randomized Control Trials Open
Background Post cardiac arrest, outcomes for most patients are poor, regardless of setting. Many patients who do achieve spontaneous return of circulation require vasopressor therapy to maintain organ perfusion. There is some evidence to s…
View article: Adherence of Clinical Practice Guidelines for Pharmacologic Treatments of Hospitalized Patients With COVID-19 to Trustworthy Standards
Adherence of Clinical Practice Guidelines for Pharmacologic Treatments of Hospitalized Patients With COVID-19 to Trustworthy Standards Open
PROSPERO Identifier: CRD42021245239.
View article: Risk of dispersion or aerosol generation and infection transmission with nasopharyngeal and oropharyngeal swabs for detection of COVID-19: a systematic review
Risk of dispersion or aerosol generation and infection transmission with nasopharyngeal and oropharyngeal swabs for detection of COVID-19: a systematic review Open
Objectives SARS-CoV-2-related disease, referred to as COVID-19, has emerged as a global pandemic since December 2019. While there is growing recognition regarding possible airborne transmission, particularly in the setting of aerosol-gener…
View article: High-Flow Nasal Cannula Compared With Conventional Oxygen Therapy or Noninvasive Ventilation Immediately Postextubation: A Systematic Review and Meta-Analysis
High-Flow Nasal Cannula Compared With Conventional Oxygen Therapy or Noninvasive Ventilation Immediately Postextubation: A Systematic Review and Meta-Analysis Open
Objectives: Reintubation after failed extubation is associated with increased mortality and longer hospital length of stay. Noninvasive oxygenation modalities may prevent reintubation. We conducted a systematic review and meta-analysis to …
View article: Moderate Certainty Evidence Suggests the Use of High-Flow Nasal Cannula Does Not Decrease Hypoxia When Compared With Conventional Oxygen Therapy in the Peri-Intubation Period: Results of a Systematic Review and Meta-Analysis
Moderate Certainty Evidence Suggests the Use of High-Flow Nasal Cannula Does Not Decrease Hypoxia When Compared With Conventional Oxygen Therapy in the Peri-Intubation Period: Results of a Systematic Review and Meta-Analysis Open
Objective: The role of high-flow nasal cannula during and before intubation is unclear despite a number of randomized clinical trials. Our objective was to conduct a systematic review and meta-analysis examining the benefits of high-flow n…
View article: Don't stop at the top: plasma volume expansion and pulmonary vasodilatation restore left ventricular function at rest but not during exercise at high altitude
Don't stop at the top: plasma volume expansion and pulmonary vasodilatation restore left ventricular function at rest but not during exercise at high altitude Open
At a given level of oxygen consumption, cardiac output is similar at high altitude compared to at sea level; however it is achieved with a greater heart rate and lesser stroke volume (SV), which is related to reduced left ventricular (LV) …