Felix D. Guerrero
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View article: A reverse vaccinology approach identified novel recombinant tick proteins with protective efficacy against Rhipicephalus microplus infestation
A reverse vaccinology approach identified novel recombinant tick proteins with protective efficacy against Rhipicephalus microplus infestation Open
The cattle tick, Rhipicephalus microplus, causes significant economic losses to the cattle industry. Tick control is predominately achieved via pesticide applications. However, alternative control methods such as vaccines are needed due to…
View article: Horn fly transcriptome data of ten populations from the southern United States with varying degrees and molecular mechanisms of pesticide resistance
Horn fly transcriptome data of ten populations from the southern United States with varying degrees and molecular mechanisms of pesticide resistance Open
Haematobia irritans irritans (Linnaeus, 1758: Diptera: Muscidae), the horn fly, is an external parasite of penned and pastured livestock that causes a major economic impact on cattle production worldwide. Pesticides such as synthetic pyret…
View article: Supplementary Data from BMP4 Induces M2 Macrophage Polarization and Favors Tumor Progression in Bladder Cancer
Supplementary Data from BMP4 Induces M2 Macrophage Polarization and Favors Tumor Progression in Bladder Cancer Open
Supplementary Table 1. Bladder Cancer cell lines. Supplementary Table 2. Primers and TaqMan probes used for qPCR. Supplementary Figure 1.Characterization of monocyte/macrophage polarization. Supplementary Figure 2. Resistance of BCCs to mo…
View article: Data from BMP4 Induces M2 Macrophage Polarization and Favors Tumor Progression in Bladder Cancer
Data from BMP4 Induces M2 Macrophage Polarization and Favors Tumor Progression in Bladder Cancer Open
Purpose: Bladder cancer is a current clinical and social problem. At diagnosis, most patients present with nonmuscle-invasive tumors, characterized by a high recurrence rate, which could progress to muscle-invasive disease and metastasis. …
View article: Data from BMP4 Induces M2 Macrophage Polarization and Favors Tumor Progression in Bladder Cancer
Data from BMP4 Induces M2 Macrophage Polarization and Favors Tumor Progression in Bladder Cancer Open
Purpose: Bladder cancer is a current clinical and social problem. At diagnosis, most patients present with nonmuscle-invasive tumors, characterized by a high recurrence rate, which could progress to muscle-invasive disease and metastasis. …
View article: Supplementary Data from BMP4 Induces M2 Macrophage Polarization and Favors Tumor Progression in Bladder Cancer
Supplementary Data from BMP4 Induces M2 Macrophage Polarization and Favors Tumor Progression in Bladder Cancer Open
Supplementary Table 1. Bladder Cancer cell lines. Supplementary Table 2. Primers and TaqMan probes used for qPCR. Supplementary Figure 1.Characterization of monocyte/macrophage polarization. Supplementary Figure 2. Resistance of BCCs to mo…
View article: Biochemical characterisation of Cytochrome P450 oxidoreductase from the cattle tick, Rhipicephalus microplus, highlights potential new acaricide target
Biochemical characterisation of Cytochrome P450 oxidoreductase from the cattle tick, Rhipicephalus microplus, highlights potential new acaricide target Open
Management of the cattle tick, Rhipicephalus microplus, presents a challenge because some populations of this cosmopolitan and economically important ectoparasite are resistant to multiple classes of acaricides. Cytochrome P450 oxidoreduct…
View article: The adult horn fly transcriptome and its complement of transcripts encoding cytochrome P450s, glutathione S-transferases, and esterases
The adult horn fly transcriptome and its complement of transcripts encoding cytochrome P450s, glutathione S-transferases, and esterases Open
The horn fly, Haematobia irritans, is a blood-feeding parasitic fly with a global distribution that includes Europe, Africa, Asia, and the Americas. The fly has a major detrimental economic impact upon cattle production, with losses estima…
View article: Rhipicephalus(Boophilus) microplus resistant to acaricides and ivermectin in cattle farms of Mexico
Rhipicephalus(Boophilus) microplus resistant to acaricides and ivermectin in cattle farms of Mexico Open
Ticks and the diseases they transmit cause great economic losses to livestock in tropical countries. Non-chemical control alternatives include the use of resistant cattle breeds, biological control and vaccines. However, the most widely us…
View article: Identification of anti-horn fly vaccine antigen candidates using a reverse vaccinology approach
Identification of anti-horn fly vaccine antigen candidates using a reverse vaccinology approach Open
Background The horn fly, Haematobia irritans irritans , causes significant production losses to the cattle industry. Horn fly control relies on insecticides; however, alternative control methods such as vaccines are needed due to the fly's…
View article: Raw pacific biosciences and illumina sequencing reads and assembled genome data for the cattle ticks Rhipicephalus microplus and Rhipicephalus annulatus
Raw pacific biosciences and illumina sequencing reads and assembled genome data for the cattle ticks Rhipicephalus microplus and Rhipicephalus annulatus Open
Ticks from the genus Rhipicephalus have enormous global economic impact as ectoparasites of cattle. Rhipicephalus microplus and Rhipicephalus annulatus are known to harbor infectious pathogens such as Babesia bovis, Babesia bigemina, and A…
View article: Additional file 6 of Identification of anti-horn fly vaccine antigen candidates using a reverse vaccinology approach
Additional file 6 of Identification of anti-horn fly vaccine antigen candidates using a reverse vaccinology approach Open
Additional file 6: Dataset S5. Results of the mass spectrometry analysis. The LC/MS data were searched against multiple custom databases, including the NCBI protein database (4837 horn fly sequences as of January 08, 2018) and the database…
View article: Additional file 2 of Identification of anti-horn fly vaccine antigen candidates using a reverse vaccinology approach
Additional file 2 of Identification of anti-horn fly vaccine antigen candidates using a reverse vaccinology approach Open
Additional file 2: Dataset S2. Horn fly longest ORFs translated with Virtual Ribosome.
View article: Additional file 4 of Identification of anti-horn fly vaccine antigen candidates using a reverse vaccinology approach
Additional file 4 of Identification of anti-horn fly vaccine antigen candidates using a reverse vaccinology approach Open
Additional file 4: Dataset S3. Vaxign, Vacceed, and Vaxign results for all ORFs analyzed with these tools, and Gene Ontology, InterPro, BLASTN and BLASTX annotations for the 100 ORFs with highest VaxiJen score.
View article: Immunogenic potential of Rhipicephalus (Boophilus) microplus aquaporin 1 against Rhipicephalus sanguineus in domestic dogs
Immunogenic potential of Rhipicephalus (Boophilus) microplus aquaporin 1 against Rhipicephalus sanguineus in domestic dogs Open
This study evaluated a recombinant aquaporin 1 protein of Rhipicephalus (Boophilus) microplus (RmAQP1) as antigen in a vaccine against R. sanguineus. Five dogs were immunized with RmAQP1 (10 µg) + adjuvant (Montanide) (G1), and five were i…
View article: Additional file 5 of Identification of anti-horn fly vaccine antigen candidates using a reverse vaccinology approach
Additional file 5 of Identification of anti-horn fly vaccine antigen candidates using a reverse vaccinology approach Open
Additional file 5: Dataset S4. Transcript and ORF sequences of the 10 vaccine candidate antigens selected for expression in Pichia pastoris, including their respective BLASTX, BLASTN, InterPro, GO and CDD annotations, and B cell and T cell…
View article: Additional file 1 of Identification of anti-horn fly vaccine antigen candidates using a reverse vaccinology approach
Additional file 1 of Identification of anti-horn fly vaccine antigen candidates using a reverse vaccinology approach Open
Additional file 1: Dataset S1. Horn fly contigs used in the in silico analysis.
View article: Sex Chromosome Evolution in Muscid Flies
Sex Chromosome Evolution in Muscid Flies Open
Sex chromosomes and sex determining genes can evolve fast, with the sex-linked chromosomes often differing between closely related species. Population genetics theory has been developed and tested to explain the rapid evolution of sex chro…
Small-Molecule Inhibitors of Inward Rectifier Potassium (Kir) Channels Reduce Bloodmeal Feeding and Have Insecticidal Activity Against the Horn Fly (Diptera: Muscidae) Open
Bloodmeal feeding by the horn fly, Haematobia irritans (L.), is associated with reduced milk production and blood loss that ultimately prevents weight gain of calves and yearlings. Thus, blood feeding by H. irritans causes significant econ…
View article: Sex chromosome evolution in muscid flies
Sex chromosome evolution in muscid flies Open
Sex chromosomes and sex determining genes can evolve fast, with the sex-linked chromosomes often differing between closely related species. A substantial body of population genetics theory has been developed and tested to explain the rapid…
View article: Prevalence of Ehrlichia canis (Rickettsiales: Ehrlichieae) DNA in Tissues From Rhipicephalus sanguineus (Acari: Ixodidae) Ticks in Areas Endemic for Canine Monocytic Ehrlichiosis in Brazil
Prevalence of Ehrlichia canis (Rickettsiales: Ehrlichieae) DNA in Tissues From Rhipicephalus sanguineus (Acari: Ixodidae) Ticks in Areas Endemic for Canine Monocytic Ehrlichiosis in Brazil Open
Canine monocytic ehrlichiosis (CME) is a disease caused by the obligate intracellular bacterium Ehrlichia canis. Tropical lineages of Rhipicephalus sanguineus ticks play an essential role in the transmission of this pathogen. The aim of th…
View article: Pyrethroid and organophosphate pesticide resistance in field populations of horn fly in Brazil
Pyrethroid and organophosphate pesticide resistance in field populations of horn fly in Brazil Open
Pesticides are used worldwide to control arthropod parasites in cattle herds. The indiscriminate and/or inappropriate use of pesticides without veterinary guidance is a reality in several countries of South America. Improper pesticide use …
View article: Molecular Characterization of the 2016 New World Screwworm (Diptera: Calliphoridae) Outbreak in the Florida Keys
Molecular Characterization of the 2016 New World Screwworm (Diptera: Calliphoridae) Outbreak in the Florida Keys Open
New World screwworm (NWS), Cochliomyia hominivorax (Coquerel 1858) (Diptera: Calliphoridae), is a myiasis-causing fly that can be a serious threat to the health of livestock, wildlife, and humans. Its progressive eradication from the south…
View article: A Whole Genome Assembly of the Horn Fly, <i>Haematobia irritans</i>, and Prediction of Genes with Roles in Metabolism and Sex Determination
A Whole Genome Assembly of the Horn Fly, <i>Haematobia irritans</i>, and Prediction of Genes with Roles in Metabolism and Sex Determination Open
Haematobia irritans, commonly known as the horn fly, is a globally distributed blood-feeding pest of cattle that is responsible for significant economic losses to cattle producers. Chemical insecticides are the primary means for controllin…