David Haslam
YOU?
Author Swipe
View article: Maternal antibiotic exposure-mediated alterations in basal, and allergen-induced lung function are associated with altered recruitment of eosinophils to the developing lung
Maternal antibiotic exposure-mediated alterations in basal, and allergen-induced lung function are associated with altered recruitment of eosinophils to the developing lung Open
Introduction Early-life dysbiosis is associated with increased risk of asthma development but the underlying mechanisms remain unclear. Although eosinophils have been reported in the developing lung, their contributions to alveolar morphog…
View article: Evaluating the Risk of Postoperative Infection and Complications in Lumbar Spine Surgery Patients with Preoperative Methicillin-resistant Staphylococcus aureus (MRSA) Colonization
Evaluating the Risk of Postoperative Infection and Complications in Lumbar Spine Surgery Patients with Preoperative Methicillin-resistant Staphylococcus aureus (MRSA) Colonization Open
Introduction Preoperative methicillin-resistant Staphylococcus aureus (MRSA) colonization is a known risk factor for surgical site infections (SSIs) in orthopaedic procedures. However, its impact on a comprehensive range of postoperative c…
View article: Acute pancreatitis gut dysbiosis persists at 1‐year follow‐up and is associated with clinical outcomes
Acute pancreatitis gut dysbiosis persists at 1‐year follow‐up and is associated with clinical outcomes Open
Objectives Pediatric acute pancreatitis (AP) is associated with gut dysbiosis. We aimed to determine if dysbiosis persisted during follow‐up and whether it is associated with clinical outcomes. Methods Prospective enrollment of participant…
View article: Skin Staphylococcus aureus detection and relationship to atopic dermatitis outcomes using culture and metagenomic sequencing
Skin Staphylococcus aureus detection and relationship to atopic dermatitis outcomes using culture and metagenomic sequencing Open
Staphylococcus aureus (SA) skin colonization in pediatric atopic dermatitis (AD) increases risk for severe AD and development of other allergic diseases. Despite this, there is no consensus regarding the optimal method to detect SA. Studie…
View article: Vancomycin dosing in neonates: enhancing outcomes using population pharmacokinetics and simulation
Vancomycin dosing in neonates: enhancing outcomes using population pharmacokinetics and simulation Open
Introduction Optimizing vancomycin dosing in neonates is a critical yet complex goal. Traditional trough concentration-based dosing strategies correlate poorly with therapeutic efficacy and often fail to account for the significant renal f…
View article: Microbial metabolite drives ageing-related clonal haematopoiesis via ALPK1
Microbial metabolite drives ageing-related clonal haematopoiesis via ALPK1 Open
Clonal haematopoiesis of indeterminate potential (CHIP) involves the gradual expansion of mutant pre-leukaemic haematopoietic cells, which increases with age and confers a risk for multiple diseases, including leukaemia and immune-related …
View article: SARS-CoV-2 neutralizing antibody specificities differ dramatically between recently infected infants and immune-imprinted individuals
SARS-CoV-2 neutralizing antibody specificities differ dramatically between recently infected infants and immune-imprinted individuals Open
The immune response to viral infection is shaped by past exposures to related virus strains, a phenomenon known as imprinting. For severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), much of the population has been imprinted by a…
View article: P-1133. Preferred (Spoken) Language was a Major Correlate of Disparate Antibiotic Prescribing in the Pediatric Outpatient Setting Throughout the COVID-19 Pandemic
P-1133. Preferred (Spoken) Language was a Major Correlate of Disparate Antibiotic Prescribing in the Pediatric Outpatient Setting Throughout the COVID-19 Pandemic Open
Background No studies have explored sociodemographic variation in antibiotic prescribing across phases of the COVID-19 pandemic. We explored relationships between race, language, socioeconomic measures, and outpatient antibiotic prescribin…
View article: SARS-CoV-2 neutralizing antibody specificities differ dramatically between recently infected infants and immune-imprinted individuals
SARS-CoV-2 neutralizing antibody specificities differ dramatically between recently infected infants and immune-imprinted individuals Open
The immune response to viral infection is shaped by past exposures to related virus strains, a phenomenon known as imprinting. For SARS-CoV-2, much of the population has been imprinted by a viral spike from an early strain, either through …
View article: Thermoneutral Housing Enables Studies of Vertical Transmission of Obesogenic Diet-Driven Metabolic Diseases
Thermoneutral Housing Enables Studies of Vertical Transmission of Obesogenic Diet-Driven Metabolic Diseases Open
Vertical transmission of obesity is a critical contributor to the unabated obesity pandemic and the associated surge in metabolic diseases. Existing experimental models insufficiently recapitulate “human-like” obesity phenotypes, limiting …
View article: 1453. Whole Genome Sequencing: A Useful Tool in a VRE Outbreak Among Immunocompromised Pediatric Patients
1453. Whole Genome Sequencing: A Useful Tool in a VRE Outbreak Among Immunocompromised Pediatric Patients Open
Background Vancomycin-resistant enterococcus (VRE) colonization and infection is an increasing threat in pediatric oncology and bone marrow transplant (BMT) patients. We identified a cluster of 13 hospitalized patients who acquired VRE (E.…
View article: Obesity Alters cytokine signaling and gut microbiome in septic mice
Obesity Alters cytokine signaling and gut microbiome in septic mice Open
Sepsis is a leading cause of mortality. Plasma cytokine levels may identify those at increased risk of mortality from sepsis. Our aim was to understand how obesity alters cytokine levels during early sepsis and its correlation with surviva…
View article: The microbiome in adolescents with irritable bowel syndrome and changes with percutaneous electrical nerve field stimulation
The microbiome in adolescents with irritable bowel syndrome and changes with percutaneous electrical nerve field stimulation Open
Background Irritable bowel syndrome (IBS), a disorder of the gut–brain axis, is affected by the microbiome. Microbial studies in pediatric IBS, especially for centrally mediated treatments, are lacking. We compared the microbiome between p…
View article: Intestinal permeability in patients undergoing stem cell transplantation correlates with systemic acute phase responses and dysbiosis
Intestinal permeability in patients undergoing stem cell transplantation correlates with systemic acute phase responses and dysbiosis Open
Intestinal permeability may correlate with adverse outcomes during hematopoietic stem cell transplantation (HSCT), but longitudinal quantification with traditional oral mannitol and lactulose is not feasible in HSCT recipients because of m…
View article: IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation
IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation Open
Intestinal epithelial cells (IECs) constitute a critical first line of defense against microbes. While IECs are known to respond to various microbial signals, the precise upstream cues regulating diverse IEC responses are not clear. Here, …
View article: Analysis of the fecal metagenome in long‐term survivors of pancreas cancer
Analysis of the fecal metagenome in long‐term survivors of pancreas cancer Open
Background The 5‐year overall survival of pancreas adenocarcinoma (PCa) remains less than 10%. Clinical and tumor genomic characteristics have not differentiated PCa long‐term survivors (LTSs) from unselected patients. Preclinical studies …
View article: Systems biological assessment of the temporal dynamics of immunity to a viral infection in the first weeks and months of life
Systems biological assessment of the temporal dynamics of immunity to a viral infection in the first weeks and months of life Open
The dynamics of innate and adaptive immunity to infection in infants remain obscure. Here, we used a multi-omics approach to perform a longitudinal analysis of immunity to SARS-CoV-2 infection in infants and young children in the first wee…
View article: Gut Microbiome Composition and Metabolic Capacity Differ by FUT2 Secretor Status in Exclusively Breastfed Infants
Gut Microbiome Composition and Metabolic Capacity Differ by FUT2 Secretor Status in Exclusively Breastfed Infants Open
A major polymorphism in the fucosyltransferase2 (FUT2) gene influences risk of multiple gut diseases, but its impact on the microbiome of breastfed infants was unknown. In individuals with an active FUT2 enzyme (“secretors”), the intestina…
View article: Delayed Microbial Maturation Durably Exacerbates Th17-driven Asthma in Mice
Delayed Microbial Maturation Durably Exacerbates Th17-driven Asthma in Mice Open
Microbial maturation disrupted by early-life dysbiosis has been linked with increased asthma risk and severity; however, the immunological mechanisms underpinning this connection are poorly understood. We sought to understand how delaying …
View article: Intestinal epithelial HDAC3 and MHC class II coordinate microbiota-specific immunity
Intestinal epithelial HDAC3 and MHC class II coordinate microbiota-specific immunity Open
Aberrant immune responses to resident microbes promote inflammatory bowel disease and other chronic inflammatory conditions. However, how microbiota-specific immunity is controlled in mucosal tissues remains poorly understood. Here, we fou…
View article: Additional file 1 of MGS2AMR: a gene-centric mining of metagenomic sequencing data for pathogens and their antimicrobial resistance profile
Additional file 1 of MGS2AMR: a gene-centric mining of metagenomic sequencing data for pathogens and their antimicrobial resistance profile Open
Additional file 1: Fig. S1. Resolving shortest paths with loops in GFA. Green segment is the start and end of the loop. 1. Loop that begins and ends on the different sides of the start-segment. Resolved by generating two paths (A,B,C,D) an…