David M. Hunt
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View article: Mycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids
Mycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids Open
Tuberculosis (TB) is the biggest cause of death from infectious disease worldwide. The causative agent, Mycobacterium tuberculosis (Mtb), possesses a complex cell envelope comprised of multiple classes of unique lipids. The macrophage phag…
View article: Upregulation versus loss of function of NTRK2 in 44 affected individuals leads to 2 distinct neurodevelopmental disorders
Upregulation versus loss of function of NTRK2 in 44 affected individuals leads to 2 distinct neurodevelopmental disorders Open
View article: Mycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids
Mycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids Open
Tuberculosis (TB) is the biggest cause of death from infectious disease worldwide. The causative agent, Mycobacterium tuberculosis (Mtb), possesses a complex cell envelope that determines many of the key physiologic and virulence propertie…
View article: Activation of L-histidine biosynthesis as a new antibiotic strategy against Mycobacterium tuberculosis
Activation of L-histidine biosynthesis as a new antibiotic strategy against Mycobacterium tuberculosis Open
The increasing prevalence of antimicrobial resistance is an important challenge that warrants new approaches to antibiotic development. Currently, all antibiotics inhibit biological processes. To explore whether activation of a biochemical…
View article: Divergent downstream biosynthetic pathways are supported by L-cysteine synthases of Mycobacterium tuberculosis
Divergent downstream biosynthetic pathways are supported by L-cysteine synthases of Mycobacterium tuberculosis Open
Mycobacterium tuberculosis ’s ( Mtb ) autarkic lifestyle within the host involves rewiring its transcriptional networks to combat host-induced stresses. With the help of RNA sequencing performed under various stress conditions, we identifi…
View article: Author response: Divergent downstream biosynthetic pathways are supported by L-cysteine synthases of Mycobacterium tuberculosis
Author response: Divergent downstream biosynthetic pathways are supported by L-cysteine synthases of Mycobacterium tuberculosis Open
View article: Divergent downstream biosynthetic pathways are supported by L-cysteine synthases of Mycobacterium tuberculosis
Divergent downstream biosynthetic pathways are supported by L-cysteine synthases of Mycobacterium tuberculosis Open
Mycobacterium tuberculosis ’s ( Mtb ) autarkic lifestyle within the host involves rewiring its transcriptional networks to combat host-induced stresses. With the help of RNA sequencing performed under various stress conditions, we identifi…
View article: The origins of the full-field flash electroretinogram b-wave
The origins of the full-field flash electroretinogram b-wave Open
The electroretinogram (ERG) measures the electrical activity of retinal neurons and glial cells in response to a light stimulus. Amongst other techniques, clinicians utilize the ERG to diagnose various eye diseases, including inherited con…
View article: An empirical comparison of the Extended Parallel Process Model with the Terror Management Health Model
An empirical comparison of the Extended Parallel Process Model with the Terror Management Health Model Open
The Extended Parallel Process Model posits that fear-appeal messages are processed only when message recipients perceive a critical level of threat. The more recent Terror Management Health Model suggests that, in addition to level of perc…
View article: Molecular, Cellular and Functional Changes in the Retinas of Young Adult Mice Lacking the Voltage-Gated K+ Channel Subunits Kv8.2 and K2.1
Molecular, Cellular and Functional Changes in the Retinas of Young Adult Mice Lacking the Voltage-Gated K+ Channel Subunits Kv8.2 and K2.1 Open
Cone Dystrophy with Supernormal Rod Response (CDSRR) is a rare autosomal recessive disorder leading to severe visual impairment in humans, but little is known about its unique pathophysiology. We have previously shown that CDSRR is caused …
View article: Validating Fluorescent Chrnb4.EGFP Mouse Models for the Study of Cone Photoreceptor Degeneration
Validating Fluorescent Chrnb4.EGFP Mouse Models for the Study of Cone Photoreceptor Degeneration Open
This work validates research tools that could potentially offer more reliable preclinical data in the development of treatments for cone-mediated vision loss conditions, shortening the gap to clinical translation.
View article: Comparative transcriptome analysis of cone photoreceptors from inherited retinal degeneration mouse models using single cell RNA-seq
Comparative transcriptome analysis of cone photoreceptors from inherited retinal degeneration mouse models using single cell RNA-seq Open
Purpose : Cone photoreceptors (PR) play a critical role in vision as they are responsible for acuity and colour vision. Their dysfunction is behind vision loss in different types of inherited retinal degeneration (IRD). A complete understa…
View article: Spectral Diversification and Trans-Species Allelic Polymorphism during the Land-to-Sea Transition in Snakes
Spectral Diversification and Trans-Species Allelic Polymorphism during the Land-to-Sea Transition in Snakes Open
View article: Visual Opsin Diversity in Sharks and Rays
Visual Opsin Diversity in Sharks and Rays Open
The diversity of color vision systems found in extant vertebrates suggests that different evolutionary selection pressures have driven specializations in photoreceptor complement and visual pigment spectral tuning appropriate for an animal…
View article: An essential bifunctional enzyme in <i>Mycobacterium tuberculosis</i> for itaconate dissimilation and leucine catabolism
An essential bifunctional enzyme in <i>Mycobacterium tuberculosis</i> for itaconate dissimilation and leucine catabolism Open
Mycobacterium tuberculosis (Mtb) is the etiological agent of tuberculosis. One-fourth of the global population is estimated to be infected with Mtb, accounting for ∼1.3 million deaths in 2017. As part of the immune response to Mtb infectio…
View article: Pathophysiology of voltage-gated potassium channels in a mouse model of cone-rod dystrophy
Pathophysiology of voltage-gated potassium channels in a mouse model of cone-rod dystrophy Open
View article: Phototactic tails: Evolution and molecular basis of a novel sensory trait in sea snakes
Phototactic tails: Evolution and molecular basis of a novel sensory trait in sea snakes Open
Dermal phototaxis has been reported in a few aquatic vertebrate lineages spanning fish, amphibians and reptiles. These taxa respond to light on the skin of their elongate hind‐bodies and tails by withdrawing under cover to avoid detection …
View article: Evolution of the eyes of vipers with and without infrared-sensing pit organs
Evolution of the eyes of vipers with and without infrared-sensing pit organs Open
We examined lens and brille transmittance, photoreceptors, visual pigments, and visual opsin gene sequences of viperid snakes with and without infrared-sensing pit organs. Ocular media transmittance was high in both groups. Contrary to pre…
View article: Flexible nitrogen utilisation by the metabolic generalist pathogen Mycobacterium tuberculosis
Flexible nitrogen utilisation by the metabolic generalist pathogen Mycobacterium tuberculosis Open
Bacterial metabolism is fundamental to survival and pathogenesis. We explore how Mycobacterium tuberculosis utilises amino acids as nitrogen sources, using a combination of bacterial physiology and stable isotope tracing coupled to mass sp…
View article: Flexible nitrogen utilisation by the metabolic generalist pathogen Mycobacterium tuberculosis
Flexible nitrogen utilisation by the metabolic generalist pathogen Mycobacterium tuberculosis Open
Data on uptake and metabolism of all 20 amino acids by Mycobacterium tuberculosis H37Rv (20 amino acids uptake.zip), shown in Figure 2. Data on kinetics of labelling on 15N-Asp (15N Asp.zip), shown in Figure 4g and h. Data on kinetics of l…
View article: Flexible nitrogen utilisation by the metabolic generalist pathogen Mycobacterium tuberculosis
Flexible nitrogen utilisation by the metabolic generalist pathogen Mycobacterium tuberculosis Open
Data on uptake and metabolism of all 20 amino acids by Mycobacterium tuberculosis H37Rv (20 amino acids uptake.zip), shown in Figure 2. Data on kinetics of labelling on 15N-Asp (15N Asp.zip), shown in Figure 4g and h. Data on kinetics of l…
View article: Author response: Flexible nitrogen utilisation by the metabolic generalist pathogen Mycobacterium tuberculosis
Author response: Flexible nitrogen utilisation by the metabolic generalist pathogen Mycobacterium tuberculosis Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Bacterial metabolism is funda…
View article: Differential stability of variant <i>OPN1LW</i> gene transcripts in myopic patients.
Differential stability of variant <i>OPN1LW</i> gene transcripts in myopic patients. Open
None of the variants identified in myopic individuals appeared to alter the efficiency of transcript splicing. However, two resulted in a significant reduction in the number of spliced and unspliced transcripts, indicating an overall reduc…
View article: The Role of the Voltage-Gated Potassium Channel Proteins Kv8.2 and Kv2.1 in Vision and Retinal Disease: Insights from the Study of Mouse Gene Knock-Out Mutations
The Role of the Voltage-Gated Potassium Channel Proteins Kv8.2 and Kv2.1 in Vision and Retinal Disease: Insights from the Study of Mouse Gene Knock-Out Mutations Open
Mutations in the KCNV2 gene, which encodes the voltage-gated K + channel protein Kv8.2, cause a distinctive form of cone dystrophy with a supernormal rod response (CDSRR). Kv8.2 channel subunits only form functional channels when combined …
View article: Evolution of the calcium feedback steps of vertebrate phototransduction
Evolution of the calcium feedback steps of vertebrate phototransduction Open
We examined the genes encoding the proteins that mediate the Ca-feedback regulatory system in vertebrate rod and cone phototransduction. These proteins comprise four families: recoverin/visinin, the guanylyl cyclase activating proteins (GC…
View article: Nitrogen utilisation by the metabolic generalist pathogen <i>Mycobacterium tuberculosis</i>
Nitrogen utilisation by the metabolic generalist pathogen <i>Mycobacterium tuberculosis</i> Open
Bacterial metabolism is fundamental to pathogenesis and has a dominant effect on bacterial killing by antibiotics. Here we explore how Mycobacterium tuberculosis utilises amino acids as nitrogen sources, using a combination of bacterial ph…
View article: Validation and comparison of Achromatopsia mouse lines expressing a fluorescent marker in cone photoreceptors
Validation and comparison of Achromatopsia mouse lines expressing a fluorescent marker in cone photoreceptors Open
View article: Role of the voltage-gated potassium channel subunit Kv8.2 in inherited retinal disease and interaction with other channel proteins
Role of the voltage-gated potassium channel subunit Kv8.2 in inherited retinal disease and interaction with other channel proteins Open
View article: Missing Affiliation
Missing Affiliation Open
Elisabeth Castellanos, PhD; Adrià Plana, MD; Cristina Carrato, MD, PhD; Meritxell Carrió, PhD; Inma Rosas, LT; Emilio Amilibia, MD; Francesc Roca-Ribas, MD, PhD; Cristina Hostalot, MD; Alicia Castillo, BN; Andrea Ros, BS; Ariadna Quer, MD;…
View article: Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-&#945;
Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α Open
The main aim of this protocol is to describe the development and validation of an interferon (IFN)-α single molecule array digital Enzyme-Linked ImmunoSorbent Assay (ELISA) assay. This system enables the quantification of human IFN-α prote…