David J. Hunter
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View article: Organoids and organs-on-chips for accelerating R&D and clinical translation in Orthopaedics: Emerging opportunities and regulatory pathways
Organoids and organs-on-chips for accelerating R&D and clinical translation in Orthopaedics: Emerging opportunities and regulatory pathways Open
View article: Reducing the burden of osteoarthritis in Australia: A 2024–2025 research priority-setting study
Reducing the burden of osteoarthritis in Australia: A 2024–2025 research priority-setting study Open
View article: Genetic diversity fuels gene discovery for tobacco and alcohol use
Genetic diversity fuels gene discovery for tobacco and alcohol use Open
View article: Healthy aging in midlife and menopausal transition in Asia: nutrient synergy with dietary supplements
Healthy aging in midlife and menopausal transition in Asia: nutrient synergy with dietary supplements Open
Women in early midlife often experience specific health issues due to aging and the menopausal transition. Hormonal changes, systemic chronic inflammation and micronutrient deficiencies contribute to symptoms such as vasomotor disturbances…
View article: Proteomic signatures of smoking and their associations with risk of incident diseases and mortality in diverse populations
Proteomic signatures of smoking and their associations with risk of incident diseases and mortality in diverse populations Open
Smoking is the most important behavioural determinant of morbidity and mortality. Here we used a machine learning model to assess plasma levels of 2,917 proteins in the UK Biobank (n=43,914) and generated a proteomic Smoking INdex (pSIN). …
View article: Retatrutide for the treatment of obesity, obstructive sleep apnea and knee osteoarthritis: Rationale and design of the <scp>TRIUMPH</scp> registrational clinical trials
Retatrutide for the treatment of obesity, obstructive sleep apnea and knee osteoarthritis: Rationale and design of the <span>TRIUMPH</span> registrational clinical trials Open
Aims Retatrutide, a novel synthetic molecule, is a triple agonist activating the glucose‐dependent insulinotropic polypeptide, glucagon‐like peptide‐1 and glucagon receptors. The TRIUMPH clinical development program evaluates its safety an…
View article: Do rates of femorotibial cartilage loss in Kellgren-Lawrence 2 and 3 knees differ between those with mild-moderate vs. severe patellofemoral structural damage? – Data from the FNIH and IMI-APPROACH cohorts
Do rates of femorotibial cartilage loss in Kellgren-Lawrence 2 and 3 knees differ between those with mild-moderate vs. severe patellofemoral structural damage? – Data from the FNIH and IMI-APPROACH cohorts Open
Screening for PF cartilage damage and BMLs does not appear to be required in a disease-modifying OA drug trial.
View article: Biochemical biomarkers of knee osteoarthritis progression: Results from the FNIH biomarkers consortium progress OA study
Biochemical biomarkers of knee osteoarthritis progression: Results from the FNIH biomarkers consortium progress OA study Open
View article: Associations between metabolic heterogeneity of obesity and osteoarthritis: A prospective cohort study
Associations between metabolic heterogeneity of obesity and osteoarthritis: A prospective cohort study Open
Background Previous studies have shown that obesity accelerates the development of osteoarthritis (OA). However, obesity is metabolically heterogeneous. The association between metabolic heterogeneity of obesity and incident OA remains unc…
View article: Magnetic Resonance Imaging Biomarkers of Knee Osteoarthritis Progression
Magnetic Resonance Imaging Biomarkers of Knee Osteoarthritis Progression Open
Objective The Foundation for the National Institutes of Health (FNIH) OA Biomarkers Consortium aims to identify, develop, and qualify biomarkers to support drug development in knee osteoarthritis (OA). The project's second phase, the PROGR…
View article: Predicting knee osteoarthritis progression using neural network with longitudinal MRI radiomics, and biochemical biomarkers: A modeling study
Predicting knee osteoarthritis progression using neural network with longitudinal MRI radiomics, and biochemical biomarkers: A modeling study Open
Background Knee osteoarthritis (KOA) worsens both structurally and symptomatically, yet no model predicts KOA progression using Magnetic Resonance Image (MRI) radiomics and biomarkers. This study aimed to develop and test the longitudinal …
View article: Exploring individuals’ perspectives on participating in a feasibility trial assessing a combined program of education plus exercise versus general advice for ankle osteoarthritis
Exploring individuals’ perspectives on participating in a feasibility trial assessing a combined program of education plus exercise versus general advice for ankle osteoarthritis Open
Participants in a feasibility study comparing general advice and education plus exercise had a positive experience with the trial processes, research team, physiotherapists and exercise program. However, perspectives on general advice and …
View article: Cartilage loss is greater in knees with virtual joint replacement status than in matched controls without
Cartilage loss is greater in knees with virtual joint replacement status than in matched controls without Open
Substantially greater cartilage thickness loss was detected in knees reaching vKR case status defined by patient-reported clinical criteria vs. vKR controls. This was found independently of whether this status was maintained at a later ann…
View article: Comparison between coronal FLASH and sagittal double echo steady state MRI in detecting longitudinal cartilage thickness change by fully automated segmentation – Data from the FNIH biomarker cohort
Comparison between coronal FLASH and sagittal double echo steady state MRI in detecting longitudinal cartilage thickness change by fully automated segmentation – Data from the FNIH biomarker cohort Open
Clinicaltrials.gov identification: NCT00080171.
View article: Global and Regional Temporal Changes in Cross‐Country Inequalities of Site‐Specific Osteoarthritis Burden, 1990 to 2021
Global and Regional Temporal Changes in Cross‐Country Inequalities of Site‐Specific Osteoarthritis Burden, 1990 to 2021 Open
Objective This study examined the global and regional temporal changes in cross‐country inequalities of site‐specific osteoarthritis (OA) burden from 1990 to 2021. Methods Age‐standardized years lived with disability rates (ASYRs) for site…
View article: The Hidden Toll: Demographic Changes in Suicide Attempts During the Coronavirus Disease-19 Era
The Hidden Toll: Demographic Changes in Suicide Attempts During the Coronavirus Disease-19 Era Open
The pandemic was associated with a similar rate of suicide attempts among trauma patients but has led to a shift in demographics. Specifically, increased suicide attempts among Blacks, Hispanics, young adults, and those with mental health …
View article: The Influence of Regional Landmarks on Sex Differences in Spatial Navigation: The Moderating Role of Sense of Direction
The Influence of Regional Landmarks on Sex Differences in Spatial Navigation: The Moderating Role of Sense of Direction Open
View article: Protocol for the comparison of remote versus face-to-face osteoarthritis management programs (COASTAL): A randomized implementation trial
Protocol for the comparison of remote versus face-to-face osteoarthritis management programs (COASTAL): A randomized implementation trial Open
View article: Association between body weight fluctuation and progression of radiographic knee osteoarthritis: a longitudinal cohort study
Association between body weight fluctuation and progression of radiographic knee osteoarthritis: a longitudinal cohort study Open
Objectives To investigate the relationship between body weight fluctuation and the progression of knee pain and joint space loss (JSL) in people with radiographic knee osteoarthritis (RKOA) during a 48-month follow-up period. Design We con…
View article: Intra-articular injections for knee osteoarthritis management: Analysis of cost-effectiveness
Intra-articular injections for knee osteoarthritis management: Analysis of cost-effectiveness Open
CS could offer good value for knee OA management if the impact on OA progression is small. Value of PRP depends greatly on its price, with current prices leading to value exceeding well - accepted cost-effectiveness thresh…
View article: OP0227 ASSESSMENT OF DIFFERENTIAL TREATMENT EFFECT BETWEEN PREDICTED ENDOTYPE SUBGROUPS OF KNEE OSTEOARTHRITIS IN THE MIV-711, UBX0101, AND ORAL SALMON CALCITONIN TRIALS
OP0227 ASSESSMENT OF DIFFERENTIAL TREATMENT EFFECT BETWEEN PREDICTED ENDOTYPE SUBGROUPS OF KNEE OSTEOARTHRITIS IN THE MIV-711, UBX0101, AND ORAL SALMON CALCITONIN TRIALS Open
View article: Elucidating the initial symptoms and experiences of knee osteoarthritis: An international patient survey
Elucidating the initial symptoms and experiences of knee osteoarthritis: An international patient survey Open
Individuals with knee OA recalled varied knee symptoms within the first year and few sought healthcare. We were unable to ascertain, from the perspective of patients, specific clinical features that indicated they had OA and not another co…
View article: Predictors of Discharge Home Versus Inpatient Rehabilitation Following Total Hip and Knee Arthroplasty—Cohort Study
Predictors of Discharge Home Versus Inpatient Rehabilitation Following Total Hip and Knee Arthroplasty—Cohort Study Open
Background This study aims to identify the prevalence of inpatient rehabilitation (IPR) use in an Australian private total joint arthroplasty (TJA) cohort and to identify factors predictive of IPR discharge, including components of the Ris…
View article: Moderators and Mediators of Pain and Function Outcomes in a New Service Delivery Model for Management of Knee Osteoarthritis in Primary Care: Secondary Exploratory Analysis of a Randomized Controlled Trial
Moderators and Mediators of Pain and Function Outcomes in a New Service Delivery Model for Management of Knee Osteoarthritis in Primary Care: Secondary Exploratory Analysis of a Randomized Controlled Trial Open
Objective Our objective was to explore moderators and mediators influenced changes in pain and function in people with knee osteoarthritis (OA) receiving a new model of primary care service delivery (Optimizing Primary Care Management of K…
View article: A cross-sectional analysis of the reliability, content and readability of orthodontic retention and retainer informed consent forms
A cross-sectional analysis of the reliability, content and readability of orthodontic retention and retainer informed consent forms Open
The reliability and quality of the informed consent forms concerning orthodontic retention and retainers was generally poor. The readability of the forms failed to meet recommended guidelines, meaning that many are likely not to comprehend…
View article: Comparison of weight loss interventions in overweight and obese adults with knee osteoarthritis: A systematic review and network meta-analysis of randomized trials
Comparison of weight loss interventions in overweight and obese adults with knee osteoarthritis: A systematic review and network meta-analysis of randomized trials Open
View article: Exploring Predictors of Brace-Wearing Adherence in Non-Surgical Treatment of Acute Knee Medial Collateral Ligament Injuries
Exploring Predictors of Brace-Wearing Adherence in Non-Surgical Treatment of Acute Knee Medial Collateral Ligament Injuries Open
Objectives: (1) To estimate adherence to brace wearing for medial collateral ligament (MCL) injuries across 3 phases of conventional treatment and (2) to explore predictors of adherence for each phase. Design: Exploratory cohort study. Set…
View article: Associations of metabolic status with all-cause mortality among individuals with osteoarthritis: A prospective cohort study
Associations of metabolic status with all-cause mortality among individuals with osteoarthritis: A prospective cohort study Open
View article: Metformin treatment for patients with hand osteoarthritis: protocol for the multicentre, randomised, placebo-controlled METRO trial
Metformin treatment for patients with hand osteoarthritis: protocol for the multicentre, randomised, placebo-controlled METRO trial Open
Introduction Hand osteoarthritis (OA) is a prevalent joint disorder with limited treatment options. Accumulating evidence suggests that the antidiabetic drug metformin has beneficial effects on knee OA and may likewise be beneficial for ha…
View article: Integrating the environmental and genetic architectures of aging and mortality
Integrating the environmental and genetic architectures of aging and mortality Open
Both environmental exposures and genetics are known to play important roles in shaping human aging. Here we aimed to quantify the relative contributions of environment (referred to as the exposome) and genetics to aging and premature morta…