David Hurlbut
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View article: Application of Foundation Models for Colorectal Cancer Tissue Classification in Mass Spectrometry Imaging
Application of Foundation Models for Colorectal Cancer Tissue Classification in Mass Spectrometry Imaging Open
Colorectal cancer (CRC) remains a leading global health challenge, with early and accurate diagnosis crucial for effective treatment. Histopathological evaluation, the current diagnostic gold standard, faces limitations including subjectiv…
View article: Downregulation of the Unfolded Protein Response Links Metformin Treatment to Good Clinical Outcomes in Colorectal Cancer Patients
Downregulation of the Unfolded Protein Response Links Metformin Treatment to Good Clinical Outcomes in Colorectal Cancer Patients Open
Type 2 diabetes is a risk factor for colorectal cancer (CRC) development and progression. However, metformin-treated diabetic CRC patients tend to have better clinical outcomes than those managed by other means. To better characterize the …
View article: MassVis <i>ion</i>: An open-source end-to-end platform for AI-driven mass spectrometry image analysis
MassVis <i>ion</i>: An open-source end-to-end platform for AI-driven mass spectrometry image analysis Open
Mass spectrometry imaging (MSI) combines spatial and spectral data to reveal detailed molecular compositions within biological samples. Despite their immense potential, MSI workflows are hindered by the complexity and high dimensionality o…
View article: Planning and Development Pathways to Interregional Transmission
Planning and Development Pathways to Interregional Transmission Open
This report was prepared in connection with the National Transmission Planning (NTP) Study, which the U.S. Department of Energy’s (DOE’s) Grid Deployment Office led in partnership with National Renewable Energy Laboratory (NREL) and Pacifi…
View article: Solar Energy Zone Market Analysis for the Afton Region of New Mexico
Solar Energy Zone Market Analysis for the Afton Region of New Mexico Open
This report examines the commercial viability of the Afton solar energy zone (SEZ) in southern New Mexico based on market conditions in 2022. The Bureau of Land Management may designate a SEZ on federal land to expedite environmental revie…
View article: Quantifying the Level of Cross-State Renewable Energy Transactions
Quantifying the Level of Cross-State Renewable Energy Transactions Open
This analysis provides first-ever assessment of the extent to which renewable energy is crossing state borders to be used to meet renewable portfolio standard (RPS) requirements. Two primary methods for data collection are Renewable Energy…
View article: Interregional Renewable Energy Zones
Interregional Renewable Energy Zones Open
A growing number of studies suggest that fundamental changes in the nation’s power sector have major implications for transmission planning (FERC 2022). The changing landscape suggests, among other things, the need for a concerted reexamin…
View article: A314 UNDIFFERENTIATED PANCREATIC CARCINOMA WITH OSTEOCLAST-LIKE GIANT CELLS: A CASE REPORT
A314 UNDIFFERENTIATED PANCREATIC CARCINOMA WITH OSTEOCLAST-LIKE GIANT CELLS: A CASE REPORT Open
Background Pancreatic undifferentiated carcinoma with osteoclast-like giant cells (UCOGC) is a rare form of pancreatic cancer representing under 1% of cases. UCOGC is hypothesized to be a variant of pancreatic adenocarcinoma and while the …
View article: Evolving acidic microenvironments during colitis provide selective analgesic targets for a pH-sensitive opioid
Evolving acidic microenvironments during colitis provide selective analgesic targets for a pH-sensitive opioid Open
Targeting the acidified inflammatory microenvironment with pH-sensitive opioids is a novel approach for managing visceral pain while mitigating side effects. The analgesic efficacy of pH-dependent opioids has not been studied during the ev…
View article: Metabolically Active Zones Involving Fatty Acid Elongation Delineated by DESI-MSI Correlate with Pathological and Prognostic Features of Colorectal Cancer
Metabolically Active Zones Involving Fatty Acid Elongation Delineated by DESI-MSI Correlate with Pathological and Prognostic Features of Colorectal Cancer Open
Colorectal cancer (CRC) is the second leading cause of cancer deaths. Despite recent advances, five-year survival rates remain largely unchanged. Desorption electrospray ionization mass spectrometry imaging (DESI) is an emerging nondestruc…
View article: The Impacts on California of Expanded Regional Cooperation to Operate the Western Grid (Final Report)
The Impacts on California of Expanded Regional Cooperation to Operate the Western Grid (Final Report) Open
Policy makers in California and other western states are exploring options for greater regional cooperation in managing the western power grid to better achieve public policy goals. This report, requested by the California State Assembly a…
View article: Interregional Renewable Energy Zones in National Transmission Analysis
Interregional Renewable Energy Zones in National Transmission Analysis Open
This report describes the interregional renewable energy zone (IREZ) methodology for national application in the United States. The aim is to develop a data-driven, replicable methodology for use in long-term regional and interregional tra…
View article: Solar Energy Zone Market Analysis for the San Luis Valley Region of Colorado
Solar Energy Zone Market Analysis for the San Luis Valley Region of Colorado Open
This report examines the commercial viability of solar energy zones (SEZs) in the San Luis Valley of Colorado ("the Valley") based on market conditions in 2022. The Bureau of Land Management (BLM) may designate a SEZ on federal land to exp…
View article: Integrating Hydrogen Production and Electricity Markets: Analytical Insights from California
Integrating Hydrogen Production and Electricity Markets: Analytical Insights from California Open
This report compares the cost of different pathways for producing hydrogen in California. In addition to capturing the current cost of electrolyzers and other equipment, the pathways apply current retail electricity tariff options offered …
View article: Long-term follow-up of liver-directed, adeno-associated vector-mediated gene therapy in the canine model of hemophilia A
Long-term follow-up of liver-directed, adeno-associated vector-mediated gene therapy in the canine model of hemophilia A Open
Questions remain concerning the long-term efficacy, safety, and site(s) of transgene expression following adeno-associated vector (AAV) therapy. We report a long-term follow-up of 8 (male = 4, hemizygous, and female = 4, homozygous) dogs w…
View article: Mexico Clean Energy Report
Mexico Clean Energy Report Open
This report provides an assessment of Mexico's clean energy resource potential and pathways for rapidly deploying renewable energy technologies to enable Mexico to reach its goal of 35% renewable energy by 2024 within the current legal and…
View article: Surgical practice patterns and outcomes in T2 and T3 gallbladder cancer: a population-based study
Surgical practice patterns and outcomes in T2 and T3 gallbladder cancer: a population-based study Open
Extended resection improved overall survival in T2 disease regardless of nodal status but appeared most beneficial in node-negative T3 disease. The finding that extended resection was offered only to a small proportion of eligible patients…
View article: Interregional Renewable Energy Zones
Interregional Renewable Energy Zones Open
Interregional Renewable Energy Zones (IREZs) are a component of the National Transmission Planning Study (NTPS), which analyzes strategies for building out transmission infrastructure to support decarbonizing the electricity sector by 2035…
View article: A Primer on FERC Order No. 2222: Insights for International Power Systems
A Primer on FERC Order No. 2222: Insights for International Power Systems Open
The U.S. Federal Energy Regulatory Commission (FERC) Order No. 2222 is heralded as a landmark rule on distributed energy resources (DER). Issued in September 2020, it is specifically designed for organized wholesale power markets. The rule…
View article: Clean Grid Vision: A U.S. Perspective - Chapter 5. Global Power Market Trends
Clean Grid Vision: A U.S. Perspective - Chapter 5. Global Power Market Trends Open
The evolution of the electricity sector toward competitive modern markets is occurring over a long period and responding to rapid changes in technologies, business models, and other market factors. No reformed power market anywhere in the …
View article: Clean Grid Vision: A U.S. Perspective - Executive Summary
Clean Grid Vision: A U.S. Perspective - Executive Summary Open
Clean Grid Vision: A U.S. Perspective aims to present a range of possible pathways for future grid development and call attention to some common trends. It focuses on the lessons learned through NREL’s studies of the U.S. power sector that…
View article: Physiological responses during ascent to high altitude and the incidence of acute mountain sickness
Physiological responses during ascent to high altitude and the incidence of acute mountain sickness Open
Acute mountain sickness (AMS) occurs when there is failure of acclimatisation to high altitude. The aim of this study was to describe the relationship between physiological variables and the incidence of AMS during ascent to 5300 m. A tota…
View article: A135 ASSESSING THE HISTOLOGICAL QUALITY OF ENDOSCOPIC BIOPSY SAMPLES OBTAINED USING NOVEL MULTIBITE FORCEPS FROM A PORCINE GASTRIC SPECIMEN
A135 ASSESSING THE HISTOLOGICAL QUALITY OF ENDOSCOPIC BIOPSY SAMPLES OBTAINED USING NOVEL MULTIBITE FORCEPS FROM A PORCINE GASTRIC SPECIMEN Open
Background Tissue sampling is often limited to acquisition of one to two biopsy samples during a single pass. The ability to obtain more than two biopsies during a single pass can improve diagnostic yield however is potentially limited by …
View article: Ready for Renewables: Grid Planning and Competitive Renewable Energy Zones (CREZ) in the Philippines
Ready for Renewables: Grid Planning and Competitive Renewable Energy Zones (CREZ) in the Philippines Open
The Department of Energy of the Philippines launched the competitive renewable energy zones (CREZ) process to help achieve the country's goals of scaling up renewable energy generation on the power system and to ensure sustainable, secure,…
View article: Cross-Border Electricity Trading and Renewable Energy Zones
Cross-Border Electricity Trading and Renewable Energy Zones Open
India's national renewable energy zones for wind power and solar photovoltaics (PV) could become regional green power resources if South Asian countries liberalize their rules for cross-border energy trading (CBET). Similarly, Nepal's weal…
View article: Simulation of Cross-Border Renewable Energy Trading in South Asia [Slides]
Simulation of Cross-Border Renewable Energy Trading in South Asia [Slides] Open
India's national renewable energy zones for wind power and solar photovoltaics (PV) could become regional green power resources if South Asian countries liberalize their rules for cross-border energy trading (CBET). Similarly, Nepal's weal…